| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K E Bowenkamp, P A Lapchak, B J Hoffer, P J Miller, P C Bickfor. Intracerebroventricular glial cell line-derived neurotrophic factor improves motor function and supports nigrostriatal dopamine neurons in bilaterally 6-hydroxydopamine lesioned rats. Experimental neurology. vol 145. issue 1. 1997-06-27. PMID:9184114. |
in order to evaluate the efficacy of glial cell line-derived neurotrophic factor (gdnf) in a model of advanced parkinson's disease, we studied rats with extensive bilateral lesions of the nigrostriatal pathway. |
1997-06-27 |
2023-08-12 |
rat |
| K Krieglstein, D Maysinger, K Unsicke. The survival response of mesencephalic dopaminergic neurons to the neurotrophins BDNF and NT-4 requires priming with serum: comparison with members of the TGF-beta superfamily and characterization of the serum-free culture system. Journal of neural transmission. Supplementum. vol 47. 1997-06-11. PMID:8841970. |
transforming growth factor-beta 3 (tgf-beta 3) and glial cell line-derived neurotrophic factor (gdnf), two members of the tgf-beta superfamily, both promoted the survival of th-positive cells (tgf-beta 3: 2-fold; gdnf: 1.6-fold) over the 8-day culture period. |
1997-06-11 |
2023-08-12 |
rat |
| Y Iwasaki, T Shiojima, N Tagaya, T Kobayashi, M Kinoshit. Effect of transforming growth factor beta 1 on spinal motor neurons after axotomy. Journal of the neurological sciences. vol 147. issue 1. 1997-06-11. PMID:9094054. |
glial cell line-derived neurotrophic factor (gdnf), a member of the transforming growth factor beta (tgf-beta) family, has potent effects on developing motor neurons. |
1997-06-11 |
2023-08-12 |
rat |
| Y Wang, S Z Lin, A L Chiou, L R Williams, B J Hoffe. Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151750. |
glial cell line-derived neurotrophic factor (gdnf), a recently described and cloned member of the transforming growth factor (tgf)-beta superfamily, has been shown to have marked trophic activity on several populations of central neurons. |
1997-06-10 |
2023-08-12 |
Not clear |
| M Trupp, N Belluardo, H Funakoshi, C F Ibáñe. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133379. |
complementary and overlapping expression of glial cell line-derived neurotrophic factor (gdnf), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat cns. |
1997-06-02 |
2023-08-12 |
rat |
| M Trupp, N Belluardo, H Funakoshi, C F Ibáñe. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 10. 1997-06-02. PMID:9133379. |
glial cell line-derived neurotrophic factor (gdnf), the most potent trophic factor yet described for both dopaminergic neurons of the substantia nigra and spinal motorneurons, has recently been shown to signal through a multireceptor complex composed of a novel glycosylphosphatidylinositol-anchored gdnf receptor-alpha (gdnfr-alpha) and the receptor tyrosine kinase product of the c-ret proto-oncogene (ret). |
1997-06-02 |
2023-08-12 |
rat |
| V Gattei, A Celetti, A Cerrato, M Degan, A De Iuliis, F M Rossi, G Chiappetta, C Consales, S Improta, V Zagonel, D Aldinucci, V Agosti, M Santoro, G Vecchio, A Pinto, M Griec. Expression of the RET receptor tyrosine kinase and GDNFR-alpha in normal and leukemic human hematopoietic cells and stromal cells of the bone marrow microenvironment. Blood. vol 89. issue 8. 1997-05-19. PMID:9108413. |
the ret proto-oncogene product is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the glial cell line-derived neurotrophic factor (gdnf), in which a novel glycosyl-phosphatidylinositol (pi)-linked protein (termed gdnfr-alpha) acts as the ligand-binding component. |
1997-05-19 |
2023-08-12 |
human |
| P A Lapchak, S Jiao, F Collins, P J Mille. Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection. Brain research. vol 747. issue 1. 1997-05-14. PMID:9042532. |
glial cell line-derived neurotrophic factor (gdnf) has been shown to increase dopaminergic parameters in vitro and in vivo and can reduce parkinsonian behaviors in animal models of the disease. |
1997-05-14 |
2023-08-12 |
rat |
| S Hunot, V Bernard, B Faucheux, F Boissière, E Leguern, C Brana, P P Gautris, J Guérin, B Bloch, Y Agid, E C Hirsc. Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: a post mortem in situ hybridization study with special reference to Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 8-9. 1997-05-12. PMID:9013392. |
glial cell line-derived neurotrophic factor (gdnf) gene expression in the human brain: a post mortem in situ hybridization study with special reference to parkinson's disease. |
1997-05-12 |
2023-08-12 |
human |
| S Hunot, V Bernard, B Faucheux, F Boissière, E Leguern, C Brana, P P Gautris, J Guérin, B Bloch, Y Agid, E C Hirsc. Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: a post mortem in situ hybridization study with special reference to Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 8-9. 1997-05-12. PMID:9013392. |
glial cell line-derived neurotrophic factor (gdnf) is a potent neurotrophic factor for dopaminergic neurons. |
1997-05-12 |
2023-08-12 |
human |
| K J Bär, P Facer, N S Williams, P K Tam, P Anan. Glial-derived neurotrophic factor in human adult and fetal intestine and in Hirschsprung's disease. Gastroenterology. vol 112. issue 4. 1997-05-01. PMID:9098026. |
glial cell line-derived neurotrophic factor (gdnf) signals through the product of the ret proto-oncogene, which is known to be mutated in hirschsprung's disease and other conditions with gut dysmotility. |
1997-05-01 |
2023-08-12 |
human |
| P Suvanto, J O Hiltunen, U Arumäe, M Moshnyakov, H Sariola, K Sainio, M Saarm. Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. The European journal of neuroscience. vol 8. issue 4. 1997-04-03. PMID:9081633. |
localization of glial cell line-derived neurotrophic factor (gdnf) mrna in embryonic rat by in situ hybridization. |
1997-04-03 |
2023-08-12 |
rat |
| P Suvanto, J O Hiltunen, U Arumäe, M Moshnyakov, H Sariola, K Sainio, M Saarm. Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. The European journal of neuroscience. vol 8. issue 4. 1997-04-03. PMID:9081633. |
the localization of glial cell line-derived neurotrophic factor (gdnf) mrna was studied by in situ hybridization in rat from embryonic (e) day e10 to e15. |
1997-04-03 |
2023-08-12 |
rat |
| S Jiao, P J Miller, P A Lapcha. Enhanced delivery of [125I]glial cell line-derived neurotrophic factor to the rat CNS following osmotic blood-brain barrier modification. Neuroscience letters. vol 220. issue 3. 1997-04-02. PMID:8994224. |
subsequent to osmotic (mannitol-induced) blood-brain barrier (bbb) opening, [125i]glial cell line-derived neurotrophic factor (gdnf) was detected throughout the ventricular system, associated with the ependymal cell layer and extracellular matrix and to some extent penetrated into the cerebral cortex, subcortical gray matter, substantia nigra, septum, eye and optic nerve at 1 and 24 h following an intracarotid administration. |
1997-04-02 |
2023-08-12 |
rat |
| P Naveilhan, I Neveu, D Wion, P Brache. 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport. vol 7. issue 13. 1997-03-28. PMID:8930983. |
glial cell line-derived neurotrophic factor (gdnf) has significant therapeutic potentials, in particular for neurodegenerative disorders. |
1997-03-28 |
2023-08-12 |
Not clear |
| C R Matheson, J Carnahan, J L Urich, D Bocangel, T J Zhang, Q Ya. Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins. Journal of neurobiology. vol 32. issue 1. 1997-03-26. PMID:8989660. |
glial cell line-derived neurotrophic factor (gdnf) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins. |
1997-03-26 |
2023-08-12 |
rat |
| C R Matheson, J Carnahan, J L Urich, D Bocangel, T J Zhang, Q Ya. Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins. Journal of neurobiology. vol 32. issue 1. 1997-03-26. PMID:8989660. |
we compared the effects of glial cell line-derived neurotrophic factor (gdnf) on dorsal root ganglion (drg) sensory neurons to that of nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin 3 (nt-3). |
1997-03-26 |
2023-08-12 |
rat |
| A C Granholm, N Srivastava, J L Mott, S Henry, M Henry, H Westphal, J G Pichel, L Shen, B J Hoffe. Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994069. |
morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (gdnf): immunohistochemical studies. |
1997-03-17 |
2023-08-12 |
mouse |
| A C Granholm, N Srivastava, J L Mott, S Henry, M Henry, H Westphal, J G Pichel, L Shen, B J Hoffe. Morphological alterations in the peripheral and central nervous systems of mice lacking glial cell line-derived neurotrophic factor (GDNF): immunohistochemical studies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994069. |
glial cell line-derived neurotrophic factor (gdnf) is a member of the tgf-beta superfamily of growth factors with neurotrophic activity on midbrain dopaminergic neurons and on developing and mature motoneurons of the brainstem and spinal cord. |
1997-03-17 |
2023-08-12 |
mouse |
| E Pérez-Navarro, E Arenas, J Reiriz, N Calvo, J Alberc. Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage. Neuroscience. vol 75. issue 2. 1997-03-14. PMID:8931001. |
the neostriatum is one of the areas with relatively high levels of glial cell line-derived neurotrophic factor (gdnf) messenger rna expression in the developing and adult brain. |
1997-03-14 |
2023-08-12 |
rat |