| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nick Di Girolam. Stem cells of the human cornea. British medical bulletin. vol 100. 2012-03-15. PMID:21680602. |
blindness affects 50 million individuals worldwide; a significant proportion of them require a cell or tissue-based repair or replacement strategy to mend their damaged or diseased cornea. |
2012-03-15 |
2023-08-12 |
human |
| H S Wong, K Y Then, R Raml. Osteo-odonto-keratoprosthesis for end-stage cornea blindness. The Medical journal of Malaysia. vol 66. issue 4. 2012-02-28. PMID:22299563. |
osteo-odonto-keratoprosthesis for end-stage cornea blindness. |
2012-02-28 |
2023-08-12 |
Not clear |
| Rajiv R Mohan, Jonathan C K Tovey, Ajay Sharma, Ashish Tando. Gene therapy in the cornea: 2005--present. Progress in retinal and eye research. vol 31. issue 1. 2012-02-17. PMID:21967960. |
identification of next generation viral and nanoparticle vectors, characterization of delivered gene levels, localization, and duration in the cornea, and significant success in controlling corneal disorders, particularly fibrosis and angiogenesis, in experimental animal disease models, with no major side effects have propelled gene therapy a step closer toward establishing gene-based therapies for corneal blindness. |
2012-02-17 |
2023-08-12 |
human |
| Kathryn P Burdon, Stuart Macgregor, Yelena Bykhovskaya, Sharhbanou Javadiyan, Xiaohui Li, Kate J Laurie, Dorota Muszynska, Richard Lindsay, Judith Lechner, Talin Haritunians, Anjali K Henders, Durga Dash, David Siscovick, Seema Anand, Anthony Aldave, Douglas J Coster, Loretta Szczotka-Flynn, Richard A Mills, Sudha K Iyengar, Kent D Taylor, Tony Phillips, Grant W Montgomery, Jerome I Rotter, Alex W Hewitt, Shiwani Sharma, Yaron S Rabinowitz, Colin Willoughby, Jamie E Crai. Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus. Investigative ophthalmology & visual science. vol 52. issue 11. 2012-01-18. PMID:22003120. |
keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. |
2012-01-18 |
2023-08-12 |
Not clear |
| Haleh Bakhshandeh, Masoud Soleimani, Saied Shah Hosseini, Hassan Hashemi, Iman Shabani, Abbas Shafiee, Amir Houshang Behesht Nejad, Mohammad Erfan, Rassoul Dinarvand, Fatemeh Atyab. Poly (epsilon-caprolactone) nanofibrous ring surrounding a polyvinyl alcohol hydrogel for the development of a biocompatible two-part artificial cornea. International journal of nanomedicine. vol 6. 2011-12-07. PMID:21845040. |
the study aimed to fabricate and characterize a 2-part artificial cornea as a substitute for penetrating keratoplasty in patients with corneal blindness. |
2011-12-07 |
2023-08-12 |
human |
| Douglas J Lansk. Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. Handbook of clinical neurology. vol 95. 2010-12-16. PMID:19892132. |
vitamin a: in 1913, ishihara proposed that a "fatty substance" in blood is necessary for synthesis of both rhodopsin and the surface layer of the cornea, and that night blindness and keratomalacia develop when this substance is deficient. |
2010-12-16 |
2023-08-12 |
rat |
| Ming-Chang Zhan. [Strategies to resolve the problem of lack of keratoplasty materials in China]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 43. issue 4. 2010-10-05. PMID:17605921. |
lack of donors' cornea for keratoplasty remains the major obstacle for the treatment of blindness due to corneal diseases in china. |
2010-10-05 |
2023-08-12 |
Not clear |
| Ming-Chang Zhan. [Strategies to resolve the problem of lack of keratoplasty materials in China]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. vol 43. issue 4. 2010-10-05. PMID:17605921. |
in addition, more attention should be paid on the selection of suitable surgery approaches and indications of keratoplasty, the improvement of peri-operation management, to utilize any possible way to improve the cornea diseases-induced blindness patients' sight, to improve the successful rate of transplantation as well as to reduce the waste of corneal grafts. |
2010-10-05 |
2023-08-12 |
Not clear |
| Mary Ann Stepp, William P Daley, Audrey M Bernstein, Sonali Pal-Ghosh, Gauri Tadvalkar, Alexey Shashurin, Sarah Palsen, Rosalyn A Jurjus, Melinda Larse. Syndecan-1 regulates cell migration and fibronectin fibril assembly. Experimental cell research. vol 316. issue 14. 2010-08-06. PMID:20580707. |
corneal scarring is a major cause of blindness worldwide and can result from the deposition of abnormal amounts of collagen fibers lacking the correct size and spacing required to produce a clear cornea. |
2010-08-06 |
2023-08-12 |
Not clear |
| Yeshegeta Gelaw, Fentie Amba. Socio-demographic correlates of attitude towards corneal donation among health science students and academic staff of Jimma University. Ethiopian medical journal. vol 48. issue 1. 2010-07-29. PMID:20607997. |
diseases affecting the cornea are a major cause of blindness worldwide, and affect mainly the young and those of middle age resulting in blindness during the normally productive years and beyond cornea transplants can cure corneal blindness; however, the number of corneas available in ethiopia is small. |
2010-07-29 |
2023-08-12 |
Not clear |
| Todd R Wuest, Daniel J J Car. VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis. The Journal of experimental medicine. vol 207. issue 1. 2010-02-17. PMID:20026662. |
herpes simplex virus 1 (hsv-1) infection of the cornea is a leading cause of blindness and depends on aberrant host immune responses to antigen within the normally immunologically privileged cornea. |
2010-02-17 |
2023-08-12 |
mouse |
| J S Batista, A F Oliveira, C M F Rodrigues, C A R Damasceno, I R S Oliveira, H M Alves, E S Paiva, P D Brito, J M F Medeiros, A C Rodrigues, M M G Teixeir. Infection by Trypanosoma vivax in goats and sheep in the Brazilian semiarid region: from acute disease outbreak to chronic cryptic infection. Veterinary parasitology. vol 165. issue 1-2. 2010-02-03. PMID:19665308. |
infected animals, approximately 25% in both surveys, manifested apathy, pale mucous membranes, enlarged lymph nodes, weakness, weight loss, opacity of the cornea, blindness and abortion. |
2010-02-03 |
2023-08-12 |
Not clear |
| C T Ntim-Amponsah, W M K Amoak. Causes of childhood visual impairment and unmet low-vision care in blind school students in Ghana. International ophthalmology. vol 28. issue 5. 2008-11-25. PMID:17898940. |
pathology of the cornea and then the lens were the commonest causes of blindness. |
2008-11-25 |
2023-08-12 |
Not clear |
| Almogit Abu, Moshe Frydman, Dina Marek, Eran Pras, Uri Nir, Haike Reznik-Wolf, Elon Pra. Deleterious mutations in the Zinc-Finger 469 gene cause brittle cornea syndrome. American journal of human genetics. vol 82. issue 5. 2008-07-16. PMID:18452888. |
brittle cornea syndrome (bcs) is an autosomal-recessive disorder characterized by a thin cornea that tends to perforate, causing progressive visual loss and blindness. |
2008-07-16 |
2023-08-12 |
Not clear |
| Heathcote R Wright, Angus Turner, Hugh R Taylo. Trachoma. Lancet (London, England). vol 371. issue 9628. 2008-06-24. PMID:18539226. |
trichiasis develops when scarring distorts the upper eyelid sufficiently to cause one or more lashes to abrade the cornea, scarring it in turn and causing blindness. |
2008-06-24 |
2023-08-12 |
Not clear |
| Shamila Khan, Nerida Cole, Emma B Hume, Linda Garthwaite, Timothy C R Conibear, David H Miles, Yulina Aliwaga, Mark B Krockenberger, Mark D P Willco. The role of CXC chemokine receptor 2 in Pseudomonas aeruginosa corneal infection. Journal of leukocyte biology. vol 81. issue 1. 2007-03-05. PMID:17028201. |
despite the use of antibiotics, the host inflammatory response continues to cause damage to the cornea, which may lead to blindness. |
2007-03-05 |
2023-08-12 |
mouse |
| J Lin, K M Nishiguchi, M Nakamura, T P Dryja, E L Berson, Y Miyak. Recessive mutations in the CYP4V2 gene in East Asian and Middle Eastern patients with Bietti crystalline corneoretinal dystrophy. Journal of medical genetics. vol 42. issue 6. 2006-05-02. PMID:15937078. |
bietti crystalline corneoretinal dystrophy (bcd) is an autosomal recessively inherited disorder characterised by tiny yellowish glittering retinal crystals, choroidal sclerosis, and crystals in the peripheral cornea, associated with progressive night blindness. |
2006-05-02 |
2023-08-12 |
Not clear |
| I Mazhdrakova, Z Demerdjiev. [Neovascularisation of the cornea]. Klinische Monatsblatter fur Augenheilkunde. vol 222. issue 8. 2006-01-11. PMID:16118742. |
the penetration of blood vessels in the cornea causes a reduction of transparency and as a result reduced vision or even blindness. |
2006-01-11 |
2023-08-12 |
Not clear |
| Alexander Kuhlmann, Kerstin Amann, Ursula Schlötzer-Schrehardt, Friedrich E Kruse, Claus Cursiefe. Endothelin-1 and ETA/ETB receptor protein and mRNA: expression in normal and vascularized human corneas. Cornea. vol 24. issue 7. 2005-12-05. PMID:16160501. |
neovascularization of the cornea causes blindness and increases the risk of immune rejections after keratoplasty. |
2005-12-05 |
2023-08-12 |
human |
| Emma B H Hume, Nerida Cole, Shamila Khan, Linda L Garthwaite, Yulina Aliwarga, Tracey L Schubert, Mark D P Willco. A Staphylococcus aureus mouse keratitis topical infection model: cytokine balance in different strains of mice. Immunology and cell biology. vol 83. issue 3. 2005-10-17. PMID:15877608. |
even with the use of antibiotic therapy, the host inflammatory response continues to damage the cornea, which may lead to blindness. |
2005-10-17 |
2023-08-12 |
mouse |