| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilene K Gipso. Age-related changes and diseases of the ocular surface and cornea. Investigative ophthalmology & visual science. vol 54. issue 14. 2014-02-18. PMID:24335068. |
another major age-related eye disease of the cornea that leads to vision impairment and potentially blindness if left untreated is fuchs' endothelial corneal dystrophy. |
2014-02-18 |
2023-08-12 |
Not clear |
| Zaidah A Rahman, Azian Harun, Habsah Hasan, Zeehaida Mohamed, Siti S Md Noor, Zakuan Z Deris, Nabilah Ismail, Asma S Hassan, Fadzhilah Ahmad, Azhany Yaaku. Ocular surface infections in northeastern state of malaysia: a 10-year review of bacterial isolates and antimicrobial susceptibility. Eye & contact lens. vol 39. issue 5. 2014-02-06. PMID:23982472. |
ocular surface infections that include infections of conjunctiva, adnexa, and cornea have the potential risk of causing blindness within a given population. |
2014-02-06 |
2023-08-12 |
Not clear |
| Marianne Rohrbach, Helen L Spencer, Louise F Porter, Emma M M Burkitt-Wright, Céline Bürer, Andreas Janecke, Madhura Bakshi, David Sillence, Hailah Al-Hussain, Matthias Baumgartner, Beat Steinmann, Graeme C M Black, Forbes D C Manson, Cecilia Giunt. ZNF469 frequently mutated in the brittle cornea syndrome (BCS) is a single exon gene possibly regulating the expression of several extracellular matrix components. Molecular genetics and metabolism. vol 109. issue 3. 2014-01-22. PMID:23680354. |
it is characterized by extreme thinning and fragility of the cornea that may rupture in the absence of significant trauma leading to blindness. |
2014-01-22 |
2023-08-12 |
Not clear |
| Vladimir Holan, Eliska Javorkova, Peter Trosa. The growth and delivery of mesenchymal and limbal stem cells using copolymer polyamide 6/12 nanofiber scaffolds. Methods in molecular biology (Clifton, N.J.). vol 1014. 2013-12-03. PMID:23690014. |
if the limbus where lsc reside is also damaged or nonfunctional, the cornea cannot heal properly and this defect leads to impaired vision that can result in blindness. |
2013-12-03 |
2023-08-12 |
mouse |
| R Khoramnia, G U Auffarth, C Mogler, S A Cordeiro, A F Scheuerl. [Severe bilateral keratomalacia]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. vol 110. issue 1. 2013-11-25. PMID:23329120. |
longer lasting and severe cases of vitamin a deficiency may be complicated by the occurrence of keratinizing metaplasia in the cornea and conjunctiva, xerosis, keratomalacia or blindness. |
2013-11-25 |
2023-08-12 |
Not clear |
| Rajiv R Mohan, Jason T Rodier, Ajay Sharm. Corneal gene therapy: basic science and translational perspective. The ocular surface. vol 11. issue 3. 2013-10-22. PMID:23838017. |
gene therapy is an emerging technology for corneal blindness due to the accessibility and immune-privileged nature of the cornea, ease of vector administration and visual monitoring, and ability to perform frequent noninvasive corneal assessment. |
2013-10-22 |
2023-08-12 |
Not clear |
| Xinyu Li, Qinbo Zhou, Jakub Hanus, Chastain Anderson, Hongmei Zhang, Michael Dellinger, Rolf Brekken, Shusheng Wan. Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model. Molecular pharmaceutics. vol 10. issue 1. 2013-09-19. PMID:23186311. |
neovascularization (nv) in the cornea is a major cause of vision impairment and corneal blindness. |
2013-09-19 |
2023-08-12 |
Not clear |
| Darlene Mille. Pharmacological treatment for infectious corneal ulcers. Expert opinion on pharmacotherapy. vol 14. issue 5. 2013-08-23. PMID:23441746. |
cornea ulceration and infectious keratitis are leading causes of corneal morbidity and blindness. |
2013-08-23 |
2023-08-12 |
Not clear |
| Tomoko Orita, Kazuhiro Kimura, Teruo Nishida, Koh-Hei Sonod. Cytokine and chemokine secretion induced by poly(I:C) through NF-κB and phosphoinositide 3-kinase signaling pathways in human corneal fibroblasts. Current eye research. vol 38. issue 1. 2013-06-04. PMID:22954322. |
viral infection of the cornea can result in inflammation and scarring and eventually lead to blindness. |
2013-06-04 |
2023-08-12 |
human |
| Afsun Sahin, Pedram Hamra. Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel? Ophthalmology and eye diseases. vol 4. 2013-05-08. PMID:23650455. |
recurrent infectious or immune keratitis cause structural damage to the cornea, scarring, and may lead to blindness. |
2013-05-08 |
2023-08-12 |
Not clear |
| Catherine E Oldenburg, Prajna Lalitha, Muthiah Srinivasan, Palanisamy Manikandan, M Jayahar Bharathi, Revathi Rajaraman, Meenakshi Ravindran, Jeena Mascarenhas, Natalie Nardone, Kathryn J Ray, David V Glidden, Nisha R Acharya, Thomas M Lietma. Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis. Investigative ophthalmology & visual science. vol 54. issue 2. 2013-04-24. PMID:23385795. |
bacterial keratitis is a sight-threatening infection of the cornea that is one of the leading causes of blindness globally. |
2013-04-24 |
2023-08-12 |
Not clear |
| Fang Duan, Jingyu Liao, Qiang Huang, Yuhong Nie, Kaili W. HSV-1 miR-H6 inhibits HSV-1 replication and IL-6 expression in human corneal epithelial cells in vitro. Clinical & developmental immunology. vol 2012. 2013-03-01. PMID:22550533. |
hsv-1 infection in the cornea could lead to blindness. |
2013-03-01 |
2023-08-12 |
human |
| Maria Andreasen, Søren B Nielsen, Kasper Runager, Gunna Christiansen, Niels Chr Nielsen, Jan J Enghild, Daniel E Otze. Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates. The Journal of biological chemistry. vol 287. issue 41. 2012-12-31. PMID:22893702. |
mutations in the transforming growth factor β-induced protein (tgfbip) are linked to the development of corneal dystrophies in which abnormal protein deposition in the cornea leads to a loss of corneal transparency and ultimately blindness. |
2012-12-31 |
2023-08-12 |
Not clear |
| Murugan Elavazhagan, Rajamani Lakshminarayanan, Lei Zhou, Lim Wei Ting, Louis Tong, Roger W Beuerman, Shyam S Chaurasia, Jodhbir S Meht. Expression, purification and characterization of fourth FAS1 domain of TGFβIp-associated corneal dystrophic mutants. Protein expression and purification. vol 84. issue 1. 2012-12-18. PMID:22575305. |
these mutations have been found to induce atypical aggregation and progressive accumulation of protein aggregates in the cornea that leads to loss of corneal transparency and hence blindness. |
2012-12-18 |
2023-08-12 |
Not clear |
| Anastasios John Kanellopoulo. The management of cornea blindness from severe corneal scarring, with the Athens Protocol (transepithelial topography-guided PRK therapeutic remodeling, combined with same-day, collagen cross-linking). Clinical ophthalmology (Auckland, N.Z.). vol 6. 2012-10-02. PMID:22347790. |
the management of cornea blindness from severe corneal scarring, with the athens protocol (transepithelial topography-guided prk therapeutic remodeling, combined with same-day, collagen cross-linking). |
2012-10-02 |
2023-08-12 |
Not clear |
| Anastasios John Kanellopoulo. The management of cornea blindness from severe corneal scarring, with the Athens Protocol (transepithelial topography-guided PRK therapeutic remodeling, combined with same-day, collagen cross-linking). Clinical ophthalmology (Auckland, N.Z.). vol 6. 2012-10-02. PMID:22347790. |
this protocol was used for the management of cornea blindness due to severe corneal scarring. |
2012-10-02 |
2023-08-12 |
Not clear |
| Abigail M Oelker, Mark W Grinstaf. Synthesis, characterization, and in vitro evaluation of a hydrogel-based corneal onlay. IEEE transactions on nanobioscience. vol 11. issue 1. 2012-07-17. PMID:21908258. |
blindness due to opacity of the cornea is treated by corneal transplantation with donor tissue. |
2012-07-17 |
2023-08-12 |
human |
| Sixto M Leal, Eric Pearlma. The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models. Cytokine. vol 58. issue 1. 2012-06-25. PMID:22280957. |
fungal infections of the cornea are an important cause of blindness and visual impairment worldwide, with contact lens wear being the main risk factor in the usa and other industrialized countries, and traumatic injury being the main risk factor in developing countries. |
2012-06-25 |
2023-08-12 |
mouse |
| Donald T H Tan, John K G Dart, Edward J Holland, Shigeru Kinoshit. Corneal transplantation. Lancet (London, England). vol 379. issue 9827. 2012-05-21. PMID:22559901. |
penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea, has been the dominant procedure for more than half a century, and successfully caters to most causes of corneal blindness. |
2012-05-21 |
2023-08-12 |
Not clear |
| Namrata Sharma, Ritika Sachdev, Jeewan S Titiyal, Radhika Tandon, Rasik B Vajpaye. Penetrating autokeratoplasty for unilateral corneal opacification. Eye & contact lens. vol 38. issue 2. 2012-04-18. PMID:22317847. |
the aim was to evaluate the efficacy of autokeratoplasty as an alternative to conventional allograft transplantation for the management of corneal blindness in patients with a healthy cornea in the fellow blind eye. |
2012-04-18 |
2023-08-12 |
Not clear |