| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Juárez, L I Tártara, A G Cid, J P Real, J M Bermúdez, V B Rajal, S D Palm. Acanthamoeba in the eye, can the parasite hide even more? Latest developments on the disease. Contact lens & anterior eye : the journal of the British Contact Lens Association. vol 41. issue 3. 2019-05-21. PMID:29273391. |
acanthamoeba keratitis (ak), a severe and painful eye infection, must be treated as soon as possible to prevent ulceration of the cornea, loss of visual acuity, and eventually blindness or enucleation. |
2019-05-21 |
2023-08-13 |
Not clear |
| Rachel E Riccio, Seo J Park, Richard Longnecker, Sarah J Kop. Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice. mSphere. vol 4. issue 2. 2019-05-20. PMID:30918059. |
herpes simplex virus 1 (hsv-1) causes chronic inflammatory disease in the cornea, an immune-privileged tissue, resulting in irreversible damage and blindness in affected individuals (a. rowe, a. st leger, s. jeon, d. k. dhaliwal, et al., prog retin eye res 32:88-101, 2013, https://doi.org/10.1016/j.preteyeres.2012.08.002). |
2019-05-20 |
2023-08-13 |
mouse |
| E R Abah, A F Mahmud-Ajeigbe, S Sharief, D Chinda, P Y Jiya, O Bob-Egb. Central Corneal Thickness and Intraocular Pressure of Adult Nigerians: An Assessment of Zaria Community. West African journal of medicine. vol 35. issue 3. 2019-05-17. PMID:30387087. |
glaucoma is the commonest cause of irreversible blindness globally and intraocular pressure is the only known risk factor that can be therapeutically manipulated to change the course of the disease.1 central corneal thickness (cct) is known to affect the accuracy of intraocular pressure (iop) measurements by applanation tonometry.2 a thicker cornea requires greater force to flatten and, conversely, a thinner cornea is more easily flattened. |
2019-05-17 |
2023-08-13 |
Not clear |
| Steffi Matthyssen, Bert Van den Bogerd, Sorcha Ní Dhubhghaill, Carina Koppen, Nadia Zakari. Corneal regeneration: A review of stromal replacements. Acta biomaterialia. vol 69. 2019-05-08. PMID:29374600. |
corneal blindness is traditionally treated by transplantation of a donor cornea, or in severe cases by implantation of an artificial cornea or keratoprosthesis. |
2019-05-08 |
2023-08-13 |
Not clear |
| Eleonora Maurizi, Davide Schiroli, Sarah D Atkinson, Laura Mairs, David G Courtney, Barry O'Hagan, Victoria E McGilligan, Alastair T Pagnamenta, Jenny C Taylor, Jesus J D Vasquez, Daniel E Illanes-Velarde, Dave Goldsmith, Pieter Gouws, Jonathan E Moore, M Andrew Nesbit, C B Tara Moor. A novel role for CRIM1 in the corneal response to UV and pterygium development. Experimental eye research. vol 179. 2019-04-15. PMID:30365943. |
pterygium is a pathological proliferative condition of the ocular surface, characterised by formation of a highly vascularised, fibrous tissue arising from the limbus that invades the central cornea leading to visual disturbance and, if untreated, blindness. |
2019-04-15 |
2023-08-13 |
Not clear |
| Susumu Hara, Motokazu Tsujikawa, Kazuichi Maruyama, Kohji Nishid. STAT3 signaling maintains homeostasis through a barrier function and cell survival in corneal endothelial cells. Experimental eye research. vol 179. 2019-04-15. PMID:30439348. |
the cornea protects the eye from inflammation, which is one of the leading causes of blindness. |
2019-04-15 |
2023-08-13 |
mouse |
| Vinicius José Maschio, Veridiana Gomes Virginio, Henrique Bunselmeyer Ferreira, Marilise Brittes Rot. Comparative proteomic analysis of soluble and surface-enriched proteins from Acanthamoeba castellanii trophozoites. Molecular and biochemical parasitology. vol 225. 2019-03-20. PMID:30205118. |
keratitis is an acute, sight threatening infection of cornea with potential to cause permanent blindness without prompt treatment. |
2019-03-20 |
2023-08-13 |
Not clear |
| William Foulsham, Giulia Coco, Afsaneh Amouzegar, Sunil K Chauhan, Reza Dan. When Clarity Is Crucial: Regulating Ocular Surface Immunity. Trends in immunology. vol 39. issue 4. 2018-12-17. PMID:29248310. |
these mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea - blindness. |
2018-12-17 |
2023-08-13 |
Not clear |
| Ebbe Toftgaard Poulsen, Kasper Runager, Nadia Sukusu Nielsen, Marie V Lukassen, Karen Thomsen, Paige Snider, Olga Simmons, Henrik Vorum, Simon J Conway, Jan J Enghil. Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies. The FEBS journal. vol 285. issue 1. 2018-10-29. PMID:29117645. |
significantly, more than 60 point mutations within the tgfbi gene have been reported to result in aberrant tgfbip folding and aggregation in the cornea, resulting in severe visual impairment and blindness. |
2018-10-29 |
2023-08-13 |
mouse |
| Mukty Sinha, Tanvi Gupt. Design and evaluation of artificial cornea with core-skirt design using polyhydroxyethyl methacrylate and graphite. International ophthalmology. vol 38. issue 3. 2018-07-09. PMID:28602017. |
artificial cornea is the effective treatment option for corneal blindness. |
2018-07-09 |
2023-08-13 |
Not clear |
| Van Charles Lansing. Trachoma. BMJ clinical evidence. vol 2016. 2018-05-04. PMID:26860629. |
infection can lead to: scarring of the tarsal conjunctiva; inversion of the eyelashes (trichiasis), so that they abrade the cornea; and corneal opacity, resulting in blindness. |
2018-05-04 |
2023-08-13 |
Not clear |
| S V Trufanov, A M Subbot, S A Malozhen, D A Krakhmalev. [Hypothesis of immune privilege of the cornea and pathophysiology of graft rejection]. Vestnik oftalmologii. vol 132. issue 5. 2018-04-30. PMID:28635736. |
transplantation of donated cornea is a radical and pathogenetically oriented measure of rehabilitation for patients with corneal blindness. |
2018-04-30 |
2023-08-13 |
Not clear |
| Raffaella Mercatelli, Fulvio Ratto, Francesca Rossi, Francesca Tatini, Luca Menabuoni, Alex Malandrini, Riccardo Nicoletti, Roberto Pini, Francesco Saverio Pavone, Riccardo Cicch. Three-dimensional mapping of the orientation of collagen corneal lamellae in healthy and keratoconic human corneas using SHG microscopy. Journal of biophotonics. vol 10. issue 1. 2018-01-05. PMID:27472438. |
keratoconus is an eye disorder that causes the cornea to take an abnormal conical shape, thus impairing its refractive functions and causing blindness. |
2018-01-05 |
2023-08-13 |
human |
| Ye Liu, Mujie Kan, Aipeng Li, Lulu Hou, Hui Jia, Ying Xin, Yang Li. Inhibitory Effects of Tranilast on Cytokine, Chemokine, Adhesion Molecule, and Matrix Metalloproteinase Expression in Human Corneal Fibroblasts Exposed to Poly(I:C). Current eye research. vol 41. issue 11. 2017-10-18. PMID:27115203. |
purpose/aim: viral infection of the cornea can result in inflammation and scarring and eventually cause blindness. |
2017-10-18 |
2023-08-13 |
human |
| Y-J Yang, X-L Li, Y Xue, C-X Zhang, Y Wang, X Hu, Q Da. Bone marrow cells differentiation into organ cells using stem cell therapy. European review for medical and pharmacological sciences. vol 20. issue 13. 2017-08-21. PMID:27424992. |
it is known that limbal epithelial stem cells in the cornea can repair the eye sight and remove symptoms of blindness. |
2017-08-21 |
2023-08-13 |
human |
| V Kocaba, O Damour, C Auxenfans, C Burillo. [Limbal stem cell deficiency management. A review]. Journal francais d'ophtalmologie. vol 39. issue 9. 2017-05-23. PMID:27742136. |
these abnormalities collectively result in the progressive opacification of the cornea responsible for blindness that is driven by chronic corneal ulceration and neovascularization. |
2017-05-23 |
2023-08-13 |
Not clear |
| Che-Yi Chang, Ming-Chen Wang, Takuya Miyagawa, Zhi-Yu Chen, Feng-Huei Lin, Ko-Hua Chen, Guei-Sheung Liu, Ching-Li Tsen. Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization. International journal of nanomedicine. vol 12. 2017-03-27. PMID:28115846. |
neovascularization (nv) of the cornea can disrupt visual function, causing ocular diseases, including blindness. |
2017-03-27 |
2023-08-13 |
human |
| Melisa Vance, Telmo Llanga, Will Bennett, Kenton Woodard, Giridhar Murlidharan, Neil Chungfat, Aravind Asokan, Brian Gilger, Joanne Kurtzberg, R Jude Samulski, Matthew L Hirsc. AAV Gene Therapy for MPS1-associated Corneal Blindness. Scientific reports. vol 6. 2017-01-30. PMID:26899286. |
although cord blood transplantation has significantly extended the lifespan of mucopolysaccharidosis type 1 (mps1) patients, over 95% manifest cornea clouding with about 50% progressing to blindness. |
2017-01-30 |
2023-08-13 |
human |
| Melisa Vance, Telmo Llanga, Will Bennett, Kenton Woodard, Giridhar Murlidharan, Neil Chungfat, Aravind Asokan, Brian Gilger, Joanne Kurtzberg, R Jude Samulski, Matthew L Hirsc. AAV Gene Therapy for MPS1-associated Corneal Blindness. Scientific reports. vol 6. 2017-01-30. PMID:26899286. |
the collective preclinical data demonstrate safe and efficient idua delivery to human corneas, which may prevent and potentially reverse mps1-associated cornea blindness. |
2017-01-30 |
2023-08-13 |
human |
| Yang Liu, Huilin Lv, Li Ren, Guanhua Xue, Yingjun Wan. Improving the moisturizing properties of collagen film by surface grafting of chondroitin sulfate for corneal tissue engineering. Journal of biomaterials science. Polymer edition. vol 27. issue 8. 2016-12-29. PMID:26948819. |
cornea disease is the second cause of blindness and keratoplasty is the most commonly performed option for visual rehabilitation of patients with corneal blindness. |
2016-12-29 |
2023-08-13 |
human |