| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvie L Lesuis, Paul J Lucassen, Harm J Kruger. Early life stress impairs fear memory and synaptic plasticity; a potential role for GluN2B. Neuropharmacology. vol 149. 2020-01-27. PMID:30641077. |
in this study, we examined the effects of early life stress (els) - by housing mouse dams with limited nesting and bedding material from postnatal days 2-9 and examined in 6 month old offspring; 1) auditory fear conditioning, 2) expression of the hippocampal n-methyl-d-aspartate receptor (nmda-r) subunits 2a and 2b (glun2a, glun2b), and expression of psd-95 and synaptophysin, and 3) short- and long-term (ltp) synaptic plasticity. |
2020-01-27 |
2023-08-13 |
mouse |
| Tsutomu Kataoka, Manabu Fuchikami, Shinji Nojima, Nobuyuki Nagashima, Motoaki Araki, Jun Omura, Tatsuhiro Miyagi, Yasumasa Okamoto, Shigeru Morinob. Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder. Genes, brain, and behavior. vol 18. issue 7. 2020-01-16. PMID:30246290. |
we also examined whether bdnf infusion into the ventral mpfc or hippocampus alleviated the impaired ext of sps rats in the contextual fear conditioning paradigm. |
2020-01-16 |
2023-08-13 |
rat |
| Caleb Hudgins, Tim Ott. Hippocampal Arc protein expression and conditioned fear. Neurobiology of learning and memory. vol 161. 2019-12-24. PMID:30991091. |
hippocampal arc protein expression and conditioned fear. |
2019-12-24 |
2023-08-13 |
human |
| Caleb Hudgins, Tim Ott. Hippocampal Arc protein expression and conditioned fear. Neurobiology of learning and memory. vol 161. 2019-12-24. PMID:30991091. |
hence the primary goal of the present study was to characterize the expression of arc protein across both the septotemporal and transverse axes of the hippocampus induced by hippocampal dependent trace fear conditioning and compare these expression patterns to those induced by other fear conditioning paradigms. |
2019-12-24 |
2023-08-13 |
human |
| Caleb Hudgins, Tim Ott. Hippocampal Arc protein expression and conditioned fear. Neurobiology of learning and memory. vol 161. 2019-12-24. PMID:30991091. |
this additional hippocampal processing may account for the greater enhancement in arc protein in dorsal and ventral ca3 for subjects trained in trace fear conditioning compared to novel context exposure, or contextual and delay fear conditioning. |
2019-12-24 |
2023-08-13 |
human |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. |
pacap can alter synaptic plasticity and has direct actions on neurons in the amygdala and hippocampus that could contribute to its acute and persistent effects on the consolidation and expression of conditioned fear. |
2019-11-25 |
2023-08-13 |
rat |
| Edward G Meloni, Karen T Kaye, Archana Venkataraman, William A Carlezo. PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats. Neurobiology of learning and memory. vol 157. 2019-11-25. PMID:30458282. |
we recently demonstrated that intracerebroventricular (icv) infusion of pacap prior to fear conditioning (fc) results in initial amnestic-like effects followed by hyper-expression of conditioned freezing with repeated testing, and analyses of immediate-early gene c-fos expression suggested that the central nucleus of the amygdala (cea), but not the lateral/basolateral amygdala (la/bla) or hippocampus, are involved in these pacap effects. |
2019-11-25 |
2023-08-13 |
rat |
| Jonathan Laugharne, Claire Kullack, Christopher W Lee, Tracy McGuire, Simone Brockman, Peter D Drummond, Sergio Starkstei. Amygdala Volumetric Change Following Psychotherapy for Posttraumatic Stress Disorder. The Journal of neuropsychiatry and clinical neurosciences. vol 28. issue 4. 2019-11-20. PMID:27255857. |
the authors investigated the impact of eye movement desensitization and reprocessing (emdr) and prolonged exposure (pe) on the volumes of the amygdala and hippocampus, structures known to be important in fear conditioning, in 20 patients with posttraumatic stress disorder (ptsd). |
2019-11-20 |
2023-08-13 |
Not clear |
| Cui-Ping Guo, Zhen Wei, Fang Huang, Min Qin, Xing Li, Yu-Man Wang, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Hong-Lian Li, Xiao-Chuan Wan. High salt induced hypertension leads to cognitive defect. Oncotarget. vol 8. issue 56. 2019-11-20. PMID:29221166. |
fear conditioning and morris water maze behavioral test revealed that high salt diet induced hippocampal dependent spatial reference memory deficits, while a decreased synaptogenesis without neuronal loss in hippocampus was observed in high salt treated rats. |
2019-11-20 |
2023-08-13 |
rat |
| Qin Wang, Qi Wang, Xing-Lei Song, Qin Jiang, Yan-Jiao Wu, Ying Li, Ti-Fei Yuan, Siyu Zhang, Nan-Jie Xu, Michael Xi Zhu, Wei-Guang Li, Tian-Le X. Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates. Science advances. vol 4. issue 10. 2019-09-30. PMID:30417090. |
extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mpfc), and basolateral amygdala (bla), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. |
2019-09-30 |
2023-08-13 |
Not clear |
| Fu-Sheng Ding, Xiang Cheng, Tong Zhao, Yong-Qi Zhao, Guang-Bo Zhang, Hai-Tao Wu, Ling-Ling Zhu, Kui-Wu W. [Intermittent hypoxic preconditioning relieves fear and anxiety behavior in post-traumatic stress model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440750. |
the levels of fear and anxiety were valued by the open field, the elevated plus maze (epm) and the fear conditioning tests; the level of spatial memory was valued by y maze test; the number of fos positive neurons in hippocampus, amygdala and medial prefrontal cortex was valued by immunohistochemical staining; and the protein expressions of hypoxia inducible factor-1α (hif-1α), vascular endothelial growth factor (vegf) and brain derived neurotrophic factor (bdnf) in these brain area were valued by western blot. |
2019-09-26 |
2023-08-13 |
mouse |
| Bronwyn M Graham, Vanessa Dong, Rick Richardso. The impact of chronic fluoxetine on conditioned fear expression and hippocampal FGF2 in rats: Short- and long-term effects. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30195047. |
the impact of chronic fluoxetine on conditioned fear expression and hippocampal fgf2 in rats: short- and long-term effects. |
2019-09-23 |
2023-08-13 |
rat |
| Bronwyn M Graham, Vanessa Dong, Rick Richardso. The impact of chronic fluoxetine on conditioned fear expression and hippocampal FGF2 in rats: Short- and long-term effects. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30195047. |
hippocampal fgf2 correlates negatively with conditioned fear expression, and antidepressants, the first-line pharmacological treatment for anxiety, increase hippocampal fgf2. |
2019-09-23 |
2023-08-13 |
rat |
| Bronwyn M Graham, Vanessa Dong, Rick Richardso. The impact of chronic fluoxetine on conditioned fear expression and hippocampal FGF2 in rats: Short- and long-term effects. Neurobiology of learning and memory. vol 155. 2019-09-23. PMID:30195047. |
together, these results provide further indirect evidence that endogenous hippocampal fgf2 may mediate individual differences in conditioned fear expression. |
2019-09-23 |
2023-08-13 |
rat |
| Mirelle A Casagrande, Josué Haubrich, Lizeth K Pedraza, Bruno Popik, Jorge A Quillfeldt, Lucas de Oliveira Alvare. Synaptic consolidation as a temporally variable process: Uncovering the parameters modulating its time-course. Neurobiology of learning and memory. vol 150. 2019-09-16. PMID:29518494. |
in the rodent contextual fear conditioning paradigm, we compared weak and strong training protocols and found that in the latter memory is susceptible to post-training hippocampal inactivation for a shorter period of time. |
2019-09-16 |
2023-08-13 |
Not clear |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Eiji Shimiz. Development of the fear regulation system from early adolescence to young adulthood in female mice. Neurobiology of learning and memory. vol 150. 2019-09-16. PMID:29535045. |
we also measured phosphorylation of erk2 in the medial prefrontal cortex (mpfc) and the dorsal hippocampus following fear conditioning or extinction in 6- and 15-week-old mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Hiroshi Nomura, Chie Teshirogi, Daisuke Nakayama, Masabumi Minami, Yuji Ikegay. Prior observation of fear learning enhances subsequent self-experienced fear learning with an overlapping neuronal ensemble in the dorsal hippocampus. Molecular brain. vol 12. issue 1. 2019-07-31. PMID:30871580. |
we visualized hippocampal neurons that were activated during the observation and self-experience of fear conditioning and found that self-experienced fear conditioning preferentially activated dorsal ca1 neurons that were activated during the observation. |
2019-07-31 |
2023-08-13 |
mouse |
| Tianhai Wang, Hongge Zhu, Yanshen Hou, Weixin Gu, Haichuan Wu, Yiwen Luan, Cheng Xiao, Chunyi Zho. Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus. European journal of pharmacology. vol 846. 2019-07-29. PMID:30586550. |
in comparison with sham mice (anesthesia only), the surgery mice exhibited cognitive deficits in a fear conditioning paradigm at postsurgery day 3-7, and increased numbers of microglia and elevated levels of pro-inflammatory cytokines (il-1β, il-6 and tnf-α) without change of anti-inflammatory cytokines (il-4 and il-10) in the hippocampus. |
2019-07-29 |
2023-08-13 |
mouse |
| Bronwyn M Graha. Postnatal stress is associated with impaired fear conditioning and extinction, and heightened hippocampal fibroblast growth factor 2, in mother rats. Hormones and behavior. vol 105. 2019-06-12. PMID:30114429. |
postnatal stress is associated with impaired fear conditioning and extinction, and heightened hippocampal fibroblast growth factor 2, in mother rats. |
2019-06-12 |
2023-08-13 |
rat |
| Da-Wei Li, Jin-Zhi Liu, Shu-Chen Li, Jin-Bin Yang, Huan-Huan Sun, Ai-Hua Wan. Fear conditioning downregulates miR-138 expression in the hippocampus to facilitate the formation of fear memory. Neuroreport. vol 29. issue 16. 2019-04-10. PMID:30199441. |
fear conditioning downregulates mir-138 expression in the hippocampus to facilitate the formation of fear memory. |
2019-04-10 |
2023-08-13 |
Not clear |