| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K U Bayer, P De Koninck, A S Leonard, J W Hell, H Schulma. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature. vol 411. issue 6839. 2001-08-09. PMID:11459059. |
here we show that regulated camkii interaction with two sites on the nmda receptor subunit nr2b provides a mechanism for the glutamate-induced translocation of the kinase to the synapse in hippocampal neurons. |
2001-08-09 |
2023-08-12 |
Not clear |
| S Mori, M Popoli, N Brunello, G Racagni, J Pere. Effect of reboxetine treatment on brain cAMP- and calcium/calmodulin-dependent protein kinases. Neuropharmacology. vol 40. issue 3. 2001-07-19. PMID:11166338. |
in the hippocampal subsynaptosomal fractions (synaptic vesicles and synaptosomal membranes) reboxetine induced a robust increase in the activity but not in the expression of camkii. |
2001-07-19 |
2023-08-12 |
rat |
| S Yechikhov, E Morenkov, T Chulanova, O Godukhin, T Shchipakin. Involvement of cAMP- and Ca(2+)/calmodulin-dependent neuronal protein phosphorylation in mechanisms underlying genetic predisposition to audiogenic seizures in rats. Epilepsy research. vol 46. issue 1. 2001-07-19. PMID:11395284. |
ca(2+)-independent, functional camkii activity was considerably increased in hippocampus but decreased in neocortex of gpas rats in comparison with wistar ones. |
2001-07-19 |
2023-08-12 |
rat |
| S Yechikhov, E Morenkov, T Chulanova, O Godukhin, T Shchipakin. Involvement of cAMP- and Ca(2+)/calmodulin-dependent neuronal protein phosphorylation in mechanisms underlying genetic predisposition to audiogenic seizures in rats. Epilepsy research. vol 46. issue 1. 2001-07-19. PMID:11395284. |
daily repeated audiogenic seizures induced the decrease of ca(2+)-independent camkii activity in hippocampus and the increase of pka activity in neocortex of agpas rats in comparison with gpas ones. |
2001-07-19 |
2023-08-12 |
rat |
| E Consogno, G Racagni, M Popol. Modifications in brain CaM kinase II after long-term treatment with desmethylimipramine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 1. 2001-01-18. PMID:11106872. |
similar to selective and non-selective serotonin reuptake inhibitors, long-term, but not acute, treatment with desmethylimipramine markedly increased the activity of camkii in the hippocampal synaptic vesicle fraction (+51.9%). |
2001-01-18 |
2023-08-12 |
Not clear |
| L Lu, S Zeng, D Liu, X Cen. Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats. Neuroscience letters. vol 291. issue 3. 2000-11-30. PMID:10984639. |
based on the recent finding that calcium/calmodulin protein kinase ii (camkii) is essential in learning and memory processes, the present study was performed to examine whether inhibition of hippocampal and amygdala camkii prevents the dependence and relapse to morphine. |
2000-11-30 |
2023-08-12 |
rat |
| L Lu, S Zeng, D Liu, X Cen. Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats. Neuroscience letters. vol 291. issue 3. 2000-11-30. PMID:10984639. |
the results showed that inhibition of camkii by microinjection of specific inhibitors kn-62 into hippocampus decreased the morphine withdrawal syndromes induced by opiate antagonist naloxone. |
2000-11-30 |
2023-08-12 |
rat |
| L Lu, S Zeng, D Liu, X Cen. Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats. Neuroscience letters. vol 291. issue 3. 2000-11-30. PMID:10984639. |
however, inhibition of camkii in amygdala, but not in hippocampus, could attenuate the maintenance of morphine cpp. |
2000-11-30 |
2023-08-12 |
rat |
| L Lu, S Zeng, D Liu, X Cen. Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats. Neuroscience letters. vol 291. issue 3. 2000-11-30. PMID:10984639. |
these results suggest that hippocampal camkii is critically involved in the development of morphine physical and psychological dependence, and amygdala camkii is some different from hippocampal camkii in regulating the dependence and relapse to opiates. |
2000-11-30 |
2023-08-12 |
rat |
| M R Vianna, M Alonso, H Viola, J Quevedo, F de Paris, M Furman, M L de Stein, J H Medina, I Izquierd. Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat. Learning & memory (Cold Spring Harbor, N.Y.). vol 7. issue 5. 2000-11-21. PMID:11040265. |
the detection of spatial novelty is associated with a sequential activation of pka, erks (p44 and p42 mapks) and camkii and the phosphorylation of c-amp responsive element-binding protein (creb) in the hippocampus. |
2000-11-21 |
2023-08-12 |
rat |
| M R Vianna, M Alonso, H Viola, J Quevedo, F de Paris, M Furman, M L de Stein, J H Medina, I Izquierd. Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat. Learning & memory (Cold Spring Harbor, N.Y.). vol 7. issue 5. 2000-11-21. PMID:11040265. |
these findings suggest that memory formation of spatial habituation depends on the functional integrity of nmda and ampa/kainate receptors and camkii activity in the ca1 region of the hippocampus and that the detection of spatial novelty is accompanied by the activation of at least three different hippocampal protein kinase signaling cascades. |
2000-11-21 |
2023-08-12 |
rat |
| T J Blanck, M Haile, F Xu, J Zhang, P Heerdt, R A Veselis, J Beckman, R Kang, A Adamo, H Hemming. Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model. Anesthesiology. vol 93. issue 5. 2000-11-21. PMID:11046218. |
to determine whether isoflurane at a clinically relevant concentration is neuroprotective in a canine model of cardiac arrest, we measured neurologic function and hippocampal ca2+/calmodulin-dependent protein kinase ii (camkii) content 20 h after cardiac arrest. |
2000-11-21 |
2023-08-12 |
rat |
| E Consogno, C Dorigo, G Racagni, M Popol. Modification of presynaptic CaM kinase II affinity for ATP in hippocampus after long term blockade of serotonin reuptake. Life sciences. vol 67. issue 16. 2000-11-15. PMID:11072872. |
camkii has also been found to be involved in the long-term action of antidepressants on post-receptor signaling mechanisms, because monoamine reuptake inhibitors induced an increase in autophosphorylation and activity of the kinase in nerve terminals of hippocampus. |
2000-11-15 |
2023-08-12 |
Not clear |
| J H Pak, F L Huang, J Li, D Balschun, K G Reymann, C Chiang, H Westphal, K P Huan. Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 21. 2000-11-09. PMID:11016969. |
furthermore, hippocampal slices of the mutant mice displayed a reduced ability to generate activated camkii after stimulation of protein phosphorylation and oxidation by treatments with okadaic acid and sodium nitroprusside, respectively. |
2000-11-09 |
2023-08-12 |
mouse |
| N Inagaki, M Nishizawa, N Arimura, H Yamamoto, Y Takeuchi, E Miyamoto, K Kaibuchi, M Inagak. Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons. The Journal of biological chemistry. vol 275. issue 35. 2000-10-03. PMID:10852918. |
this approach was used to monitor the activities of post-synaptic camkii in cultured hippocampal neurons. |
2000-10-03 |
2023-08-12 |
Not clear |
| S Alberi, P H Boeijinga, M Raggenbass, H W Boddek. Involvement of calmodulin-dependent protein kinase II in carbachol-induced rhythmic activity in the hippocampus of the rat. Brain research. vol 872. issue 1-2. 2000-09-20. PMID:10924670. |
our data suggest that activation of camkii by carbachol is crucial for local theta-like activity in the ca1 area of the rat hippocampus in vitro. |
2000-09-20 |
2023-08-12 |
rat |
| C P Wiedenmayer, M M Myers, M Mayford, G A Bar. Olfactory based spatial learning in neonatal mice and its dependence on CaMKII. Neuroreport. vol 11. issue 5. 2000-07-10. PMID:10790881. |
however, mouse pups that over-expressed ca2+/calmodulin-dependent protein kinase (camkii) in hippocampal neurons were impaired in olfactory based spatial learning. |
2000-07-10 |
2023-08-12 |
mouse |
| A Dosemeci, T S Reese, J Petersen, J H Tao-Chen. A novel particulate form of Ca(2+)/calmodulin-dependent [correction of Ca(2+)/CaMKII-dependent] protein kinase II in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 9. 2000-06-02. PMID:10777771. |
exposure of cultured hippocampal neurons to a mitochondrial uncoupler in glucose-free medium promotes the formation of numerous camkii-immunopositive structures identical in size and shape to the camkii clusters observed in subcellular fractions. |
2000-06-02 |
2023-08-12 |
Not clear |
| C Wolfman, L A Izquierdo, N Schröder, I Izquierd. Intra-hippocampal KN-62 hinders the memory of habituation acquired alone, but not simultaneously with a water-finding task. Behavioural pharmacology. vol 10. issue 1. 2000-05-18. PMID:10780306. |
thus, depending on circumstances, habituation can be memorized with or without hippocampal camkii activity. |
2000-05-18 |
2023-08-12 |
rat |
| C Solà, J M Tusell, J Serratos. Comparative study of the distribution of calmodulin kinase II and calcineurin in the mouse brain. Journal of neuroscience research. vol 57. issue 5. 1999-10-15. PMID:10462689. |
we found that camkii and can were mainly expressed in cerebral cortex, hippocampus, and striatum and that low levels of expression were observed in midbrain and brainstem. |
1999-10-15 |
2023-08-12 |
mouse |