| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Gardoni, L H Schrama, J J van Dalen, W H Gispen, F Cattabeni, M Di Luc. AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation. FEBS letters. vol 456. issue 3. 1999-09-07. PMID:10462051. |
glutathione s-transferase (gst)-nr2a(1349-1464) binds native camkii from solubilised hippocampal psds in 'pull-out' and overlay experiments and this binding is competed by recombinant alphacamkii(1-315). |
1999-09-07 |
2023-08-12 |
Not clear |
| G H Fan, L Z Wang, H C Qiu, L Ma, G Pe. Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Molecular pharmacology. vol 56. issue 1. 1999-07-22. PMID:10385682. |
based on the recent findings that calcium/calmodulin-dependent protein kinase ii (camkii) is essential in learning and memory processes, and morphine treatment increases camkii activity in hippocampus, the present study was undertaken to examine whether inhibition of hippocampal camkii prevents morphine tolerance and dependence. |
1999-07-22 |
2023-08-12 |
rat |
| G H Fan, L Z Wang, H C Qiu, L Ma, G Pe. Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Molecular pharmacology. vol 56. issue 1. 1999-07-22. PMID:10385682. |
furthermore, administration of camkii antisense oligonucleotide into rat hippocampal dentate gyrus, which decreased the expression of camkii specifically, also attenuated morphine tolerance and dependence, while the corresponding sense oligonucleotide of camkii did not exhibit such inhibitory effect. |
1999-07-22 |
2023-08-12 |
rat |
| G H Fan, L Z Wang, H C Qiu, L Ma, G Pe. Inhibition of calcium/calmodulin-dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Molecular pharmacology. vol 56. issue 1. 1999-07-22. PMID:10385682. |
these results suggest that hippocampal camkii is critically involved in the development of morphine tolerance and dependence, and inhibition of this kinase may have some therapeutic benefit in the treatment of opiate tolerance and dependence. |
1999-07-22 |
2023-08-12 |
rat |
| R Schnabel, M J Palmer, I C Kilpatrick, G L Collingridg. A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221764. |
a camkii inhibitor, kn-62, facilitates dhpg-induced ltd in the ca1 region of the hippocampus. |
1999-07-02 |
2023-08-12 |
Not clear |
| K Shen, T Meye. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science (New York, N.Y.). vol 284. issue 5411. 1999-04-22. PMID:10102820. |
dynamic control of camkii translocation and localization in hippocampal neurons by nmda receptor stimulation. |
1999-04-22 |
2023-08-12 |
Not clear |
| A Caputi, F Gardoni, M Cimino, L Pastorino, F Cattabeni, M Di Luc. CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP. The European journal of neuroscience. vol 11. issue 1. 1999-04-01. PMID:9987018. |
to examine in vivo the implication of camkii activity in synaptic plasticity, we used an animal model characterized by developmentally induced targeted neuronal ablation within the cortex and the hippocampus, and showing, at presynaptic level, molecular alterations leading to facilitation of glutamate release in hippocampal synapses (methylazoxymethanol-treated rats, mam-rats). |
1999-04-01 |
2023-08-12 |
rat |
| S Zanotti, S Mori, R Radaelli, J Perez, G Racagni, M Popol. Modifications in brain cAMP- and calcium/calmodulin-dependent protein kinases induced by treatment with S-adenosylmethionine. Neuropharmacology. vol 37. issue 8. 1999-02-26. PMID:9833637. |
however, this modification was found in the cerebral cortex rather than in the hippocampus, where typical ad affect camkii. |
1999-02-26 |
2023-08-12 |
Not clear |
| D M Barros, L A Izquierdo, M K Sant'Anna, J Quevedo, J H Medina, J L McGaugh, I Izquierd. Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration. Neurobiology of learning and memory. vol 71. issue 1. 1999-02-26. PMID:9889075. |
the findings bear on the participation of camkii and of the camp/pka cascade in memory processes in the hippocampus and the amygdala. |
1999-02-26 |
2023-08-12 |
rat |
| D M Barros, L A Izquierdo, M K Sant'Anna, J Quevedo, J H Medina, J L McGaugh, I Izquierd. Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration. Neurobiology of learning and memory. vol 71. issue 1. 1999-02-26. PMID:9889075. |
in contrast, in the amygdala, only the camkii cascade is active, and it does not play a central role in memory, inasmuch as its deleterious effect may be fully recovered by stimulation of the pka cascade in the hippocampus. |
1999-02-26 |
2023-08-12 |
rat |
| F Gardoni, A Caputi, M Cimino, L Pastorino, F Cattabeni, M Di Luc. Calcium/calmodulin-dependent protein kinase II is associated with NR2A/B subunits of NMDA receptor in postsynaptic densities. Journal of neurochemistry. vol 71. issue 4. 1998-10-14. PMID:9751209. |
here we report that camkii binds to nr2a and nr2b subunits of nmda receptors in psd isolated from cortex and hippocampus. |
1998-10-14 |
2023-08-12 |
Not clear |
| S Strack, R J Colbra. Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor. The Journal of biological chemistry. vol 273. issue 33. 1998-09-14. PMID:9694809. |
activation and thr286 autophosphorylation of calcium/calmodulindependent kinase ii (camkii) following ca2+ influx via n-methyl-d-aspartate (nmda)-type glutamate receptors is essential for hippocampal long term potentiation (ltp), a widely investigated cellular model of learning and memory. |
1998-09-14 |
2023-08-12 |
Not clear |
| H J Chen, M Rojas-Soto, A Oguni, M B Kenned. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron. vol 20. issue 5. 1998-06-26. PMID:9620694. |
inhibition of p135 syngap by camkii will stop inactivation of gtp-bound ras and thus could result in activation of the mitogen-activated protein (map) kinase pathway in hippocampal neurons upon activation of nmda receptors. |
1998-06-26 |
2023-08-12 |
Not clear |
| C Solà, J M Tusell, J Serratos. Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures. Journal of neurochemistry. vol 70. issue 4. 1998-04-23. PMID:9523577. |
no significant alterations in camkii or can immunolabelling were observed in the hippocampus of kainic acid-treated mice. |
1998-04-23 |
2023-08-12 |
mouse |
| K P Giese, N B Fedorov, R K Filipkowski, A J Silv. Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science (New York, N.Y.). vol 279. issue 5352. 1998-02-23. PMID:9452388. |
the calcium-calmodulin-dependent kinase ii (camkii) is required for hippocampal long-term potentiation (ltp) and spatial learning. |
1998-02-23 |
2023-08-12 |
mouse |
| A M Shirke, R Malino. Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons. Journal of neurophysiology. vol 78. issue 5. 1997-12-22. PMID:9356418. |
preactivated recombinant alpha-calcium-calmodulin dependent multifunctional protein kinase ii (camkii*) was perfused internally into ca1 hippocampal slice neurons to test the effect on synaptic transmission and responses to exogenous application of glutamate analogues. |
1997-12-22 |
2023-08-12 |
rat |
| A M Shirke, R Malino. Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons. Journal of neurophysiology. vol 78. issue 5. 1997-12-22. PMID:9356418. |
after measurement of baseline transmission, internal perfusion of camkii* increased synaptic strength in rat hippocampal neurons and diminished the fraction of synaptic failures. |
1997-12-22 |
2023-08-12 |
rat |
| Y Ouyang, D Kantor, K M Harris, E M Schuman, M B Kenned. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204925. |
autophosphorylation of calcium/calmodulin-dependent protein kinase ii (camkii) at threonine-286 produces ca2+-independent kinase activity and has been proposed to be involved in induction of long-term potentiation by tetanic stimulation in the hippocampus. |
1997-07-21 |
2023-08-12 |
Not clear |
| Y Ouyang, D Kantor, K M Harris, E M Schuman, M B Kenned. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204925. |
we have used an immunocytochemical method to visualize and quantify the pattern of autophosphorylation of camkii in hippocampal slices after tetanization of the schaffer collateral pathway. |
1997-07-21 |
2023-08-12 |
Not clear |
| S Strack, S Choi, D M Lovinger, R J Colbra. Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density. The Journal of biological chemistry. vol 272. issue 21. 1997-07-02. PMID:9153188. |
translocation of camkii to psds occurs in hippocampal slices following treatments that induce camkii autophosphorylation and a form of long term potentiation. |
1997-07-02 |
2023-08-12 |
Not clear |