| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pauline Belujon, Anthony A Grac. Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815264. |
the nucleus accumbens (nac) is an integral part of limbic circuits proposed to play a central role in the pathophysiology of schizophrenia, and is positioned to integrate information from limbic and cortical regions, including the medial prefrontal cortex (mpfc) and the hippocampus. |
2008-11-12 |
2023-08-12 |
rat |
| Pauline Belujon, Anthony A Grac. Critical role of the prefrontal cortex in the regulation of hippocampus-accumbens information flow. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815264. |
the ventral subiculum (vsub) of the hippocampus, in particular, is proposed to gate information flow within the nac, a factor that is disrupted in models of schizophrenia. |
2008-11-12 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
this study investigated the frequency of apoptosis in rat hippocampal neural cells after intraperitoneal nicotine injection, examining the roles of the inflammatory markers myeloperoxidase (mpo) and tumor necrosis factor alpha (tnf-alpha) in nicotine-induced brain damage and the protective effects of three known antioxidant agents, n-acetylcysteine (nac), erdosteine, and vitamin e. female wistar rats were divided into seven groups, each composed of nine rats: 2 negative control groups, 2 positive control groups, one erdosteine-treated group (500 mg/kg), one nac-treated group (500 mg/kg), and one vitamin e-treated group (500 mg/kg). |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
the treatments with erdosteine, nac and vitamin e significantly reduced the rate of nicotine-induced hippocampal neural cell apoptosis. |
2008-10-17 |
2023-08-12 |
rat |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
this findings suggest that erdosteine and nac can be as effective as vitamin e in protecting against nicotine-induced hippocampal neural cell apoptosis. |
2008-10-17 |
2023-08-12 |
rat |
| Fabien Lanté, Johann Meunier, Janique Guiramand, Marie-Céleste De Jesus Ferreira, Gilles Cambonie, Rose Aimar, Catherine Cohen-Solal, Tangui Maurice, Michel Vignes, Gérard Barbane. Late N-acetylcysteine treatment prevents the deficits induced in the offspring of dams exposed to an immune stress during gestation. Hippocampus. vol 18. issue 6. 2008-09-22. PMID:18306297. |
post-treatment with nac, four hours after the lps challenge fully prevented the drop in the gsh hippocampal content. |
2008-09-22 |
2023-08-12 |
rat |
| Thomas F Tropea, Barry E Kosofsky, Anjali M Rajadhyaksh. Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18554320. |
to better understand the mechanism of cocaine-conditioned place preference we have used western blot analysis to examine changes in phosphorylation of camp-response element binding protein (creb), dopamine- and cyclic amp-regulated phosphoprotein 32 (darpp-32), extracellular signal-regulated kinase (erk) and glur1, key molecular substrates altered by cocaine, in the nucleus accumbens (nac) and dorsal hippocampus (dhc) of c57bl/6 mice. |
2008-09-12 |
2023-08-12 |
mouse |
| Rutsuko Ito, Trevor W Robbins, Cyriel M Pennartz, Barry J Everit. Functional interaction between the hippocampus and nucleus accumbens shell is necessary for the acquisition of appetitive spatial context conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 27. 2008-08-12. PMID:18596169. |
the nucleus accumbens (nac) has been implicated in a variety of associative processes that are dependent on the integrity of the amygdala and hippocampus (hpc). |
2008-08-12 |
2023-08-12 |
rat |
| Aderbal S Aguiar, Talita Tuon, Fernanda S Soares, Luís Gustavo C da Rocha, Paulo César Silveira, Ricardo A Pinh. The effect of n-acetylcysteine and deferoxamine on exercise-induced oxidative damage in striatum and hippocampus of mice. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17940892. |
these results indicate intense exercise as oxidant and nac and dfx as antioxidant to the hippocampus and the striatum. |
2008-08-11 |
2023-08-12 |
mouse |
| Samira S Valvassori, Fabrícia C Petronilho, Gislaine Z Réus, Amanda V Steckert, Virgínia B M Oliveira, Carina R Boeck, Flávio Kapczinski, Felipe Dal-Pizzol, João Queved. Effect of N-acetylcysteine and/or deferoxamine on oxidative stress and hyperactivity in an animal model of mania. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 4. 2008-07-22. PMID:18403082. |
at the same model, nac plus dfx reversed the protein damage in the hippocampus, but nac alone increased this damage. |
2008-07-22 |
2023-08-12 |
rat |
| Priscila B Di-Pietro, Márcia L Dias, Giselli Scaini, Márcio Burigo, Larissa Constantino, Roberta A Machado, Felipe Dal-Pizzol, Emilio L Strec. Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. Neuroscience letters. vol 434. issue 1. 2008-07-03. PMID:18304734. |
considering that creatine kinase (ck) is important for brain energy homeostasis and is inhibited by free radicals, and that oxidative stress is probably involved in the pathogenesis of uremic encephalopathy, we measured ck activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats submitted to renal ischemia and the effect of administration of antioxidants (n-acetylcysteine, nac and deferoxamine, dfx) on this enzyme. |
2008-07-03 |
2023-08-12 |
human |
| Hui-Fen Liu, Wen-Hua Zhou, Hua-Qiang Zhu, Miao-Jun Lai, Wei-Sheng Che. Microinjection of M(5) muscarinic receptor antisense oligonucleotide into VTA inhibits FosB expression in the NAc and the hippocampus of heroin sensitized rats. Neuroscience bulletin. vol 23. issue 1. 2007-07-31. PMID:17592519. |
microinjection of m(5) muscarinic receptor antisense oligonucleotide into vta inhibits fosb expression in the nac and the hippocampus of heroin sensitized rats. |
2007-07-31 |
2023-08-12 |
rat |
| Hui-Fen Liu, Wen-Hua Zhou, Hua-Qiang Zhu, Miao-Jun Lai, Wei-Sheng Che. Microinjection of M(5) muscarinic receptor antisense oligonucleotide into VTA inhibits FosB expression in the NAc and the hippocampus of heroin sensitized rats. Neuroscience bulletin. vol 23. issue 1. 2007-07-31. PMID:17592519. |
to investigate the effect of m(5) muscarinic receptor subtype on the locomotor sensitization induced by heroin priming, and it's effect on the fosb expression in the nucleus accumbens (nac) and the hippocampus in the heroin sensitized rats. |
2007-07-31 |
2023-08-12 |
rat |
| Valentina Ferretti, Francesca Sargolini, Alberto Oliverio, Andrea Mele, Pascal Roulle. Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task. Behavioural brain research. vol 179. issue 1. 2007-07-24. PMID:17289166. |
in particular, it has been suggested that glutamatergic afferences from the hippocampus and the prefrontal cortex provide the main source of contextual information to the nac. |
2007-07-24 |
2023-08-12 |
mouse |
| Liana Fattore, Daniela Viganò, Paola Fadda, Tiziana Rubino, Walter Fratta, Daniela Parolar. Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2. The European journal of neuroscience. vol 25. issue 7. 2007-06-21. PMID:17419755. |
this study examines the effect of intravenous self-administration (sa) of either heroin or the cannabinoid receptor agonist win 55,212-2 on levels and functionality of mu-opioid (mor) and cb1-cannabinoid receptors (cb1r) in reward-related brain areas, such as the prefrontal cortex (pfc), nucleus accumbens (nac), caudate putamen (cp), hippocampus (hippo), amygdala (amy), hypothalamus (hypo) and ventral tegmental area (vta). |
2007-06-21 |
2023-08-12 |
rat |
| Caio M Moreira, Sueli Masson, Milene C Carvalho, Marcus L Brandã. Exploratory behaviour of rats in the elevated plus-maze is differentially sensitive to inactivation of the basolateral and central amygdaloid nuclei. Brain research bulletin. vol 71. issue 5. 2007-04-05. PMID:17259015. |
in the present study, we carried out an ethopharmacological analysis of the behaviour of rats submitted to the elevated plus-maze test together with analysis of the tissue content of monoamine dopamine (da) and serotonin (5-ht) and their metabolites in the dorsal hippocampus (dh), nucleus accumbens (nac) and dorsal striatum (ds) of animals injected with saline or muscimol (1.0 nmol/0.2 microl) into the bla or cea. |
2007-04-05 |
2023-08-12 |
rat |
| Yao-Ying Ma, Ning-Ning Chu, Chang-Yong Guo, Ji-Sheng Han, Cai-Lian Cu. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17014848. |
parallel with this, protein levels of the nmda receptor 2b subunit (nr2b) were elevated in the nucleus accumbens (nac) and the hippocampus, but not the prefrontal cortex, of reinstated rats. |
2007-03-20 |
2023-08-12 |
rat |
| Yao-Ying Ma, Ning-Ning Chu, Chang-Yong Guo, Ji-Sheng Han, Cai-Lian Cu. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17014848. |
ifenprodil (2.0 microg/rat) directly injected into the nac shell or the ca1 region of the dorsal hippocampus produced a similar effect. |
2007-03-20 |
2023-08-12 |
rat |
| Yao-Ying Ma, Ning-Ning Chu, Chang-Yong Guo, Ji-Sheng Han, Cai-Lian Cu. NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17014848. |
these results indicate that the nr2b-containing nmda receptors in the nac and the dorsal hippocampus play a significant role in mediating the reinstatement of rewarding responses to morphine. |
2007-03-20 |
2023-08-12 |
rat |
| Fang Dai, Jing Yu Yang, Pei Fei Gu, Yue Hou, Chun Fu W. Effect of drug-induced ascorbic acid release in the striatum and the nucleus accumbens in hippocampus-lesioned rats. Brain research. vol 1125. issue 1. 2007-02-20. PMID:17112479. |
in the present study, the roles of the hippocampus in drug-induced aa release in the striatum and nac were studied by using microdialysis coupled to high performance liquid chromatography with electrochemical detection (hplc-ecd). |
2007-02-20 |
2023-08-12 |
rat |