| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A Bonney, Arum Han, Ramkumar Meno. Stress Signaler p38 Mitogen-Activated Kinase Activation: A Cause for Concern? Clinical science (London, England : 1979). 2022-10-17. PMID:36250628. |
we created p38 ko aec using the crispr/cas9 approach and tested cell fate in response to os on an aec-free fetal membrane extracellular matrix (ecm). |
2022-10-17 |
2023-08-14 |
mouse |
| DaNae R Woodard, Steffi Daniel, Emi Nakahara, Ali Abbas, Sophia M DiCesare, Gracen E Collier, John D Hullema. A loss-of-function cysteine mutant in fibulin-3 (EFEMP1) forms aberrant extracellular disulfide-linked homodimers and alters extracellular matrix composition. Human mutation. 2022-08-23. PMID:35998264. |
f3 ko cells produced lower levels of the ecm remodeling enzyme, matrix metalloproteinase 2 and reduced formation of collagen vi ecm filaments, both of which were partially rescued by wt f3 overexpression. |
2022-08-23 |
2023-08-14 |
Not clear |
| Shingo Yasuda, Takayoshi Sumioka, Masayasu Miyazima, Hiroki Iwanishi, Tomoya Morii, Naoki Mochizuki, Peter S Reinach, Winston W Y Kao, Yuka Okada, Chia-Yang Liu, Shizuya Saik. Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice. The ocular surface. 2022-08-21. PMID:35988880. |
histology showed that the corneal stroma was thinner with less extracellular matrix accumulation, e.g., collagen and keratocan in the ko mouse. |
2022-08-21 |
2023-08-14 |
mouse |
| Siddharth Sunilkumar, Esma I Yerlikaya, Allyson L Toro, William P Miller, Han Chen, Kebin Hu, Scot R Kimball, Michael D Denni. REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice. Diabetes. 2022-08-19. PMID:35984399. |
histopathologic examination revealed that glomerular damage including mesangial expansion, matrix deposition, and podocytopenia in the kidneys of diabetic wildtype mice were reduced or absent in diabetic redd1 ko mice. |
2022-08-19 |
2023-08-14 |
mouse |
| Constantinos Kolliopoulos, Mohamad Moustafa Ali, Casimiro Castillejo-Lopez, Carl-Henrik Heldin, Paraskevi Heldi. CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence. Cancers. vol 14. issue 15. 2022-08-12. PMID:35954411. |
interestingly, the expression of molecules involved in hyaluronan synthesis, degradation, and interacting matrix proteins, as well as of platelet-derived growth factor (pdgf) isoforms and pdgf receptors, were also deregulated in cd44 ko cells. |
2022-08-12 |
2023-08-14 |
Not clear |
| Samuel J Stephen, Stacyann Bailey, Danielle N D'Erminio, Divya Krishnamoorthy, James C Iatridis, Deepak Vashisht. Bone matrix quality in a developing high-fat diet mouse model is altered by RAGE deletion. Bone. 2022-06-19. PMID:35718325. |
rage ko mitigated glycoxidative matrix accumulation, preserved mineral quantity, and led to increased e/h ratio in females. |
2022-06-19 |
2023-08-14 |
mouse |
| Nicole J Martucci, John W Stoops, William C Bowen, Wendy M Mars, George K Michalopoulo. Inhibition of Phosphoinositide 3-kinase delta (PIK3CD) Suppresses Hepatocyte Proliferation by More than 50% in the Regenerating Liver after Partial Hepatectomy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555353. |
previous data from our lab has shown that with hepatocyte specific knockout of integrin linked kinase (hilk ko), there is hepatocyte proliferation, increased matrix deposition, and unorganized biliary cell/ductal proliferation; this led us to investigate the signaling pathways downstream of hilk ko that might be responsible for the observed phenotype. |
2022-05-13 |
2023-08-13 |
Not clear |
| Tiina Lehtola, Elina Nummenmaa, Lauri Tuure, Mari Hämäläinen, Riina M Nieminen, Teemu Moilanen, Antti Pemmari, Eeva Moilane. Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35409238. |
dexamethasone was found to significantly attenuate the expression of matrix metalloproteinase (mmp)-13 in human oa chondrocytes as well as in chondrocytes from mkp-1 wt mice, but not in chondrocytes from mkp-1 ko mice. |
2022-04-12 |
2023-08-13 |
mouse |
| Lena Cook, Marie Sengelmann, Birte Winkler, Constanze Nagl, Sarah Koch, Uwe Schlomann, Emily P Slater, Miles A Miller, Elke Pogge von Strandmann, Bastian Dörsam, Christian Preußer, Jörg W Bartsc. ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216088. |
in evs, adam8 is present as an active protease and associated with lipocalin 2 (lcn2) and matrix metalloprotease 9 (mmp-9) in an adam8-dependent manner, as adam8 ko cells show a lower abundance of lcn2 and mmp-9. |
2022-02-26 |
2023-08-13 |
Not clear |
| Kristina Allen-Brady, Maria A T Bortolini, Margot S Damase. Mouse Knockout Models for Pelvic Organ Prolapse: a Systematic Review. International urogynecology journal. 2022-01-28. PMID:35088092. |
mouse knockout (ko) models of pelvic organ prolapse (pop) have contributed mechanistic evidence for the role of connective tissue defects, specifically impaired elastic matrix remodeling. |
2022-01-28 |
2023-08-13 |
mouse |
| Chunyan Hu, Katherine Beebe, Edgar J Hernandez, Jose M Lazaro-Guevara, Monica P Revelo, Yufeng Huang, J Alan Maschek, James E Cox, Donald E Koha. Multiomic identification of factors associated with progression to cystic kidney disease in mice with nephron Ift88 disruption. American journal of physiology. Renal physiology. 2021-12-20. PMID:34927449. |
mrnas involved in extracellular matrix (ecm) synthesis and degradation were selectively upregulated in male ko mice. |
2021-12-20 |
2023-08-13 |
mouse |
| Brynna S Eisele, Zigmund Luka, Alice J Wu, Fei Yang, Andrew T Hale, John D Yor. Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. The Journal of biological chemistry. vol 297. issue 5. 2021-12-08. PMID:34634304. |
ko of bpnt2 in mice leads to skeletal abnormalities because of impaired gag sulfation, especially chondroitin-4-sulfation, which is critical for proper extracellular matrix development. |
2021-12-08 |
2023-08-13 |
mouse |
| Benjamin Bonnard, Jaime Ibarrola, Ixchel Lima-Posada, Amaya Fernández-Celis, Manon Durand, Marie Genty, Natalia Lopez-Andreés, Frédéric Jaisse. Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway. Hypertension (Dallas, Tex. : 1979). 2021-11-19. PMID:34794340. |
in ctl mice, nas increased the renal expression of extracellular matrix proteins, such as collagen i, αsma, and fibronectin associated with interstitial fibrosis which were blunted in mΦ ko ngal mice. |
2021-11-19 |
2023-08-13 |
mouse |
| Shree Sharma, Matthew Plotki. Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury. FEBS open bio. vol 10. issue 8. 2021-11-04. PMID:31957231. |
expression of id1 was observed to be increased 15-fold in wt kidney ec, and id1 ko mice exhibited increased mesangial and myofibroblast proliferation, matrix deposition, and albuminuria compared with wt mice. |
2021-11-04 |
2023-08-13 |
mouse |
| Oualid Haddad, John R Hawse, Malayannan Subramaniam, Thomas C Spelsberg, Sabine F Bensamou. TIEG1-NULL OSTEOCYTES DISPLAY DEFECTS IN THEIR MORPHOLOGY, DENSITY AND SURROUNDING BONE MATRIX. Journal of musculoskeletal research. vol 12. issue 3. 2021-10-21. PMID:22121306. |
moreover, there was a decrease in the amount of hypomineralized bone matrix surrounding the osteocytes in tieg1 ko mice relative to wild-type controls. |
2021-10-21 |
2023-08-12 |
mouse |
| Rui Hua, Qingwen Ni, Travis D Eliason, Yan Han, Sumin Gu, Daniel P Nicolella, Xiaodu Wang, Jean X Jian. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix biology : journal of the International Society for Matrix Biology. vol 94. 2021-10-18. PMID:33002580. |
the amount of total gags and cs in the mineralized compartment of bgn ko mouse bone matrix decreased significantly, associated with the reduction of the toughness of bone, in comparison with those of wt mice. |
2021-10-18 |
2023-08-13 |
mouse |
| Rui Hua, Qingwen Ni, Travis D Eliason, Yan Han, Sumin Gu, Daniel P Nicolella, Xiaodu Wang, Jean X Jian. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix biology : journal of the International Society for Matrix Biology. vol 94. 2021-10-18. PMID:33002580. |
however, such differences between wt and bgn ko mice diminished once the bound water was removed from bone matrix. |
2021-10-18 |
2023-08-13 |
mouse |
| Rui Hua, Qingwen Ni, Travis D Eliason, Yan Han, Sumin Gu, Daniel P Nicolella, Xiaodu Wang, Jean X Jian. Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix. Matrix biology : journal of the International Society for Matrix Biology. vol 94. 2021-10-18. PMID:33002580. |
after intradermal administration of cs, the toughness of wt bone was greatly improved, with the gags and bound water amount in the bone matrix increased, while such improvement was not observed in bgn ko mice or with supplementation of dermatan sulfate (ds). |
2021-10-18 |
2023-08-13 |
mouse |
| Fiona L Roberts, Nabil A Rashdan, Kanchan Phadwal, Greg R Markby, Scott Dillon, Janna Zoll, Julian Berger, Elspeth Milne, Isabel R Orriss, Gerard Karsenty, Olivier Le Saux, Nicholas M Morton, Colin Farquharson, Vicky E MacRa. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. Journal of cellular physiology. vol 236. issue 6. 2021-10-04. PMID:33305372. |
furthermore, an enhanced ability of isolated osteoblasts from the osteoblast-specific ko to calcify their matrix in vitro compared to fl/fl osteoblasts was observed (p < .05). |
2021-10-04 |
2023-08-13 |
mouse |
| Feng Yue, Changyou Song, Di Huang, Naagarajan Narayanan, Jiamin Qiu, Zhihao Jia, Zhengrong Yuan, Stephanie N Oprescu, Bruno T Roseguini, Meng Deng, Shihuan Kuan. PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33068545. |
unbiased rna sequencing reveals that pten ko upregulates extracellular matrix and basement membrane components positively correlated with wound healing and suppresses negative regulators of wound healing and lipid biosynthesis, thus improving the integrity of muscle basement membrane at the ultrastructural level. |
2021-09-30 |
2023-08-13 |
mouse |