| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryan D Ross, Maleeha Mashiatulla, Alexander G Robling, Lisa M Miller, D Rick Sumne. Bone Matrix Composition Following PTH Treatment is Not Dependent on Sclerostin Status. Calcified tissue international. vol 98. issue 2. 2016-10-19. PMID:26514840. |
humeral trabecular and cortical bone sites from 16 week old male wild-type (wt) and sclerostin knockout (ko) mice, which had been treated with vehicle or ipth from age 10-16 weeks, were examined by micro-computed tomography (µct) to measure bone volume, backscatter scanning electron microscopy (bsem) to assess global mineralization, and fourier transform infrared microspectroscopy (ftirm) to examine matrix composition (mineral-to-matrix ratio, crystallinity, collagen cross-link ratio, and carbonate substitution). |
2016-10-19 |
2023-08-13 |
mouse |
| Seong Ji Woo, Sang-Myeong Lee, Hye Song Lim, Young-Sool Hah, In Duk Jung, Yeong-Min Park, Hyun-Ok Kim, Yun-Hong Cheon, Min-Gyu Jeon, Kyu Yun Jang, Kyeong Min Kim, Byung-Hyun Park, Sang-Il Le. Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation. Experimental & molecular medicine. vol 48. 2016-10-18. PMID:26987484. |
the expression levels of inflammatory cytokines, matrix metalloproteinases and ror-γt were also reduced in the msirt1 ko mice compared with the wt mice and were paralleled by reductions in the numbers of th1 and th17 cells and cd80- or cd86-positive dendritic cells (dcs). |
2016-10-18 |
2023-08-13 |
mouse |
| B Javaheri, A Carriero, K A Staines, Y-M Chang, D A Houston, K J Oldknow, J L Millan, Bassir N Kazeruni, P Salmon, S Shefelbine, C Farquharson, A A Pitsillide. Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. Bone. vol 81. 2016-08-18. PMID:26232374. |
matrix mineralisation has also been reported to influence terminal osteoblast differentiation into osteocytes and we have also explored whether hypomineralised bones in phospho1 ko mice exhibit modified osteocyte lacunar and vascular porosity. |
2016-08-18 |
2023-08-13 |
mouse |
| B Javaheri, A Carriero, K A Staines, Y-M Chang, D A Houston, K J Oldknow, J L Millan, Bassir N Kazeruni, P Salmon, S Shefelbine, C Farquharson, A A Pitsillide. Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. Bone. vol 81. 2016-08-18. PMID:26232374. |
our in vitro studies examining the behaviour of osteoblast derived from phospho1 ko and wild-type mice reveal reduced levels of matrix mineralisation and modified osteocytogenic programming in cells deficient in phospho1. |
2016-08-18 |
2023-08-13 |
mouse |
| Milica Ninkovic, Ivana Stevanovic, Ivana Stojanovic, Srdjan Ljubisavljevic, Jelena Basic, Predrag Peri. The Use of Agmatine Provides the New Insight in an Experimental Model of Multiple Sclerosis. Neurochemical research. vol 40. issue 8. 2016-05-27. PMID:26141226. |
the significant elevations of matrix metalloproteinases (mmps)-mmp-3 and mmp-9 in wt and ko eae animals were decreased during agm treatment in both groups. |
2016-05-27 |
2023-08-13 |
mouse |
| Hyun Sun Park, Seon Pil Jin, Youngae Lee, In Gyung Oh, Serah Lee, Jung Ho Kim, Kwang Hyun Cho, Jin Ho Chun. Toll-like receptor 2 mediates a cutaneous reaction induced by repetitive ultraviolet B irradiation in C57/BL6 mice in vivo. Experimental dermatology. vol 23. issue 8. 2016-04-29. PMID:24962024. |
quantitative rt-pcr revealed significantly lower gene expression levels of uvb-induced interleukin (il)-1β, il-6 and matrix metalloproteinase (mmp)-13 in tlr2 ko mice. |
2016-04-29 |
2023-08-13 |
mouse |
| Kai Zhu, Tomoko Kakehi, Misaki Matsumoto, Kazumi Iwata, Masakazu Ibi, Yoichi Ohshima, Jia Zhang, Junjie Liu, Xiaopeng Wen, Ashraf Taye, Chunyuan Fan, Masato Katsuyama, Kumar Sharma, Chihiro Yabe-Nishimur. NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. Free radical biology & medicine. vol 83. 2016-03-14. PMID:25701431. |
urinary albumin and expression of inflammatory or fibrotic mediators were similarly elevated in diabetic wild-type and ko; however, increases in glomerular volume and mesangial matrix area were attenuated in diabetic ko. |
2016-03-14 |
2023-08-13 |
mouse |
| Hua Zhang, Yong Jiang, Chunlin Qin, Ying Liu, Sunita P Ho, Jian Q Fen. Essential role of osterix for tooth root but not crown dentin formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 4. 2016-01-08. PMID:25349111. |
however, the osx conditional ko (cko) mice (crossed to the 2.3-kb collagen type 1 [col1]-cre) displayed an increase in cell proliferation but great decreases in expressions of root dentin matrix proteins (dentin matrix protein 1 [dmp1] and dentin sialophosphoprotein [dspp]), leading to an inhibition in odontoblast differentiation, and short, thin root dentin with few dentin tubules. |
2016-01-08 |
2023-08-13 |
mouse |
| Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J Jenkins, Gary P Anderson, Ross Vlaho. Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice. Clinical science (London, England : 1979). vol 129. issue 9. 2015-11-17. PMID:26201093. |
il-17a knockout (ko) mice and neutralization of il-17a in wild-type (wt) mice reduced macrophage and neutrophil recruitment and chemokine (c-c motif) ligand 2 (ccl2), ccl3 and matrix metalloproteinase (mmp)-12 mrna expression in response to acute cs exposure. |
2015-11-17 |
2023-08-13 |
mouse |
| Yueqian Zhu, Yingying Zhang, Yu Liu, Ran Tao, Huitang Xia, Rui Zheng, Yuan Shi, Shengjian Tang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zho. The influence of Chm-I knockout on ectopic cartilage regeneration and homeostasis maintenance. Tissue engineering. Part A. vol 21. issue 3-4. 2015-11-16. PMID:25251892. |
interestingly, cell morphology, cartilage-specific matrix expression, and pellet culture demonstrated that chm-i knockout had no obvious influence on the phenotype, function, and chondrogenic ability of chondrocytes in vitro, except that cells in the wt group proliferated a little faster than those in the ko group. |
2015-11-16 |
2023-08-13 |
mouse |
| Anton Baysa, Julia Sagave, Andrea Carpi, Tania Zaglia, Marika Campesan, Christen P Dahl, Dusan Bilbija, Maria Troitskaya, Lars Gullestad, Marco Giorgio, Marco Mongillo, Fabio Di Lisa, Jarle I Vaage, Guro Vale. The p66ShcA adaptor protein regulates healing after myocardial infarction. Basic research in cardiology. vol 110. issue 2. 2015-09-14. PMID:25680868. |
expression of cardiac matrix metalloproteinase 2 (mmp-2) was reduced; fibroblast activation and collagen accumulation were facilitated, while oxidative stress was attenuated in ko early post-infarction. |
2015-09-14 |
2023-08-13 |
mouse |
| Ping-An Fang, Kostas Verdelis, Xu Yang, Lyudmila Lukashova, Adele L Boskey, Elia Benias. Ultrastructural organization of dentin in mice lacking dentin sialo-phosphoprotein. Connective tissue research. vol 55 Suppl 1. 2015-08-12. PMID:25158189. |
scanning electron microscopy in the back-scattered mode (bs-sem) of the dspp ko dentin revealed that circumpulpal dentin comprises large areas of non-mineralized matrix, with numerous spherulitic mineralized inclusions, while the mantle dentin appeared largely unaffected. |
2015-08-12 |
2023-08-13 |
mouse |
| Maozhou Yang, Liang Zhang, Jeff Stevens, Gary Gibso. CRISPR/Cas9 mediated generation of stable chondrocyte cell lines with targeted gene knockouts; analysis of an aggrecan knockout cell line. Bone. vol 69. 2015-07-31. PMID:25260929. |
acan ko cells failed to form a substantial chondrosarcoma when injected subcutaneously in nude mice consistent with previous suggestions that the glycosaminoglycan-rich matrix surrounding the chondrosarcoma protects it from destruction by the host immune system. |
2015-07-31 |
2023-08-13 |
mouse |
| Carlos B Rueda, Javier Traba, Ignacio Amigo, Irene Llorente-Folch, Paloma González-Sánchez, Beatriz Pardo, José A Esteban, Araceli del Arco, Jorgina Satrústegu. Mitochondrial ATP-Mg/Pi carrier SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716855. |
scamc-3 ko neurons show an earlier delayed ca(2+) deregulation, and scamc-3-deficient mitochondria incubated with adp or atp-mg had reduced ca(2+) retention capacity, suggesting a failure to maintain matrix adenine nucleotides as a cause for premature delayed ca(2+) deregulation. |
2015-06-29 |
2023-08-13 |
mouse |
| Einat Levy-Apter, Eynat Finkelshtein, Vidyasiri Vemulapalli, Shawn S-C Li, Mark T Bedford, Ari Elso. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts. The Journal of biological chemistry. vol 289. issue 52. 2015-04-14. PMID:25381250. |
loss of cyt-ptpe reduces src activity in osteoclasts, reduces resorption of mineralized matrix both in vivo and in cell culture, and induces mild osteopetrosis in young female ptpe ko mice. |
2015-04-14 |
2023-08-13 |
mouse |
| Mayssam Khaddam, Eric Huet, Benoît Vallée, Morad Bensidhoum, Dominique Le Denmat, Anna Filatova, Lucia Jimenez-Rojo, Sandy Ribes, Georg Lorenz, Maria Morawietz, Gael Y Rochefort, Andreas Kiesow, Thimios A Mitsiadis, Anne Poliard, Matthias Petzold, Eric E Gabison, Suzanne Menashi, Catherine Chaussai. EMMPRIN/CD147 deficiency disturbs ameloblast-odontoblast cross-talk and delays enamel mineralization. Bone. vol 66. 2015-03-30. PMID:24970041. |
the mild tooth phenotype observed in emmprin ko mice suggests that the direct effect of emmprin may be limited to a short time window, comprised between basement membrane degradation allowing direct cell contact and calcified matrix deposition. |
2015-03-30 |
2023-08-13 |
mouse |
| Guoyong Yin, Tzong-Jen Sheu, Prashanthi Menon, Jinjiang Pang, Hsin-Chiu Ho, Shanshan Shi, Chao Xie, Elaine Smolock, Chen Yan, Michael J Zuscik, Bradford C Ber. Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. PloS one. vol 9. issue 2. 2015-01-10. PMID:24586541. |
alcian blue staining of fracture callus indicated a persistence of cartilagenous matrix in day 21 callus samples from git1 ko mice which was temporally correlated with increased type 2 collagen immunostaining. |
2015-01-10 |
2023-08-12 |
mouse |
| Michel Goldberg, O Kellermann, S Dimitrova-Nakov, Y Harichane, A Baudr. Comparative studies between mice molars and incisors are required to draw an overview of enamel structural complexity. Frontiers in physiology. vol 5. 2014-10-06. PMID:25285079. |
the incisors from 5ht2br knockout (ko) mice exhibit mineralization defects mostly in the outer maturation zone and porous matrix network in the inner zone. |
2014-10-06 |
2023-08-13 |
mouse |
| Michel Goldberg, O Kellermann, S Dimitrova-Nakov, Y Harichane, A Baudr. Comparative studies between mice molars and incisors are required to draw an overview of enamel structural complexity. Frontiers in physiology. vol 5. 2014-10-06. PMID:25285079. |
differences of enamel structure were also observed between incisor and molar from other ko mice depleted for genes encoding enamel extracellular matrix proteins. |
2014-10-06 |
2023-08-13 |
mouse |
| R Takahashi, H Amano, T Satoh, K Tabata, M Ikeda, H Kitasato, S Akira, M Iwamura, M Majim. Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 68. issue 1. 2014-09-22. PMID:24291175. |
in addition, the expressions of matrix metalloproteinases (mmp)-9, and metalloproteinases (mmp)-2 were down-regulated in metastatic lungs in mpges-1 ko mice. |
2014-09-22 |
2023-08-12 |
mouse |