| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ciprian B Anea, M Irfan Ali, Jessica M Osmond, Jennifer C Sullivan, David W Stepp, Ana M Merloiu, R Daniel Rudi. Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice. Arteriosclerosis, thrombosis, and vascular biology. vol 30. issue 12. 2010-12-21. PMID:20829506. |
to determine if elasticity in blood vessels is compromised in circadian clock-mutant mice (bmal1-knockout [ko] and per-triple ko) and if matrix metalloproteinases (mmps) might confer these changes in compliance. |
2010-12-21 |
2023-08-12 |
mouse |
| Kazuyo Yamaji-Kegan, Qingning Su, Daniel J Angelini, Allen C Myers, Chris Cheadle, Roger A John. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 9. 2010-11-12. PMID:20889544. |
we also found that himf-induced proliferative activity, hypertrophy, collagen, and extracellular matrix deposition in the pulmonary arteries are significantly less in il-4 ko mice than in wt mice. |
2010-11-12 |
2023-08-12 |
mouse |
| Marcela Claudino, Thiago P Garlet, Cristina R B Cardoso, Gerson F de Assis, Rumio Taga, Fernando Q Cunha, João S Silva, Gustavo P Garle. Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice. European journal of oral sciences. vol 118. issue 1. 2010-05-10. PMID:20156261. |
the levels of expression of messenger rna (mrna) for tumor necrosis factor-alpha (tnf-alpha), il-1beta, il-6, transforming growth factor-beta (tgf-beta), receptor activator of nuclear factor kappab ligand (rankl), osteoprotegerin (opg), and matrix metalloproteinase 13 (mmp13) were similar between both strains, whereas a significant decrease of tissue inhibitor of metalloproteinase 1 (timp1) mrna expression was found at 48 wk in il-10 ko mice. |
2010-05-10 |
2023-08-12 |
mouse |
| Marcela Claudino, Thiago P Garlet, Cristina R B Cardoso, Gerson F de Assis, Rumio Taga, Fernando Q Cunha, João S Silva, Gustavo P Garle. Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice. European journal of oral sciences. vol 118. issue 1. 2010-05-10. PMID:20156261. |
the osteoblast markers core binding factor alpha1 (cbfa1) and type i collagen (col-i) were expressed at similar levels in both strains, whereas the levels of alkaline phosphatase (alp) and osteocalcin (ocn), and those of the osteocyte markers phosphate-regulating gene endopeptidases (phex) and dentin matrix protein 1 (dmp1) were significantly lower in il-10 ko mice. |
2010-05-10 |
2023-08-12 |
mouse |
| Veronica Ulici, Katie D Hoenselaar, Hanga Agoston, David D McErlain, Joseph Umoh, Subrata Chakrabarti, David W Holdsworth, Frank Beie. The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone. vol 45. issue 6. 2010-01-26. PMID:19679212. |
the expression of matrix metalloproteinase-14 (mmp-14), the main protease responsible for development of secondary ossification centers, was decreased in the epiphysis of akt1 ko mice, possibly explaining the delay in secondary ossification centers seen in the akt1 ko mice. |
2010-01-26 |
2023-08-12 |
mouse |
| Alan A Thomay, Jean M Daley, Edmond Sabo, Patrick J Worth, Leslie J Shelton, Mark W Harty, Jonathan S Reichner, Jorge E Albin. Disruption of interleukin-1 signaling improves the quality of wound healing. The American journal of pathology. vol 174. issue 6. 2009-06-23. PMID:19389930. |
there were no differences in either total collagenolytic activity or in the expression of selected matrix metalloproteinases or tissue inhibitors of metalloproteinases between the wound fluids from wild-type or il-1r ko mice. |
2009-06-23 |
2023-08-12 |
mouse |
| Angela Satie Nishikaku, Raphael Fagnani Sanchez Molina, Luciana Cristina Ribeiro, Renata Scavone, Bernardo Paulo Albe, Cláudia Silva Cunha, Eva Burge. Nitric oxide participation in granulomatous response induced by Paracoccidioides brasiliensis infection in mice. Medical microbiology and immunology. vol 198. issue 2. 2009-05-06. PMID:19360439. |
the role of nitric oxide (no) in granulomas of paracoccidioides brasiliensis-infected inducible no synthase-deficient c57bl/6 mice (inos ko) and their wild-type counterparts and its association with osteopontin (opn) and matrix metalloproteinases (mmps) was studied. |
2009-05-06 |
2023-08-12 |
mouse |
| Michel Goldberg, Mitsuaki Ono, Dominique Septier, Mireille Bonnefoix, Tina M Kilts, Yanming Bi, Mildred Embree, Laurent Ameye, Marian F Youn. Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation. Cells, tissues, organs. vol 189. issue 1-4. 2009-02-10. PMID:18698127. |
the extracellular matrix of newborn, 7- and 21-day-old fibromodulin-deficient (fmod ko) mice was compared with age-matched wild-type (wt) mice. |
2009-02-10 |
2023-08-12 |
mouse |
| Michel Goldberg, Mitsuaki Ono, Dominique Septier, Mireille Bonnefoix, Tina M Kilts, Yanming Bi, Mildred Embree, Laurent Ameye, Marian F Youn. Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation. Cells, tissues, organs. vol 189. issue 1-4. 2009-02-10. PMID:18698127. |
dentin matrix protein1 (dmp1) was slightly increased in fmod ko versus wt tooth extracts. |
2009-02-10 |
2023-08-12 |
mouse |
| Zhongsheng Peng, Patricia Fernandez, Tuere Wilder, Herman Yee, Luis Chiriboga, Edwin S L Chan, Bruce N Cronstei. Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 7. 2008-08-12. PMID:18263696. |
after ccl(4) treatment, the mrna level of a(1), a(2a), a(2b), and a(3) adenosine receptors, tumor necrosis factor-alpha, interleukin (il) -1beta, il-13r alpha1, matrix metalloproteinase (mmp)-2, mmp-14, tissue inhibitor of metalloproteinase (timp) -1, and timp-2, and il-13 level increased markedly in both cd73ko and wt mice, but col1 alpha1, col3 alpha1, and transforming growth factor-beta1 mrna increased much more in wt mice than that in ko mice. |
2008-08-12 |
2023-08-12 |
mouse |
| Ferda Cevikbas, Liliana Schaefer, Philipp Uhlig, Horst Robenek, Gregor Theilmeier, Frank Echtermeyer, Peter Bruckne. Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice. Matrix biology : journal of the International Society for Matrix Biology. vol 27. issue 1. 2008-06-11. PMID:17681770. |
60 days after unilateral nephrectomy (unx), mesangial expansion, enhanced matrix production (collagens i and iv, fibronectin) and focal segmental glomerulosclerosis, resembling early stages of diabetic nephropathy, was apparent in male but not female syndecan-4 ko mice. |
2008-06-11 |
2023-08-12 |
mouse |
| Carly LaCroix, Jessica Freeling, Alese Giles, Jürgen Wess, Yi-Fan L. Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress. American journal of physiology. Heart and circulatory physiology. vol 294. issue 2. 2008-03-31. PMID:18055517. |
furthermore, chronic iso infusion significantly increased matrix metalloproteinase (mmp) activity in the heart in m(2)-achr ko mice. |
2008-03-31 |
2023-08-12 |
mouse |
| Rungnapa Warotayanont, Danhong Zhu, Malcolm L Snead, Yan Zho. Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochemical and biophysical research communications. vol 367. issue 1. 2008-03-07. PMID:18086559. |
our data indicate that lrap treatment of wt and ko es cells induces a significant increase in mineral matrix formation, and significant increases in bone sialoprotein and osterix gene expression. |
2008-03-07 |
2023-08-12 |
mouse |
| Brian Tomkowicz, Katherine Rybinski, Brian Foley, Wolfgang Ebel, Brad Kline, Eric Routhier, Philip Sass, Nicholas C Nicolaides, Luigi Grasso, Yuhong Zho. Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 46. 2008-01-10. PMID:17986615. |
this abnormal angiogenic response could be responsible for the reduced tumor growth and invasion observed in endosialin/tem1 ko mice, suggesting a role for endosialin/tem1 in controlling the interaction among tumor cells, endothelia, and stromal matrix. |
2008-01-10 |
2023-08-12 |
mouse |
| Stefano Menini, Lorena Amadio, Giovanna Oddi, Carlo Ricci, Carlo Pesce, Francesco Pugliese, Marco Giorgio, Enrica Migliaccio, PierGiuseppe Pelicci, Carla Iacobini, Giuseppe Puglies. Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress. Diabetes. vol 55. issue 6. 2007-07-23. PMID:16731826. |
mesangial cells from ko mice grown under high-glucose conditions showed lower cell death rate, matrix production, ros levels, and activation of nf-kappab than those from wild-type mice. |
2007-07-23 |
2023-08-12 |
mouse |
| Syed M Meeran, Suchitra Katiyar, Craig A Elmets, Santosh K Katiya. Interleukin-12 deficiency is permissive for angiogenesis in UV radiation-induced skin tumors. Cancer research. vol 67. issue 8. 2007-05-23. PMID:17440092. |
we found that the protein, mrna expression and/or activity of the matrix metalloproteinases (mmp)-2, mmp-3, mmp-7, and mmp-9, and basic fibroblast growth factor, which play crucial roles in tumor growth, were significantly higher in uvb-exposed skin and tumors of il-12 ko mice compared with wt mice. |
2007-05-23 |
2023-08-12 |
mouse |
| Takahiko Nakagawa, Waichi Sato, Olena Glushakova, Marcelo Heinig, Tracy Clarke, Martha Campbell-Thompson, Yukio Yuzawa, Mark A Atkinson, Richard J Johnson, Byron Croke. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. Journal of the American Society of Nephrology : JASN. vol 18. issue 2. 2007-04-10. PMID:17202420. |
diabetic enos ko mice developed hypertension, albuminuria, and renal insufficiency with arteriolar hyalinosis, mesangial matrix expansion, mesangiolysis with microaneurysms, and kimmelstiel-wilson nodules. |
2007-04-10 |
2023-08-12 |
mouse |
| Carlos Martínez-Salgado, Isabel Fuentes-Calvo, Begoña García-Cenador, Eugenio Santos, José M López-Novo. Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis. Experimental cell research. vol 312. issue 11. 2006-08-04. PMID:16624289. |
we study the role of n- and h-ras isoforms, and the involvement of the ras effectors erk and akt, in tgf-beta1-mediated extracellular matrix (ecm) synthesis and proliferation, using embrionary fibroblasts from double knockout (ko) mice for h- and n-ras (h-ras(-/-)/n-ras(-/-)) isoforms and from heterozygote mice (h-ras(+/-)/n-ras(+/-)). |
2006-08-04 |
2023-08-12 |
mouse |
| Hanjun Zhao, Akihiko Ito, Naohiko Sakai, Yuji Matsuzawa, Shizuya Yamashita, Hiroshi Nojim. RECS1 is a negative regulator of matrix metalloproteinase-9 production and aged RECS1 knockout mice are prone to aortic dilation. Circulation journal : official journal of the Japanese Circulation Society. vol 70. issue 5. 2006-07-31. PMID:16636500. |
the present study was designed to assess whether recs1 ko mice have altered gelatinase (matrix metalloproteinase (mmp)-2 and mmp-9) levels and whether they are prone to aortic dilation. |
2006-07-31 |
2023-08-12 |
mouse |
| Elia Beniash, Ziedonis Skobe, John D Bartlet. Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisors. European journal of oral sciences. vol 114 Suppl 1. 2006-07-28. PMID:16674658. |
an anomalous dentino-enamel junction (dej), manifested by delamination of the enamel layer, was reported in enamelysin [matrix metalloproteinase-20 (mmp-20)] knockout (ko) mice. |
2006-07-28 |
2023-08-12 |
mouse |