| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takuya Kameda, Joel Zvick, Miriam Vuk, Aleksandra Sadowska, Wai Kit Tam, Victor Y Leung, Kata Bölcskei, Zsuzsanna Helyes, Lee Ann Applegate, Oliver N Hausmann, Juergen Klasen, Olga Krupkova, Karin Wuertz-Koza. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30974795. |
the matrix structure and composition in caudal motion segments from trpa1 and trpv1 wild-type (wt) and knock-out (ko) mice was visualized by fast staining. |
2019-07-30 |
2023-08-13 |
mouse |
| Aswin Hari, Shelly A Cruz, Zhaohong Qin, Pascal Couture, Ragnar O Vilmundarson, Hua Huang, Alexandre F R Stewart, Hsiao-Huei Che. IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care. Scientific reports. vol 7. issue 1. 2019-04-23. PMID:28852125. |
proteoglycan 4 (prg4), prostaglandin d2 synthase (ptgds) and extracellular matrix protease inhibitor itih2 were suppressed by epc in wt but elevated in ko mice. |
2019-04-23 |
2023-08-13 |
mouse |
| Xu Chen Lin, Xin Liu, Kai Li, Chang Zhao, Song Xu, Yue Zhang, Xiao Chun Bai, Dao Zhang Ca. B-cell-specific mammalian target of rapamycin complex 1 activation results in severe osteoarthritis in mice. International immunopharmacology. vol 65. 2019-04-08. PMID:30408629. |
importantly, inflammatory cytokine production was also increased in b cells from the spleen of cd19-tsc1 conditional ko mice, but the oa phenotype was significantly elevated in conditional ko mice after dmm surgery compared with con mice, as indicated by more severe articular cartilage destruction, increased protein expression of matrix metalloproteinase-13 and mrna of type x collagen in the articular cartilage, decreased mrna expression of type ii collagen in the articular cartilage, and increased inflammatory cytokines in serum and the synovial membrane. |
2019-04-08 |
2023-08-13 |
mouse |
| James B Papizan, Alexander H Vidal, Svetlana Bezprozvannaya, Rhonda Bassel-Duby, Eric N Olso. Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice. The Journal of biological chemistry. vol 293. issue 23. 2019-01-22. PMID:29653945. |
many of the proteins whose expression was significantly changed in the skm-cul3 ko were components of the extracellular matrix and sarcomere, whereas proteins altered in the cm-cul3 ko were involved in metabolism. |
2019-01-22 |
2023-08-13 |
mouse |
| Rafael Ramirez-Carracedo, Laura Tesoro, Ignacio Hernandez, Javier Diez-Mata, Marco Filice, Rocío Toro, Manuel Rodriguez-Piñero, Jose Luis Zamorano, Marta Saura, Carlos Zaragoz. Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide. International journal of molecular sciences. vol 19. issue 10. 2019-01-21. PMID:30347750. |
to test whether the absence of no may aggravate atherosclerosis through emmprin activation, double nos3/apoe knockout (ko) mice expressed high levels of emmprin in carotid plaques, suggesting that targeting extracellular matrix degradation may represent a new mechanism by which endothelial no prevents atherosclerosis. |
2019-01-21 |
2023-08-13 |
mouse |
| Zhihui Tian, Xiaolin Lv, Min Zhang, Xueer Wang, Yinghua Chen, Pei Tang, Pengcheng Xu, Lu Zhang, Buling Wu, Lin Zhan. Deletion of epithelial cell-specific Cdc42 leads to enamel hypermaturation in a conditional knockout mouse model. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 8. 2018-08-06. PMID:29684584. |
in addition, he staining indicated a remarkable difference in the ameloblast morphology and function between ko and wt mice, and immunohistochemistry showed increased expression of amelogenin, ameloblastin, matrix metallopeptidase 20, kallikrein-related peptidase 4 and amelotin in the ko mice teeth. |
2018-08-06 |
2023-08-13 |
mouse |
| Nina J Kristofik, Lingfeng Qin, Nicole E Calabro, Sashka Dimitrievska, Guangxin Li, George Tellides, Laura E Niklason, Themis R Kyriakide. Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix. Biomaterials. vol 141. 2018-04-30. PMID:28667900. |
in the present study, we investigated the use of mouse thrombospondin-2 knockout (tsp2 ko) cells, which secrete a non-thrombogenic and pro-migratory extracellular matrix (tsp2 ko ecm), to modify small diameter vascular grafts. |
2018-04-30 |
2023-08-13 |
mouse |
| Alan Boyde, Katherine A Staines, Behzad Javaheri, Jose Luis Millan, Andrew A Pitsillides, Colin Farquharso. A distinctive patchy osteomalacia characterises Phospho1-deficient mice. Journal of anatomy. vol 231. issue 2. 2018-04-17. PMID:28737011. |
extensive regions of both compact cortical and trabecular bone matrix in phospho1 ko mice contained no significant mineral and/or showed arrested mineralisation fronts, characterised by a failure in the fusion of the calcospherite-like, separately mineralising, individual micro-volumes within bone. |
2018-04-17 |
2023-08-13 |
mouse |
| Alan Boyde, Katherine A Staines, Behzad Javaheri, Jose Luis Millan, Andrew A Pitsillides, Colin Farquharso. A distinctive patchy osteomalacia characterises Phospho1-deficient mice. Journal of anatomy. vol 231. issue 2. 2018-04-17. PMID:28737011. |
osteoclastic resorption of the uncalcified matrix in phospho1 ko mice was attenuated compared with surrounding normally mineralised bone. |
2018-04-17 |
2023-08-13 |
mouse |
| Hyunjung Min, Boomin Choi, Yong Ho Jang, Ik-Hyun Cho, Sung Joong Le. Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage. Molecular brain. vol 10. issue 1. 2018-04-16. PMID:28646881. |
this effect was most likely due to reduced matrix metalloproteinase 9 (mmp9) activity in the tlr2 ko mice compared to wt mice. |
2018-04-16 |
2023-08-13 |
mouse |
| Akira Nagaoka, Hiroaki Takehara, Akiko Hayashi-Takagi, Jun Noguchi, Kazuhiko Ishii, Fukutoshi Shirai, Sho Yagishita, Takanori Akagi, Takanori Ichiki, Haruo Kasa. Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo. Scientific reports. vol 6. 2018-04-02. PMID:27221801. |
accordingly, the application of matrix metalloproteinase-9 inhibitors selectively restored the abnormal spine dynamics observed in fmr1 ko mice, without affecting the intrinsic dynamics of spine turnover in wild-type mice. |
2018-04-02 |
2023-08-13 |
mouse |
| Zhenghao Piao, Haiying Yuan, Cuili Wang, Liyun Sh. IRF3 Inhibits Neutrophil Recruitment in Mice Infected with Pseudomonas aeruginosa. Inflammation. vol 40. issue 3. 2018-03-12. PMID:28181039. |
furthermore, neutrophils from the bone marrow (bm) of irf3 ko mice showed greater adhesiveness to the extracellular matrix when compared with those of wt mice, post-p. aeruginosa infection. |
2018-03-12 |
2023-08-13 |
mouse |
| Man J Livingston, Han-Fei Ding, Shuang Huang, Joseph A Hill, Xiao-Ming Yin, Zheng Don. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy. vol 12. issue 6. 2017-11-13. PMID:27123926. |
consistently, proliferation and activation of fibroblasts, as indicated by the expression of acta2/α-smooth muscle actin and vim (vimentin), was inhibited in pt-atg7 ko mice, so was the accumulation of extracellular matrix components including fn1 (fibronectin 1) and collagen fibrils. |
2017-11-13 |
2023-08-13 |
mouse |
| Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Par. Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice. PloS one. vol 12. issue 10. 2017-10-19. PMID:29016649. |
transcriptional profiling with a microarray revealed that genes participating in cell growth, cytokine signalling, phospholipid metabolism, and extracellular matrix are up-regulated in the myocardia of shp knockout (ko) mice compared to those of wild-type (wt) mice (nominal p value < 0.05). |
2017-10-19 |
2023-08-13 |
mouse |
| Nina Kristofik, Nicole E Calabro, Weiming Tian, Aaron Meng, Susan MacLauchlan, Yinong Wang, Christopher K Breuer, George Tellides, Laura E Niklason, Themis R Kyriakide. Impaired von Willebrand factor adhesion and platelet response in thrombospondin-2 knockout mice. Blood. vol 128. issue 12. 2017-08-28. PMID:27471233. |
in the present study, we investigated the contribution of an extracellular matrix (ecm) abnormality to the bleeding diathesis in thrombospondin-2 (tsp2) knockout (ko) mice. |
2017-08-28 |
2023-08-13 |
mouse |
| Manuela Funke, Lars Knudsen, David Lagares, Simone Ebener, Clemens K Probst, Benjamin A Fontaine, Alicia Franklin, Manuela Kellner, Mark Kühnel, Stephanie Matthieu, Roman Grothausmann, Jerold Chun, Jesse D Roberts, Matthias Ochs, Andrew M Tage. Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization. American journal of respiratory cell and molecular biology. vol 55. issue 1. 2017-06-30. PMID:27082727. |
tropoelastin messenger rna expression was decreased in ko lungs, whereas expression of matrix metalloproteinases degrading elastic fibers was either decreased or unchanged. |
2017-06-30 |
2023-08-13 |
mouse |
| Manuela Funke, Lars Knudsen, David Lagares, Simone Ebener, Clemens K Probst, Benjamin A Fontaine, Alicia Franklin, Manuela Kellner, Mark Kühnel, Stephanie Matthieu, Roman Grothausmann, Jerold Chun, Jesse D Roberts, Matthias Ochs, Andrew M Tage. Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization. American journal of respiratory cell and molecular biology. vol 55. issue 1. 2017-06-30. PMID:27082727. |
peripheral septal fibroblasts and myofibroblasts, which direct septation in late alveolarization, demonstrated reduced production of tropoelastin and matrix metalloproteinases, and diminished lpa-induced migration, when isolated from lpa1 ko mice. |
2017-06-30 |
2023-08-13 |
mouse |
| Ming Gao, Haoqian Zhang, Alpa Trivedi, Kiran V Mahasenan, Valerie A Schroeder, William R Wolter, Mark A Suckow, Shahriar Mobashery, Linda J Noble-Haeusslein, Mayland Chan. Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury. ACS chemical neuroscience. vol 7. issue 11. 2017-06-21. PMID:27551907. |
matrix metalloproteinase (mmp)-2 knockout (ko) mice show impaired neurological recovery after spinal cord injury (sci), suggesting that this proteinase is critical to recovery processes. |
2017-06-21 |
2023-08-13 |
mouse |
| Haruhiko Sakiyama, Noriko Fujiwara, Yuka Yoneoka, Daisaku Yoshihara, Hironobu Eguchi, Keiichiro Suzuk. Cu,Zn-SOD deficiency induces the accumulation of hepatic collagen. Free radical research. vol 50. issue 6. 2017-03-29. PMID:26981929. |
the level of expression of hsp47, a chaperone of collagen, and a tissue inhibitor (timp1) of matrix metalloproteinases (a collagen degradating enzyme) was also increased in sod1 ko mice livers. |
2017-03-29 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Teresa H Wen, Sarah Reinhard, Mike S Hsu, Harpreet Sidhu, Iryna M Ethell, Devin K Binder, Khaleel A Raza. Matrix metalloproteinase-9 deletion rescues auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome. Neurobiology of disease. vol 89. 2016-12-13. PMID:26850918. |
we report a repetition-rate dependent reduction in habituation of n1 amplitude in fmr1 ko mice and show that matrix metalloproteinase-9 (mmp-9), one of the known fmrp targets, contributes to the reduced erp habituation. |
2016-12-13 |
2023-08-13 |
mouse |