| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Harpreet Sidhu, Lorraine E Dansie, Peter W Hickmott, Douglas W Ethell, Iryna M Ethel. Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 30. 2014-09-22. PMID:25057190. |
here we provide conclusive evidence that matrix metalloproteinase-9 (mmp-9) is necessary to the development of fxs-associated defects in fmr1 ko mice. |
2014-09-22 |
2023-08-13 |
mouse |
| A Lu, Y Suofu, F Guan, J P Broderick, K R Wagner, J F Clar. Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1 h of cerebral ischemia and 23 h of reperfusion. Neuroscience. vol 253. 2014-06-19. PMID:24035828. |
although elevated matrix metalloproteinase (mmp)-2 levels were highly related to the degradation of tight junction (tj) proteins and basal lamina and neuronal injury after ischemia, until very recently, little experimental evidence was available to test the role of the mmp-2 knockout (ko) in blood-brain-barrier (bbb) injury and the development of hemorrhage transformation (ht). |
2014-06-19 |
2023-08-12 |
mouse |
| Matheus Correa-Costa, Vinicius Andrade-Oliveira, Tarcio T Braga, Angela Castoldi, Cristhiane F Aguiar, Clarice S T Origassa, Andrea C D Rodas, Meire I Hiyane, Denise M A C Malheiros, Francisco J O Rios, Sonia Jancar, Niels O S Câmar. Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 4. 2014-05-15. PMID:24492283. |
pafr ko animals compared with wt mice present: (a) less renal dysfunction, evaluated by urine protein/creatinine ratio; (b) less fibrosis evaluated by collagen deposition, type i collagen, lysyl oxidase-1 (lox-1) and transforming growth factor β (tgf-β) gene expression, and higher expression of bone morphogenetic protein 7 (bmp-7) (3.3-fold lower tgf-β/bmp-7 ratio); (c) downregulation of extracellular matrix (ecm) and adhesion molecule-related machinery genes; and (d) lower levels of pro-inflammatory cytokines. |
2014-05-15 |
2023-08-12 |
mouse |
| Fang Wang, Pei-xia Wang, Xiao-lin Wu, Su-ying Dang, Yan Chen, Ying-yin Ni, Li-hong Gao, Shun-yuan Lu, Ying Kuang, Lei Huang, Jian Fei, Zhu-gang Wang, Xiao-fen Pan. Deficiency of adiponectin protects against ovariectomy-induced osteoporosis in mice. PloS one. vol 8. issue 7. 2014-02-07. PMID:23844209. |
further studies using bone marrow derived mesenchymal stem cells (mscs) demonstrate an enhanced osteogenic differentiation and extracellular matrix calcification in apn ko mice. |
2014-02-07 |
2023-08-12 |
mouse |
| Faezeh Vasheghani, Roxana Monemdjou, Hassan Fahmi, Yue Zhang, Gemma Perez, Meryem Blati, René St-Arnaud, Jean-Pierre Pelletier, Frank Beier, Johanne Martel-Pelletier, Mohit Kapoo. Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. The American journal of pathology. vol 182. issue 4. 2013-08-27. PMID:23375622. |
adult pparγ ko mice exhibited a spontaneous oa phenotype associated with enhanced cartilage degradation, hypocellularity, synovial and cartilage fibrosis, synovial inflammation, mononuclear cell influx in the synovium, and increased expression of catabolic factors, including matrix metalloproteinase-13, accompanied by an increase in staining for matrix metalloproteinase-generated aggrecan and type ii collagen neoepitopes (vdipen and c1-2c). |
2013-08-27 |
2023-08-12 |
mouse |
| Young-Hyun You, Shinichi Okada, San Ly, Karin Jandeleit-Dahm, David Barit, Tamehachi Namikoshi, Kumar Sharm. Role of Nox2 in diabetic kidney disease. American journal of physiology. Renal physiology. vol 304. issue 7. 2013-05-23. PMID:23389458. |
all functional and structural features of early and later stage diabetic kidney disease (albuminuria, mesangial matrix, tubulointerstitial disease, and gene expression of matrix and transforming growth factor-β) were similar in both diabetic groups compared with their respective nondiabetic groups, except for reduction of macrophage infiltration and monocyte chemoattractant protein-1 in the diabetic nox2 ko mice. |
2013-05-23 |
2023-08-12 |
mouse |
| Chandrika D Mahalingam, Bharat Reddy Sampathi, Sonali Sharma, Tanuka Datta, Varsha Das, Abdul B Abou-Samra, Nabanita S Datt. MKP1-dependent PTH modulation of bone matrix mineralization in female mice is osteoblast maturation stage specific and involves P-ERK and P-p38 MAPKs. The Journal of endocrinology. vol 216. issue 3. 2013-04-30. PMID:23197743. |
changes in matrix gla protein expression with pth in ko osteoblasts did not correlate with mineralization, indicative of mkp1-dependent additional mechanisms essential for pth action on osteoblast mineralization. |
2013-04-30 |
2023-08-12 |
mouse |
| Xia Chen, Ziran Wei, Weimin Wang, Ronlin Yan, Xudong Xu, Qingping Ca. Role of RNA-binding protein tristetraprolin in tumor necrosis factor-α mediated gene expression. Biochemical and biophysical research communications. vol 428. issue 3. 2013-03-25. PMID:22995314. |
through a study of 2-dimentional gene set matrix analysis, we also found the genes upregulated by tnf-α in ttp ko cells were correlated with the pathologic phenotypes in inflammation, joint, or bone diseases. |
2013-03-25 |
2023-08-12 |
mouse |
| Biswajit Chowdhury, Richard Hemming, Sabine Hombach-Klonisch, Bruno Flamion, Barbara Triggs-Rain. Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. The Journal of biological chemistry. vol 288. issue 1. 2013-02-28. PMID:23172227. |
histological studies of the heart revealed that the valves of all hyal2 ko mice were expanded and the extracellular matrix was disorganized. |
2013-02-28 |
2023-08-12 |
mouse |
| Biswajit Chowdhury, Richard Hemming, Sabine Hombach-Klonisch, Bruno Flamion, Barbara Triggs-Rain. Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. The Journal of biological chemistry. vol 288. issue 1. 2013-02-28. PMID:23172227. |
both acute and non-acute hyal2 ko mice also exhibited increased ha in the interstitial extracellular matrix of atrial cardiomyocytes compared with control mice. |
2013-02-28 |
2023-08-12 |
mouse |
| Anna M D Watson, Stephen P Gray, Li Jiaze, Aino Soro-Paavonen, Benedict Wong, Mark E Cooper, Angelika Bierhaus, Raelene Pickering, Christos Tikellis, Despina Tsorotes, Merlin C Thomas, Karin A M Jandeleit-Dah. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes. vol 61. issue 8. 2012-10-08. PMID:22698914. |
however, treatment with alagebrium in diabetic rage apoe ko mice reduced renal age levels and further reduced glomerular matrix accumulation. |
2012-10-08 |
2023-08-12 |
mouse |
| Diana Lindner, Moritz Hilbrandt, Katharina Marggraf, P Moritz Becher, Denise Hilfiker-Kleiner, Karin Klingel, Matthias Pauschinger, Heinz-Peter Schultheiss, Carsten Tschöpe, Dirk Westerman. Protective Function of STAT3 in CVB3-Induced Myocarditis. Cardiology research and practice. vol 2012. 2012-08-23. PMID:22675647. |
furthermore, the matrix degradation was reduced in stat3 ko mice which might be an explanation for the observed matrix deposition. |
2012-08-23 |
2023-08-12 |
mouse |
| J Lu, X Wang, W Wang, H Muniyappa, C Hu, S Mitra, B Long, K Das, J L Meht. LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse. Gene therapy. vol 19. issue 5. 2012-08-02. PMID:21938018. |
the lox-1 ko mice hearts exhibited a disintegrin and metalloproteinase 10 (adam10) and a disintegrin and metalloproteinase 17 (adam17) expression and matrix metalloproteinase 2 activity, and increased at2r expression (p<0.05). |
2012-08-02 |
2023-08-12 |
mouse |
| Jae Youn Cho, Alexa Pham, Peter Rosenthal, Marina Miller, Taylor Doherty, David H Broid. Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling. International immunopharmacology. vol 11. issue 8. 2012-01-10. PMID:21382533. |
in addition, tnf-r ko mice had significantly reduced thickness of the peribronchial smooth muscle layer, area of peribronchial α-smooth muscle actin immunostaining, and levels of the extracellular matrix protein fibronectin. |
2012-01-10 |
2023-08-12 |
mouse |
| Mieke Sinnesael, Steven Boonen, Frank Claessens, Evelien Gielen, Dirk Vanderschuere. Testosterone and the male skeleton: a dual mode of action. Journal of osteoporosis. vol 2011. 2011-11-10. PMID:21941679. |
selective ko studies of the androgen receptor in osteoblasts in male mice suggest that the osteoblast in the target cell for androgen receptor mediated maintenance of trabecular bone volume and coordination of bone matrix synthesis and mineralization. |
2011-11-10 |
2023-08-12 |
mouse |
| Biquan Luo, Ben S Lam, Sung Hyung Lee, Shiuan Wey, Hui Zhou, Miao Wang, Si-Yi Chen, Gregor B Adams, Amy S Le. The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche. PloS one. vol 6. issue 5. 2011-09-22. PMID:21647226. |
investigating this, we further determined that there was a near complete loss of integrin α4 expression on the cell surface of grp94 ko hscs, which showed impaired binding with fibronectin, an extracellular matrix molecule known to play a role in mediating hsc-niche interactions. |
2011-09-22 |
2023-08-12 |
mouse |
| Inmaculada Bañón-Rodríguez, James Monypenny, Chiara Ragazzini, Ana Franco, Yolanda Calle, Gareth E Jones, Inés M Antó. The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cells. European journal of cell biology. vol 90. issue 2-3. 2011-07-20. PMID:20952093. |
infection of wip ko dcs with lentivirus expressing wip restored both podosome formation and their ability to degrade the extracellular matrix, implicating wip-induced podosomes as foci of functional mmp location. |
2011-07-20 |
2023-08-12 |
Not clear |
| Inmaculada Bañón-Rodríguez, James Monypenny, Chiara Ragazzini, Ana Franco, Yolanda Calle, Gareth E Jones, Inés M Antó. The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cells. European journal of cell biology. vol 90. issue 2-3. 2011-07-20. PMID:20952093. |
when wip ko dcs were infected with a mutant form of wip lacking the cortactin-binding domain (wipΔ110-170) dcs were only able to elaborate disorganised podosomes that were unable to support mmp-mediated matrix degradation. |
2011-07-20 |
2023-08-12 |
Not clear |
| Timea Csak, Arumugam Velayudham, Istvan Hritz, Jan Petrasek, Ivan Levin, Dora Lippai, Donna Catalano, Pranoti Mandrekar, Angela Dolganiuc, Evelyn Kurt-Jones, Gyongyi Szab. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 3. 2011-04-21. PMID:21233280. |
markers of liver fibrosis [collagen by sirius red and α-smooth muscle actin (sma) staining, procollagen-i, transforming growth factor-β1, α-sma, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 mrna] were attenuated in md-2 and tlr4 ko compared with their control genotype counterparts. |
2011-04-21 |
2023-08-12 |
mouse |
| Stephen J Mnich, Patrick M Blanner, Liangbiao G Hu, Alexander F Shaffer, Fernando A Happa, Shawn O'Neil, Okechukwu Ukairo, Dave Weiss, Eric Welsh, Chad Storer, Gabriel Mbalaviele, Hidenori Ichijo, Joseph B Monahan, Medora M Hardy, Hiroyuki Ed. Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis. International immunopharmacology. vol 10. issue 10. 2011-02-15. PMID:20609399. |
transcriptional profiling of mrna prepared from paw tissue demonstrated that the production of many proinflammatory genes including cytokines, chemokines, and extracellular matrix degradative enzymes were maintained at basal levels by either ask1 ko or prophylactic p38 mapk inhibition. |
2011-02-15 |
2023-08-12 |
mouse |