| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seungje Jeon, Yi-Seul Yoon, Hyoung Kyu Kim, Jin Han, Kwang Min Lee, Jung Eun Seol, Steve K Cho, Chul-Seung Par. Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. Aging. vol 13. issue 5. 2021-07-21. PMID:33658395. |
in this study, crbn knockout (ko) mice exhibited decreased levels of stratum corneum hydration (sch) and collagen i expression with an elevated protein level of matrix metalloprotease 1 (mmp1). |
2021-07-21 |
2023-08-13 |
mouse |
| Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zh. Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis. Disease models & mechanisms. vol 14. issue 6. 2021-07-07. PMID:34080006. |
tmem30a ko mice displayed albuminuria, podocyte degeneration, mesangial cell proliferation with prominent extracellular matrix accumulation and eventual progression to focal segmental glomerulosclerosis. |
2021-07-07 |
2023-08-13 |
mouse |
| Jonathan W Lovelace, Maham Rais, Arnold R Palacios, Xinghao S Shuai, Steven Bishay, Otilia Popa, Patricia S Pirbhoy, Devin K Binder, David L Nelson, Iryna M Ethell, Khaleel A Raza. Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile X Syndrome. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 3. 2021-06-08. PMID:31364704. |
we previously showed that elevated levels of matrix metalloproteinase-9 (mmp-9) may contribute to these phenotypes by affecting perineuronal nets (pnns) around parvalbumin (pv) interneurons in the auditory cortex of fmr1 ko mice. |
2021-06-08 |
2023-08-13 |
mouse |
| Slater A Jameson, Ganesh Swaminathan, Shataakshi Dahal, Bruna Couri, Mei Kuang, Anna Rietsch, Robert S Butler, Anand Ramamurthi, Margot S Damase. Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase-like 1 knockout mouse model. Physiological reports. vol 8. issue 11. 2021-06-07. PMID:32533648. |
using loxl1 ko mice, we investigated the effects of genetic absence of loxl1, vaginal parity, and presence of pop on the expression of genes and proteins key to the production and regulation of elastic matrix. |
2021-06-07 |
2023-08-13 |
mouse |
| Isabel Fuentes-Calvo, Carlos Martinez-Salgad. Sos1 Modulates Extracellular Matrix Synthesis, Proliferation, and Migration in Fibroblasts. Frontiers in physiology. vol 12. 2021-04-24. PMID:33889087. |
for this purpose, we isolated and cultured sos1 knock-out (ko) mouse embryonic fibroblasts, the main extracellular matrix proteins (ecm)-producing cells, and we analyzed ecm synthesis, cell proliferation and migration in the absence of sos1, as well as the role of the main sos1-ras effectors, erk1/2 and akt, in these processes. |
2021-04-24 |
2023-08-13 |
mouse |
| Fatima El Marjou, Colin Jouhanneau, Denis Krndij. Targeted Transgenic Mice Using CRISPR /Cas9 Technology. Methods in molecular biology (Clifton, N.J.). vol 2214. 2021-03-30. PMID:32944907. |
detailed instructions for the design of single guide rnas (sgrna ) for ko approaches and single-strand oligonucleotide (ssodn ) matrix for generation of ki animals are included. |
2021-03-30 |
2023-08-13 |
mouse |
| Patricia S Pirbhoy, Maham Rais, Jonathan W Lovelace, Walker Woodard, Khaleel A Razak, Devin K Binder, Iryna M Ethel. Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32374912. |
acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in fmr1 ko mice. |
2021-03-02 |
2023-08-13 |
mouse |
| Patricia S Pirbhoy, Maham Rais, Jonathan W Lovelace, Walker Woodard, Khaleel A Razak, Devin K Binder, Iryna M Ethel. Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice. Journal of neurochemistry. vol 155. issue 5. 2021-03-02. PMID:32374912. |
previously, we showed that elevated levels of matrix metalloproteinase-9 (mmp-9) may contribute to abnormal development of parvalbumin (pv) interneurons and perineuronal nets (pnns) in the developing auditory cortex (ac) of fmr1 knock-out (ko) mice, which likely underlie auditory hypersensitivity. |
2021-03-02 |
2023-08-13 |
mouse |
| Natalie Filippov-Levy, Reuven Reich, Ben Davidso. The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma. International journal of molecular sciences. vol 21. issue 15. 2021-02-16. PMID:32718068. |
following loc642852 knockout (ko) using the crispr/cas9 system, ovcar-8 hgsc cells were analyzed for spheroid formation, migration, invasion, proliferation, matrix metalloproteinase (mmp) activity, and expression of cell signaling proteins. |
2021-02-16 |
2023-08-13 |
Not clear |
| Natalie Filippov-Levy, Reuven Reich, Ben Davidso. The Biological and Clinical Role of the Long Non-Coding RNA LOC642852 in Ovarian Carcinoma. International journal of molecular sciences. vol 21. issue 15. 2021-02-16. PMID:32718068. |
ovcar-8 cells with loc642852 ko were significantly less motile and less invasive compared to controls, with no differences in spheroid formation, proliferation, or matrix metalloproteinase (mmp) activity. |
2021-02-16 |
2023-08-13 |
Not clear |
| Antonella D'Amore, Ali Ahmed Hanbashi, Silvia Di Agostino, Fioretta Palombi, Andrea Sacconi, Aniruddha Voruganti, Marilena Taggi, Rita Canipari, Giovanni Blandino, John Parrington, Antonio Filippin. Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry. Cancers. vol 12. issue 9. 2020-10-27. PMID:32846966. |
tpc2 ko increased these cells' ability to invade the extracelullar matrix and was associated with the increased expression of mesenchymal markers zeb-1, vimentin and n-cadherin, and the enhanced secretion of mmp9. |
2020-10-27 |
2023-08-13 |
human |
| Boyan Woychyshyn, Joan Papillon, Julie Guillemette, José R Navarro-Betancourt, Andrey V Cybulsk. Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice. American journal of physiology. Renal physiology. vol 318. issue 6. 2020-10-07. PMID:32308020. |
glomeruli of adriamycin-treated slk ko mice showed diffuse increases in the matrix and sclerosis as well as collapse of the actin cytoskeleton. |
2020-10-07 |
2023-08-13 |
mouse |
| L Venkataraman, A T Lenis, B M Couri, M S Damaser, A Ramamurth. Induced Regenerative Elastic Matrix Repair in LOXL1 Knockout Mouse Cell Cultures: Towards Potential therapy for Pelvic Organ Prolapse. Journal of tissue science & engineering. vol 3. issue 3. 2020-10-01. PMID:30854248. |
the goal of this study was to ascertain if these factors similarly improve the quantity and quality of elastic matrix deposition by vaginal smcs (vsmcs) isolated from lysyl oxidase like-1 knock out (loxl1 ko) mouse model of pop. |
2020-10-01 |
2023-08-13 |
mouse |
| Ayako Sato, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Tomoyuki Tsunoda, Shun Kaneko, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanab. Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts. Hepatology communications. vol 4. issue 2. 2020-09-28. PMID:32025608. |
to identify candidate factors contributing to this cell-cell interaction, mesenchymal cells were isolated from embryonic day 16.5 matrix metalloproteinase 14 (mmp14)-deficient (knockout [ko]) mice livers, in which ihbd formation is retarded, and compared with those of the wild type (wt). |
2020-09-28 |
2023-08-13 |
mouse |
| Lan Chen, Noboru Fukuda, Tomoyasu Otsuki, Sho Tanaka, Yoshihiro Nakamura, Hiroki Kobayashi, Taro Matsumoto, Masanori Ab. Increased Complement 3 With Suppression of miR-145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats. Journal of the American Heart Association. vol 8. issue 10. 2020-08-24. PMID:31070083. |
in the current study, we investigated the mechanisms underlying the increased expression of c3 and the role of endogenous c3 in the synthetic phenotype of shr vsmc s in comparison to cells from wistar-kyoto ( wky) rats and c3 ko shr s. methods and results nonmuscle myosin heavy chain staining of aortas from shr s at 1 day after birth was stronger in comparison to wky rats and c3 ko shr s. dna synthesis in vsmc s from shr s was significantly higher in comparison to wky rats and c3 ko shr s. immunohistochemical staining of renin and liver x receptor α in vsmc s from shr s was stronger in comparison to wky rats and c3 ko shr s. the expression of renin, krüppel-like factor 5, and liver x receptor α proteins in vsmc s from shr s was significantly higher in comparison to wky rats and c3 ko shr s. the expression of synthetic phenotype markers osteopontin, matrix gla, and l-caldesmon, growth factors transforming growth factor-β1 and platelet-derived growth factor-a, transcription factors krüppel-like factor 5 and liver x receptor α, and angiotensinogen mrna s in vsmc s from shr s was significantly higher in comparison to wky rats and c3 ko shr s. the expression of mir-145 mrna in vsmc s from shr s was suppressed in comparison to cells from wky rats. |
2020-08-24 |
2023-08-13 |
rat |
| Qixin Wang, Isaac K Sundar, Dongmei Li, Joseph H Lucas, Thivanka Muthumalage, Samantha R McDonough, Irfan Rahma. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation. Respiratory research. vol 21. issue 1. 2020-07-21. PMID:32552811. |
interestingly, matrix metalloproteinases (mmps), such as mmp2, mmp8 and mmp9, were altered both at the protein and mrna transcript levels in female and male ko mice, but wt mice exposed to pg alone showed a sex-dependent phenotype. |
2020-07-21 |
2023-08-13 |
mouse |
| Caroline Klindt, Maria Reich, Birte Hellwig, Jan Stindt, Jörg Rahnenführer, Jan G Hengstler, Karl Köhrer, Kristina Schoonjans, Dieter Häussinger, Verena Keite. The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver. Cells. vol 8. issue 11. 2020-07-07. PMID:31752395. |
thus, tgr5 knockout (ko) mice and wildtype (wt) littermates were fed a diet supplemented with 1% lca for 84 h. liver injury and gene expression changes induced by the lca diet revealed an enrichment of pathways associated with inflammation, proliferation, and matrix remodeling. |
2020-07-07 |
2023-08-13 |
mouse |
| Teresa H Wen, Sonia Afroz, Sarah M Reinhard, Arnold R Palacios, Kendal Tapia, Devin K Binder, Khaleel A Razak, Iryna M Ethel. Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 11. 2019-12-20. PMID:29040407. |
similar sensory deficits are also observed in adult fmr1 knock-out (ko) mice and are reversed by genetic deletion of matrix metalloproteinase-9 (mmp-9) through yet unknown mechanisms. |
2019-12-20 |
2023-08-13 |
mouse |
| Ivana Rajkovic, Raymond Wong, Eloise Lemarchand, Jack Rivers-Auty, Olivera Rajkovic, Cecilia Garlanda, Stuart M Allan, Emmanuel Pinteau. Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke. Journal of molecular medicine (Berlin, Germany). vol 96. issue 12. 2019-11-05. PMID:30315331. |
immunohistochemical analysis revealed that ptx3 ko mice have significantly greater neuronal loss, significantly decreased vessel diameter, vessel proliferation, vascular density, and reactive astrocytes and decreased expression of vascular endothelial growth factor receptor 2 (vegr2), vascular extracellular matrix (ecm)-proteins (collagen iv, laminin), and integrin-β, in the ipsilateral (stroke) hemisphere compared to wt mice, 28 days after mcao. |
2019-11-05 |
2023-08-13 |
mouse |
| Kazuyuki Saito, Katsu Takahashi, Boyen Huang, Masakazu Asahara, Honoka Kiso, Yumiko Togo, Hiroko Tsukamoto, Sayaka Mishima, Masaki Nagata, Machiko Iida, Yoshihito Tokita, Masato Asai, Akira Shimizu, Toshihisa Komori, Hidemitsu Harada, Mary MacDougall, Manabu Sugai, Kazuhisa Bessh. Loss of Stemness, EMT, and Supernumerary Tooth Formation in Cebpb Scientific reports. vol 8. issue 1. 2019-10-25. PMID:29581460. |
in this study, cebpb ko mice demonstrated cementum-like hard tissue in dental pulp, loss of polarity by ameloblasts, enamel matrix in ameloblastic layer, and increased expression of epithelial-mesenchymal transition (emt) markers in a cebpb knockdown mouse enamel epithelial stem cell line. |
2019-10-25 |
2023-08-13 |
mouse |