| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Wang, Jie Song, Xuedong Wang, Qiuhui Qian, Huili Wan. Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis. The Science of the total environment. 2022-06-30. PMID:35772538. |
tcs-chronic exposure affected the development of zebrafish, induced feminization, obesity physical signs and abnormal organ index and caused neurobehavioral abnormalities by inhibiting both neurotransmitter acetylcholinesterase and dopamine activity, promoting brain neuron apoptosis and accelerating diencephalic lesions. |
2022-06-30 |
2023-08-14 |
zebrafish |
| Li Dong, Ting Zhou, Qiuyun She, Xiaoqi Nie, Zhong Liu, Ronghua Pan, Yujia Wei, Yunhua Den. Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo. The Journal of investigative dermatology. 2022-06-11. PMID:35690140. |
furthermore, mir-493-3p overexpression in keratinocytes increased dopamine concentration in the culture supernatant, which led to a significant increase in ros and melanocyte apoptosis as well as a decrease in melanocyte proliferation and melanin synthesis in the co-culture system by targeting heterogeneous nuclear ribonucleoprotein u (hnrnpu). |
2022-06-11 |
2023-08-14 |
human |
| Kailash Prasad Prajapati, Bibin Gnanadhason Anand, Masihuzzaman Ansari, Mayur Temgire, Ashu Bhan Tiku, Karunakar Ka. Amyloid-mimicking toxic nanofibers generated Nanoscale. 2022-06-06. PMID:35667124. |
furthermore, dopamine nanostructures were found to be highly toxic to human neuroblastoma cells, revealing apoptosis and necrosis-mediated cytotoxicity. |
2022-06-06 |
2023-08-14 |
human |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
alterations in the mrna expression of genes involved in dopamine signaling and apoptosis pathway were assessed. |
2022-05-20 |
2023-08-13 |
zebrafish |
| Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng W. Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio). Environmental toxicology and pharmacology. 2022-05-20. PMID:35595013. |
meanwhile, behavioral changes were accompanied by increased apoptosis and malondialdehyde (mda) content, decreased superoxide dismutase (sod) activity and dopamine (da) content, and perturbed the expression of genes associated with the synthesis (th), reuptake (dat) and metabolism (mao) of da, with dopamine receptors (drs), and with the apoptosis pathway (p53, bax, bcl2, caspase-3, caspase-8, caspase-9). |
2022-05-20 |
2023-08-13 |
zebrafish |
| Sek Ying Chair, Bernard M H Law, Judy Y W Chan, Winnie K W So, Mary M Y Way. Association of genetic polymorphisms with psychological symptoms in cancer: A systematic review. Asia-Pacific journal of oncology nursing. vol 9. issue 1. 2022-05-09. PMID:35528795. |
other genes found to show associations with anxiety, depression, and ptsd among cancer patients are those involved in neurotrophic signalling, serotonergic signalling, regulation of stress response, antioxidation, dopamine catabolism and cellular apoptosis, despite some inconsistencies in findings between studies. |
2022-05-09 |
2023-08-13 |
Not clear |
| Wei Hang, Hui-Jie Fan, Yan-Rong Li, Qi Xiao, Lu Jia, Li-Juan Song, Yao Gao, Xiao-Ming Jin, Bao-Guo Xiao, Jie-Zhong Yu, Cun-Gen Ma, Zhi Cha. Wuzi Yanzong pill attenuates MPTP-induced Parkinson's Disease via PI3K/Akt signaling pathway. Metabolic brain disease. 2022-04-30. PMID:35488941. |
apoptosis, dopamine and neurotrophic factors as well as expression of pi3k/akt pathway were detected by tunel staining, elisa and western blotting, respectively. |
2022-04-30 |
2023-08-13 |
mouse |
| Binglong Li, Di An, Shasha Zh. PBX1 attenuates 6-OHDA-induced oxidative stress and apoptosis and affects PINK1/PARKIN expression in dopaminergic neurons via FOXA1. Cytotechnology. vol 74. issue 2. 2022-04-25. PMID:35464170. |
pbx1 expression has been found to be significantly reduced in nigrostriatal neurons of pd patients, but the effect of pbx1 on ros and apoptosis in nigrostriatal dopamine neurons is not yet known. |
2022-04-25 |
2023-08-13 |
Not clear |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Sushma Tanwar, Vishal Thakur, Davinder Parsa. Dopamine toxicity contributes to melanocyte loss via melanocytorrhagy: an in vitro study. International journal of dermatology. 2022-03-24. PMID:35325470. |
dopamine has been observed to cause apoptosis in melanocytes via reactive oxygen species development, but the effect on melanocyte adhesion and proliferation still remains to be elucidated. |
2022-03-24 |
2023-08-13 |
Not clear |
| Hongzhu Li, Ren Wu, Yuxin Xi, Hongxia Li, Guiquan Chang, Fengqi Sun, Can Wei, Lijie Jiao, Xin Wen, Gensheng Zhang, Altaany Zaid, Jinghui Ha. Dopamine 1 receptors inhibit apoptosis via activating CSE/H Cell biology international. 2022-03-16. PMID:35293655. |
dopamine 1 receptors inhibit apoptosis via activating cse/h high glucose (hg) induced dysfunction of vascular endothelial cells plays a crucial role in the development of diabetic vascular complications. |
2022-03-16 |
2023-08-13 |
Not clear |
| Min Chen, Li Peng, Ping Gong, Xiaoli Zheng, Tao Sun, Xiaoqiao Zhang, Jiangtao Hu. Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson's Disease in Rats Frontiers in neurology. vol 12. 2022-03-03. PMID:35237220. |
dopamine (da) content, neuronal apoptosis, neuronal injury, neuronal mitochondria, and autophagy were assessed. |
2022-03-03 |
2023-08-13 |
rat |
| Zhu-Qing He, Peng-Fei Huan, Li Wang, Jian-Cheng H. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metabolic brain disease. 2022-03-01. PMID:35230626. |
the results of the experiments indicated that pf ameliorated behavioral impairments and upregulated the expression of the dopamine (da) neurons, suppressed cell apoptosis in substantia nigra pars compacta (snpc) of pd. |
2022-03-01 |
2023-08-13 |
mouse |
| Yongjie Xu, Tao Peng, Yang Xiang, Gengze Liao, Fei Zou, Xiaojing Men. Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure. The Science of the total environment. 2022-02-12. PMID:35150691. |
the terminal deoxynucleotidyl transferase dutp nick end labeling assay and acridine orange staining were performed to monitor cell apoptosis, while dopamine transporter (dat) and tyrosine hydroxylase (th) expression were detected by immunohistochemical staining. |
2022-02-12 |
2023-08-13 |
zebrafish |
| Xuling Tan, Junjian Hu, Fengyu Ming, Lingling Lv, Weiqian Yan, Xinke Peng, Rongrong Bai, Qile Xiao, Hainan Zhang, Beisha Tang, Chunyu Wang, Jieqiong Ta. MicroRNA-409-3p Targeting at ATXN3 Reduces the Apoptosis of Dopamine Neurons Based on the Profile of miRNAs in the Cerebrospinal Fluid of Early Parkinson's Disease. Frontiers in cell and developmental biology. vol 9. 2022-02-03. PMID:35111747. |
microrna-409-3p targeting at atxn3 reduces the apoptosis of dopamine neurons based on the profile of mirnas in the cerebrospinal fluid of early parkinson's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Jianjun Ma, Xiaoxue Shi, Mingjian Li, Siyuan Chen, Qi Gu, Jinhua Zheng, Dongsheng Li, Shaopu Wu, Hongqi Yang, Xue L. MicroRNA-181a-2-3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and NOX4. Cell death discovery. vol 8. issue 1. 2022-01-25. PMID:35075150. |
furthermore, in pd mice, mir-181a-2-3p was carried by evs from mscs to alleviate apoptosis of dopamine neurons and os, accompanied by increased expressions of α-syn and decreased 4-hne in sn tissues. |
2022-01-25 |
2023-08-13 |
mouse |
| Yiwei Zeng, Yunhui Chen, Su Zhang, Huan Ren, Jialin Xia, Mengnan Liu, Baozhi Shan, Yulan Re. Natural Products in Modulating Methamphetamine-Induced Neuronal Apoptosis. Frontiers in pharmacology. vol 12. 2022-01-21. PMID:35058785. |
in this review, we summarized and analyzed the improvement effect of natural products on meth-induced neuronal apoptosis and their potential molecular mechanisms on modulating dopamine release, oxidative stress, mitochondrial-dependent apoptotic pathway, endoplasmic reticulum stress-mediated apoptotic pathway, and neuroinflammation. |
2022-01-21 |
2023-08-13 |
Not clear |
| Manqing Wu, Hang Su, Min Zha. The Role of α-Synuclein in Methamphetamine-Induced Neurotoxicity. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33555547. |
meth produces damage dopamine neurons and apoptosis via multiple inter-regulating mechanisms, including dopamine overload, hyperthermia, oxidative stress, mitochondria dysfunction, endoplasmic reticulum stress, protein degradation system dysfunction, and neuroinflammation. |
2021-11-29 |
2023-08-13 |
human |
| Junya Sango, Taichi Kakihana, Masahiko Takahashi, Yoshinori Katsuragi, Sergei Anisimov, Masaaki Komatsu, Masahiro Fuji. USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity. The Journal of biological chemistry. 2021-11-28. PMID:34838592. |
dopamine treatment of neuronal cells stimulates the production of reactive oxygen species (ros) and increases ros-dependent neuronal apoptosis. |
2021-11-28 |
2023-08-13 |
human |
| Peiqiang Liu, Danxue Qin, Hao Lv, Wenjun Fan, Zezhang Tao, Yu X. Neuroprotective effects of dopamine D2 receptor agonist on neuroinflammatory injury in olfactory bulb neurons in vitro and in vivo in a mouse model of allergic rhinitis. Neurotoxicology. vol 87. 2021-11-22. PMID:34624383. |
quinpirole (a dopamine d2 receptor agonist) improved olfactory function in mice, ameliorated apoptosis injury in the olfactory bulb but not in the olfactory mucosa, and inhibited the internalization of glur2-containing ampa receptor in vitro and in vivo. |
2021-11-22 |
2023-08-13 |
mouse |