| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Surendra Kumar Anand, Manas Ranjan Sahu, Amal Chandra Monda. Bacopaside-I Alleviates the Detrimental Effects of Acute Paraquat Intoxication in the Adult Zebrafish Brain. Neurochemical research. vol 46. issue 11. 2021-10-04. PMID:34357519. |
pq treatment also affected the expression of particular genes concerned with the apoptosis and dopamine signaling, which was not altered by bs-i administration. |
2021-10-04 |
2023-08-13 |
zebrafish |
| Taruna Pandey, Aparna Shukla, Mashu Trivedi, Feroz Khan, Rakesh Pande. Swertiamarin from Enicostemma littorale, counteracts PD associated neurotoxicity via enhancement α-synuclein suppressive genes and SKN-1/NRF-2 activation through MAPK pathway. Bioorganic chemistry. vol 108. 2021-09-30. PMID:33548732. |
sw (25 μm) administration decreased the α-synuclein (α-syn) deposition, inhibited apoptosis and increased dopamine level mediated through upregulating the expression of genes linked to ceramide synthesis, mitochondrial morphology and function regulation, fatty acid desaturase genes along with stress responsive mapk (mitogen-activated protein kinase) pathway genes. |
2021-09-30 |
2023-08-13 |
caenorhabditis_elegans |
| Yiqun Zhang, Lanlan Zhou, Howard Safran, Robyn Borsuk, Rishi Lulla, Nikos Tapinos, Attila A Seyhan, Wafik S El-Deir. EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG. Neoplasia (New York, N.Y.). vol 23. issue 8. 2021-09-23. PMID:34246076. |
dopamine did not rescue apoptosis by onc201 in different tumor cell lines (n = 10) including 2 gbm, 3 dipg and did not prevent dr5 activation or apoptosis. |
2021-09-23 |
2023-08-13 |
human |
| Emily M Pitzer, Michael T Williams, Charles V Vorhee. Effects of pyrethroids on brain development and behavior: Deltamethrin. Neurotoxicology and teratology. vol 87. 2021-09-21. PMID:33848594. |
but existing data clearly show there are lasting effects on locomotor activity, acoustic startle, learning and memory, apoptosis, and dopamine in mice and rats after early exposure. |
2021-09-21 |
2023-08-13 |
mouse |
| Yu Shang, Siyan Wang, Yingying Jin, Wanlei Xue, Yufang Zhong, Hongli Wang, Jing An, Hui L. Polystyrene nanoparticles induced neurodevelopmental toxicity in Caenorhabditis elegans through regulation of dpy-5 and rol-6. Ecotoxicology and environmental safety. vol 222. 2021-08-19. PMID:34273852. |
in wild-type c. elegans, polystyrene nps (diameter 50 nm) could concentration-dependently induce significant inhibition in body length, survival rate, head thrashes, and body bending, accompanying with increase of reactive oxygen species (ros) production, lipofuscin accumulation, and apoptosis and decrease of dopamine (da) contents. |
2021-08-19 |
2023-08-13 |
human |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| Julio Aguila, Shangli Cheng, Nigel Kee, Ming Cao, Menghan Wang, Qiaolin Deng, Eva Hedlun. Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-27. PMID:34305528. |
network analysis reveal gene interactions unique to each subpopulation and highlight differences in regulation of mitochondrial stability, apoptosis, neuronal survival, cytoskeleton regulation, extracellular matrix modulation as well as synapse integrity, which could explain the relative resilience of vta dopamine neurons. |
2021-07-27 |
2023-08-13 |
human |
| Chenyang Han, Heping Shen, Yi Yang, Yongjia Sheng, Jin Wang, Wenyan Li, Xiaohong Zhou, Li Guo, Liping Zhai, Qiaobing Gua. Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation. Brain and behavior. vol 10. issue 11. 2021-06-24. PMID:32902155. |
the main pathological change is the apoptosis of dopaminergic neurons in the substantia nigra pars compacta (snpc), thereby leading to dopamine reduction in nigral striatum. |
2021-06-24 |
2023-08-13 |
mouse |
| Beata Grembecka, Wojciech Glac, Magdalena Listowska, Grażyna Jerzemowska, Karolina Plucińska, Irena Majkutewicz, Piotr Badtke, Danuta Wron. Subthalamic Deep Brain Stimulation Affects Plasma Corticosterone Concentration and Peripheral Immunity Changes in Rat Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 2. 2021-06-18. PMID:32648088. |
in this study, we examined the effects of unilateral dbs-stn applied in male wistar rats with 6-hydroxydopamine pd model (dbs-6ohda) and rats without nigral dopamine depletion (dbs) on corticosterone (cort) plasma concentration, blood natural killer cell cytotoxicity (nkcc), leukocyte numbers, lymphocyte population and apoptosis numbers, plasma interferon gamma (ifn-γ), interleukin 6 (il-6), and tumor necrosis factor (tnf-α) concentration. |
2021-06-18 |
2023-08-13 |
rat |
| Hariharan Saminathan, Anamitra Ghosh, Danhui Zhang, Chunjuan Song, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease. Frontiers in pharmacology. vol 12. 2021-05-18. PMID:33995031. |
oxidative stress, neuroinflammation and apoptosis are some of the key etiological factors responsible for dopamin(da)ergic degeneration during parkinson's disease (pd), yet the downstream molecular mechanisms underlying neurodegeneration are largely unknown. |
2021-05-18 |
2023-08-13 |
Not clear |
| Weishan Zhuge, Qichuan Zhuge, Weikan Wang, Xiaoai Lu, Ruimin You, Leping Liu, He Yu, Jian Wang, Xuebao Wang, Yiru Ye, Saidan Din. Hydrogen sulphide ameliorates dopamine-induced astrocytic inflammation and neurodegeneration in minimal hepatic encephalopathy. Journal of cellular and molecular medicine. vol 24. issue 23. 2021-05-14. PMID:33118312. |
it has been demonstrated that the action of dopamine (da) could enhance the production of tumour necrosis factor-α (tnf-α) by astrocytes and potentiate neuronal apoptosis in minimal hepatic encephalopathy (mhe). |
2021-05-14 |
2023-08-13 |
rat |
| Hong-Xu Chen, Fu-Chao Liang, Ping Gu, Bian-Ling Xu, Hong-Jun Xu, Wen-Ting Wang, Jia-Yang Hou, Dong-Xiao Xie, Xi-Qing Chai, Sheng-Jun A. Exosomes derived from mesenchymal stem cells repair a Parkinson's disease model by inducing autophagy. Cell death & disease. vol 11. issue 4. 2021-03-31. PMID:32341347. |
furthermore, exos reached the substantia nigra through the blood-brain barrier (bbb) in vivo, relieved apomorphine-induced asymmetric rotation, reduced substantia nigra dopaminergic neuron loss and apoptosis, and upregulated the level of dopamine in the striatum. |
2021-03-31 |
2023-08-13 |
human |
| Tadeusz Plus. [Anti-inflammatory effects of amantadine and memantine in SARS-CoV-2 infection]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 49. issue 289. 2021-03-16. PMID:33713098. |
amantadine and memantine, apart from their action on cholinergic receptors and dopamine secretion, have a significant influence on the inflammatory process, including the so-called "cytokine storm" and reduction of apoptosis and oxidative stress. |
2021-03-16 |
2023-08-13 |
Not clear |
| Su-Mei Tsai, Kuo-Chang Chu, Yun-Jin Jian. Newly identified Gon4l/Udu-interacting proteins implicate novel functions. Scientific reports. vol 10. issue 1. 2021-03-05. PMID:32848183. |
the most enriched phenotypes identified include increased embryonic tissue cell apoptosis, embryonic lethality, increased t cell derived lymphoma incidence, decreased cell proliferation, chromosome instability, and abnormal dopamine level, characteristics that largely resemble those observed in reported gon4l/udu mutant animals. |
2021-03-05 |
2023-08-13 |
mouse |
| Yun-Zhe Ci, Haiyan Li, Lin-Hao You, Yu Jin, Rui Zhou, Guofen Gao, Maggie Pui Man Hoi, Chunyan Wang, Yan-Zhong Chang, Peng Y. Iron overload induced by IRP2 gene knockout aggravates symptoms of Parkinson's disease. Neurochemistry international. vol 134. 2021-02-23. PMID:31904393. |
data from neurobehavioral, immunohistochemistry, tunel and elisa studies showed that mptp treatment enhanced the symptoms of pd in vivo, increased cell apoptosis and decreased dopamine levels in irp2 |
2021-02-23 |
2023-08-13 |
mouse |
| Corina Anastasaki, Michelle L Wegscheid, Kelly Hartigan, Jason B Papke, Nathan D Kopp, Jiayang Chen, Olivia Cobb, Joseph D Dougherty, David H Gutman. Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations. Stem cell reports. vol 14. issue 4. 2021-02-05. PMID:32243842. |
although all mutations increased proliferation and ras activity in 2d neural progenitor cells (npcs) and astrocytes, we observed striking differences between nf1 mutations on 2d npc dopamine levels, and 3d npc proliferation, apoptosis, and neuronal differentiation in developing cerebral organoids. |
2021-02-05 |
2023-08-13 |
human |
| Chengqian Li, Li Xue, Yumei Liu, Zhengjie Yang, Song Chi, Anmu Xi. Zonisamide for the Treatment of Parkinson Disease: A Current Update. Frontiers in neuroscience. vol 14. 2021-01-11. PMID:33408605. |
the mechanisms underlying neuroprotection, including modulation of dopamine turnover, induction of neurotrophic factor expression, inhibition of oxidative stress and apoptosis, inhibition of neuroinflammation, modulation of synaptic transmission, and modulation of gene expression, have been most extensively studied. |
2021-01-11 |
2023-08-13 |
Not clear |
| Allen L Pan, Ermal Hasalliu, Manjola Hasalliu, Jesus A Angul. Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:32080803. |
previously, our laboratory found that epigallocatechin gallate (egcg), a strong antioxidant found in green tea, can protect against the meth-induced apoptosis and dopamine terminal toxicity in the striatum of mice. |
2020-12-21 |
2023-08-13 |
mouse |
| Omid Reza Tamtaji, Russel J Reiter, Reza Alipoor, Ehsan Dadgostar, Ebrahim Kouchaki, Zatollah Asem. Melatonin and Parkinson Disease: Current Status and Future Perspectives for Molecular Mechanisms. Cellular and molecular neurobiology. vol 40. issue 1. 2020-10-20. PMID:31388798. |
administration of melatonin leads to inhibition of some pathways related to apoptosis, autophagy, oxidative stress, inflammation, α-synuclein aggregation, and dopamine loss in pd. |
2020-10-20 |
2023-08-13 |
Not clear |
| Xu Wang, Zhi-Bin Wang, Chao Luo, Xiao-Yuan Mao, Xi Li, Ji-Ye Yin, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Li. The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor. Journal of Cancer. vol 10. issue 7. 2020-09-29. PMID:31205518. |
recently, some studies showed that dopamine receptors could regulate several ways of death of the tumor cell, including apoptosis, autophagy-induced death, and ferroptosis, which cannot only directly affect tumor behavior, but also limit tumor progress via activating tumor immunity. |
2020-09-29 |
2023-08-13 |
Not clear |