| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Gao, Feng Ga. Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway. Clinical and experimental pharmacology & physiology. vol 44. issue 11. 2018-05-22. PMID:28699280. |
this study explored the effects and mechanisms of dopamine d1 receptors (dr1) activation on the apoptosis of osteosarcoma cells (os732).the dr1 agonist skf-38393 decreased the viability of os732 cells and increased their rate of apoptosis, whereas the dr1 antagonist sch-23390 abolished the effects of skf-38393. |
2018-05-22 |
2023-08-13 |
Not clear |
| Ivan Carrera, Lucia Fernandez-Novoa, Carolina Sampedro, Ramon Cacabelo. Neuroprotective Effect of Atremorine in an Experimental Model of Parkinson's Disease. Current pharmaceutical design. vol 23. issue 18. 2018-05-09. PMID:28190394. |
data demonstrated that atremorine promotes neuroprotection and behavior recovery in the injured mtpt-mouse brain by modulating the expression levels of tyrosine hydroxylase, glial proteins, apoptosis and endogenous dopamine and neuromelanin concentrations, probably the key to recover the basal ganglia function. |
2018-05-09 |
2023-08-13 |
mouse |
| Junde Han, Lingqi Gao, Jing Dong, Yingtian Wang, Mazhong Zhang, Jijian Zhen. Dopamine attenuates ethanol-induced neuroapoptosis in the developing rat retina via the cAMP/PKA pathway. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28656313. |
the present study aimed to explore the effects of dopamine on alcohol‑induced neuronal apoptosis using whole‑mount cultures of rat retinas (postnatal day 7). |
2018-04-09 |
2023-08-13 |
rat |
| Junde Han, Lingqi Gao, Jing Dong, Yingtian Wang, Mazhong Zhang, Jijian Zhen. Dopamine attenuates ethanol-induced neuroapoptosis in the developing rat retina via the cAMP/PKA pathway. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28656313. |
dopamine treatment significantly attenuated ethanol‑induced neuronal apoptosis. |
2018-04-09 |
2023-08-13 |
rat |
| Junde Han, Lingqi Gao, Jing Dong, Yingtian Wang, Mazhong Zhang, Jijian Zhen. Dopamine attenuates ethanol-induced neuroapoptosis in the developing rat retina via the cAMP/PKA pathway. Molecular medicine reports. vol 16. issue 2. 2018-04-09. PMID:28656313. |
d1r, d2r and aa2ar antagonists partially inhibited the protective effects of dopamine against ethanol‑induced apoptosis; similar results were observed with ac and pka inhibitor treatments. |
2018-04-09 |
2023-08-13 |
rat |
| Meirong Bai, Roman Vozdek, Aleš Hnízda, Chenxiao Jiang, Bingying Wang, Ladislav Kuchar, Tiejun Li, Yuefan Zhang, Chase Wood, Liang Feng, Yongjun Dang, Dengke K M. Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection. Nature communications. vol 9. issue 1. 2018-04-03. PMID:29497057. |
mesencephalic astrocyte-derived neurotrophic factor (manf) is an endoplasmic reticulum (er) protein that can be secreted and protects dopamine neurons and cardiomyocytes from er stress and apoptosis. |
2018-04-03 |
2023-08-13 |
human |
| Kamal Awad, Abdelrahman Ibrahim Abushouk, Ahmed Helal AbdelKarim, Maged Mohammed, Ahmed Negida, Ali S Shalas. Bee venom for the treatment of Parkinson's disease: How far is it possible? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28477460. |
several mechanisms were suggested for these findings including the ability of bvt to attenuate neuroinflammation, inhibit apoptosis of dopaminergic neurons, protect against glutamate-induced neurotoxicity, and restore normal dopamine levels in the nigrostriatal pathway. |
2018-03-26 |
2023-08-13 |
bee |
| Mohammad Furkan, Asim Rizvi, Md Tauqir Alam, Masihuz Zaman, Rizwan Hasan Khan, Aabgeena Naee. Serotonin abrogates dopamine induced aggregation of cytochrome c. International journal of biological macromolecules. vol 102. 2018-03-12. PMID:28396269. |
serotonin abrogates dopamine induced aggregation of cytochrome c. importance of cytochrome c arises from its involvement in apoptosis, sequence homology and conserveness during molecular evolution. |
2018-03-12 |
2023-08-13 |
human |
| Jing Dong, Lingqi Gao, Junde Han, Junjie Zhang, Jijian Zhen. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27177547. |
dopamine attenuates ketamine-induced neuronal apoptosis in the developing rat retina independent of early synchronized spontaneous network activity. |
2018-03-09 |
2023-08-13 |
rat |
| Jing Dong, Lingqi Gao, Junde Han, Junjie Zhang, Jijian Zhen. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27177547. |
the present study investigated the effects of dopamine, an enhancer of spontaneous rhythmic electrical activity, on ketamine-induced neuronal apoptosis in the developing rat retina. |
2018-03-09 |
2023-08-13 |
rat |
| Jing Dong, Lingqi Gao, Junde Han, Junjie Zhang, Jijian Zhen. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27177547. |
dopamine administration reversed ketamine-induced neuronal apoptosis, but did not reverse the inhibitory effects of ketamine on early synchronized spontaneous network activity despite enhancing it in controls. |
2018-03-09 |
2023-08-13 |
rat |
| Jing Dong, Lingqi Gao, Junde Han, Junjie Zhang, Jijian Zhen. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27177547. |
blockade of d1, d2, and a2a receptors and inhibition of camp/pka signaling partially antagonized the protective effect of dopamine against ketamine-induced apoptosis. |
2018-03-09 |
2023-08-13 |
rat |
| Jing Dong, Lingqi Gao, Junde Han, Junjie Zhang, Jijian Zhen. Dopamine Attenuates Ketamine-Induced Neuronal Apoptosis in the Developing Rat Retina Independent of Early Synchronized Spontaneous Network Activity. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27177547. |
together, these data indicate that dopamine attenuates ketamine-induced neuronal apoptosis in the developing rat retina by activating the d1, d2, and a2a receptors, and upregulating camp/pka signaling, rather than through modulation of early synchronized spontaneous network activity. |
2018-03-09 |
2023-08-13 |
rat |
| Tarek K Motawi, Hebatallah A Darwish, Manal A Hamed, Nagy S El-Rigal, Asmaa F Aboul Nase. A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26867655. |
the evaluation was done through the estimation of the levels of blood glucose, serum insulin, and oxidative stress markers: malondialdehyde (mda), superoxide dismutase (sod), and glutathione (gsh); neurotransmitters: acetylcholinesterase (ache) and dopamine (da); vasoconstrictor indices: intercellular adhesion molecule-1 (icam-1), vascular cell adhesion molecule-1(vcam-1), and angiotensin ii (ang ii); and apoptosis markers: tumor necrosis factor-α (tnf-α) and caspase-3 as well as the histopathological picture of the cerebellum region of the brain. |
2018-02-07 |
2023-08-13 |
rat |
| Zahra Shahpiri, Roodabeh Bahramsoltani, Mohammad Hosein Farzaei, Fatemeh Farzaei, Roja Rahim. Phytochemicals as future drugs for Parkinson's disease: a comprehensive review. Reviews in the neurosciences. vol 27. issue 6. 2018-01-02. PMID:27124673. |
phytochemicals perform their antiparkinsonian effect through several mechanisms of action, including suppressing apoptosis (via the reduction of bax/bcl-2, caspase-3, -8, and -9, and α-synuclein accumulation), decreasing dopaminergic neuronal loss and dopamine depletion, reducing the expression of proinflammatory cytokines (such as prostaglandin e2, interleukin-6, interleukin-1β, and nuclear factor-κb), and modulating nuclear and cellular inflammatory signaling, elevation of neurotrophic factors, and improvement of antioxidant status. |
2018-01-02 |
2023-08-13 |
Not clear |
| Daisuke Sakano, Sungik Choi, Masateru Kataoka, Nobuaki Shiraki, Motonari Uesugi, Kazuhiko Kume, Shoen Kum. Dopamine D2 Receptor-Mediated Regulation of Pancreatic β Cell Mass. Stem cell reports. vol 7. issue 1. 2017-11-29. PMID:27373926. |
drd2 overexpression sensitized the dopamine responsiveness of β cells and increased apoptosis. |
2017-11-29 |
2023-08-13 |
Not clear |
| M G Akimov, A M Ashba, N M Gretskaya, V V Bezuglo. N-acyl dopamines induce apoptosis in PC12 cell line via the GPR55 receptor activation. Doklady. Biochemistry and biophysics. vol 474. issue 1. 2017-09-06. PMID:28726104. |
dopamine amides of arachidonic, docosahexaenoic, and oleic acids were found to induce apoptosis in pc12 cells, which was blocked exclusively by antagonists and preincubation agonists of the receptor gpr55, belonging to the group of non-cb1/cb2 receptors. |
2017-09-06 |
2023-08-13 |
Not clear |
| Peizhou Jiang, Peng Huang, Shu-Hui Yen, Abba C Zubair, Dennis W Dickso. Genetic modification of H2AX renders mesenchymal stromal cell-derived dopamine neurons more resistant to DNA damage and subsequent apoptosis. Cytotherapy. vol 18. issue 12. 2017-08-03. PMID:27720638. |
genetic modification of h2ax renders mesenchymal stromal cell-derived dopamine neurons more resistant to dna damage and subsequent apoptosis. |
2017-08-03 |
2023-08-13 |
Not clear |
| Eun-Joo Shin, Duy-Khanh Dang, The-Vinh Tran, Hai-Quyen Tran, Ji Hoon Jeong, Seung-Yeol Nah, Choon-Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Current understanding of methamphetamine-associated dopaminergic neurodegeneration and psychotoxic behaviors. Archives of pharmacal research. vol 40. issue 4. 2017-06-19. PMID:28243833. |
evidence from animal models has suggested a considerable role of excess dopamine or glutamate, oxidative stress, neuroinflammation, and apoptosis in ma-induced neurotoxicity, and that protein kinase cδ might mediate the interaction among these factors. |
2017-06-19 |
2023-08-13 |
human |
| Shaletha Holmes, Meharvan Singh, Chang Su, Rebecca L Cunningha. Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line. Endocrinology. vol 157. issue 7. 2017-06-05. PMID:27167771. |
our data show that testosterone increased the expression of cox2 and apoptosis in dopamine neurons. |
2017-06-05 |
2023-08-13 |
rat |