| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadian. Preconditioning as a potential strategy for the prevention of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24696268. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2015-10-20 |
2023-08-13 |
Not clear |
| Shaobin Yu, Ling Zhu, Qiang Shen, Xue Bai, Xuhui D. Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology. Behavioural neurology. vol 2015. 2015-09-28. PMID:25861156. |
subsequent to these acute effects, meth produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis. |
2015-09-28 |
2023-08-13 |
Not clear |
| Xiao-na Cai, Sa Shi, Hong-zhu Li, Wang Li-na, Hong L. [Effects and mechanisms of low concentration dopamine on hydrogen peroxide-induced apoptosis in cultured neonatal rat cardiomyocytes]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 31. issue 1. 2015-07-26. PMID:26016244. |
[effects and mechanisms of low concentration dopamine on hydrogen peroxide-induced apoptosis in cultured neonatal rat cardiomyocytes]. |
2015-07-26 |
2023-08-13 |
rat |
| Xiao-na Cai, Sa Shi, Hong-zhu Li, Wang Li-na, Hong L. [Effects and mechanisms of low concentration dopamine on hydrogen peroxide-induced apoptosis in cultured neonatal rat cardiomyocytes]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 31. issue 1. 2015-07-26. PMID:26016244. |
to study the effects of low concentration dopamine(da) on hydrogen peroxide-induced apoptosis in cultured rat cardiomyocytes as well as the possible molecular mechanisms. |
2015-07-26 |
2023-08-13 |
rat |
| Siyuan Wang, Zhenzhen Mou, Yuanheng Ma, Jian Li, Jingyun Li, Xiwei Ji, Kehua Wu, Liang Li, Wei Lu, Tianyan Zho. Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: Involvement of eradicating cancer stem-like cells. Biochemical pharmacology. vol 95. issue 2. 2015-06-25. PMID:25824241. |
in addition, dopamine remarkably induced the apoptosis of bcscs, markedly inhibited the wnt signaling pathway and activated the apoptotic associated signals. |
2015-06-25 |
2023-08-13 |
Not clear |
| Se Joon Choi, Anne Panhelainen, Yvonne Schmitz, Kristin E Larsen, Ellen Kanter, Min Wu, David Sulzer, Eugene V Mosharo. Changes in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure. The Journal of biological chemistry. vol 290. issue 11. 2015-05-29. PMID:25596531. |
1-methyl-4-phenylpyridinium (mpp(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, selectively kills dopaminergic neurons in vivo and in vitro via a variety of toxic mechanisms, including mitochondrial dysfunction, generation of peroxynitrite, induction of apoptosis, and oxidative stress due to disruption of vesicular dopamine (da) storage. |
2015-05-29 |
2023-08-13 |
mouse |
| A Parlog, D Schlüter, I R Duna. Toxoplasma gondii-induced neuronal alterations. Parasite immunology. vol 37. issue 3. 2015-05-06. PMID:25376390. |
the parasites are able to induce direct modifications in the infected cells, for example by altering dopamine metabolism, by functionally silencing neurons as well as by hindering apoptosis. |
2015-05-06 |
2023-08-13 |
human |
| Jimena Ferraris, Sandra Zárate, Gabriela Jaita, Florence Boutillon, Marie Bernadet, Julien Auffret, Adriana Seilicovich, Nadine Binart, Vincent Goffin, Daniel Piser. Prolactin induces apoptosis of lactotropes in female rodents. PloS one. vol 9. issue 5. 2015-02-27. PMID:24859278. |
we showed that acute hyperprolactinemia induced in ovariectomized rats using prl injection or dopamine antagonist treatment rapidly increased apoptosis and decreased proliferation specifically of prl producing cells (lactotropes), suggesting a direct regulation of these cell responses by prl. |
2015-02-27 |
2023-08-13 |
mouse |
| Kunio Doi, Koji Uetsuk. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. International journal of molecular sciences. vol 12. issue 8. 2015-01-29. PMID:21954354. |
ota causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neuronal cell apoptosis in the substantia nigra, striatum and hippocampus. |
2015-01-29 |
2023-08-12 |
Not clear |
| Adrián González-López, Guillermo M Albaiceta, Konrad Talbo. Newly identified precipitating factors in mechanical ventilation-induced brain damage: implications for treating ICU delirium. Expert review of neurotherapeutics. vol 14. issue 6. 2015-01-13. PMID:24852225. |
that mechanism consists of aberrant vagal sensory input driving sustained dopamine d2 receptor (d2r) signaling in the hippocampal formation, which induces apoptosis in that brain area within 90 min without causing hypoxia, oxidative stress, or inflammatory responses. |
2015-01-13 |
2023-08-13 |
Not clear |
| Wei-Che Lin, Nai-Wen Tsai, Yung-Cheng Huang, Kuei-Yueh Cheng, Hsiu-Ling Chen, Shau-Hsuan Li, Chia-Te Kung, Yu-Jih Su, Wei-Ming Lin, Meng-Hsiang Chen, Tsui-Min Chiu, I-Hsiao Yang, Cheng-Hsien L. Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings. BioMed research international. vol 2014. 2014-12-19. PMID:24795890. |
the present study demonstrated that leukocyte apoptosis is significantly higher in pd patients and is associated with central dopamine neuron loss by using (99m)tc-trodat-1 spect. |
2014-12-19 |
2023-08-13 |
Not clear |
| Wei-Che Lin, Nai-Wen Tsai, Yung-Cheng Huang, Kuei-Yueh Cheng, Hsiu-Ling Chen, Shau-Hsuan Li, Chia-Te Kung, Yu-Jih Su, Wei-Ming Lin, Meng-Hsiang Chen, Tsui-Min Chiu, I-Hsiao Yang, Cheng-Hsien L. Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings. BioMed research international. vol 2014. 2014-12-19. PMID:24795890. |
the leukocyte apoptosis and striatal dopamine transporter uptake ratios were further associated with increased severity and longer duration of disease. |
2014-12-19 |
2023-08-13 |
Not clear |
| D Ouazia, L-C Levros, E Rassart, R R Desrosier. Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. Neuroscience. vol 267. 2014-12-09. PMID:24631677. |
this suggests that ros generated from cytosolic dopamine could reduce both the pcmt1 gene promoter activity and the pimt protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in pd. |
2014-12-09 |
2023-08-12 |
Not clear |
| Poonam Thakur, Bimla Nehr. Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model. Neuropharmacology. vol 79. 2014-12-03. PMID:24296154. |
in addition, the decrease in apoptosis and oxidative stress following hsp upregulation prevented the decline in tyrosine hydroxylase (th) and dopamine levels in mid-brain region, which in turn resulted in improved motor functions. |
2014-12-03 |
2023-08-12 |
rat |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Dhanraj Vijayraja, Nataraj Ashokkumar, Srinivasagam Rajasankar, Thamilarasan Manivasaga. Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice. Annals of neurosciences. vol 17. issue 3. 2014-10-24. PMID:25205886. |
parkinson's disease (pd) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure. |
2014-10-24 |
2023-08-13 |
mouse |
| Dae Hong Kim, Ik Hwan Lee, Seung Taek Nam, Ji Hong, Peng Zhang, Jae Sam Hwang, Heon Seok, Hyemin Choi, Dong Gun Lee, Jae Il Kim, Ho Ki. Neurotropic and neuroprotective activities of the earthworm peptide Lumbricusin. Biochemical and biophysical research communications. vol 448. issue 3. 2014-08-20. PMID:24796676. |
lumbricusin also significantly inhibited the apoptosis and decreased viability induced by treatment with 6-hydroxy dopamine, a parkinson's disease-mimicking agent. |
2014-08-20 |
2023-08-13 |
human |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
using a human mesencephalic neuronal/glial culture model, which contains dopaminergic neurons, microglia, and astrocytes, we were able to show that the cb1/cb2 agonist win55,212-2 blunts gp120-induced neuronal damage as measured by dopamine transporter function, apoptosis and lipid peroxidation; these actions were mediated principally by the cb2 receptor. |
2014-08-05 |
2023-08-12 |
human |
| Hui-Hsing Hung, Wei-Pang Huang, Chien-Yuan Pa. Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival. Cell biology and toxicology. vol 29. issue 6. 2014-07-07. PMID:24077806. |
ly294002 or sirna-directed members of the autophagy pathway increased the fraction of phosphatidylserine present on the outer membrane leaflet in pc12 cells treated with dopamine or zn2+, suggesting an increase in apoptosis. |
2014-07-07 |
2023-08-12 |
Not clear |
| Hongzhu Li, Can Wei, Jun Gao, Shuzhi Bai, Hongxia Li, Yajun Zhao, Hong Li, Liping Han, Ye Tian, Guangdong Yang, Rui Wang, Lingyun Wu, Changqing X. Mediation of dopamine D2 receptors activation in post-conditioning-attenuated cardiomyocyte apoptosis. Experimental cell research. vol 323. issue 1. 2014-06-05. PMID:24412422. |
mediation of dopamine d2 receptors activation in post-conditioning-attenuated cardiomyocyte apoptosis. |
2014-06-05 |
2023-08-12 |
Not clear |
| Benjawan Meesarapee, Anusorn Thampithak, Yamaratee Jaisin, Pimtip Sanvarinda, Apichart Suksamrarn, Patoomratana Tuchinda, Noppawan Phumala Morales, Yupin Sanvarind. Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells. Phytotherapy research : PTR. vol 28. issue 4. 2014-05-30. PMID:23857913. |
6-hydroxydopamine (6-ohda) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. |
2014-05-30 |
2023-08-12 |
Not clear |