| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanxia Li, Zhaoyang Liu, Dan Wang, Hua Gao, Zhengquan Zhu, Yuling Wang, Qin Luo, Sen Jiang, Ji Zhang, Xinling Yan. Ucf-101 protects in vivoandin vitro models of PD against 6-hydroxydopamine toxicity by alleviating endoplasmic reticulum stress via the Wnt/β-catenin pathway. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 71. 2020-07-22. PMID:31883812. |
the accumulation of α-syn which induce endoplasmic reticulum stress (ers) and mediate various signaling pathways involved in da neuronal degeneration, and the apoptosis of dopamine (da) neurons are pathological markers of parkinson's disease (pd). |
2020-07-22 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Reza Tahvilian, Komail Amini, Hossein Zhale. Signal Transduction of Improving Effects of Ibudilast on Methamphetamine Induced Cell Death. Asian Pacific journal of cancer prevention : APJCP. vol 20. issue 9. 2020-02-14. PMID:31554375. |
the σ receptors induced apoptosis in some parts of the brain by increasing calcium, dopamine, ros,mitochondrial pores and caspase activity. |
2020-02-14 |
2023-08-13 |
Not clear |
| Yun Yu, Xiu-Yuan Lang, Xi-Xi Li, Run-Ze Gu, Qing-Shan Liu, Rongfeng Lan, Xiao-Yan Qi. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside attenuates MPP+/MPTP-induced neurotoxicity in vitro and in vivo by restoring the BDNF-TrkB and FGF2-Akt signaling axis and inhibition of apoptosis. Food & function. vol 10. issue 9. 2020-02-11. PMID:31482900. |
in cultured mesencephalic dopamine neurons and sh-sy5y cell line, it was found that thsg protected the integrity of the cell body and neurite branching from mpp+-induced toxicity by restoring the expression of fgf2 and bdnf and their downstream signaling pathways to inhibit apoptosis and promote cell survival. |
2020-02-11 |
2023-08-13 |
mouse |
| Yu-Long Lan, Xun Wang, Jin-Shan Xing, Zhen-Long Yu, Jia-Cheng Lou, Xiao-Chi Ma, Bo Zhan. Anti-cancer effects of dopamine in human glioma: involvement of mitochondrial apoptotic and anti-inflammatory pathways. Oncotarget. vol 8. issue 51. 2019-11-20. PMID:29179451. |
we investigated the biological functions of dopamine via migration, colony formation and apoptosis assays in glioma cells. |
2019-11-20 |
2023-08-13 |
human |
| Elizabeth S. Betts, Irina N. Krasnova, Michael T. McCoy, Bruce Ladenheim, Jean Lud Cade. Analysis of methamphetamine-induced changes in the expression of integrin family members in the cortex of wild-type and c-fos knockout mice. Neurotoxicity research. vol 4. issue 7-8. 2019-11-20. PMID:12709300. |
recent studies suggest that in addition to dopamine terminal degeneration in the striatum, meth causes apoptosis in cortical neurons. |
2019-11-20 |
2023-08-12 |
mouse |
| Jun Gao, Yang Liu, Gaijing Han, Kan Deng, Xiaohai Liu, Xinjie Bao, Ming Feng, Yong Yao, Wei Lian, Bing Xing, Xiang Lv, Renzhi Wan. Metformin inhibits growth and prolactin secretion of pituitary prolactinoma cells and xenografts. Journal of cellular and molecular medicine. vol 22. issue 12. 2019-10-31. PMID:30334324. |
we analysed ampk phosphorylation, dopamine d2 receptor (d2r), and oestrogen receptor (er) expression in both bc-sensitive and -resistant prloma samples; effects of the ampk agonist met (alone or with bc) on in vitro proliferation and apoptosis, xenograft growth and prolactin (prl) secretion of bc-sensitive and -resistant cells, and er expression in xenografts. |
2019-10-31 |
2023-08-13 |
Not clear |
| Mohammed A Elmetwally, Yasser Lenis, Wanjin Tang, Guoyao Wu, Fuller W Baze. Effects of catecholamines on secretion of interferon tau and expression of genes for synthesis of polyamines and apoptosis by ovine trophectoderm. Biology of reproduction. vol 99. issue 3. 2019-09-16. PMID:29668843. |
ovine trophectoderm (otr1) cells were used to investigate effects of epinephrine (ep), norepinephrine (ne), and dopamine (da) on their proliferation, migration and adhesion, secretion of interferon tau (ifnt), and expression of genes for synthesis of polyamines and apoptosis. |
2019-09-16 |
2023-08-13 |
Not clear |
| Matteo Dal Ben, Rosario Bongiovanni, Simone Tuniz, Emanuela Fioriti, Claudio Tiribelli, Rita Moretti, Silvia Gazzi. Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra. International journal of molecular sciences. vol 20. issue 9. 2019-08-20. PMID:31064126. |
significant microglia activation, apoptosis, a reduction in dopamine vesicle transporters, and the ubiquitination of misfolded protein clearance pathways were late (96 h, consequential) events. |
2019-08-20 |
2023-08-13 |
human |
| H Liu, C Yu, H Yu, L Zhong, Y Wang, J Liu, S Zhang, J Sun, L Duan, L Gong, J Yan. Cerebral dopamine neurotrophic factor protects H9c2 cardiomyocytes from apoptosis. Herz. vol 43. issue 4. 2019-07-29. PMID:28444413. |
cerebral dopamine neurotrophic factor protects h9c2 cardiomyocytes from apoptosis. |
2019-07-29 |
2023-08-13 |
Not clear |
| Hui-Ju Huang, Yi-Ting Wang, Hui-Ching Lin, Yi-Hsuan Lee, Anya Maan-Yuh Li. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28822080. |
attenuated mptp-induced reduction in striatal dopamine content, th-positive cell numbers, th, and pro-caspase 9 protein levels (an initiator caspase of apoptosis) in mouse sn. |
2019-05-08 |
2023-08-13 |
mouse |
| Xiaotong Zheng, Xuechai Chen, Minjun Guo, Sakhawat Ali, Yinghui Huang, Feiyi Sun, Kefu Liu, Zixuan Chen, Yulin Deng, Rugang Zhon. Changes in salsolinol production and salsolinol synthase activity in Parkinson's disease model. Neuroscience letters. vol 673. 2019-03-11. PMID:29454627. |
salsolinol is an endogenous neurotoxin derived from dopamine, and has been proved to cause the apoptosis of the dopaminergic neurons involved in the pathogenesis of parkinson's disease (pd). |
2019-03-11 |
2023-08-13 |
rat |
| Yutian Tian, Shuhan Guo, Cengceng Chen, Li Zhao, Zhen Li, Yongjian Ya. Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects. Environmental toxicology and pharmacology. vol 64. 2019-01-28. PMID:30300793. |
sgk1, hcrtr1, hspb1, rem2, oprd1, atf5, and trhr identified in this study may be involved in oxidative stress mechanisms, dopamine (da) synthesis, and neuronal survival during apoptosis and may affect susceptibility to manganese poisoning. |
2019-01-28 |
2023-08-13 |
Not clear |
| Lei Zhou, Li Yang, Yu-Jin Li, Rong Mei, Hua-Lin Yu, Yi Gong, Ming-Yue Du, Fei Wan. MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson's Disease by Binding to AXIN1. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 5. 2019-01-25. PMID:30537735. |
microrna-128 protects dopamine neurons from apoptosis and upregulates the expression of excitatory amino acid transporter 4 in parkinson's disease by binding to axin1. |
2019-01-25 |
2023-08-13 |
mouse |
| Lei Zhou, Li Yang, Yu-Jin Li, Rong Mei, Hua-Lin Yu, Yi Gong, Ming-Yue Du, Fei Wan. MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson's Disease by Binding to AXIN1. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 51. issue 5. 2019-01-25. PMID:30537735. |
in this study, we established mouse models of pd to investigate the expression of microrna-128 (mir-128) and mechanism through which it affects apoptosis of dopamine (da) neurons and the expression of excitatory amino acid transporter 4 (eaat4) via binding to axis inhibition protein 1 (axin1). |
2019-01-25 |
2023-08-13 |
mouse |
| Sneha Potdar, Mayur S Parmar, Sidhartha D Ray, Jane E Cavanaug. Protective effects of the resveratrol analog piceid in dopaminergic SH-SY5Y cells. Archives of toxicology. vol 92. issue 2. 2019-01-17. PMID:28980048. |
since oxidative stress is considered a master operator of apoptosis, our study also scrutinized dopamine-induced apoptosis and whether caspase-3/7 and bcl-2 are involved, following piceid pretreatment followed by dopamine exposure. |
2019-01-17 |
2023-08-13 |
Not clear |
| Yuxiang Yuan, Ying Zhu, Yinwei Song, Yin Zhao, Xiaoqin Yan, Wei Chen, Mu Li, Jieling Gong, Ketao Mu, Junming Wang, Hong Zhang, Zhiqi Che. Morphological and Functional Changes of Locus Coeruleus in Patients with Primary Open-Angle Glaucoma and Animal Models. Neuroscience. vol 372. 2018-11-13. PMID:29294337. |
immunohistochemistry and immunofluorescence staining were used to investigate lc tyrosine hydroxylase (th) and dopamine β-hydroxylase (dβh) expression, as well as cell apoptosis by terminal deoxynucleotidyl transferase dutp nick-end labeling staining. |
2018-11-13 |
2023-08-13 |
mouse |
| Yu-Long Lan, Xun Wang, Jin-Shan Xing, Jia-Cheng Lou, Xiao-Chi Ma, Bo Zhan. The potential roles of dopamine in malignant glioma. Acta neurologica Belgica. vol 117. issue 3. 2018-07-02. PMID:27995487. |
additionally, dopamine might exert an anti-glioma, cytotoxic effect by modulating apoptosis and autophagy. |
2018-07-02 |
2023-08-13 |
human |
| Jun Gao, Feng Ga. Dopamine D1 receptors induce apoptosis of osteosarcoma cells via changes of MAPK pathway. Clinical and experimental pharmacology & physiology. vol 44. issue 11. 2018-05-22. PMID:28699280. |
dopamine d1 receptors induce apoptosis of osteosarcoma cells via changes of mapk pathway. |
2018-05-22 |
2023-08-13 |
Not clear |