| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S P Hamilton, F Haghighi, G A Heiman, D F Klein, S E Hodge, A J Fyer, M M Weissman, J A Knowle. Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898909. |
in this study, we examined the genes for the d4 dopamine receptor (drd4) and the dopamine transporter (dat) using three common sequence polymorphisms. |
2000-08-10 |
2023-08-12 |
human |
| U Müller, T Wächter, H Barthel, M Reuter, D Y von Cramo. Striatal [123I]beta-CIT SPECT and prefrontal cognitive functions in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 3. 2000-08-02. PMID:10821439. |
significant (p < 0.05) correlations were observed between dopamine transporter (dat) density in the putamen and motor deficits as well as between dat density in both striatal compartments (head of the caudate nucleus and putamen) and prefrontal functioning. |
2000-08-02 |
2023-08-12 |
Not clear |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
dopamine [dat], norepinephrine [net], and sert, respectively), odam showed a strong inhibition on sert (k(i) = 0.12 +/- 0.02 nm). |
2000-07-27 |
2023-08-12 |
rat |
| C Saunders, J V Ferrer, L Shi, J Chen, G Merrill, M E Lamb, L M Leeb-Lundberg, L Carvelli, J A Javitch, A Gall. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10823899. |
the dopamine transporter (dat) is a target of amphetamine (amph) and cocaine. |
2000-07-13 |
2023-08-12 |
human |
| C Saunders, J V Ferrer, L Shi, J Chen, G Merrill, M E Lamb, L M Leeb-Lundberg, L Carvelli, J A Javitch, A Gall. Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 12. 2000-07-13. PMID:10823899. |
these psychostimulants attenuate dat clearance efficiency, thereby increasing synaptic dopamine (da) levels. |
2000-07-13 |
2023-08-12 |
human |
| M M Goodman, C D Kilts, R Keil, B Shi, L Martarello, D Xing, J Votaw, T D Ely, P Lambert, M J Owens, V M Camp, E Malveaux, J M Hoffma. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755640. |
fluorine-18 labeled 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nort ropane (fecnt) was synthesized in the development of a dopamine transporter (dat) imaging ligand for positron emission tomography (pet). |
2000-07-07 |
2023-08-12 |
human |
| P Fang, C Y Wu, Z G Liu, W X Wan, T S Wang, S D Chen, Z P Chen, X Zho. The preclinical pharmacologic study of dopamine transporter imaging agent [99mTc]TRODAT-1. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755648. |
the purpose of this study was to investigate the pharmacologic characteristics of trodat-1 (2beta-((n,n'-bis(2-mercaptoethyl)ethylene diamino)methyl), 3beta-(4-chlorophenyl)tropane) labeled with [99mtc] as an imaging agent for dopamine transporter (dat). |
2000-07-07 |
2023-08-12 |
rat |
| T Hamano, T Tsuchida, M Hirayama, J Fujiyama, T Mutoh, Y Yonekura, M Kuriyam. [Dopamine transporter SPECT in patients with Parkinson's disease]. Kaku igaku. The Japanese journal of nuclear medicine. vol 37. issue 2. 2000-07-07. PMID:10783572. |
dopamine transporter (dat) is an important protein in the regulation of da neurotransmission. |
2000-07-07 |
2023-08-12 |
Not clear |
| T C Yen, C S Lu, K Y Tzen, S P Wey, Y H Chou, Y H Weng, P F Kao, G Tin. Decreased dopamine transporter binding in Machado-Joseph disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 6. 2000-07-07. PMID:10855623. |
the aim of this study was to use 99mtc-trodat-1 brain spect for investigation of the binding of dopamine transporter (dat) in the nigrostriatal dopaminergic pathway of symptomatic machado-joseph disease (mjd) and to compare the results with the abnormal cytidylate, adenylate, and guanylate (cag) expansion in the mjd1 gene and other clinical factors. |
2000-07-07 |
2023-08-12 |
Not clear |
| A A Bonab, A J Fischman, N M Alper. Comparison of 4 methods for quantification of dopamine transporters by SPECT with [123I]IACFT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 41. issue 6. 2000-07-07. PMID:10855640. |
2beta-carbomethoxy-3beta-(4-fluorophenyl)-n-(1-iodoprop-1-en -3-yl) nortropane (iacft) is a highly selective ligand for dopamine transporter (dat) sites in the striatum. |
2000-07-07 |
2023-08-12 |
Not clear |
| A Hoepping, K M Johnson, C George, J Flippen-Anderson, A P Kozikowsk. Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. Journal of medicinal chemistry. vol 43. issue 10. 2000-06-29. PMID:10821718. |
(1s,3r, 6s)-(z)-9-(thienylmethylene)-7-azatricyclo[4.3.1.0(3, 7)]decane-2beta-carboxylic acid methyl ester (5h) exhibits reasonable activity at the dopamine transporter (dat) (k(i) = 268 nm) and good activity at the norepinephrine transporter (net) (k(i) = 26 nm). |
2000-06-29 |
2023-08-12 |
rat |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
polar residues in dopamine transporter (dat) transmembrane domains (tms) are likely to act individually and even interactively in recognizing cocaine and dopamine. |
2000-06-22 |
2023-08-12 |
Not clear |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
we initially evaluated the effects of alanine substitution mutants that remove the polar side chains from residues in each of the 12 putative dat tms on the recognition of dopamine and the cocaine analog cft. |
2000-06-22 |
2023-08-12 |
Not clear |
| M Itokawa, Z Lin, N S Cai, C Wu, S Kitayama, J B Wang, G R Uh. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Molecular pharmacology. vol 57. issue 6. 2000-06-22. PMID:10825379. |
eleven combination mutants with multiple substitutions in dat tms 4, 5, 7, or 11 were then selected as candidates for more detailed evaluation based on mutation effects on dopamine and cocaine analog affinities. |
2000-06-22 |
2023-08-12 |
Not clear |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
the dose-response and duration effects of acute administration of the dopamine transporter (dat) blocker cocaine and gbr12909 on dopamine synthesis and transporter availability were evaluated in the brains of conscious monkeys using high-resolution positron emission tomography (pet) in combination with microdialysis. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
rate of dopamine synthesis and dat availability were evaluated using l-[beta-11c]dopa and [11c]beta-cft (win35,428), respectively. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
at 0.5 post-injection, cocaine reduced dopamine synthesis rate and dat availability in a dose-dependent manner. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
when gbr12909 (0.5, 2 and 5 mg/kg) was administered 0.5 h before tracer injection, dopamine synthesis rate and dat availability were significantly decreased in a dose-dependent manner. |
2000-06-15 |
2023-08-12 |
monkey |
| H Tsukada, N Harada, S Nishiyama, H Ohba, T Kakiuch. Dose-response and duration effects of acute administrations of cocaine and GBR12909 on dopamine synthesis and transporter in the conscious monkey brain: PET studies combined with microdialysis. Brain research. vol 860. issue 1-2. 2000-06-15. PMID:10727633. |
gbr12909 induced dose-dependent elevation of dopamine level in ecf, and the elevation lasted up to 7 h. the present results indicated that cocaine and gbr12909 affect dopamine synthesis rate and dat availability in the striatum with difference time courses as measured by pet in the conscious monkey brains. |
2000-06-15 |
2023-08-12 |
monkey |
| K Yoshimoto, S Ueda, M Nishi, Y Yang, H Matsushita, Y Takeuchi, B Kato, Y Kawai, K Noritake, S Kaneda, Y Sorimachi, M Yasuhar. Changes in dopamine transporter and c-Fos expression in the nucleus accumbens of alcohol-tolerant rats. Alcoholism, clinical and experimental research. vol 24. issue 3. 2000-06-12. PMID:10776677. |
in the present study, the effects of chronic alcohol consumption on the functions of the dopamine transporter (dat) and the expression of c-fos proteins were investigated using in vivo brain microdialysis and immunocytochemistry. |
2000-06-12 |
2023-08-12 |
rat |