| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N S Kula, R J Baldessarini, F I Tarazi, R Fisser, S Wang, J Trometer, J L Neumeye. [3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue. European journal of pharmacology. vol 385. issue 2-3. 2000-02-17. PMID:10607889. |
with rat forebrain tissue, [3h]beta-cit showed high affinity for dopamine transporters (dat), with selectivity for dat over norepinephrine transporters, but not serotonin transporters, as well as dat-stereoselectivity with beta-cit, amphetamine and methylphenidate. |
2000-02-17 |
2023-08-12 |
rat |
| M Mu, M P Kung, K Plössl, P D Acton, P D Mozley, H F Kun. A simplified method to determine [99mTc]TRODAT-1 in human plasma. Nuclear medicine and biology. vol 26. issue 7. 2000-02-17. PMID:10628563. |
[99mtc]trodat-1 is a useful imaging agent in evaluating changes in presynaptic dopamine transporters (dat) for parkinson's disease and other central nervous system (cns) neurodegenerative diseases, for which a reduction of dopamine neurons is indicated. |
2000-02-17 |
2023-08-12 |
human |
| P Sacchetti, L A Brownschidle, J G Granneman, M J Banno. Characterization of the 5'-flanking region of the human dopamine transporter gene. Brain research. Molecular brain research. vol 74. issue 1-2. 2000-02-15. PMID:10640687. |
the dopamine transporter (dat) plays a major role in modulating dopamine (da) neurotransmission by controlling the levels of this neurotransmitter in the extracellular space. |
2000-02-15 |
2023-08-12 |
human |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
the dopamine transporter (dat; slc6a3) is densely expressed by the dopaminergic midbrain neurons that play central roles in drug reward and is believed to be a primary site of action for cocaine reward. |
2000-02-14 |
2023-08-12 |
mouse |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
to study possible influences of variant dat expression on these processes, we have constructed transgenic mice (thdat) in which tyrosine hydroxylase (th) promoter sequences drive expression of a rat dat cdna variant, increase striatal dat expression by 20-30%, and provide modest alterations in striatal levels of dopamine and its metabolites. |
2000-02-14 |
2023-08-12 |
mouse |
| L Chen, D M Segal, C T Moraes, D C Mas. Dopamine transporter mRNA in autopsy studies of chronic cocaine users. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581411. |
the effects of chronic cocaine abuse on transcriptional regulation of human dopamine transporter (dat) mrna in midbrain dopaminergic neurons was assessed by reverse transcription-polymerase chain reaction (rt-pcr). |
2000-02-14 |
2023-08-12 |
human |
| A Heinz, D Goldman, D W Jones, R Palmour, D Hommer, J G Gorey, K S Lee, M Linnoila, D R Weinberge. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 2. 2000-02-14. PMID:10649826. |
in vivo availability of striatal dopamine transporter (dat) protein has been reported to be reduced among alcoholics, and allelic variation of the dat gene (slc6a3) has been associated with severity of alcohol withdrawal. |
2000-02-14 |
2023-08-12 |
human |
| N P Verhoef. Radiotracer imaging of dopaminergic transmission in neuropsychiatric disorders. Psychopharmacology. vol 147. issue 3. 2000-02-11. PMID:10639681. |
the presynaptic site can be labeled with probes for the dopamine transporter (dat) or the synthetic enzyme aromatic l-amino acid decarboxylase ("dopa decarboxylase"). |
2000-02-11 |
2023-08-12 |
Not clear |
| E Repo, J T Kuikka, K A Bergström, J Karhu, J Hiltunen, J Tiihone. Dopamine transporter and D2-receptor density in late-onset alcoholism. Psychopharmacology. vol 147. issue 3. 2000-02-11. PMID:10639691. |
therefore, it is relevant to study both postsynaptic d2-receptor and presynaptic dopamine transporter (dat) densities among alcoholics. |
2000-02-11 |
2023-08-12 |
Not clear |
| S L Ingram, S G Amar. Arachidonic acid stimulates a novel cocaine-sensitive cation conductance associated with the human dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632584. |
the dopamine transporter (dat) exhibits several ionic currents that are either coupled to or uncoupled from the transport of substrate. |
2000-02-09 |
2023-08-12 |
human |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
the effects of the dopamine transporter (dat) inhibitors cocaine and gbr12909 on dat and dopamine d(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (pet) in combination with microdialysis. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
the striatal dat availability and dopamine d(2) receptor binding were assayed with [11c]beta-cft (win35,428) and [11c]raclopride, respectively. |
2000-01-28 |
2023-08-12 |
monkey |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harada, S Nakanish. Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain research. vol 849. issue 1-2. 2000-01-28. PMID:10592290. |
taken together, these observations indicated that isoflurane anesthesia enhanced not only the direct inhibitory effects of cocaine and gbr12909 on dat, but also their indirect effects on dopamine d(2) receptors. |
2000-01-28 |
2023-08-12 |
monkey |
| S Z Meng, Y Ozawa, M Itoh, S Takashim. Developmental and age-related changes of dopamine transporter, and dopamine D1 and D2 receptors in human basal ganglia. Brain research. vol 843. issue 1-2. 2000-01-24. PMID:10528120. |
the developmental and age-related changes of the dopamine transporter (dat), and the dopamine d1 and d2 receptor (d1r and d2r) subtypes were investigated in basal ganglia (bg) of human brain. |
2000-01-24 |
2023-08-12 |
human |
| M Bliziotes, S McLoughlin, M Gunness, F Fumagalli, S R Jones, M G Caro. Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. Bone. vol 26. issue 1. 2000-01-20. PMID:10617152. |
the dopamine transporter (dat) is believed to control the temporal and spatial activity of released da by rapid uptake of the neurotransmitter into presynaptic terminals. |
2000-01-20 |
2023-08-12 |
mouse |
| D B Lewis, D Matecka, Y Zhang, L W Hsin, C M Dersch, D Stafford, J R Glowa, R B Rothman, K C Ric. Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents. Journal of medicinal chemistry. vol 42. issue 24. 2000-01-04. PMID:10585212. |
an investigation into the preparation of potential extended-release cocaine-abuse therapeutic agents afforded a series of compounds related to 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (1a) and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (1b) (gbr 12935 and gbr 12909, respectively), which were designed, synthesized, and evaluated for their ability to bind to the dopamine transporter (dat) and to inhibit the uptake of [(3)h]-labeled dopamine (da). |
2000-01-04 |
2023-08-12 |
monkey |
| S R Jones, J D Joseph, L S Barak, M G Caron, R M Wightma. Dopamine neuronal transport kinetics and effects of amphetamine. Journal of neurochemistry. vol 73. issue 6. 1999-12-27. PMID:10582600. |
the dopamine (da) transporter (dat) regulates da neurotransmission by recycling da back into neurons. |
1999-12-27 |
2023-08-12 |
mouse |
| A Hoepping, J Babich, J A Zubieta, K M Johnson, S Machill, A P Kozikowsk. Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine. Bioorganic & medicinal chemistry letters. vol 9. issue 22. 1999-12-20. PMID:10576690. |
two new technetium complexes containing a piperidine template have been synthesized and evaluated as possible leads for the development of dopamine transporter (dat) imaging agents. |
1999-12-20 |
2023-08-12 |
rat |
| G W Miller, M L Kirby, A I Levey, J R Bloomquis. Heptachlor alters expression and function of dopamine transporters. Neurotoxicology. vol 20. issue 4. 1999-12-10. PMID:10499361. |
here we report that subchronic administration of the organochlorine insecticide heptachlor (0, 3, 6, 9, or 12 mg/kg given 3 times over a 2 week period) leads to a pronounced increase in both the plasma membrane transport of dopamine and the expression of the plasma membrane dopamine transporter (dat), as well as the vesicular monoamine transporter (vmat2) in the striatum of c57bl mice. |
1999-12-10 |
2023-08-12 |
mouse |
| G W Miller, M L Kirby, A I Levey, J R Bloomquis. Heptachlor alters expression and function of dopamine transporters. Neurotoxicology. vol 20. issue 4. 1999-12-10. PMID:10499361. |
in a dat expressing cell line, acute treatment with the putative toxic species of heptachlor, heptachlor epoxide, did not alter plasma membrane dopamine uptake. |
1999-12-10 |
2023-08-12 |
mouse |