| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kugaya, M Fujita, R B Inni. Applications of SPECT imaging of dopaminergic neurotransmission in neuropsychiatric disorders. Annals of nuclear medicine. vol 14. issue 1. 2000-06-08. PMID:10770574. |
we have developed the in vivo dopamine transporter (dat) imaging with [123i]beta-cit ((1r)-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane). |
2000-06-08 |
2023-08-12 |
human |
| S H Lee, M Y Chang, K H Lee, B S Park, Y S Lee, H R Chin, Y S Le. Importance of valine at position 152 for the substrate transport and 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding of dopamine transporter. Molecular pharmacology. vol 57. issue 5. 2000-05-25. PMID:10779370. |
human and bovine dopamine transporters (dat) demonstrate discrete functional differences in dopamine (da), 1-methyl-4-phenylpyridium (mpp(+)) transport, and cocaine analog binding. |
2000-05-25 |
2023-08-12 |
human |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
the dopamine transporter (dat) mediates complex actions in recognizing cocaine and in recognizing and translocating dopamine, sodium, and chloride. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
we examine effects of these modifications on dat expression, dopamine uptake, and cocaine analog binding. |
2000-05-01 |
2023-08-12 |
Not clear |
| Z Lin, M Itokawa, G R Uh. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 5. 2000-05-01. PMID:10744628. |
these dat proline mutants identify dat regions likely for dopamine translocation and for recognition of dopamine and cocaine. |
2000-05-01 |
2023-08-12 |
Not clear |
| H Umegaki, H Ikari, H Nakahata, J Yoshimura, H Endo, T Yamamoto, A Iguch. Low plasma epinephrine in elderly female subjects of dementia of Alzheimer type. Brain research. vol 858. issue 1. 2000-04-25. PMID:10700598. |
in the present study, we measured the plasma level of epinephrine, norepinephrine, dopamine, glucose, and insulin during a fasting state in the morning in hospitalized dat (n=66), vascular dementia (vd) (n=28), or non-demented (nd) (n=21) females (mean age dat=82. |
2000-04-25 |
2023-08-12 |
human |
| S Han, P P Rowell, L A Car. D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine. Research communications in molecular pathology and pharmacology. vol 104. issue 3. 2000-04-21. PMID:10741383. |
it has been shown previously that chronic inhibition of dopamine synthesis decreases dopamine transporter (dat) density and function. |
2000-04-21 |
2023-08-12 |
Not clear |
| S Han, P P Rowell, L A Car. D2 autoreceptors are not involved in the down-regulation of the striatal dopamine transporter caused by alpha-methyl-p-tyrosine. Research communications in molecular pathology and pharmacology. vol 104. issue 3. 2000-04-21. PMID:10741383. |
the results indicate that chronic inhibition of dopamine synthesis and stimulation of d2 receptors have similar, but independent, effects on dat binding and function. |
2000-04-21 |
2023-08-12 |
Not clear |
| H L Kimmel, F I Carroll, M J Kuha. Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76. Neuropharmacology. vol 39. issue 4. 2000-04-20. PMID:10728879. |
intracerebroventricular injections of the irreversible dopamine transporter (dat) inhibitor, rti-76 [3beta-(3-p-chlorophenyl) tropan-2beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride], decreased dat binding in both the striatum and nucleus accumbens as measured by both [3h]gbr12935 and by [3h]win35,428. |
2000-04-20 |
2023-08-12 |
rat |
| G A Siebert, S M Pond, L J Bryan-Lluk. Further characterisation of the interaction of haloperidol metabolites with neurotransmitter transporters in rat neuronal cultures and in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 3. 2000-04-13. PMID:10731037. |
we recently showed that haloperidol and its metabolites are inhibitors of the human noradrenaline transporter (nat), dopamine transporter (dat) and serotonin transporter (sert), and determined their ki values for inhibition of the three transporters expressed in transfected cos-7 cells. |
2000-04-13 |
2023-08-12 |
human |
| C Deleuze-Masquefa, M Michaud-Dutreilh, J Vignon, J M Kamenk. 1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vivo. Identification and quantification of BTCP primary metabolites in mice plasma, urine, and brain and their affinity for the neuronal dopamine transporter. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 9. issue 4. 2000-04-11. PMID:10664474. |
1-[1-(2-benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (btcp) and cocaine bind to the neuronal dopamine transporter (dat) to strongly inhibit dopamine (da) reuptake. |
2000-04-11 |
2023-08-12 |
mouse |
| M Laruelle, A Abi-Dargham, C van Dyck, R Gil, D C D'Souza, J Krystal, J Seibyl, R Baldwin, R Inni. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. Biological psychiatry. vol 47. issue 5. 2000-03-28. PMID:10704949. |
the aim of this study was to investigate potential alterations of striatal dopamine transporters (dat) and brainstem serotonin transporters (sert) density in schizophrenia. |
2000-03-28 |
2023-08-12 |
Not clear |
| D Xing, P Chen, R Keil, C D Kilts, B Shi, V M Camp, G Malveaux, T Ely, M J Owens, J Votaw, M Davis, J M Hoffman, R A BaKay, T Subramanian, R L Watts, M M Goodma. Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography. Journal of medicinal chemistry. vol 43. issue 4. 2000-03-16. PMID:10691690. |
2beta-(r)-carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane ((r)-fipct, r-6) and 2beta-(s)-carbo-1-fluoro-2-propoxy-3beta-(4-chlorophenyl) tro pane ((s)-fipct, s-6) were prepared and evaluated in vitro and in vivo for dopamine transporter (dat) selectivity and specificity. |
2000-03-16 |
2023-08-12 |
human |
| W P Melega, G Lacan, A A Desalles, M E Phelp. Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF: PET studies in the vervet monkey. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657033. |
win, a cocaine analog that binds to the dopamine transporter (dat), was used to provide an index of striatal dopamine terminal integrity. |
2000-03-13 |
2023-08-12 |
human |
| M R Kilbourn, K Kuszpit, P Sherma. Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657034. |
rapid and differential losses of in vivo dopamine transporter (dat) and vesicular monoamine transporter (vmat2) radioligand binding in mptp-treated mice. |
2000-03-13 |
2023-08-12 |
mouse |
| M R Kilbourn, K Kuszpit, P Sherma. Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice. Synapse (New York, N.Y.). vol 35. issue 4. 2000-03-13. PMID:10657034. |
the dose- and time-dependent changes of in vivo radioligand binding to the neuronal membrane dopamine transporter (dat) and vesicular monoamine transporter type 2 (vmat2) were examined in mouse brain after mptp (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administrations. |
2000-03-13 |
2023-08-12 |
mouse |
| S Wang, S Sakamuri, I J Enyedy, A P Kozikowski, O Deschaux, B C Bandyopadhyay, S R Tella, W A Zaman, K M Johnso. Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. Journal of medicinal chemistry. vol 43. issue 3. 2000-03-13. PMID:10669562. |
a novel, fairly potent dopamine transporter (dat) inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone (3, k(i) values of 492 and 360 nm in binding affinity and inhibition of dopamine reuptake, respectively), with significant functional antagonism against cocaine and a different in vitro pharmacological profile from cocaine at the three transporter sites (dopamine, serotonin, and norepinephrine) was discovered through 3d-database pharmacophore searching. |
2000-03-13 |
2023-08-12 |
mouse |
| T Sato, S Kitayama, C Mitsuhata, T Ikeda, K Morita, T Doh. Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 2. 2000-03-08. PMID:10685879. |
among the las tested, procaine and other ester-type las inhibited [3h]da uptake and binding of [3h]2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (cft), a cocaine analogue, in cos cells expressing rat dopamine transporter (dat). |
2000-03-08 |
2023-08-12 |
mouse |
| S W Choi, D R Elmaleh, R N Hanson, A J Fischma. Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: synthesis and evaluation as dopamine transporter ligands. Journal of medicinal chemistry. vol 43. issue 2. 2000-02-28. PMID:10649976. |
we have undertaken a program to develop cocaine antagonists based on the premise that such compounds should block cocaine binding but permit reuptake of dopamine at the dopamine transporter (dat). |
2000-02-28 |
2023-08-12 |
Not clear |
| N D Volkow, J S Fowler, G J Wan. Imaging studies on the role of dopamine in cocaine reinforcement and addiction in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667609. |
these studies have shown that the rate at which cocaine and methylphenidate enter the brain and block the dopamine transporters (dat) is the variable associated with the 'high', rather than the presence per se of the drug in the brain. |
2000-02-18 |
2023-08-12 |
Not clear |