| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Jaber, B Dumartin, C Sagné, J W Haycock, C Roubert, B Giros, B Bloch, M G Caro. Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. The European journal of neuroscience. vol 11. issue 10. 1999-12-08. PMID:10564358. |
the paradoxical hyperdopaminergia in the dat ko mice despite a marked decrease in th and dopamine levels suggests a parallel to parkinson's disease implying that blockade of dat may be beneficial in this condition. |
1999-12-08 |
2023-08-12 |
mouse |
| E C Mallard, A Rehn, S Rees, M Tolcos, D Copolo. Ventriculomegaly and reduced hippocampal volume following intrauterine growth-restriction: implications for the aetiology of schizophrenia. Schizophrenia research. vol 40. issue 1. 1999-11-30. PMID:10541002. |
in contrast, there were no significant alterations in the optical density of tyrosine hydroxylase (th), a rate-limiting enzyme in the biosynthesis of catecholamines and the dopamine transporter (dat) in the striatum in growth-restricted animals compared with controls. |
1999-11-30 |
2023-08-12 |
Not clear |
| S Chalon, L Garreau, P Emond, L Zimmer, M P Vilar, J C Besnard, D Guillotea. Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n ortropane as a selective and potent inhibitor of the neuronal dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 291. issue 2. 1999-11-24. PMID:10525084. |
binding experiments on rat striatal membranes showed that pe2i selectively recognized the dopamine transporter (dat) according to a single binding site model with high affinity (k(d) = 4 nm, b(max) = 12 pmol/mg protein). |
1999-11-24 |
2023-08-12 |
rat |
| C Pifl, E A Singe. Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion. Molecular pharmacology. vol 56. issue 5. 1999-11-24. PMID:10531412. |
the mechanism of release mediated by the human dopamine and norepinephrine transporter (dat and net, respectively) was studied by a superfusion technique in human embryonic kidney 293 cells stably transfected with the respective transporter cdna and loaded with the metabolically inert substrate [(3)h]1-methyl-4-phenylpyridinium. |
1999-11-24 |
2023-08-12 |
human |
| J Helfenbein, J Sandell, C Halldin, S Chalon, P Emond, Y Okubo, Y H Chou, Y Frangin, L Douziech, L Gareau, C G Swahn, J C Besnard, L Farde, D Guillotea. PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. Nuclear medicine and biology. vol 26. issue 5. 1999-11-22. PMID:10473187. |
rti-364, rti-330, and rti-357 (3-beta-(4'-n-propyl-,4'-iso-propyl-, and 4'-iso-propenyl-phenyl)nortropane-2-beta-carboxylic acid methyl ester) are three recently synthesized cocaine analogues with higher affinity for the serotonin (5-htt) than the dopamine transporter (dat). |
1999-11-22 |
2023-08-12 |
monkey |
| A Bocchetta, M P Piccardi, M A Palmas, C Chillotti, A Oi, M Del Zomp. Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490710. |
polymorphism at dopamine receptor genes drd2, drd4, and dopamine and serotonin transporter genes (dat, sert) has been used in previous association studies. |
1999-11-17 |
2023-08-12 |
Not clear |
| H Tsukada, S Nishiyama, T Kakiuchi, H Ohba, K Sato, N Harad. Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [11C]raclopride?: PET studies combined with microdialysis in conscious monkeys. Brain research. vol 841. issue 1-2. 1999-11-17. PMID:10546998. |
the systemic administration of the direct dopamine enhancers, gbr12909 (a dopamine transporter (dat) blocker, at 0.5, 2 and 5 mg/kg) or methamphetamine (a dopamine releaser, at 0.1, 0.3 and 1 mg/kg) dose-dependently increased the dopamine concentration in the striatal ecf, and decreased in vivo [11c]raclopride binding in the striatum. |
1999-11-17 |
2023-08-12 |
monkey |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
in this study, the hypothesis was partially investigated by determining the potencies of haloperidol and reduced haloperidol and the corresponding pyridinium and tetrahydropyridine metabolites, compared with mpp+ and mptp, as inhibitors of the noradrenaline transporter (nat), dopamine transporter (dat) and 5-ht transporter (sert). |
1999-11-08 |
2023-08-12 |
human |
| L J Bryan-Lluka, G A Siebert, S M Pon. Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494878. |
two days after cos-7 cells were transiently transfected with the cdna for the human nat, dat or sert (lipofectamine method), the cells were incubated with 10 nm [3h]noradrenaline, dopamine or 5-ht, respectively, for 2 min at 37 c, in the absence or presence of various concentrations of the eight compounds or a specific uptake inhibitor (nat: nisoxetine 1 microm; dat: gbr 12909 1 microm; sert: citalopram 10 microm). |
1999-11-08 |
2023-08-12 |
human |
| G W Miller, R R Gainetdinov, A I Levey, M G Caro. Dopamine transporters and neuronal injury. Trends in pharmacological sciences. vol 20. issue 10. 1999-11-05. PMID:10498956. |
the plasma membrane dopamine transporter (dat) and the vesicular monoamine transporter (vmat2) are essential for normal dopamine neurotransmission. |
1999-11-05 |
2023-08-12 |
Not clear |
| G W Miller, R R Gainetdinov, A I Levey, M G Caro. Dopamine transporters and neuronal injury. Trends in pharmacological sciences. vol 20. issue 10. 1999-11-05. PMID:10498956. |
dat terminates the actions of dopamine by rapidly removing dopamine from the synapse, whereas vmat2 loads cytoplasmic dopamine into vesicles for storage and subsequent release. |
1999-11-05 |
2023-08-12 |
Not clear |
| S R Letchworth, T Sexton, S R Childers, K E Vrana, R A Vaughan, H M Davies, L J Porrin. Regulation of rat dopamine transporter mRNA and protein by chronic cocaine administration. Journal of neurochemistry. vol 73. issue 5. 1999-11-05. PMID:10537056. |
this study describes a direct comparison of dopamine transporter (dat) mrna and protein, as well as its binding sites, in tissue from the same animals after chronic cocaine administration. |
1999-11-05 |
2023-08-12 |
rat |
| S Y Lee, S Y Im, K M Ki. Preparation of dopamine transporter-specific antibodies using molecular cloned genes. Archives of pharmacal research. vol 22. issue 3. 1999-11-04. PMID:10403128. |
dopamine transporter (dat) plays the most important role in terminating the actions of dopamines released into the synaptic cleft. |
1999-11-04 |
2023-08-12 |
human |
| S Y Lee, S Y Im, K M Ki. Preparation of dopamine transporter-specific antibodies using molecular cloned genes. Archives of pharmacal research. vol 22. issue 3. 1999-11-04. PMID:10403128. |
considering the specificity for dat with wide range of applications such as elisa, immunoblotting, and immunoprecipitation, these antibodies would be valuable tool for understanding the pharmacological actions of dopamine transporter and drug addiction. |
1999-11-04 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
cocaine is a highly addictive drug that binds to the dopamine transporter (dat), inhibits the reuptake of dopamine, and initiates multiple actions within midbrain dopaminergic systems. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
furthermore, we observed that dat mrna was differentially expressed within fetal midbrain dopamine neurons with the highest levels detected in the ventral tier of the substantia nigra pars compacta, and the lowest levels in the ventral tegmental area and the linear/interfascicular nuclei. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
in utero cocaine exposure between days 22 and 70 significantly increased dat mrna expression, and the density of [125i]rti-121 binding sites within midbrain dopamine neurons in the 70-d-old fetus. |
1999-10-28 |
2023-08-12 |
human |
| Y Fang, O K Ronneklei. Cocaine upregulates the dopamine transporter in fetal rhesus monkey brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 20. 1999-10-28. PMID:10516315. |
this increased dat expression is accompanied by other presynaptic and postsynaptic neuronal changes, which collectively suggest that midbrain dopamine neurons are hypoactive after prolonged cocaine exposure, a state that may be a contributing factor in the development of attention deficit disorders observed in subjects exposed prenatally to cocaine. |
1999-10-28 |
2023-08-12 |
human |
| A M Kang, M A Palmatier, K K Kid. Global variation of a 40-bp VNTR in the 3'-untranslated region of the dopamine transporter gene (SLC6A3). Biological psychiatry. vol 46. issue 2. 1999-10-25. PMID:10418689. |
the dopamine transporter (dat) is the primary mechanism for dopamine clearance from the synapse in midbrain dopaminergic neurons, and the target of psychostimulant and neurotoxic drugs such as cocaine, amphetamine, and mptp. |
1999-10-25 |
2023-08-12 |
Not clear |
| M Garzón, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Cholinergic axon terminals in the ventral tegmental area target a subpopulation of neurons expressing low levels of the dopamine transporter. The Journal of comparative neurology. vol 410. issue 2. 1999-10-21. PMID:10414527. |
these dopaminergic neurons differentially project to cortical and limbic forebrain regions, where their terminals differ in levels of expression of the plasmalemmal dopamine transporter (dat). |
1999-10-21 |
2023-08-12 |
rat |