| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T P Laine, A Ahonen, P Räsänen, J Tiihone. Dopamine transporter availability and depressive symptoms during alcohol withdrawal. Psychiatry research. vol 90. issue 3. 1999-10-21. PMID:10466734. |
the aim of this study was to investigate whether or not depressive symptoms correlate with reduced dopamine transporter (dat) availability. |
1999-10-21 |
2023-08-12 |
human |
| A L Svingos, C L Clarke, V M Picke. Localization of the delta-opioid receptor and dopamine transporter in the nucleus accumbens shell: implications for opiate and psychostimulant cross-sensitization. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459166. |
to investigate the cellular basis for potential functional interactions involving opiates active at the delta-opioid receptor (dor) and psychostimulants that bind selectively to the dopamine transporter (dat), we examined the electron microscopic localization of their respective antisera in rat acbsh. |
1999-10-20 |
2023-08-12 |
rat |
| R De La Garza, P C Meltzer, B K Madra. Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain. Synapse (New York, N.Y.). vol 34. issue 1. 1999-10-20. PMID:10459168. |
a series of non-amine-bearing aryloxatropanes that are potent inhibitors of the dopamine transporter (dat) challenged this precept. |
1999-10-20 |
2023-08-12 |
monkey |
| A P Kozikowski, D Simoni, M Roberti, R Rondanin, S Wang, P Du, K M Johnso. Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorganic & medicinal chemistry letters. vol 9. issue 13. 1999-10-14. PMID:10406650. |
in order to further explore the importance of cocaine's bridge nitrogen atom in binding to the dopamine transporter (dat), we have synthesized the previously known racemic 8-oxa-norcocaines 3-6 in which the nitrogen atom has been replaced by oxygen. |
1999-10-14 |
2023-08-12 |
Not clear |
| S W Choi, D R Elmaleh, R N Hanson, A J Fischma. Design, synthesis, and biological evaluation of novel non-piperazine analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines as dopamine transporter inhibitors. Journal of medicinal chemistry. vol 42. issue 18. 1999-10-14. PMID:10479296. |
congeners in which the amide nitrogen atom was attached to the aralkyl moiety of the gbr molecule showed moderate affinity (k(i) = 51-61 nm) and selectivity for the dopamine transporter (dat) site. |
1999-10-14 |
2023-08-12 |
Not clear |
| L Chen, D M Segal, D C Mas. Semi-quantitative reverse-transcriptase polymerase chain reaction: an approach for the measurement of target gene expression in human brain. Brain research. Brain research protocols. vol 4. issue 2. 1999-10-12. PMID:10446407. |
by using the constitutively expressed 'housekeeping' gene cyclophilin as a reference gene to normalize mrna levels, and by taking data from the exponential phase of the pcr amplification, we have developed a rapid and reliable semi-quantitative measurement of the relative abundance of dopamine transporter (dat) mrna. |
1999-10-12 |
2023-08-12 |
human |
| M J Kuhar, K M McGirr, R G Hunter, P D Lambert, B E Garrett, F I Carrol. Studies of selected phenyltropanes at monoamine transporters. Drug and alcohol dependence. vol 56. issue 1. 1999-10-12. PMID:10462087. |
in this study, 18 3-phenyltropane analogues were characterized in uptake and binding studies at dopamine (dat), norepinephrine (net) and serotonin (sert) transporters from the rat, and in binding at dat in rat, rhesus monkey, and human brain tissue. |
1999-10-12 |
2023-08-12 |
human |
| P D Acton, M P Kung, M Mu, K Plössl, C Hou, M Siciliano, S Oya, H F Kun. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436198. |
in vitro binding studies suggest a high selectivity of idam for sert (k(i)=0.097 nm), with considerably lower affinities for norepinephrine and dopamine transporters (net k(i)= 234 nm and dat k(i)>10 microm, respectively). |
1999-10-07 |
2023-08-12 |
Not clear |
| H E Melikian, K M Buckle. Membrane trafficking regulates the activity of the human dopamine transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 18. 1999-10-04. PMID:10479674. |
here, we present a detailed analysis of the downregulation and intracellular trafficking of the cocaine- and amphetamine-sensitive dopamine transporter (dat), a presynaptic plasma membrane protein responsible for the regulation of extracellular da concentrations. |
1999-10-04 |
2023-08-12 |
human |
| R B Innis, K L Marek, K Sheff, S Zoghbi, J Castronuovo, A Feigin, J P Seiby. Effect of treatment with L-dopa/carbidopa or L-selegiline on striatal dopamine transporter SPECT imaging with [123I]beta-CIT. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 3. 1999-09-17. PMID:10348466. |
the effect of subchronic treatment with l-dopa/carbidopa or l-selegiline on striatal dopamine transporters (dat) was examined in patients with idiopathic parkinson's disease with spect (single photon emission computed tomography) using [123i]beta-cit (2beta-carbomethoxy-3beta-[4-iodophenyl]tropane) as the radiotracer. |
1999-09-17 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, T Kopajtic, R S Revay, G R Uh. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Molecular pharmacology. vol 56. issue 2. 1999-08-19. PMID:10419565. |
cocaine blocks the normal role of the dopamine transporter (dat) in terminating dopamine signaling through molecular interactions that are only partially understood. |
1999-08-19 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, T Kopajtic, R S Revay, G R Uh. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Molecular pharmacology. vol 56. issue 2. 1999-08-19. PMID:10419565. |
cocaine analog structure-activity studies have suggested roles for both cationic and aromatic interactions among dat, dopamine, and cocaine. |
1999-08-19 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, T Kopajtic, R S Revay, G R Uh. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Molecular pharmacology. vol 56. issue 2. 1999-08-19. PMID:10419565. |
we hypothesized that phenylalanine residues lying in putative dat transmembrane (tm) domains were good candidates to contribute to aromatic and/or cationic interactions among dat, dopamine, and cocaine. |
1999-08-19 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, T Kopajtic, R S Revay, G R Uh. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Molecular pharmacology. vol 56. issue 2. 1999-08-19. PMID:10419565. |
in a current dat structural model, each of the residues at which alanine substitution selectively reduces cocaine analog or dopamine affinities faces a central transporter cavity, whereas mutations that influence expression levels are more likely to lie at potential helix/helix interfaces. |
1999-08-19 |
2023-08-12 |
Not clear |
| Z Lin, W Wang, T Kopajtic, R S Revay, G R Uh. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Molecular pharmacology. vol 56. issue 2. 1999-08-19. PMID:10419565. |
specific, overlapping sets of phenylalanine residues contribute selectively to dat recognition of dopamine and cocaine. |
1999-08-19 |
2023-08-12 |
Not clear |
| K S Danek Burgess, J B Justic. Effects of serine mutations in transmembrane domain 7 of the human norepinephrine transporter on substrate binding and transport. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428062. |
these conserved serine residues in the dopamine (da) and norepinephrine transporters (dat and net, respectively) have also been shown to affect substrate transport in the rat dat. |
1999-08-13 |
2023-08-12 |
human |
| X Wu, H H G. Molecular cloning of the mouse dopamine transporter and pharmacological comparison with the human homologue. Gene. vol 233. issue 1-2. 1999-08-05. PMID:10375632. |
we report here the cloning of the mouse dopamine transporter (mdat) cdna and its expression and comparison with the human dat. |
1999-08-05 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, X T Hu, D C Cooper, R M Wightman, F J White, M G Caro. Loss of autoreceptor functions in mice lacking the dopamine transporter. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404198. |
the function of dopamine autoreceptors was assessed in mice lacking the dopamine transporter (dat). |
1999-08-02 |
2023-08-12 |
mouse |
| S R Jones, R R Gainetdinov, X T Hu, D C Cooper, R M Wightman, F J White, M G Caro. Loss of autoreceptor functions in mice lacking the dopamine transporter. Nature neuroscience. vol 2. issue 7. 1999-08-02. PMID:10404198. |
genetic deletion of the dat gene in mice results in a persistent elevation in levels of extracellular dopamine. |
1999-08-02 |
2023-08-12 |
mouse |
| Y Itzhak, J L Martin, M D Black, S F Al. Effect of the dopaminergic neurotoxin MPTP on cocaine-induced locomotor sensitization. Pharmacology, biochemistry, and behavior. vol 63. issue 1. 1999-07-28. PMID:10340529. |
the blockade of dopamine (da) uptake via the dopamine transporter (dat) in the nucleus accumbens (nac) and striatum by cocaine has a major role in the reinforcing and psychomotor stimulating effects of the drug. |
1999-07-28 |
2023-08-12 |
mouse |