| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shane J F Cronin, Weonjin Yu, Ashley Hale, Simon Licht-Mayer, Mark J Crabtree, Joanna A Korecka, Evgenii O Tretiakov, Marco Sealey-Cardona, Mate Somlyay, Masahiro Onji, Meilin An, Jesse D Fox, Bruna Lenfers Turnes, Carlos Gomez-Diaz, Débora da Luz Scheffer, Domagoj Cikes, Vanja Nagy, Adelheid Weidinger, Alexandra Wolf, Harald Reither, Antoine Chabloz, Anoop Kavirayani, Shuan Rao, Nick Andrews, Alban Latremoliere, Michael Costigan, Gillian Douglas, Fernando Cini Freitas, Christian Pifl, Roger Walz, Robert Konrat, Don J Mahad, Andrey V Koslov, Alexandra Latini, Ole Isacson, Tibor Harkany, Penelope J Hallett, Stefan Bagby, Clifford J Woolf, Keith M Channon, Hyunsoo Shawn Je, Josef M Penninge. Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons. bioRxiv : the preprint server for biology. 2023-05-23. PMID:37214873. |
mechanistically, bh4 not only serves as an essential cofactor for dopamine synthesis, but also independently regulates tyrosine hydroxylase levels, protects against ferroptosis, scavenges mitochondrial ros, maintains neuronal excitability and promotes mitochondrial atp production, thereby enhancing mitochondrial fitness and cellular respiration in multiple preclinical pd animal models, human dopaminergic midbrain-like organoids and primary cells from pd-affected individuals. |
2023-05-23 |
2023-08-14 |
mouse |
| Ruiyong Wu, Zedong Xu, Zhenzhen Song, Fadao Ta. Providing or receiving alloparental care promote partner preference and alter central oxytocin and dopamine systems in adult mandarin voles. Hormones and behavior. vol 152. 2023-04-28. PMID:37116234. |
as the oxytocin (ot) and dopamine systems are involved in alloparental and pair-bonding behaviors, we also examined the levels of central ot and tyrosine hydroxylase (th), as well as ot receptor (otr) and dopamine d1-type and d2-type receptors (d1r and d2r) mrna expression in the nucleus accumbens (nacc) and amygdala to investigate the underlying mechanisms. |
2023-04-28 |
2023-08-14 |
Not clear |
| Emily C Mahoney-Rafferty, Heidi R Tucker, Kainat Akhtar, Rachael Herlihy, Aliyah Audil, Dia Shah, Megan Gupta, Eliyahu M Kochman, Paul J Feustel, Eric S Molho, Julie G Pilitsis, Damian S Shi. Assessing the Location, Relative Expression and Subclass of Dopamine Receptors in the Cerebellum of Hemi-Parkinsonian Rats. Neuroscience. 2023-04-28. PMID:37116741. |
limited research suggests that dopaminergic signaling exists in the cerebellum with functional dopamine receptors, tyrosine hydroxylase (th) and dopamine transporters (dats); however, much of this information is largely derived from healthy animals and humans. |
2023-04-28 |
2023-08-14 |
rat |
| Shuang-Qi Gao, Jun-Quan Chen, Hai-Yun Zhou, Lun Luo, Bao-Yu Zhang, Man-Ting Li, Hai-Yong He, Chuan Chen, Ying Gu. Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors. iScience. vol 26. issue 4. 2023-04-24. PMID:37091229. |
remarkably, recombinant human thrombospondin-1 (rhtsp1), an astrocyte-secreted protein, exerted rapidly antidepressant-like actions through tyrosine hydroxylase (th)/dopamine (da)/dopamine d2 receptors (d2rs) pathways, but not dopamine d1 receptors (d1rs), which was dependent on sh3 and multiple ankyrin repeat domains 3 (shank3) in the mpfc. |
2023-04-24 |
2023-08-14 |
human |
| I N Rozhkova, S V Okotrub, E Yu Brusentsev, K E Uldanova, E А Chuyko, V A Naprimerov, T V Lipina, T G Amstislavskaya, S Ya Amstislavsk. Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 2. 2023-04-17. PMID:37063509. |
thus, a change in social-conditioned place preference in clstn2-ko mice as well as a higher number of neurons expressing type 2 dopamine receptors and tyrosine hydroxylase in the vta, the key structure of the mesolimbic dopaminergic pathway, were observed. |
2023-04-17 |
2023-08-14 |
mouse |
| Mobina Alemi, Ana Raquel Pereira, Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo, Helder Cardoso-Cru. Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979799. |
we evaluated the impact of the inflammatory pain in the vta synapses by performing immunohistochemical characterization of specific markers for gabaergic (gad65/67) and dopaminergic neurons (dopamine transporter (dat), dopamine d2 receptor (d2r) and tyrosine hydroxylase (th)). |
2023-03-29 |
2023-08-14 |
rat |
| Lindsey D McGill, Naze G Avci, Tina Kazemi, Yoshinori Sunaga, Yasemin M Akay, Metin Aka. Prenatal nicotine exposure alters gene expression profiles of neurons in the sub-regions of the VTA during early postnatal development. Scientific reports. vol 13. issue 1. 2023-03-25. PMID:36966190. |
our results indicated that during early maturation, the dopamine marker tyrosine hydroxylase (th) showed a consistently increased significance in pn sub-region compared to pif and pbp. |
2023-03-25 |
2023-08-14 |
human |
| Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, Johannes M Dijkstr. The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2023-03-20. PMID:36939908. |
we propose the following nm synthesis pathway in these ca neurons: (1) tyrosine is converted by tyrosine hydroxylase (th) to l-3,4-dihydroxyphenylalanine (l-dopa), which is converted by aromatic l-amino acid decarboxylase to da, which in lc neurons is converted by dopamine β-hydroxylase to ne; (2) da or ne is autoxidized to dopamine quinone (daq) or norepinephrine quinone (neq); and (3) daq or neq is converted to eumelanic nm (eunm) and pheomelanic nm (pheonm) in the absence and presence of cysteine, respectively. |
2023-03-20 |
2023-08-14 |
human |
| Wanrui Li, Xuanyi Pan, Ming Li, Li Ling, MengMeng Zhang, Ziming Liu, Ke Zhang, Jiguang Guo, Hongjie Wan. Impact of age on the rotenone-induced sporadic Parkinson's disease model using Drosophila melanogaster. Neuroscience letters. 2023-03-15. PMID:36921666. |
the motor ability of drosophila was detected by negative geotaxis assay, and the number of dopamine (da) neurons and tyrosine hydroxylase (th) expression levels were evaluated. |
2023-03-15 |
2023-08-14 |
drosophila_melanogaster |
| Shanti Sibuea, Joan K Ho, Colin W Pouton, John M Hayne. TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation. Frontiers in cell and developmental biology. vol 11. 2023-02-23. PMID:36819101. |
post-patterning, differentiating dopaminergic neuron cultures are permitted time for maturation after which the success of these differentiation paradigms is usually defined by expression of tyrosine hydroxylase (th), the rate limiting enzyme in the synthesis of dopamine. |
2023-02-23 |
2023-08-14 |
Not clear |
| Yuezhi Wang, Hui Qiao, Yu Zhan. Changes of Dopamine and Tyrosine Hydroxylase Levels in the Brain of Germ-free Mice. Iranian journal of biotechnology. vol 21. issue 1. 2023-02-22. PMID:36811101. |
changes of dopamine and tyrosine hydroxylase levels in the brain of germ-free mice. |
2023-02-22 |
2023-08-14 |
mouse |
| Soo-Jin Song, Eun-Jin Lee, Cheryl Mae Craft, Jung-A Shi. Recovery of dopaminergic amacrine cells after strobe light stimulation in the developing rat retina. Experimental eye research. 2023-02-13. PMID:36780971. |
immunohistochemistry and immunoblot analysis for the rate limiting enzyme for dopamine synthesis, tyrosine hydroxylase (th), as well as high-pressure liquid chromatography for measuring dopamine and 3,4-dihydroxyphenylacetic acid (dopac) were performed at postnatal weeks 4, 6, 8, and 10. |
2023-02-13 |
2023-08-14 |
human |
| Chan Lee, Jung-Hee Jang, Gyu Hwan Par. α-Pinene Attenuates Methamphetamine-Induced Conditioned Place Preference in C57BL/6 Mice. Biomolecules & therapeutics. 2023-02-03. PMID:36733209. |
the meth-administered group exhibited increased sensitivity to place preference and significantly decreased levels of dopamine-related markers such as dopamine 2 receptor (d2r) and tyrosine hydroxylase in the striatum of the mice. |
2023-02-03 |
2023-08-14 |
mouse |
| Suresh B Rangasamy, Debashis Dutta, Susanta Mondal, Moumita Majumder, Sridevi Dasarathy, Goutam Chandra, Kalipada Paha. Protection of dopaminergic neurons in hemiparkinsonian monkeys by flavouring ingredient glyceryl tribenzoate. NeuroImmune pharmacology and therapeutics. vol 1. issue 1. 2023-01-31. PMID:36720111. |
the study conducted in mptp-induced mice demonstrated dose-dependent protection of nigral tyrosine hydroxylase (th) and striatal dopamine level by gtb oral treatment and the optimum dose was found to be 50 mg/kg/d. |
2023-01-31 |
2023-08-14 |
mouse |
| Shipra Kartik, Rishi Pal, Manju J Chaudhary, Rajendra Nath, Madhu Kumar, Monika Binwal, D U Bawankul. Neuroprotective role of chloroquine via modulation of autophagy and neuroinflammation in MPTP-induced Parkinson's disease. Inflammopharmacology. 2023-01-30. PMID:36715843. |
cq therapy preserves dopamine levels stable, inhibits tyrosine hydroxylase (th) positive dopaminergic cell death, and lowers oxidative stress. |
2023-01-30 |
2023-08-14 |
mouse |
| Eunchong Hong, Hyun Kyu Min, Heena Lim, Sun Mi Gu, Abdulaziz Jabborov, Taddesse Yayeh, Mijin Kim, Woo-Kyu Park, Jae-Chul Jung, Jaesuk Yun, Seikwan O. Derivatives of 3, 4, 5-Trimethoxycinnamic Acid Ameliorate Stress-Induced Anxiety in Mice and Rats. Molecular neurobiology. 2023-01-30. PMID:36715919. |
stress-mediated repression of tyrosine hydroxylase (th) protein expression in the amygdala regions of rat brain and dopamine levels in the pc12 cells was restored by two selected derivatives (tmca#5 and tmca#9). |
2023-01-30 |
2023-08-14 |
mouse |
| Santiago Andrés Cortasa, Alejandro Raúl Schmidt, Sofía Proietto, María Clara Corso, Pablo Ignacio Felipe Inserra, Noelia Paula Di Giorgio, Victoria Lux-Lantos, Alfredo Daniel Vitullo, Julia Halperin, Verónica Berta Dorfma. Hypothalamic GnRH expression and pulsatility depends on a balance of prolactin receptors in the plains vizcacha, Lagostomus maximus. The Journal of comparative neurology. 2023-01-30. PMID:36716283. |
using two in vivo approaches, we determined changes in the hypothalamic expression and distribution of prolactin receptor (prlr), tyrosine hydroxylase (th), and dopamine type 2 receptor. |
2023-01-30 |
2023-08-14 |
Not clear |
| Yuka Nago-Iwashita, Yuki Moriya, Satoshi Hara, Ryohei Ogawa, Rina Aida, Katsuya Miyajima, Takenobu Shimura, Shin-Ichi Muramatsu, Soichiro Ide, Kazutaka Ikeda, Hiroshi Ichinos. Overexpression of tyrosine hydroxylase in dopaminergic neurons increased sensitivity to methamphetamine. Neurochemistry international. 2023-01-28. PMID:36709046. |
dopaminergic neurons are deeply involved in addiction, and tyrosine hydroxylase (th) catalyzes the first and rate-limiting step of the biosynthesis of dopamine (da). |
2023-01-28 |
2023-08-14 |
mouse |
| Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Li. Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase. British journal of pharmacology. 2023-01-24. PMID:36692417. |
bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase. |
2023-01-24 |
2023-08-14 |
rat |
| Kimiko Sakai, Mai Asano, Masahide Hamaguchi, Hidefumi Taniguchi, Osamu Ukimura, Michiaki Fuku. A Cortisol-Secreting Adrenal Adenoma Combined With a Micro-Pheochromocytoma: Case Report and Literature Review. Clinical medicine insights. Endocrinology and diabetes. vol 16. 2023-01-23. PMID:36685045. |
all catecholamine biosynthetic enzymes, tyrosine hydroxylase, aromatic l-amino acid decarboxylase, dopamine β-hydroxylase, and phenyl ethanolamine n-methyltransferase, were detected in this micro-pcc by immunohistochemical analyses. |
2023-01-23 |
2023-08-14 |
Not clear |