| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Kolacheva, Leyla Alekperova, Ekaterina Pavlova, Alyona Bannikova, Michael V Ugrumo. Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson's Disease as a Manifestation of Neurodegeneration and Neuroplasticity. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741664. |
the synthesis of dopamine, the neurotransmitter of the nigrostriatal system, depends on the rate-limiting enzyme, tyrosine hydroxylase (th). |
2022-06-24 |
2023-08-14 |
mouse |
| Michael V Ugrumov, Ekaterina N Pavlova, Anna A Kolacheva, Liliya K Dil'mukhametova, Vsevolod V Bogdanov, Victor Blokhin, Tatiana S Pronin. The Periventricular Nucleus as a Brain Center Containing Dopaminergic Neurons and Neurons Expressing Individual Enzymes of Dopamine Synthesis. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743179. |
it has been shown that, in addition to dopaminergic neurons, most of these centers contain neurons expressing one of the enzymes of dopamine synthesis: tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2022-06-24 |
2023-08-14 |
rat |
| Minghao Yan, Haibo Jin, Chun Pan, Hexing Hang, Dongmei Li, Xiaodong Ha. Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice. Molecular neurobiology. 2022-06-22. PMID:35732866. |
meanwhile, mc-lr induced the accumulation of alpha synuclein (α-syn) in da neurons and decreased the proteins of tyrosine hydroxylase (th), dopa decarboxylase (ddc) and dopamine transporter (dat), resulting in a reduction in dopamine (da) content, which are pathological features of parkinson's disease (pd). |
2022-06-22 |
2023-08-14 |
mouse |
| D R Rossato, H Z Rosa, J L O Rosa, L H Milanesi, V G Metz, L F D'Àvila, M E Burge. Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse. Molecular neurobiology. 2022-06-22. PMID:35732868. |
our findings showed that besides amph relapse, ts prevented the dopamine transporter (dat), dopamine 1 receptor (d1r), tyrosine hydroxylase (th), mu opioid receptor (mor) increase, and amph-induced delta fosb (Δfosb). |
2022-06-22 |
2023-08-14 |
rat |
| Aakansha Sharma, Vatsala Tripathi, Vinod Kuma. Control and adaptability of seasonal changes in behavior and physiology of latitudinal avian migrants: Insights from laboratory studies in Palearctic-Indian migratory buntings. Journal of experimental zoology. Part A, Ecological and integrative physiology. 2022-06-09. PMID:35677956. |
hypothalamic expression of the thyroid hormone-responsive dio2 and dio3, light-responsive per2, cry1, and adcyap1 and th (tyrosine hydroxylase, involved in dopamine biosynthesis) genes also show significant changes with transition from wnm to the vernal migratory lhs. |
2022-06-09 |
2023-08-14 |
Not clear |
| Adithya Gopinath, Phillip Mackie, Basil Hashimi, Anna Marie Buchanan, Aidan R Smith, Rachel Bouchard, Gerry Shaw, Martin Badov, Leila Saadatpour, Aryn Gittis, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Parastoo Hashemi, Habibeh Khoshboue. DAT and TH expression marks human Parkinson's disease in peripheral immune cells. NPJ Parkinson's disease. vol 8. issue 1. 2022-06-07. PMID:35672374. |
parkinson's disease (pd) is marked by a loss of dopamine neurons, decreased dopamine transporter (dat) and tyrosine hydroxylase (th) expression. |
2022-06-07 |
2023-08-14 |
human |
| Yanmei Chen, Miaomiao Du, Na Kang, Xin Guan, Bixue Liang, Zhuangfei Chen, Jichuan Zhan. Prenatal Morphine Exposure Differentially Alters Addictive and Emotional Behavior in Adolescent and Adult Rats in a Sex-Specific Manner. Neurochemical research. 2022-06-06. PMID:35661962. |
the results showed that: (1) pnm decreased anxiety-like behavior in both adolescent and adult female rats, but not males; (2) pnm decreased depressive-like behavior in adolescent but increased depressive -like behavior in adult females; (3) pnm increased low dose morphine induced locomotor sensitization in females; (4) pnm decreased tyrosine hydroxylase (th) expression in the prefrontal cortex but decreased dopamine d1 receptor expression in the nucleus-accumbens (nac) in female rats. |
2022-06-06 |
2023-08-14 |
rat |
| Emily N Hilz, Marcelle E Olvera, Dohyun Jun, Megha Chadha, Ross Gillette, Marie-H Monfils, Andrea C Gore, Hongjoo J Le. Hormonal contraceptives alter amphetamine place preference and responsivity in the intact female rat. Behavioral neuroscience. 2022-06-06. PMID:35666921. |
because of dopamine's (da's) role in reward learning and memory, da cell number and activity were examined using tyrosine hydroxylase and fos immunohistochemistry after a final amp challenge. |
2022-06-06 |
2023-08-14 |
rat |
| Elena Schwendich, Laura Salinas Tejedor, Gernot Schmitz, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Styliani Tsiami, Jürgen Braun, Xenofon Baraliakos, Jörg Reinders, Elena Neumann, Ulf Müller-Ladner, Silvia Capellin. Modulation of Dopamine Receptors on Osteoblasts as a Possible Therapeutic Strategy for Inducing Bone Formation in Arthritis. Cells. vol 11. issue 10. 2022-05-28. PMID:35626646. |
isolated ob expressed tyrosine hydroxylase, the rate-limiting enzyme for dopamine production, and contained dopamine. |
2022-05-28 |
2023-08-13 |
human |
| María G Bilbao, Daniel Garrigos, Marta Martinez-Morga, Angel Toval, Yevheniy Kutsenko, Rosario Bautista, Alberto Barreda, Bruno Ribeiro Do-Couto, Luis Puelles, José Luis Ferra. Prosomeric Hypothalamic Distribution of Tyrosine Hydroxylase Positive Cells in Adolescent Rats. Frontiers in neuroanatomy. vol 16. 2022-05-23. PMID:35601999. |
in this study, we offered a prosomeric immunohistochemical mapping in the rat of hypothalamic cells expressing tyrosine hydroxylase (th), which is the enzyme that catalyzes the conversion of l-tyrosine to levodopa (l-dopa) and a precursor of dopamine. |
2022-05-23 |
2023-08-13 |
rat |
| Seong Soon Kim, Kyu-Seok Hwang, Hyemin Kan, Jung Yoon Yang, Yuji Son, Dae-Seop Shin, Byung Hoi Lee, Chong Hak Chae, Myung Ae Ba. Neurotoxicological Profiling of Paraquat in Zebrafish Model. Neurochemical research. 2022-05-13. PMID:35562624. |
this locomotor deficit came with a dysregulation of dopamine synthesis induced by the inhibition of tyrosine hydroxylase activity, which was also indirectly confirmed by molecular modeling studies. |
2022-05-13 |
2023-08-13 |
human |
| Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukl. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease. ACS chemical neuroscience. 2022-05-09. PMID:35533351. |
further, the dize-mediated activation of ace2 led to increased tyrosine hydroxylase (th) and dopamine transporters (dat) expression in the rat brain, indicating the protection of dopaminergic (daergic) neurons from 6-ohda induced neurotoxicity. |
2022-05-09 |
2023-08-13 |
rat |
| Tingting Liang, Ping Zhao, Xiao Zhang, Xuedan Han, Bo Hong, Lingsheng Kong, Huanxian Chang, Liyan Li. FOXA1 transcription activates TFF1 to reduce 6-OHDA-induced dopaminergic neuron damage. Experimental and therapeutic medicine. vol 23. issue 6. 2022-05-02. PMID:35495601. |
forkhead box a1 (foxa1) plays an important role in the central nervous system, and its loss can lead to the downregulation of tyrosine hydroxylase, which directly affects the synthesis of dopamine, thus leading to parkinson's disease (pd). |
2022-05-02 |
2023-08-13 |
mouse |
| Justin Buck, Matthew T C Manion, Wenyu Zhang, Erica R Glasper, Kuan Hong Wan. Comparative anatomical analysis of dopamine systems in Mus musculus and Peromyscus californicus. Brain structure & function. 2022-05-02. PMID:35501609. |
we applied tyrosine hydroxylase immunofluorescence labeling and high-throughput microscopy to establish whole-brain maps of dopamine systems in p. californicus. |
2022-05-02 |
2023-08-13 |
mouse |
| Xian-Guo Zou, Meng-Ting Xu, Xiao-Li Dong, You-Min Ying, Rong-Fa Guan, Wei-Cheng Wu, Kai Yang, Pei-Long Su. Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells. Journal of food biochemistry. 2022-04-25. PMID:35467031. |
the results showed that scmac extracts alleviated cell toxicity induced by 6-ohda and the loss of dopaminergic neurons, which was confirmed by the increase of cell viabilities, inhibition of cell apoptosis, the upregulation of tyrosine hydroxylase (th) and dopamine transporter (dat) levels and the downregulation of α-synuclein level. |
2022-04-25 |
2023-08-13 |
Not clear |
| Clarissa Catale, Luisa Lo Iacono, Alessandro Martini, Constantin Heil, Ezia Guatteo, Nicola Biagio Mercuri, Maria Teresa Viscomi, Daniela Palacios, Valeria Carol. Early Life Social Stress Causes Sex- and Region-Dependent Dopaminergic Changes that Are Prevented by Minocycline. Molecular neurobiology. 2022-04-18. PMID:35435618. |
we found that social stress in early life altered da neurons morphology, reduced dopamine transporter (dat) and tyrosine hydroxylase expression, and lowered dat-mediated currents in the ventral tegmental area but not substantia nigra of male mice only. |
2022-04-18 |
2023-08-13 |
mouse |
| Marta González-Sepúlveda, Muhammad Yusof Omar, Sally Hamdon, Guofen Ma, Santi Rosell-Vilar, Noora Raivio, Doaa Abass, Anna Martínez-Rivas, Miquel Vila, Jesús Giraldo, Montserrat Carrascal, Joaquín Abián, Carles Gil, Josefa Sabriá, Jordi Ortiz, David Moreno-Delgad. Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase. Neuropharmacology. 2022-04-16. PMID:35429504. |
spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase. |
2022-04-16 |
2023-08-13 |
rat |
| Marta González-Sepúlveda, Muhammad Yusof Omar, Sally Hamdon, Guofen Ma, Santi Rosell-Vilar, Noora Raivio, Doaa Abass, Anna Martínez-Rivas, Miquel Vila, Jesús Giraldo, Montserrat Carrascal, Joaquín Abián, Carles Gil, Josefa Sabriá, Jordi Ortiz, David Moreno-Delgad. Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase. Neuropharmacology. 2022-04-16. PMID:35429504. |
in the present paper, freshly obtained rat brain striatal minces were incubated under different times and conditions to determine dopamine biosynthesis, storage, and tyrosine hydroxylase phosphorylation. |
2022-04-16 |
2023-08-13 |
rat |
| Marta González-Sepúlveda, Muhammad Yusof Omar, Sally Hamdon, Guofen Ma, Santi Rosell-Vilar, Noora Raivio, Doaa Abass, Anna Martínez-Rivas, Miquel Vila, Jesús Giraldo, Montserrat Carrascal, Joaquín Abián, Carles Gil, Josefa Sabriá, Jordi Ortiz, David Moreno-Delgad. Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase. Neuropharmacology. 2022-04-16. PMID:35429504. |
we analyzed whether these changes in brain dopamine biosynthesis and storage were linked to dopamine feedback inhibition of its synthesis-limiting enzyme tyrosine hydroxylase. |
2022-04-16 |
2023-08-13 |
rat |
| Yu Sun, Congyu Wang, Min Sun, Zhen Fa. Bioinspired polymeric pigments to mimic natural hair coloring. RSC advances. vol 11. issue 3. 2022-04-15. PMID:35424122. |
first, in the presence of tyrosine hydroxylase and metal ions, dopamine could be oxidized into polydopamine, a mimic of human eumelanin, and then self-assembled into nanometer-scale pigments. |
2022-04-15 |
2023-08-13 |
human |