| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabriel de Farias Araujo, Renata Jurema Medeiros, Magno Maciel-Magalhães, Fábio Veríssimo Correia, Enrico Mendes Saggior. Zebrafish (Danio rerio) as a model to assess the effects of cocaine as a drug of abuse and its environmental implications. Environmental science and pollution research international. 2023-01-23. PMID:36689115. |
cocaine exposure was noted as altering the expression of several genes, such as those linked to coc transport proteins, dopamine receptors, sp substance production, the tachykinin system, and the tyrosine hydroxylase enzyme. |
2023-01-23 |
2023-08-14 |
zebrafish |
| Ilya Sukhanov, Artem Dorotenko, Zoia Fesenko, Artem Savchenko, Evgeniya V Efimova, Mikael S Mor, Irina V Belozertseva, Tatyana D Sotnikova, Raul R Gainetdino. Inhibition of PDE10A in a New Rat Model of Severe Dopamine Depletion Suggests New Approach to Non-Dopamine Parkinson's Disease Therapy. Biomolecules. vol 13. issue 1. 2023-01-21. PMID:36671394. |
a tyrosine hydroxylase inhibitor, α-methyl-dl-tyrosine (αmpt), was used as an agent to cause extreme dopamine deficiency. |
2023-01-21 |
2023-08-14 |
rat |
| George B Stefano, Richard M Kream, Tobias Esc. Mobility Coupled with Motivation Promotes Survival: The Evolution of Cognition as an Adaptive Strategy. Biology. vol 12. issue 1. 2023-01-21. PMID:36671772. |
this is consistent with observations that support the recruitment of enzymatically synthesized tetrahydrobiopterin (bh4), which is a cofactor for tyrosine hydroxylase, the enzyme responsible for dopamine production. |
2023-01-21 |
2023-08-14 |
Not clear |
| Daniel Kalinowski, Krystyna Bogus-Nowakowska, Anna Kozłowska, Maciej Równia. Dopaminergic and cholinergic modulation of the amygdala is altered in female mice with oestrogen receptor β deprivation. Scientific reports. vol 13. issue 1. 2023-01-17. PMID:36650256. |
the results show that among dopaminergic markers, the expression of tyrosine hydroxylase (th), dopamine transporter (dat) and dopamine d |
2023-01-17 |
2023-08-14 |
mouse |
| Yi Li, Xin Wang, Xiaoqian Xie, Qingsong Liu, Haonan Dong, Yong Hou, Qingyou Xia, Ping Zha. Enhanced locomotor behavior is mediated by activation of tyrosine hydroxylase in the silkworm brain. Insect molecular biology. 2023-01-13. PMID:36636859. |
in-depth analysis showed that the tyrosine hydroxylase gene might be a key candidate gene, and the content of dopamine, its downstream metabolite, increased significantly in the brain of silkworm infected with the virus. |
2023-01-13 |
2023-08-14 |
Not clear |
| Yi Li, Xin Wang, Xiaoqian Xie, Qingsong Liu, Haonan Dong, Yong Hou, Qingyou Xia, Ping Zha. Enhanced locomotor behavior is mediated by activation of tyrosine hydroxylase in the silkworm brain. Insect molecular biology. 2023-01-13. PMID:36636859. |
after injection of tyrosine hydroxylase inhibitor into the infected silkworm, the dopamine content in the silkworm brain decreased and the locomotor behavior caused by the virus was blocked successfully. |
2023-01-13 |
2023-08-14 |
Not clear |
| Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumo. Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research. Frontiers in molecular neuroscience. vol 15. 2022-12-26. PMID:36568278. |
we have developed a method for selecting a population of dns from the sn of mice, as evidenced by: (i) immunopositivity of 95% of the sorted cells for tyrosine hydroxylase, the first enzyme of dopamine synthesis; (ii) the sorted cells expressing the genes for specific proteins of the dopaminergic phenotype, tyrosine hydroxylase, the dopamine transporter, and vesicular monoamine transporter 2 and non-specific proteins, such as aromatic l-amino acid decarboxylase, non-specific enzyme of dopamine synthesis. |
2022-12-26 |
2023-08-14 |
mouse |
| Yilin Wang, Chunmei Wang, Meiyan Liu, Wuhen Xu, Simei Wang, Fang Yuan, Xiaona Luo, Quanmei Xu, Rongrong Yin, Anqi Wang, Miao Guo, Longlong Lin, Chao Wang, Hongyi Cheng, Zhiping Liu, Yuanfeng Zhang, Fanyi Zeng, Jingbin Yan, Yucai Che. Segawa syndrome caused by Frontiers in genetics. vol 13. 2022-12-26. PMID:36568392. |
the decrease in dopamine caused by tyrosine hydroxylase ( |
2022-12-26 |
2023-08-14 |
Not clear |
| Yara T Mohamed, Abeer Salama, Mostafa A Rabie, Mai A Abd El Fatta. Neuroprotective effect of secukinumab against rotenone induced Parkinson's disease in rat model: Involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade. International immunopharmacology. vol 114. 2022-12-17. PMID:36527875. |
furthermore, secukinumab increased striatal tyrosine hydroxylase immunoexpression, the rate limiting step in dopamine biosynthesis, to guard against dopaminergic neuronal loss. |
2022-12-17 |
2023-08-14 |
rat |
| Aakansha Sharma, Vatsala Tripathi, Vinod Kuma. Hypothalamic molecular correlates of photoperiod-induced spring migration in intact and castrated male redheaded buntings. Molecular and cellular endocrinology. 2022-12-16. PMID:36526025. |
these included genes associated with the appetitive phase of reproduction (spring migration drive, th and ddc genes encoding for tyrosine hydroxylase and dopamine decarboxylase enzymes, respectively), sleep/awake state (pmch gene encoding for pro-melanin concentrating hormone; hcrt and hcrtr2 encoding for the hypocretin/orexin and its receptor, respectively) and neurogenesis (dcx and neun coding for doublecortin and neuronal nuclear proteins, respectively). |
2022-12-16 |
2023-08-14 |
Not clear |
| Emi Kiyokage, Satoshi Ichikawa, Sawa Horie, Shuichi Hayashi, Kazunori Toid. Effects of estradiol on dopaminergic synapse formation in the mouse olfactory bulb. The Journal of comparative neurology. 2022-12-15. PMID:36519231. |
a subpopulation of jg cells expresses the dopamine synthetic enzymes, tyrosine hydroxylase (th), and aromatic l-amino acid decarboxylase (aadc). |
2022-12-15 |
2023-08-14 |
mouse |
| Yongjun Wang, Zhengjia Pu, Yiran Zhang, Zhaohui Du, Zeming Guo, Qunhua Ba. Exercise training has a protective effect in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model with improved neural and intestinal pathology and modified intestinal flora. Behavioural brain research. 2022-12-01. PMID:36455673. |
the results showed in these pd mice, exercise training improved their motility, increased the dopamine (da) content in the striatum, along with promoted the gene expression of tyrosine hydroxylase and brain-derived neurotrophic factor in the striatum, which suggests this exercise training might protect striatal dopaminergic neurons from mptp damage; the results also showed exercise training promoted recovery from ileal pathology, reduced the gene expression of intestinal inflammatory factors, and significantly altered the composition and structure of the intestinal flora in these mice. |
2022-12-01 |
2023-08-14 |
mouse |
| Alexandre Maisterrena, Emmanuel Matas, Helene Mirfendereski, Anais Balbous, Sandrine Marchand, Mohamed Jabe. The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder. Biomolecules. vol 12. issue 11. 2022-11-24. PMID:36421705. |
we report no alterations in the number of mesencephalic dopamine neurons or in protein levels of tyrosine hydroxylase in either the striatum or the nucleus accumbens. |
2022-11-24 |
2023-08-14 |
mouse |
| I O Ishola, A K Oloyo, T G Olubodun-Obadun, O D Godswill, S A Omilabu, O O Adeyem. Neuroprotective potential of plant derived parenchymal stem cells extract on environmental and genetic models of Parkinson disease through attenuation of oxidative stress and neuroinflammation. Metabolic brain disease. 2022-11-19. PMID:36401682. |
mptp-induced expression of microglia (iba-1), astrocytes (glia fibrillary acidic protein; gfap) as well as degeneration of dopamine neurons (tyrosine hydroxylase positive neurons) in the substantia nigra (sn) were reversed by dsc. |
2022-11-19 |
2023-08-14 |
mouse |
| Hyeon Jin Lee, Kyonghwan Choe, Jun Sung Park, Amjad Khan, Min Woo Kim, Tae Ju Park, Myeong Ok Ki. O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models. Antioxidants (Basel, Switzerland). vol 11. issue 11. 2022-11-11. PMID:36358479. |
in addition, administration of cps1p restored dopamine-related proteins such as tyrosine hydroxylase (th), vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat). |
2022-11-11 |
2023-08-14 |
mouse |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-08-14 |
rat |
| Shima Tavakol, Elham Hoveizi, Hani Tavakol, Amin Almasi, Mansoureh Soleimani, Shadi Rabiee Motmaen, Fereshteh Azedi, Mohammad Taghi Joghatae. Strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a Trojan horse decreases dopamine in dopaminergic cells: Pharmaceutical considerations in schizophrenia and Parkinson's disease. Current pharmaceutical design. 2022-11-04. PMID:36330626. |
strong binding of phytochemicals to the catalytic domain of tyrosine hydroxylase as a trojan horse decreases dopamine in dopaminergic cells: pharmaceutical considerations in schizophrenia and parkinson's disease. |
2022-11-04 |
2023-08-14 |
Not clear |
| Steven Lehrer, Peter H Rheinstei. α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. Journal of proteins and proteomics. vol 13. issue 2. 2022-10-24. PMID:36277464. |
α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. |
2022-10-24 |
2023-08-14 |
Not clear |
| Steven Lehrer, Peter H Rheinstei. α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. Journal of proteins and proteomics. vol 13. issue 2. 2022-10-24. PMID:36277464. |
tyrosine hydroxylase (th) catalyses the formation of l-dopa, the rate-limiting step in the biosynthesis of dopamine. |
2022-10-24 |
2023-08-14 |
Not clear |
| Hai-Ying Zhang, Yong-Cheng Jiang, Jun-Rui Li, Jia-Nan Yan, Xin-Jue Wang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su G. Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson's disease. Neural regeneration research. vol 18. issue 5. 2022-10-18. PMID:36254999. |
next, we pretreated cell models of parkinson's disease with insulin-like growth factor-2 and administered insulin-like growth factor-2 intranasally to a mouse model of parkinson's disease induced by 6-hydroxydopamine and found that the level of tyrosine hydroxylase, a marker of dopamine neurons, was markedly restored, α-synuclein aggregation decreased, and insulin-like growth factor-2 receptor down-regulation was alleviated. |
2022-10-18 |
2023-08-14 |
mouse |