| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dmitry Troshev, Alyona Bannikova, Victor Blokhin, Anna Kolacheva, Tatiana Pronina, Michael Ugrumo. Striatal Neurons Partially Expressing a Dopaminergic Phenotype: Functional Significance and Regulation. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232359. |
in this study, it was shown that in transgenic mice expressing green fluorescent protein (gfp) under the tyrosine hydroxylase (th) gene promoter, (i) there are striatal neurons expressing only th, only aromatic l-amino acid decarboxylase (aadc), or both enzymes of dopamine synthesis; (ii) striatal neurons expressing dopamine-synthesizing enzymes are not dopaminergic since they lack a dopamine transporter; (iii) monoenzymatic neurons expressing individual complementary dopamine-synthesizing enzymes produce this neurotransmitter in cooperation; (iv) striatal nerve fibers containing only th, only aadc, or both enzymes project into the lateral ventricles, providing delivery pathways for l-3,4-dihydroxyphenylalanine and dopamine to the cerebrospinal fluid; and (v) striatal gfp neurons express receptor genes for various signaling molecules, i.e., classical neurotransmitters, neuropeptides, and steroids, indicating fine regulation of these neurons. |
2022-10-14 |
2023-08-14 |
mouse |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Z Pidsudko, J Godlewski, K Wąsowic. The distribution and chemical coding of urinary bladder trigone-projecting neurons in testicular and aorticorenal ganglia in male pigs. Polish journal of veterinary sciences. vol 25. issue 3. 2022-09-26. PMID:36155594. |
the expression of tyrosine hydroxylase (th) or dopamine beta-hydroxylase (dbh), neuropeptide y (npy), somatostatin (som), galanin (gal), nitric oxide synthase (nos) and vesicular acetylcholine transporter (vacht) were investigated. |
2022-09-26 |
2023-08-14 |
Not clear |
| Ayumi Sato, Takehiro Yajima, Daisuke Tachiya, Hiroyuki Ichikawa, Tadasu Sat. Innervation of the human minor salivary glands; immunohistochemical study for neurochemical substances. Tissue & cell. vol 79. 2022-09-20. PMID:36126414. |
distributions of choline acetyltransferase (chat), vasoactive intestinal polypeptide (vip), dopamine β-hydroxylase (dbh), tyrosine hydroxylase (th), neuropeptide y (npy) and the transient receptor potential cation channel subfamily v member 2 (trpv2) were examined in the human minor salivary glands. |
2022-09-20 |
2023-08-14 |
human |
| Marjolaine Champagne, Gabriella A Horvath, Sébastien Perreault, Julie Gauthier, Keith Hyland, Jean-François Soucy, Grant A Mitchel. Intermittent neurologic decompensation: An underrecognized presentation of tyrosine hydroxylase deficiency. JIMD reports. vol 63. issue 5. 2022-09-14. PMID:36101825. |
tyrosine hydroxylase deficiency (thd) is a treatable inborn error of dopamine biosynthesis caused by mutations in |
2022-09-14 |
2023-08-14 |
Not clear |
| Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm, Hi-Joon Par. Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice. Biological research. vol 55. issue 1. 2022-09-10. PMID:36088447. |
in addition, biochemical changes in the brain reward regions were investigated by immunoblotting for the expression of tyrosine hydroxylase (th), dopamine d1 receptor (d1r), phospho-dopamine and camp-regulated phosphoprotein-32 kda (pdarpp-32), phospho-camp response element binding protein (pcreb), Δfosb, and brain-derived neurotrophic factor (bdnf) in the nucleus accumbens, dorsolateral striatum, and ventral tegmental area. |
2022-09-10 |
2023-08-14 |
mouse |
| Liping Zhou, Xingzhe Wang, Xueyao Wang, Jing An, Xin Zheng, Deqiang Han, Zhiguo Che. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076517. |
subsequently, the striatal content of dopamine (da) and its metabolites, tyrosine hydroxylase (th)-positive neurons and activated microglia, circulating inflammatory cytokines, gene expression of cytokines, and nod-like receptor protein 3 (nlrp3) inflammasome molecules were measured using high-performance liquid chromatography, flow cytometry, immunohistochemistry, immunofluorescent staining, and real-time polymerase chain reaction assays, respectively. |
2022-09-09 |
2023-08-14 |
mouse |
| Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Laís Angélica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteve. Protein tyrosine phosphatase receptor type delta (PTPRD) gene in an animal model of restless legs syndrome. Journal of sleep research. 2022-09-02. PMID:36053904. |
to evaluate the tyrosine hydroxylase enzyme, dopamine transporter (dat) and type 2 dopaminergic receptor, qpcr and western blotting techniques were used. |
2022-09-02 |
2023-08-14 |
rat |
| Xiaosan Tang, Heng Li, Baozeng An, Haibo Ma, Nana Huang, Xiaohong L. Transplantation of human cord blood-derived multipotent stem cells (CB-SCs) enhances the recovery of Parkinson in rats. Transplant immunology. 2022-08-29. PMID:36038047. |
after being transplanted into the striatum and substantia nigra of pd rats, most of cb-scs (>90%) developed a fate commitment to dopaminergic differentiation, expressed as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2022-08-29 |
2023-08-14 |
human |
| María Paula Bonaccorso Marinelli, Gustavo Baiardi, Susana Ruth Valdez, Ricardo Jorge Cabrer. Automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software. Medical & biological engineering & computing. 2022-08-26. PMID:36018532. |
the animals were euthanized and their brains processed for tyrosine hydroxylase immunohistochemistry for dopamine neuron identification. |
2022-08-26 |
2023-08-14 |
rat |
| Roberta Oliveira da Costa, Carlos Vinicius Jataí Gadelha-Filho, Pedro Everson Alexandre de Aquino, Ludmila Araújo Rodrigues Lima, Jalles Dantas de Lucena, Wesley Lyeverton Correia Ribeiro, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Vian. Vitamin D (VD3) Intensifies the Effects of Exercise and Prevents Alterations of Behavior, Brain Oxidative Stress, and Neuroinflammation, in Hemiparkinsonian Rats. Neurochemical research. 2022-08-26. PMID:36028736. |
the animals were then subjected to behavioral (rotarod, open field, and apomorphine tests) and their brain areas were dissected for neurochemical, dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac) determinations, and immunohistochemical studies for tyrosine hydroxylase (th), dopamine transporter (dat), and vitamin d receptor (vd3r). |
2022-08-26 |
2023-08-14 |
rat |
| Roberta Oliveira da Costa, Carlos Vinicius Jataí Gadelha-Filho, Pedro Everson Alexandre de Aquino, Ludmila Araújo Rodrigues Lima, Jalles Dantas de Lucena, Wesley Lyeverton Correia Ribeiro, Francisco Arnaldo Viana Lima, Kelly Rose Tavares Neves, Glauce Socorro de Barros Vian. Vitamin D (VD3) Intensifies the Effects of Exercise and Prevents Alterations of Behavior, Brain Oxidative Stress, and Neuroinflammation, in Hemiparkinsonian Rats. Neurochemical research. 2022-08-26. PMID:36028736. |
additionally, tyrosine hydroxylase (th) and dopamine transporter (dat) immunoexpressions were decreased in the 6-ohda-lesioned groups, with values normalized after exercise and vd3. |
2022-08-26 |
2023-08-14 |
rat |
| Shaojie Ma, Mario Skarica, Qian Li, Chuan Xu, Ryan D Risgaard, Andrew T N Tebbenkamp, Xoel Mato-Blanco, Rothem Kovner, Željka Krsnik, Xabier de Martin, Victor Luria, Xavier Martí-Pérez, Dan Liang, Amir Karger, Danielle K Schmidt, Zachary Gomez-Sanchez, Cai Qi, Kevin T Gobeske, Sirisha Pochareddy, Ashwin Debnath, Cade J Hottman, Joshua Spurrier, Leon Teo, Anthony G Boghdadi, Jihane Homman-Ludiye, John J Ely, Etienne W Daadi, Da Mi, Marcel Daadi, Oscar Marín, Patrick R Hof, Mladen-Roko Rasin, James Bourne, Chet C Sherwood, Gabriel Santpere, Matthew J Girgenti, Stephen M Strittmatter, André M M Sousa, Nenad Sesta. Molecular and cellular evolution of the primate dorsolateral prefrontal cortex. Science (New York, N.Y.). 2022-08-25. PMID:36007006. |
the latter are exemplified by human-specific switching between expression of the neuropeptide somatostatin (sst) and tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine production, in certain interneurons, and also by expression of the neuropsychiatric risk gene |
2022-08-25 |
2023-08-14 |
human |
| Agata Szlaga, Patryk Sambak, Anna Gugula, Aleksandra Trenk, Andrew L Gundlach, Anna Blasia. Catecholaminergic innervation and D2-like dopamine receptor-mediated modulation of brainstem nucleus incertus neurons in the rat. Neuropharmacology. 2022-08-16. PMID:35973599. |
our immunohistochemical and viral-based retrograde tract-tracing studies revealed a dense innervation of the ni area by fibers containing the catecholaminergic biosynthesis enzymes, tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh), and indicated the major sources of the catecholaminergic innervation of the ni as the darkschewitsch, raphe and hypothalamic a13 nuclei. |
2022-08-16 |
2023-08-14 |
rat |
| Ramona D'Amico, Daniela Impellizzeri, Tiziana Genovese, Roberta Fusco, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Gianluca Franco, Ylenia Marino, Alessia Arangia, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordar. Açai Berry Mitigates Parkinson's Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways. Molecular neurobiology. 2022-08-15. PMID:35970975. |
furthermore, açai berry administration reduced α-synuclein aggregation in neurons, enhanced tyrosine hydroxylase and dopamine transporter activities, and avoided dopamine depletion. |
2022-08-15 |
2023-08-14 |
Not clear |
| Shubhangini Tiwari, Parul Gupta, Abhishek Singh, Swati Chaturvedi, M Wahajuddin, Amit Mishra, Sarika Sing. 4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation. Neurochemical research. 2022-08-03. PMID:35922743. |
first, we observed the significant protective effects of 4pba on pd specific neuromuscular coordination, level of tyrosine hydroxylase, α-synuclein level and neurotransmitter dopamine in both substantia nigra and striatal regions of the experimental rat model of pd. |
2022-08-03 |
2023-08-14 |
rat |
| Tao Ke, Alexey A Tinkov, Anatoly V Skalny, Abel Santamaria, Marcelo Farina, João B T Rocha, Aaron B Bowman, Michael Aschne. The Human LRRK2 Modulates the Age-Dependent Effects of Developmental Methylmercury Exposure in Caenorhabditis elegans. Neurotoxicity research. 2022-07-15. PMID:35838907. |
in addition, the expression levels of caenorhabditis elegans homologs of dopamine transporter (dat-1) and tyrosine hydroxylase (cat-2) were also analyzed at these adult stages. |
2022-07-15 |
2023-08-14 |
human |
| Sanaa Ahmed, Mahmoud M El-Sayed, Mohamed A Kandeil, Marwa M Khala. Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson's disease in rats. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 6. 2022-07-11. PMID:35812142. |
however, dopamine (dp), antioxidants, tyrosine hydroxylase (th), and parkin were significantly decreased. |
2022-07-11 |
2023-08-14 |
rat |
| Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Sing. Role of Platelet in Parkinson's Disease: Insights into Pathophysiology & Theranostic Solutions. Ageing research reviews. 2022-07-07. PMID:35798236. |
this non-nucleated cell fragment can express, store, and secrete not only neuron-specific molecules and receptors but also several pd-specific biomarkers such as α-synuclein, parkin, pten-induced kinase-1, tyrosine hydroxylase, dopamine transporter, thus making platelet a suitable peripheral model for pd. |
2022-07-07 |
2023-08-14 |
Not clear |
| Anna Kolacheva, Leyla Alekperova, Ekaterina Pavlova, Alyona Bannikova, Michael V Ugrumo. Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson's Disease as a Manifestation of Neurodegeneration and Neuroplasticity. Brain sciences. vol 12. issue 6. 2022-06-24. PMID:35741664. |
changes in tyrosine hydroxylase activity and dopamine synthesis in the nigrostriatal system of mice in an acute model of parkinson's disease as a manifestation of neurodegeneration and neuroplasticity. |
2022-06-24 |
2023-08-14 |
mouse |