| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jenessa N Johnston, Bashkim Kadriu, Josh Allen, Jessica R Gilbert, Ioline D Henter, Carlos A Zarat. Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment. Neuropharmacology. 2023-01-16. PMID:36646310. |
this review summarizes the similarities and differences between the psychoactive effects associated with both ketamine and sps and the mechanisms of action of these compounds, with a focus on the monoaminergic, glutamatergic, gamma-aminobutyric acid (gaba)-ergic, opioid, and inflammatory systems. |
2023-01-16 |
2023-08-14 |
Not clear |
| Jenessa N Johnston, Bashkim Kadriu, Josh Allen, Jessica R Gilbert, Ioline D Henter, Carlos A Zarat. Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment. Neuropharmacology. 2023-01-16. PMID:36646310. |
while their main mechanisms of action differ-sps increase serotonergic signaling while ketamine is a glutamatergic modulator-evidence suggests that the downstream mechanisms of action of both ketamine and sps include mechanistic target of rapamycin complex 1 (mtorc1) signaling and downstream gaba |
2023-01-16 |
2023-08-14 |
Not clear |
| Huan Sheng, Chao Lei, Yu Yuan, Yali Fu, Dongyang Cui, Li Yang, Da Shao, Zixuan Cao, Hao Yang, Xinli Guo, Chenshan Chu, Yaxian Wen, Zhangyin Cai, Ming Chen, Bin Lai, Ping Zhen. Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice. Nature communications. vol 14. issue 1. 2023-01-05. PMID:36604429. |
in the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, lh glutamatergic neurons played an important role; dopamine d1 receptor-expressing medium spiny neurons (d1-msns) projecting from the core of nucleus accumbens (nacc) to the lh were an important upstream circuit to activate lh glutamatergic neurons; d1-msns projecting from the nacc to the lh activated lh glutamatergic neurons through inhibiting lh local gamma-aminobutyric acid (gaba) neurons. |
2023-01-05 |
2023-08-14 |
mouse |
| Ying Xing, Anjing Zhang, Congqin Li, Jing Han, Jun Wang, Lu Luo, Xuechun Chang, Zhanzhuang Tian, Yulong Ba. Corticostriatal Projections Relying on GABA Levels Mediate Exercise-Induced Functional Recovery in Cerebral Ischemic Mice. Molecular neurobiology. 2022-12-29. PMID:36580196. |
overall, those results reveal that the dorsal striatum-projecting subpopulation of cortical glutamatergic neurons can influence gaba levels in the striatum, playing a critical role in modulating exercise-induced improvement of motor and anxiety-like behavior. |
2022-12-29 |
2023-08-14 |
mouse |
| Himawari Hirai, Takeshi Sakaba, Yuki Hashimotodan. Subcortical glutamatergic inputs exhibit a Hebbian form of long-term potentiation in the dentate gyrus. Cell reports. vol 41. issue 13. 2022-12-28. PMID:36577371. |
here, we demonstrate that the hypothalamic supramammillary nucleus (sum) to the dentate granule cell (gc) synapses, which co-release glutamate and gaba, undergo associative long-term potentiation (ltp) of glutamatergic, but not gabaergic, co-transmission. |
2022-12-28 |
2023-08-14 |
Not clear |
| Brianna Vandrey, Jack Armstrong, Christina M Brown, Derek L F Garden, Matthew F Nola. Fan cells in lateral entorhinal cortex directly influence medial entorhinal cortex through synaptic connections in layer 1. eLife. vol 11. 2022-12-23. PMID:36562467. |
activation of inputs from fan cells evokes monosynaptic glutamatergic excitation of stellate and pyramidal cells in l2 of the mec, typically followed by inhibition that contains fast and slow components mediated by gaba |
2022-12-23 |
2023-08-14 |
mouse |
| Yunjiang Yu, Dongli Xie, Yue Yang, Shihui Tan, Hongyan Li, Yao Dang, Mingdeng Xiang, Haibo Che. Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans. Journal of hazardous materials. vol 445. 2022-12-09. PMID:36493651. |
in transgenic nematodes, exposure to ps-cooh at 10-100 μg/l significantly increased the fluorescence intensity of dopaminergic, glutamatergic, serotonergic, and aminobutyric acid (gaba)ergic neurons compared to that of the control. |
2022-12-09 |
2023-08-14 |
caenorhabditis_elegans |
| Bingke Ma, Xingyue Shan, Juehua Yu, Tailin Zhu, Ren Li, Hui Lv, Haidi Cheng, Tiantian Zhang, Lihua Wang, Feiyang Wei, Bo Meng, Xiaobing Yuan, Bing Mei, Xiao-Yong Zhang, Wei-Guang Li, Fei L. Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios. Cell reports. vol 41. issue 9. 2022-11-30. PMID:36450249. |
selective upregulation or downregulation of rac1 activity in glutamatergic or fast-spiking gabaergic neurons results in excessive or inadequate control of excitability combined with a decrease in glutamate or an increase in gaba concentrations and an increase in the gaba/glutamate ratio, which is responsible for social deficits. |
2022-11-30 |
2023-08-14 |
mouse |
| Joosun Shin, Kord M Kober, Carolyn Harris, Kate Oppegaard, Alejandra Calvo-Schimmel, Steven M Paul, Bruce A Cooper, Adam Olshen, Vasuda Dokiparthi, Yvette P Conley, Marilyn Hammer, Jon D Levine, Christine Miaskowsk. Perturbations in Neuroinflammatory Pathways Are Associated With a Worst Pain Profile in Oncology Patients Receiving Chemotherapy. The journal of pain. 2022-09-17. PMID:36115520. |
nine perturbed pathways were related to neuroinflammatory mechanisms (i.e., retrograde endocannabinoid signaling, gamma-aminobutyric acid synapse, glutamatergic synapse, janus kinase-signal transducer and activator of transcription signaling, phagosome, complement and coagulation cascades, cytokine-cytokine receptor interaction, chemokine signaling, calcium signaling). |
2022-09-17 |
2023-08-14 |
Not clear |
| Tao Zheng, Yi Wu, Mai-Jiao Peng, Nen-Qun Xiao, Zhou-Jin Tan, Tao Yan. Hypertension of liver-yang hyperactivity syndrome induced by a high salt diet by altering components of the gut microbiota associated with the glutamate/GABA-glutamine cycle. Frontiers in nutrition. vol 9. 2022-08-26. PMID:36017217. |
based on a kegg analysis, high salt intake mainly altered pathways related to gaba and the glutamate/glutamine metabolism, such as the gabaergic synapse pathway and glutamatergic synapse pathway. |
2022-08-26 |
2023-08-14 |
rat |
| Oliver D Howes, Ekaterina Shatalin. Integrating the Neurodevelopmental and Dopamine Hypotheses of Schizophrenia and the Role of Cortical Excitation-Inhibition Balance. Biological psychiatry. vol 92. issue 6. 2022-08-25. PMID:36008036. |
genetic advances show that schizophrenia is associated with variants linked to genes affecting gaba (gamma-aminobutyric acid) and glutamatergic signaling as well as neurodevelopmental processes. |
2022-08-25 |
2023-08-14 |
Not clear |
| Yulin Jin, Kenong Su, Ha Eun Kong, Wenjing Ma, Zhiqin Wang, Yujing Li, Ronghua Li, Emily G Allen, Hao Wu, Peng Ji. Cell-type specific DNA methylome signatures reveal epigenetic mechanisms for neuronal diversity and neurodevelopmental disorder. Human molecular genetics. 2022-08-10. PMID:35947991. |
here, we report detailed context-specific dna methylation maps for gabaergic (gaba), glutamatergic (glu) and purkinje neurons, together with matched transcriptome profiles. |
2022-08-10 |
2023-08-14 |
mouse |
| Krystyna Bogus-Nowakowska, Anna Robak, Daniel Kalinowski, Anna Kozłowska, Maciej Równia. GABAergic and Glutamatergic Phenotypes of Neurons Expressing Calcium-Binding Proteins in the Preoptic Area of the Guinea Pig. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35887305. |
double-immunofluorescence staining followed by epifluorescence and confocal microscopy was used to determine the coexpression patterns of cb, cr and pv expressing neurons with vesicular gaba transporters (vgat) as specific markers of gabaergic neurons and vesicular glutamate transporters (vglut 2) as specific markers of glutamatergic neurons. |
2022-07-27 |
2023-08-14 |
Not clear |
| Ziqian Cheng, Jingyun Su, Kai Zhang, Huiyi Jiang, Bingjin L. Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems. Frontiers in cell and developmental biology. vol 10. 2022-07-22. PMID:35865627. |
many reports indicate that different types of els induce epigenetic modifications of genes involved in the neurotransmitter systems, such as the dopaminergic system, the serotonergic system, the gamma-aminobutyric acid (gaba)-ergic system, and the glutamatergic system, which further regulate gene expression and ultimately induce depression-like behaviors. |
2022-07-22 |
2023-08-14 |
Not clear |
| Huan Chen, Dan Qiao, Yao Si, Zhen He, Bohan Zhang, Chang Wang, Yizhou Zhang, Xuelin Wang, Yichun Shi, Chengran Cui, Huixian Cui, Sha L. Effects of membrane androgen receptor binding on synaptic plasticity in primary hippocampal neurons. Molecular and cellular endocrinology. 2022-07-08. PMID:35803447. |
most neurons expressing androgen membrane binding sites are glutamatergic (excitatory), although several are γ-aminobutyric acid (gaba)ergic (inhibitory). |
2022-07-08 |
2023-08-14 |
mouse |
| Ksenija Marinkovic, Austin B Alderson Myers, Donatello Arienzo, Martin I Sereno, Graeme F Maso. Cortical GABA levels are reduced in young adult binge drinkers: Association with recent alcohol consumption and sex. NeuroImage. Clinical. vol 35. 2022-06-26. PMID:35753236. |
acute intoxication depresses neural activity via complex signaling mechanisms by enhancing inhibition mediated by gamma-amino butyric acid (gaba), and by decreasing excitatory glutamatergic effects. |
2022-06-26 |
2023-08-14 |
human |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
in this study, we used viral tracing combined with in situ hybridization targeting vesicular glutamate transporter 2 (vglut2) and glutamic acid decarboxylase 2 (gad2) to generate a comprehensive whole-brain atlas of inputs to glutamatergic and γ-aminobutyric acid (gaba)ergic neurons in the lhb. |
2022-06-01 |
2023-08-13 |
mouse |
| Scott R Burlingham, Nicole F Wong, Lindsay Peterkin, Lily Lubow, Carolina Dos Santos Passos, Orion Benner, Michael Ghebrial, Thomas P Cast, Matthew A Xu-Friedman, Thomas C Südhof, Soham Chand. Induction of synapse formation by de novo neurotransmitter synthesis. Nature communications. vol 13. issue 1. 2022-06-01. PMID:35650274. |
we demonstrate that, in both stem cell-derived human neurons as well as in vivo mouse neurons of purely glutamatergic identity, ectopic expression of gaba-synthesis enzymes and vesicular transporters is sufficient to both produce gaba from ambient glutamate and transmit it from presynaptic terminals. |
2022-06-01 |
2023-08-13 |
mouse |
| b' Mireia Tarr\\xc3\\xa9s-Gatius, Ximena L\\xc3\\xb3pez-Hill, Llu\\xc3\\xads Miquel-Rio, Laura Castarlenas, Sara Fabius, Noem\\xc3\\xad Santana, M Teresa Vilar\\xc3\\xb3, Francesc Artigas, Mar\\xc3\\xada Cecilia Scorza, Anna Casta\\xc3\\xb1\\xc3\\xa. Discrimination of motor and sensorimotor effects of phencyclidine and MK-801: Involvement of GluN2C-containing NMDA receptors in psychosis-like models. Neuropharmacology. 2022-05-13. PMID:35561792.' |
however, the nmda-r subtypes, neuronal types (e.g., gaba vs. glutamatergic neurons) and brain regions involved in psychotomimetic actions are not fully understood. |
2022-05-13 |
2023-08-13 |
mouse |
| Pragya Verma, Madhvi Shaky. Machine learning model for predicting Major Depressive Disorder using RNA-Seq data: optimization of classification approach. Cognitive neurodynamics. vol 16. issue 2. 2022-04-11. PMID:35401859. |
some of the important pathways and function observed in the study were glutamatergic synapse, gaba receptor activation, long-term synaptic depression, and morphine addiction. |
2022-04-11 |
2023-08-13 |
human |