| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sudeepta K Basu, Subechhya Pradhan, Adre J du Plessis, Yehezkel Ben-Ari, Catherine Limperopoulo. GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy. NeuroImage. vol 238. 2021-10-18. PMID:34058332. |
the gamma-aminobutyric acid (gaba) and glutamatergic neurotransmitter systems undergo rapid maturation during the crucial late gestation and early postnatal life, and are at-risk of disruption after preterm birth. |
2021-10-18 |
2023-08-13 |
human |
| Uzair Nisar, Maha Shahid, Maryam Askani, Saima Mahmood Malhi, Farzana Shaheen, Shabana Usman Simje. In vivo anticonvulsant activity of 2-propanone-1,3,5,5-trimethyl-2-cyclohexen-1-ylidine in pilocarpine and strychnine induced-seizure models. Pakistan journal of pharmaceutical sciences. vol 33. issue 4. 2021-10-13. PMID:33583776. |
earlier studies reported that dysregulation of gaba and glutamatergic activities resulted in status epilepticus (se) and ultimately support the development of temporal lobe epilepsy (tle), a type of resistant epilepsy. |
2021-10-13 |
2023-08-13 |
mouse |
| Yasunori Takahashi, Risako Yamashita, Hiromu Okano, Kazumi Takashima, Bunichiro Ogawa, Ryota Ojiro, Qian Tang, Shunsuke Ozawa, Gye-Hyeong Woo, Toshinori Yoshida, Makoto Shibutan. Aberrant neurogenesis and late onset suppression of synaptic plasticity as well as sustained neuroinflammation in the hippocampal dentate gyrus after developmental exposure to ethanol in rats. Toxicology. vol 462. 2021-10-11. PMID:34547370. |
these results suggested suppression of chrnb2-mediated cholinergic signaling in γ-aminobutyric acid (gaba)ergic interneurons in the dg hilus and increased glutamatergic signaling through the nr2b subtype of n-methyl-d-aspartate (nmda) receptors, resulting in npc reduction. |
2021-10-11 |
2023-08-13 |
rat |
| Pamodh Yasawardene, Umesh Jayarajah, Ishan De Zoysa, Suranjith L Seneviratn. Nephrotoxicity and neurotoxicity following star fruit (Averrhoa carambola) ingestion: a narrative review. Transactions of the Royal Society of Tropical Medicine and Hygiene. vol 115. issue 9. 2021-09-30. PMID:33693950. |
caramboxin inhibits gaba binding and activates the glutamatergic receptors. |
2021-09-30 |
2023-08-13 |
Not clear |
| Tomomi Nakahara, Sakiko Tsugawa, Yoshihiro Noda, Fumihiko Ueno, Shiori Honda, Megumi Kinjo, Hikari Segawa, Nobuaki Hondo, Yukino Mori, Honoka Watanabe, Kazuho Nakahara, Kazunari Yoshida, Masataka Wada, Ryosuke Tarumi, Yusuke Iwata, Eric Plitman, Sho Moriguchi, Camilo de la Fuente-Sandoval, Hiroyuki Uchida, Masaru Mimura, Ariel Graff-Guerrero, Shinichiro Nakajim. Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of Molecular psychiatry. 2021-09-29. PMID:34584230. |
glutamatergic and gabaergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of the glutamate (glu) and gamma aminobutyric acid (gaba) hypotheses of schizophrenia were proposed in the 1980s. |
2021-09-29 |
2023-08-13 |
Not clear |
| Susanne Nikolaus, Markus Beu, Hans-Jörg Wittsack, Anja Müller-Lutz, Christina Antke, Hubertus Hautzel, Yuriko Mori, Eduards Mamlins, Gerald Antoch, Hans-Wilhelm Mülle. GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat. Reviews in the neurosciences. vol 31. issue 6. 2021-09-24. PMID:32619197. |
in this review, a series of experiments is presented, in which γ-amino butyric acid (gaba)ergic and glutamatergic effects on dopamine function in the rat nigrostriatal and mesolimbic system was systematically assessed after pharmacological challenge with gabaa receptor (r) and and n-methyl d-aspartate (nmda)r agonists and antagonists. |
2021-09-24 |
2023-08-13 |
rat |
| Oriol Busquets, Antoni Parcerisas, Ester Verdaguer, Miren Ettcheto, Antoni Camins, Carlos Beas-Zarate, Rubén Darío Castro-Torres, Carme Auladel. c-Jun N-Terminal Kinases in Alzheimer's Disease: A Possible Target for the Modulation of the Earliest Alterations. Journal of Alzheimer's disease : JAD. vol 82. issue s1. 2021-09-23. PMID:33216036. |
the manuscript focuses on the molecular mechanisms of glutamatergic, gaba, and cholinergic synapses altered by the presence of amyloid-β aggregates and hyperphosphorylated tau, as well as on several consequences of the disruption of cellular processes linked to neuronal transport that is controlled by the jnk-jip (c-jun nh2-terminal kinase (jnk)-interacting proteins (jips) complex, including the transport of aβpp or autophagosomes. |
2021-09-23 |
2023-08-13 |
Not clear |
| Navatha Alugubelly, Afzaal N Mohammed, Russell L Car. Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles. Neurotoxicology. vol 85. 2021-09-22. PMID:34058248. |
these results also indicated disturbances in the balance between glutamatergic (↓ glutamate ampa receptor 2, ↓ excitatory amino acid transporter 2, and ↑ vesicular glutamate transporter 2) and gabaergic signaling (↑ gaba transporter 3 and ↑ glutamate decarboxylase 2). |
2021-09-22 |
2023-08-13 |
rat |
| Gela V Beselia, Nino C Chkhikvishvili, Maia A Burjanadze, Revaz O Solomonia, Maia Meparishvili, Barbare Nozadze, Sulkhan Asanidze, Aleksandre Nemsitsveridze, Manana G Dashnian. Modulation of prefrontal cortex function by basal forebrain cholinergic and GABAergic neurons at the behavioral and molecular level. Neuroreport. vol 32. issue 10. 2021-09-20. PMID:34029291. |
the present research aimed to study the effects of selective immunolesions of cholinergic or gamma-aminobutyric acid (gaba)ergic neurons in the nucleus basalis magnocellularis (nbm) on memory function as well as cholinergic activity and the level of expression of glutamatergic [nr2b subunit of n-methyl-d-aspartate(nmda)] receptors in the medial prefrontal cortex (mpfc) and hippocampus of behaviorally characterized rats. |
2021-09-20 |
2023-08-13 |
rat |
| Limei Zhang, Vito S Hernández, Mario A Zetter, Lee E Eide. VGLUT-VGAT expression delineates functionally specialised populations of vasopressin-containing neurones including a glutamatergic perforant path-projecting cell group to the hippocampus in rat and mouse brain. Journal of neuroendocrinology. vol 32. issue 4. 2021-09-08. PMID:31944441. |
therefore, in the present study, we characterised avp mrna co-expression with expression of mrnas marking glutamatergic (vesicular glutamate transporter [vglut]) and gabaergic (vesicular gaba transporter [vgat]) neuronal traits in rat and mouse brain, using high-resolution in situ hybridisation methods, including a radio-ribonucleotide and rnascope 2.5 hd duplex assay, with slc17a7, slc17a6, slc32a1 and avp probes corresponding to mrnas of vglut1, vglut2, vgat and avp, respectively. |
2021-09-08 |
2023-08-13 |
mouse |
| Aanya Goel, Michael Aschne. The Effect of Lead Exposure on Autism Development. International journal of molecular sciences. vol 22. issue 4. 2021-09-03. PMID:33561959. |
specifically, the mechanisms of action of lead exposure, including changes within the cholinergic, dopaminergic, glutamatergic, gamma aminobutyric acid (gaba)ergic systems, are discussed. |
2021-09-03 |
2023-08-13 |
Not clear |
| Hisahiko Kubota, Hironari Akaike, Nobuharu Okamitsu, Il-Sung Jang, Kiku Nonaka, Naoki Kotani, Norio Akaik. Xenon modulates the GABA and glutamate responses at genuine synaptic levels in rat spinal neurons. Brain research bulletin. vol 157. 2021-08-17. PMID:31987927. |
effects of xenon (xe) on whole-cell currents induced by glutamate (glu), its three ionotropic subtypes, and gaba, as well as on the fast synaptic glutamatergic and gabaergic transmissions, were studied in the mechanically dissociated "synapse bouton preparation" of rat spinal sacral dorsal commissural nucleus (sdcn) neurons. |
2021-08-17 |
2023-08-13 |
rat |
| Oliver W Gramlich, Cheyanne R Godwin, David Wadkins, Benjamin W Elwood, Markus H Kueh. Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation. International journal of molecular sciences. vol 22. issue 14. 2021-08-17. PMID:34299211. |
decreased expression was found for 378 genes associated with the γ-aminobutyric acid (gaba)ergic and glutamatergic systems and axon guidance. |
2021-08-17 |
2023-08-13 |
mouse |
| Li Yang, Ming Chen, Qianqian Ma, Huan Sheng, Dongyang Cui, Da Shao, Bin Lai, Ping Zhen. Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward. Neuropharmacology. vol 176. 2021-08-13. PMID:32679049. |
using optogenetic strategy combined with whole-cell patch-clamp, qrt-pcr, immunofluorescence and chemical genetic approach combined with behavioral methods, our results show that: 1) morphine promotes glutamate release from glutamatergic terminals of medial prefrontal cortex (mpfc) neurons projecting to vta-da neurons but does not on those from glutamatergic terminals of the lateral hypothalamus (lh) neurons projecting to vta-da neurons; 2) different response of glutamatergic neurons projecting to vta-da neurons from the mpfc or the lh to morphine is related to the expression of gaba |
2021-08-13 |
2023-08-13 |
Not clear |
| Jeffery L Cummings, D P Devanand, Stephen M Stah. Dementia-related psychosis and the potential role for pimavanserin. CNS spectrums. 2021-07-30. PMID:32811586. |
despite differences in dementia pathology, the neurobiology underlying psychosis appears to involve dysregulation of a cortical and limbic pathway involving serotonergic, gamma-aminobutyric acid ergic, glutamatergic, and dopaminergic signaling. |
2021-07-30 |
2023-08-13 |
Not clear |
| Bronac Flanagan, Liam McDaid, John Joseph Wade, Marinus Toman, KongFatt Wong-Lin, Jim Harki. A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics. Frontiers in cellular neuroscience. vol 15. 2021-07-30. PMID:34322000. |
a computational study of astrocytic gaba release at the glutamatergic synapse: eaat-2 and gat-3 coupled dynamics. |
2021-07-30 |
2023-08-13 |
Not clear |
| Bronac Flanagan, Liam McDaid, John Joseph Wade, Marinus Toman, KongFatt Wong-Lin, Jim Harki. A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics. Frontiers in cellular neuroscience. vol 15. 2021-07-30. PMID:34322000. |
key results also illustrate an astrocytic-mediated modulation of synaptic neuronal excitation by released gaba at the glutamatergic synapse. |
2021-07-30 |
2023-08-13 |
Not clear |
| Moritoshi Hirono, Fuyuki Karube, Yuchio Yanagaw. Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34194302. |
second, we review the physiological roles of perineuronal nets (pnns), which are organized components of the extracellular matrix and enwrap the cell bodies and proximal processes, in gaba release from pcs to large glutamatergic dcn neurons and in cerebellar motor learning. |
2021-07-16 |
2023-08-13 |
Not clear |
| Licong Li, Jin Zhou, Hongji Sun, Jing Liu, Hongrui Wang, Xiuling Liu, Changyong Wan. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation. Computational and mathematical methods in medicine. vol 2020. 2021-07-09. PMID:33014120. |
the model completely describes the effects of gaba on astrocytes and excitatory presynaptic terminals within the framework of glutamatergic gliotransmission according to neurophysiological findings. |
2021-07-09 |
2023-08-13 |
Not clear |
| Serap Kurt, Ayse Gaye Tomatir, Pervin Elvan Tokgun, Cagatay Once. Altered Expression of Long Non-coding RNAs in Peripheral Blood Mononuclear Cells of Patients with Alzheimer's Disease. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32885358. |
when assessed by kegg analysis of ad pbmc lncrna and mrna profiles, tnf signaling pathway, pi3k/akt, ras, and mapk pathways; glutamatergic, dopaminergic, and cholinergic synapses; gaba, and neurotrophin signaling pathways are found to be significant. |
2021-07-01 |
2023-08-13 |
human |