| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Loga. Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder. Translational psychiatry. vol 12. issue 1. 2022-03-29. PMID:35347109. |
associations with altered neurotransmission in nac were further supported by co-expression network analysis which identified oud-specific modules enriched for transcripts involved in dopamine, gaba, and glutamatergic synaptic functions. |
2022-03-29 |
2023-08-13 |
human |
| Thomas McGrath, Richard Baskerville, Marcelo Rogero, Linda Castel. Emerging Evidence for the Widespread Role of Glutamatergic Dysfunction in Neuropsychiatric Diseases. Nutrients. vol 14. issue 5. 2022-03-10. PMID:35267893. |
the glutamate microcircuit comprises excitatory glutamatergic neurons, astrocytes controlling synaptic space levels, through glutamate reuptake, and inhibitory gaba interneurons. |
2022-03-10 |
2023-08-13 |
Not clear |
| Arianna De Rosa, Andrea Fontana, Tommaso Nuzzo, Martina Garofalo, Anna Di Maio, Daniela Punzo, Massimiliano Copetti, Alessandro Bertolino, Francesco Errico, Antonio Rampino, Andrea de Bartolomeis, Alessandro Usiell. Machine Learning algorithm unveils glutamatergic alterations in the post-mortem schizophrenia brain. NPJ schizophrenia. vol 8. issue 1. 2022-02-26. PMID:35217646. |
moreover, by quantitative rt-pcr and western blotting we analyzed, respectively, the mrna and protein levels of pre- and post-synaptic key molecules involved in the glutamatergic synapse functioning, including glutamate receptors (nmda, ampa, metabotropic), their interacting scaffolding proteins (psd-95, homer1b/c), plasma membrane and vesicular glutamate transporters (eaat1, eaat2, vglut1, vglut2), enzymes involved either in glutamate-dependent gaba neurotransmitter synthesis (gad65 and 67), or in post-synaptic nmda receptor-mediated signaling (camkiiα) and the pre-synaptic marker synapsin-1. |
2022-02-26 |
2023-08-13 |
Not clear |
| R Yokoi, T Shigemoto-Kuroda, N Matsuda, A Odawara, I Suzuk. Electrophysiological responses to seizurogenic compounds dependent on E/I balance in human iPSC-derived cortical neural networks. Journal of pharmacological sciences. vol 148. issue 2. 2022-01-22. PMID:35063143. |
here, five neural networks with varying e/i ratios (88/12, 84/16, 74/26, 58/42, and 48/52) were constructed by altering the ratios of glutamatergic (e) and gaba (i) neurons. |
2022-01-22 |
2023-08-13 |
human |
| Veronika Meliskova, Tomas Havranek, Zuzana Bacova, Jan Bako. The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997728. |
pathological changes in synapse formation, plasticity, and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gamma-aminobutyric acid (gaba)ergic synapses, suggesting their involvement in the etiology of neurodevelopmental disorders, including autism. |
2022-01-08 |
2023-08-13 |
mouse |
| Aniello Lombardi, Heiko J Luhmann, Werner Kil. Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability. PLoS computational biology. vol 17. issue 11. 2021-12-10. PMID:34767548. |
to evaluate at which reversal potential a net excitatory effect was imposed by gaba (egabathr), we performed a detailed in-silico study using simple neuronal topologies and distinct spatiotemporal relations between gabaergic and glutamatergic inputs. |
2021-12-10 |
2023-08-13 |
Not clear |
| Gil D Hoftman, H Holly Bazmi, Andrew J Ciesielski, Liban A Dinka, Kehui Chen, David A Lewi. Postnatal Development of Glutamate and GABA Transcript Expression in Monkey Visual, Parietal, and Prefrontal Cortices. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 4. 2021-12-08. PMID:33279960. |
this information is conveyed via layer 3 glutamatergic neurons whose activity is regulated by gamma-aminobutyric acid (gaba)ergic interneurons. |
2021-12-08 |
2023-08-13 |
human |
| Mohammad Naderi, Pankaj Puar, Raha JavadiEsfahani, Raymond W M Kwon. Early developmental exposure to bisphenol A and bisphenol S disrupts socio-cognitive function, isotocin equilibrium, and excitation-inhibition balance in developing zebrafish. Neurotoxicology. vol 88. 2021-12-02. PMID:34808222. |
further, alterations in the transcript abundance of chloride transporters, and molecular markers of gamma-aminobutyric acid (gaba) and glutamatergic systems, were observed in the zebrafish brain, suggesting possible e/i imbalance following bpa or bps exposure. |
2021-12-02 |
2023-08-13 |
zebrafish |
| A Maryse Minnaard, Geert M J Ramakers, Louk J M J Vanderschuren, Heidi M B Lessche. Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake. Behavioural pharmacology. vol 32. issue 2&3. 2021-11-30. PMID:33315615. |
we therefore determined the effects of drugs affecting gaba, opioid and glutamatergic neurotransmission on alcohol consumption in rats that differed in baseline alcohol intake. |
2021-11-30 |
2023-08-13 |
rat |
| Dipanwita Pati, Thomas L Kas. Tumor necrosis factor-α modulates GABAergic and Dopaminergic neurons in the ventrolateral periaqueductal gray of female mice. Journal of neurophysiology. 2021-11-24. PMID:34817244. |
following exposure to tnf-α there was an increase in excitability of gaba neurons along with a reduction in glutamatergic synaptic transmission. |
2021-11-24 |
2023-08-13 |
mouse |
| Lindsey N Friend, Bridget Wu, Jeffrey G Edward. Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons. Neurochemistry international. vol 145. 2021-11-18. PMID:33617930. |
vta dopamine cells are regulated by local inhibitory gaba cells, which exhibit a form of pre-synaptic cannabinoid receptor 1-dependent long-term depression of their glutamatergic inputs. |
2021-11-18 |
2023-08-13 |
mouse |
| Jürgen Graf, Chuanqiang Zhang, Stephan Lawrence Marguet, Tanja Herrmann, Tom Flossmann, Robin Hinsch, Vahid Rahmati, Madlen Guenther, Christiane Frahm, Anja Urbach, Ricardo Melo Neves, Otto W Witte, Stefan J Kiebel, Dirk Isbrandt, Christian A Hübner, Knut Holthoff, Knut Kirms. A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 14. 2021-11-18. PMID:33782119. |
we report that nkcc1 deletion from telencephalic glutamatergic neurons decreases in vitro excitatory actions of γ-aminobutyric acid (gaba) and impairs neuronal synchrony in neonatal hippocampal brain slices. |
2021-11-18 |
2023-08-13 |
mouse |
| Yue-Ying Liu, Le Liu, Lei Zhu, Xiu Yang, Kun Tong, Yue You, Li Yang, Yin Gao, Xu Li, Di-Shi Chen, Jing-Ru Hao, Nan Sun, Can Ga. dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine. Pharmacological research. vol 172. 2021-11-16. PMID:34461223. |
we found that glutamatergic neurons of the dca1 and gamma aminobutyric acidergic (gaba) neurons of the nac shell are the key brain areas and neurons involved in the context-induced reinstatement of morphine memory. |
2021-11-16 |
2023-08-13 |
mouse |
| Santosh Pothula, Taro Kato, Rong-Jian Liu, Min Wu, Danielle Gerhard, Ryota Shinohara, Alexa-Nicole Sliby, Golam M I Chowdhury, Kevin L Behar, Gerard Sanacora, Pradeep Banerjee, Ronald S Duma. Cell-type specific modulation of NMDA receptors triggers antidepressant actions. Molecular psychiatry. vol 26. issue 9. 2021-11-15. PMID:32488125. |
we demonstrate that rapastinel directly enhances nmdar activity on principal glutamatergic neurons in medial prefrontal cortex (mpfc) without any effect on glutamate efflux, while ketamine blocks nmdar on gaba interneurons to cause glutamate efflux and indirect activation of excitatory synapses. |
2021-11-15 |
2023-08-13 |
human |
| Michihiro Toritsuka, Hiroki Yoshino, Manabu Makinodan, Daisuke Ikawa, Sohei Kimoto, Kazuhiko Yamamuro, Kazuya Okamura, Wado Akamatsu, Yohei Okada, Takuya Matsumoto, Kazumichi Hashimoto, Yoichi Ogawa, Yasuhiko Saito, Kyosuke Watanabe, Chieko Aoki, Ryohei Takada, Shin-Ichi Fukami, Kaori Hamano-Iwasa, Hideyuki Okano, Toshifumi Kishimot. Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons. Neurochemistry international. vol 150. 2021-11-11. PMID:34500023. |
the cultured neurons differentiated from hipscs were composed of a mixture of glutamatergic excitatory neurons and gamma aminobutyric acid (gaba)ergic inhibitory neurons. |
2021-11-11 |
2023-08-13 |
human |
| Claudia Vingerhoets, Desmond Hy Tse, Mathilde van Oudenaren, Dennis Hernaus, Esther van Duin, Janneke Zinkstok, Johannes G Ramaekers, Jacobus Fa Jansen, Grainne McAlonan, Therese van Amelsvoor. Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study. Journal of psychopharmacology (Oxford, England). vol 34. issue 8. 2021-11-04. PMID:32448020. |
glutamatergic pathways have been linked with cognition and are hypothesized to be disrupted in 22q11.2ds patients, possibly 'shifting' the excitatory (glutamate)/inhibitory (gaba) balance. |
2021-11-04 |
2023-08-13 |
human |
| Lise Heylen, Duc-Hung Pham, Ann-Sofie De Meulemeester, Éric Samarut, Adrianna Skiba, Daniëlle Copmans, Youcef Kazwiny, Pieter Vanden Berghe, Peter A M de Witte, Aleksandra Siekiersk. Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Frontiers in molecular neuroscience. vol 14. 2021-11-02. PMID:34720874. |
we also assessed gfp-labeled gabaergic and rfp-labeled glutamatergic neurons in double transgenic ka-injected zebrafish larvae, and examined the gaba and glutamate levels in the larval heads by liquid chromatography with tandem mass spectrometry detection (lc-ms/ms). |
2021-11-02 |
2023-08-13 |
human |
| Iska Moxon-Emre, Zafiris J Daskalakis, Daniel M Blumberger, Paul E Croarkin, Rachael E Lyon, Natalie J Forde, Hideaki Tani, Peter Truong, Meng-Chuan Lai, Pushpal Desarkar, Napapon Sailasuta, Peter Szatmari, Stephanie H Amei. Modulation of Dorsolateral Prefrontal Cortex Glutamate/Glutamine Levels Following Repetitive Transcranial Magnetic Stimulation in Young Adults With Autism. Frontiers in neuroscience. vol 15. 2021-10-26. PMID:34690671. |
here, we examined whether an excitatory rtms treatment course modulates glutamatergic (glx) or γ-aminobutyric acid (gaba) metabolite levels in emerging adults with asd. |
2021-10-26 |
2023-08-13 |
human |
| Olivier Pierrefich. Long Term Depression in Rat Hippocampus and the Effect of Ethanol during Fetal Life. Brain sciences. vol 7. issue 12. 2021-10-25. PMID:29182556. |
a synthesis of the findings indicates that prenatal ethanol exposure disturbs ltd concurrently with ltp in offspring and that both glutamatergic and γ-aminobutyric acid (gaba) neurotransmissions are altered and contribute to ltd disturbances. |
2021-10-25 |
2023-08-13 |
rat |
| b' Marc Fakhoury, Giovanni Hernandez, Daniel L\\xc3\\xa9vesque, Pierre-Paul Rompr\\xc3\\xa. Modulation of brain stimulation reward and locomotor activity by ionotropic glutamate receptors of the tail of the ventral tegmental area. Behavioural brain research. vol 393. 2021-10-25. PMID:32593543.' |
the rostromedial tegmental nucleus also referred to as the tail of the ventral tegmental area (tvta) contains a cluster of gamma-aminobutyric acid (gaba)ergic neurons that receive dense glutamatergic afferents from the lateral habenula (lhb), and project to dopamine (da) neurons of the ventral tegmental area (vta) and substantia nigra pars compacta (snc). |
2021-10-25 |
2023-08-13 |
Not clear |