| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Vigne. Regulation of spontaneous inhibitory synaptic transmission by endogenous glutamate via non-NMDA receptors in cultured rat hippocampal neurons. Neuropharmacology. vol 40. issue 6. 2001-08-09. PMID:11369028. |
therefore, both ampa and kainate receptors can regulate inhibitory synaptic transmission in cultured hippocampal neurons, the former by tonic activation, the latter when the glutamate concentration is increased by impairing glutonate uptake. |
2001-08-09 |
2023-08-12 |
rat |
| V A Skeberdis, J Lan, T Opitz, X Zheng, M V Bennett, R S Zuki. mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C. Neuropharmacology. vol 40. issue 7. 2001-08-09. PMID:11378156. |
mglur1-mediated potentiation of nmda receptors involves a rise in intracellular calcium and activation of protein kinase c. potentiation of ionotropic glutamate receptor activity by metabotropic glutamate receptors (mglurs) is thought to modulate activity at glutamatergic synapses in the hippocampus. |
2001-08-09 |
2023-08-12 |
xenopus_laevis |
| S V Vellucci, R F Parrott, M L Mimmac. Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor m RNAs, in the porcine hippocampus after acute dexamethasone treatment. Research in veterinary science. vol 70. issue 2. 2001-08-02. PMID:11356095. |
injection of the synthetic glucocorticoid, dexamethasone (dex, 5 mg kg(-1)) on gene expression for mr s, gr s, bdnf, trkb, and selected ionotropic glutamate receptor subunits (iglurs), in the porcine hippocampus. |
2001-08-02 |
2023-08-12 |
Not clear |
| Y Ben-Ar. Developing networks play a similar melody. Trends in neurosciences. vol 24. issue 6. 2001-08-02. PMID:11356508. |
relying on the giant depolarizing potentials that provide most of the synaptic activity in the developing hippocampus, this article reviews the common properties and generating mechanisms of these patterns, and particularly the role of the early depolarizing action of gaba(a) and glycine receptors and the sequential expression of gaba and glutamate synapses. |
2001-08-02 |
2023-08-12 |
Not clear |
| J E Lee, M A Yenari, G H Sun, L Xu, M R Emond, D Cheng, G K Steinberg, R G Giffar. Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions. Experimental neurology. vol 170. issue 1. 2001-08-02. PMID:11421590. |
hippocampal, but not cortical neuron cultures from these same transgenic mice were also protected against oxygen-glucose deprivation and glutamate toxicity. |
2001-08-02 |
2023-08-12 |
mouse |
| C Lu, M P Mattso. Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons. Experimental neurology. vol 170. issue 1. 2001-08-02. PMID:11421595. |
we now report that concentrations of dmso to which neurons are typically exposed in experimental studies and in human patients (0.5-1.5%) inhibit glutamate responses in hippocampal neurons. |
2001-08-02 |
2023-08-12 |
human |
| H Koinig, V Vornik, C Rueda, M H Zorno. Lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia. Brain research. vol 898. issue 2. 2001-07-26. PMID:11306016. |
lubeluzole inhibits accumulation of extracellular glutamate in the hippocampus during transient global cerebral ischemia. |
2001-07-26 |
2023-08-12 |
Not clear |
| I Harukuni, P D Hurn, B J Crai. Deleterious effect of beta-estradiol in a rat model of transient forebrain ischemia. Brain research. vol 900. issue 1. 2001-07-26. PMID:11325356. |
on the other hand, many other reported effects of estrogen in hippocampal area ca1 might confer increased sensitivity to ischemia, either by modulating the excitatory effects of glutamate or by modifying the inhibitory effects of gaba. |
2001-07-26 |
2023-08-12 |
rat |
| J Kilbride, A M Rush, M J Rowan, R Anwy. Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro. Journal of neurophysiology. vol 85. issue 6. 2001-07-26. PMID:11387397. |
inhibition of short-term plasticity by activation of presynaptic group ii metabotropic glutamate receptors (group ii mglur) was investigated in the medial perforant path of the dentate gyrus in the hippocampus in vitro. |
2001-07-26 |
2023-08-12 |
Not clear |
| T Kleppisch, V Voigt, R Allmann, S Offermann. G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 14. 2001-07-26. PMID:11438569. |
group i metabotropic glutamate receptors (mglur), which are linked to heterotrimeric g-proteins of the g(q) family (g(q) and g(11)), have been reported to facilitate both hippocampal ltp and ltd. to evaluate their functional role in synaptic plasticity, we studied ltd and ltp in the ca1 region of the hippocampus from wild-type, galpha(q)(-/-), and galpha(11)(-/-) mice. |
2001-07-26 |
2023-08-12 |
mouse |
| M Blaabjerg, B W Kristensen, C Bonde, J Zimme. The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain research. vol 898. issue 1. 2001-07-19. PMID:11292452. |
the metabotropic glutamate receptor agonist 1s,3r-acpd stimulates and modulates nmda receptor mediated excitotoxicity in organotypic hippocampal slice cultures. |
2001-07-19 |
2023-08-12 |
Not clear |
| M Blaabjerg, B W Kristensen, C Bonde, J Zimme. The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain research. vol 898. issue 1. 2001-07-19. PMID:11292452. |
the potential toxic effects of the metabotropic glutamate receptor agonist (1s,3r)-1-aminocyclopentane-1,3-dicarboxylic acid (acpd) and its interactions with the n-methyl-d-aspartate (nmda) receptor were studied in hippocampal brain slice cultures, using densitometric measurements of the cellular uptake of propidium iodide (pi) to quantify neuronal degeneration. |
2001-07-19 |
2023-08-12 |
Not clear |
| M Blaabjerg, B W Kristensen, C Bonde, J Zimme. The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain research. vol 898. issue 1. 2001-07-19. PMID:11292452. |
we conclude that, stimulation of metabotropic glutamate receptors with acpd at concentrations of 2 mm or higher induces a distinct subfield-related and time and concentration dependent pattern of hippocampal degeneration, and that acpd at subtoxic concentrations modulates nmda-induced excitotoxicity through the mglur5 receptor in a time dependent way. |
2001-07-19 |
2023-08-12 |
Not clear |
| N Kasai, Y Jimbo, O Niwa, T Matsue, K Torimits. Real-time multisite observation of glutamate release in rat hippocampal slices. Neuroscience letters. vol 304. issue 1-2. 2001-07-19. PMID:11335067. |
real-time multisite observation of glutamate release in rat hippocampal slices. |
2001-07-19 |
2023-08-12 |
rat |
| N Janssens, A S Lesag. Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. Journal of neurochemistry. vol 77. issue 6. 2001-07-19. PMID:11413230. |
we report on the expression of ionotropic glutamate receptor subunits in primary neuronal cultures from rat cortex, hippocampus and cerebellum and of metabotropic glutamate (mglu) receptor subtypes in these neuronal cultures as well as in cortical astroglial cultures. |
2001-07-19 |
2023-08-12 |
rat |
| X Lu, M Wyszynski, M Sheng, M Baudr. Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity. Journal of neurochemistry. vol 77. issue 6. 2001-07-19. PMID:11413238. |
here we report that glutamate receptor-interacting protein (grip) is a substrate of calpain, as calpain-mediated grip degradation was demonstrated using three different approaches: (i) purified calpain i digestion of synaptic membranes, (ii) calcium treatment of frozen-thawed brain sections, and (iii) nmda-stimulated organotypic hippocampal slice cultures. |
2001-07-19 |
2023-08-12 |
rat |
| C Lu, W Fu, M P Mattso. Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative disorders. Neurobiology of disease. vol 8. issue 2. 2001-07-12. PMID:11300717. |
caspase-mediated suppression of glutamate (ampa) receptor channel activity in hippocampal neurons in response to dna damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative disorders. |
2001-07-12 |
2023-08-12 |
Not clear |
| G M Khan, I Smolders, G Ebinger, Y Michott. 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311893. |
however, pilocarpine-evoked elevation of hippocampal glutamate overflow was significantly attenuated by ccpa irrespective of the mode of administration. |
2001-07-12 |
2023-08-12 |
rat |
| G M Khan, I Smolders, G Ebinger, Y Michott. 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311893. |
intrahippocampal ccpa markedly reduced basal hippocampal dopamine efflux but not gaba or glutamate and considerably attenuated the pilocarpine-evoked elevation in dopamine levels. |
2001-07-12 |
2023-08-12 |
rat |
| S M Sequeira, J O Malva, A P Carvalho, C M Carvalh. Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals. Brain research. Molecular brain research. vol 89. issue 1-2. 2001-07-12. PMID:11311981. |
n-methyl-d-aspartate dose-dependently inhibited the release of glutamate evoked by 4-aminopyridine (ic(50)=155 microm), and this effect was reversed by the n-methyl-d-aspartate receptor antagonist d-(-)-2-amino-5-phosphopentanoic acid and by the nitric oxide synthase inhibitor, l-nitroarginine, in synaptosomes isolated from whole hippocampus, ca3 and ca1 areas, but not from the dentate gyrus. |
2001-07-12 |
2023-08-12 |
rat |