| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
here we show that chronic treatment of rats with the anti-epileptic drug sodium valproate (200 mg or 400 mg/kg bodyweight, twice per day for 90 days) leads to a dose-dependent increase in hippocampal glutamate uptake capacity as measured by uptake of [(3)h]glutamate into proteoliposomes. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the level of glutamate transporters eaat1 and eaat2 in hippocampus also increased dose-dependently. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the hippocampal levels of glial fibrillary acidic protein and glutamine synthetase were unaffected by valproate treatment, whereas the levels of synapsin i and phosphate-activated glutaminase were reduced by valproate treatment, suggesting that the increase in glutamate transporters was not caused by astrocytosis or increased synaptogenesis. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the results show that hippocampal glutamate transport is an accessible target for pharmacological intervention and that sodium valproate may have a role in the treatment of excitotoxic states in the hippocampus. |
2001-07-12 |
2023-08-12 |
rat |
| C E Gee, G Woodhall, J C Lacaill. Synaptically activated calcium responses in dendrites of hippocampal oriens-alveus interneurons. Journal of neurophysiology. vol 85. issue 4. 2001-07-05. PMID:11287484. |
activation of metabotropic glutamate receptors (mglurs) by agonists increases intracellular calcium levels ([ca(2+)](i)) in interneurons of stratum oriens/alveus (oa) of the hippocampus. |
2001-07-05 |
2023-08-12 |
rat |
| S M Lasley, M C Green, M E Gilber. Rat hippocampal NMDA receptor binding as a function of chronic lead exposure level. Neurotoxicology and teratology. vol 23. issue 2. 2001-07-05. PMID:11348836. |
a crude membrane fraction was prepared from hippocampal tissue, and scatchard analysis conducted in the presence of saturating concentrations of glutamate and glycine. |
2001-07-05 |
2023-08-12 |
rat |
| S M Lasley, M C Green, M E Gilber. Rat hippocampal NMDA receptor binding as a function of chronic lead exposure level. Neurotoxicology and teratology. vol 23. issue 2. 2001-07-05. PMID:11348836. |
these findings are an approximate reflection of analogous relationships reported for hippocampal ltp and glutamate release, suggesting that the diminished glutamate release is one cause of the receptor up-regulation. |
2001-07-05 |
2023-08-12 |
rat |
| M Shapir. Plasticity, hippocampal place cells, and cognitive maps. Archives of neurology. vol 58. issue 6. 2001-07-05. PMID:11405801. |
n-methyl d-aspartate (nmda) receptors, a subtype of glutamate receptor, are crucial for inducing these plastic changes, and blocking these receptors reduces plasticity and impairs learning in tasks that require the hippocampus. |
2001-07-05 |
2023-08-12 |
mouse |
| S Uchino, T Nakamura, K Nakamura, S Nakajima-Iijima, M Mishina, S Kohsaka, Y Kud. Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207802. |
real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices. |
2001-06-28 |
2023-08-12 |
rat |
| C Culmsee, S Bondada, M P Mattso. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain research. Molecular brain research. vol 87. issue 2. 2001-06-28. PMID:11245929. |
we now report that cultured hippocampal neurons from severe combined immunodeficient (scid) mice which lack dna-pk activity are hypersensitive to apoptosis induced by exposure to topoisomerase inhibitors, amyloid beta peptide (a beta) and glutamate. |
2001-06-28 |
2023-08-12 |
mouse |
| R Schnabel, I C Kilpatrick, G L Collingridg. Protein phosphatase inhibitors facilitate DHPG-induced LTD in the CA1 region of the hippocampus. British journal of pharmacology. vol 132. issue 5. 2001-06-21. PMID:11226140. |
we have shown earlier that activation of metabotropic glutamate (mglu) receptors using a group i-specific mglu receptor agonist, (rs)-3,5-dihydroxyphenylglycine (dhpg), can induce long-term depression (ltd) in the ca1 region of the hippocampus. |
2001-06-21 |
2023-08-12 |
rat |
| T Yus. Increased extracellular ascorbate release reflects glutamate re-uptake during the early stage of reperfusion after forebrain ischemia in rats. Brain research. vol 897. issue 1-2. 2001-06-21. PMID:11282363. |
thus, the extracellular release of ascorbate and glutamate was measured during the early stage of forebrain ischemia-reperfusion in the rat hippocampus using a microdialysis biosensor system. |
2001-06-21 |
2023-08-12 |
rat |
| L A Izquierdo, H Viola, D M Barros, M Alonso, M R Vianna, M Furman, M Levi de Stein, G Szapiro, C Rodrigues, H Choi, J H Medina, I Izquierd. Novelty enhances retrieval: molecular mechanisms involved in rat hippocampus. The European journal of neuroscience. vol 13. issue 7. 2001-06-21. PMID:11298809. |
taken together, our results indicate that novelty activates hippocampal mapks, which are necessary, along with glutamate nmda receptors, for the enhancing effect of novelty on retrieval. |
2001-06-21 |
2023-08-12 |
rat |
| X X Li, T Nomura, H Aihara, T Nishizak. Adenosine enhances glial glutamate efflux via A2a adenosine receptors. Life sciences. vol 68. issue 12. 2001-06-21. PMID:11388687. |
adenosine and cgs21680 also enhanced glutamate efflux from xenopus oocytes injected with the poly (a)+ mrnas derived from cultured glial cells for the hippocampus and the superior colliculus together with and without the a2a adenosine receptor mrna, but instead such increase was not found in oocytes expressing a2a adenosine receptors alone. |
2001-06-21 |
2023-08-12 |
rat |
| X X Li, T Nomura, H Aihara, T Nishizak. Adenosine enhances glial glutamate efflux via A2a adenosine receptors. Life sciences. vol 68. issue 12. 2001-06-21. PMID:11388687. |
the results of the present study thus suggest that adenosine enhances glutamate efflux from glial cells via a2a adenosine receptors, and this may represent a mechanism underlying the facilitatory action of adenosine on hippocampal and superior colliculus neurotransmissions. |
2001-06-21 |
2023-08-12 |
rat |
| Y Yoneda, N Kuramoto, T Kitayama, E Hino. Consolidation of transient ionotropic glutamate signals through nuclear transcription factors in the brain. Progress in neurobiology. vol 63. issue 6. 2001-06-14. PMID:11165002. |
extracellular ionotropic glutamate (glu) signals lead to rapid and selective potentiation of dna binding of the nuclear transcription factor activator protein-1 (ap1) that is a homo- and heterodimeric complex between jun and fos family members, in addition to inducing expression of the corresponding proteins, in a manner unique to each glu signal in murine hippocampus. |
2001-06-14 |
2023-08-12 |
Not clear |
| F R Tang, W L Lee, J Yang, M K Sim, E A Lin. Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. Neuroscience letters. vol 300. issue 3. 2001-06-14. PMID:11226630. |
metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. |
2001-06-14 |
2023-08-12 |
rat |
| F R Tang, W L Lee, J Yang, M K Sim, E A Lin. Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. Neuroscience letters. vol 300. issue 3. 2001-06-14. PMID:11226630. |
the expression of metabotropic glutamate receptor 8 (mglur8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (apise) by light immunohistochemistry and immunoelectron microscopy. |
2001-06-14 |
2023-08-12 |
rat |
| J Yan, C He, X Q Wang, X Bao, W J Ni, C L L. The effect of CNTF on glutamate-induced increases in intracellular free Ca2+ in hippocampal neurons. Neuroreport. vol 11. issue 16. 2001-05-31. PMID:11095495. |
glutamate induces a rapid increase in [ca2+]i. incubation of hippocampal neurons with cntf for 5 min inhibited the glutamate-induced increase in [ca2+]i. |
2001-05-31 |
2023-08-12 |
Not clear |
| S Gaillet, C Plachez, F Malaval, M F Bézine, M Récasen. Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137623. |
the glial glast and glt-1 glutamate transporters are transiently expressed in hippocampal neurons as shown by immunocytochemistry (plachez et al., 2000. |
2001-05-31 |
2023-08-12 |
Not clear |