| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Gaillet, C Plachez, F Malaval, M F Bézine, M Récasen. Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137623. |
in order to test if this transient expression is associated to a transient glutamate uptake activity, [3h]-glutamate uptake was studied during the in vitro development of embryonic hippocampal neurons cultured in a defined (serum free) medium. |
2001-05-31 |
2023-08-12 |
Not clear |
| S Gaillet, C Plachez, F Malaval, M F Bézine, M Récasen. Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture. Neurochemistry international. vol 38. issue 4. 2001-05-31. PMID:11137623. |
these data indicated that, besides the regular increase in the glial-dependent glutamate uptake activity, a transient high-affinity, dhk insensitive, glutamate transport activity in hippocampal neurons in culture is present. |
2001-05-31 |
2023-08-12 |
Not clear |
| D D Limbrick, S Pal, R J DeLorenz. Hippocampal neurons exhibit both persistent Ca2+ influx and impairment of Ca2+ sequestration/extrusion mechanisms following excitotoxic glutamate exposure. Brain research. vol 894. issue 1. 2001-05-31. PMID:11245815. |
hippocampal neurons exhibit both persistent ca2+ influx and impairment of ca2+ sequestration/extrusion mechanisms following excitotoxic glutamate exposure. |
2001-05-31 |
2023-08-12 |
Not clear |
| S R Vorel, X Liu, R J Hayes, J A Spector, E L Gardne. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science (New York, N.Y.). vol 292. issue 5519. 2001-05-31. PMID:11349151. |
electrical stimulation of the hippocampus containing glutamatergic fibers, but not the medial forebrain bundle containing dopaminergic fibers, elicited cocaine-seeking behavior dependent on glutamate in the ventral tegmental area. |
2001-05-31 |
2023-08-12 |
rat |
| J H Cha, L A Farrell, S F Ahmed, A Frey, K K Hsiao-Ashe, A B Young, J B Penney, J J Locascio, B T Hyman, M C Irizarr. Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein. Neurobiology of disease. vol 8. issue 1. 2001-05-24. PMID:11162243. |
glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein. |
2001-05-24 |
2023-08-12 |
mouse |
| J H Cha, L A Farrell, S F Ahmed, A Frey, K K Hsiao-Ashe, A B Young, J B Penney, J J Locascio, B T Hyman, M C Irizarr. Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein. Neurobiology of disease. vol 8. issue 1. 2001-05-24. PMID:11162243. |
these data suggest that mutant app overexpression or age-related amyloid deposition produce a subtle specific alteration in hippocampal glutamate receptors with aging. |
2001-05-24 |
2023-08-12 |
mouse |
| S M Lasley, M E Gilber. Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity. Neurotoxicology. vol 21. issue 6. 2001-05-24. PMID:11233752. |
biochemical and neurophysiological approaches have found stimulated glutamate release to be diminished in hippocampus at blood pb values where deficits in ltp have been observed. |
2001-05-24 |
2023-08-12 |
Not clear |
| S M Lasley, M E Gilber. Glutamatergic components underlying lead-induced impairments in hippocampal synaptic plasticity. Neurotoxicology. vol 21. issue 6. 2001-05-24. PMID:11233752. |
a biphasic dose-effect relationship was also found in which stimulated glutamate release in hippocampus was decreased at intermediate exposures, but not at higher levels. |
2001-05-24 |
2023-08-12 |
Not clear |
| L D Partridge, C F Valenzuel. Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248433. |
neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices. |
2001-05-24 |
2023-08-12 |
rat |
| L D Partridge, C F Valenzuel. Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248433. |
pregnenolone sulfate, one of the most abundantly produced neurosteroids in the hippocampus, has well characterized effects at postsynaptic receptors including the n-methyl-d-asparate type of glutamate receptor. |
2001-05-24 |
2023-08-12 |
rat |
| L D Partridge, C F Valenzuel. Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248433. |
thus, we propose a novel mechanism of action of neurosteroids in hippocampal neurons that involves the modulation of glutamate release. |
2001-05-24 |
2023-08-12 |
rat |
| A F Ambrósio, A P Silva, J O Malva, P Soares-da-Silva, A P Carvalho, C M Carvalh. Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels. Biochemical pharmacology. vol 61. issue 10. 2001-05-24. PMID:11322931. |
we investigated the mechanism(s) of action of two new putative antiepileptic drugs (aeds), (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide (bia 2-093) and 10,11-dihydro-10-hydroxyimino-5h-dibenz[b,f]azepine-5-carboxamide (bia 2-024), by comparing their effects on the release of endogenous glutamate in hippocampal synaptosomes, with those of carbamazepine (cbz) and oxcarbazepine (oxc). |
2001-05-24 |
2023-08-12 |
Not clear |
| J P Hodgkiss, J S Kell. Effect of FK960, a putative cognitive enhancer, on synaptic transmission in CA1 neurons of rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303051. |
it is concluded that fk960 increases the quantal release of glutamate from schaffer collateral-commissural nerve terminals in area ca1 of the hippocampus either by changing the ambient level of acetylcholine or by positively modulating the activity of alpha 7nachrs located on glutamatergic nerve terminals. |
2001-05-21 |
2023-08-12 |
rat |
| M Penkowa, A Molinero, J Carrasco, J Hidalg. Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures. Neuroscience. vol 102. issue 4. 2001-05-17. PMID:11182244. |
the role of interleukin-6 in hippocampal tissue damage after injection with kainic acid, a rigid glutamate analogue inducing epileptic seizures, has been studied by means of interleukin-6 null mice. |
2001-05-17 |
2023-08-12 |
mouse |
| M P Flavin, G Zha. Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury. Journal of neuroscience research. vol 63. issue 5. 2001-05-17. PMID:11223913. |
whereas glutamate receptor-mediated events are important in cerebral ischemia and tpa has previously been shown to enhance excitotoxicity in hippocampus, we hypothesized that tpa would exaggerate oxygen glucose deprivation (ogd) injury in cultures of hippocampal neurons. |
2001-05-17 |
2023-08-12 |
human |
| P L Chazo. CP-101606 Pfizer Inc. Current opinion in investigational drugs (London, England : 2000). vol 1. issue 3. 2001-05-17. PMID:11249721. |
cp-101606 prevents glutamate-induced toxicity in cultured hippocampal neurons when given during or immediately after glutamate perfusion, (ic50 = 11 and 35 nm, respectively). |
2001-05-17 |
2023-08-12 |
Not clear |
| S Eliasof, H B McIlvain, R E Petroski, A C Foster, J Dunlo. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299317. |
finally, t3mg acts as a poor ionotropic glutamate receptor agonist in cultured hippocampal neurons: concentrations greater than 100 microm t3mg were required to elicit significant nmda receptor-mediated currents. |
2001-05-17 |
2023-08-12 |
xenopus_laevis |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
the authors recently identified prostate apoptosis response-4 (par-4) as a protein that participates in the death of cultured hippocampal neurons induced by trophic factor withdrawal and exposure to glutamate. |
2001-05-17 |
2023-08-12 |
mouse |
| B J Xue, Z A Wang, R R He, S Y H. [Inhibitory effects of nitric oxide on glutamate-induced neuronal activity of CA1 area in rat hippocampal slices]. Sheng li xue bao : [Acta physiologica Sinica]. vol 50. issue 1. 2001-05-17. PMID:11324518. |
taken together, it is likely that glutamate binding with nmda receptors in hippocampal neurons not only induces an increase in discharge, but also activates the l-arg: no pathway to generate no responsible for neuroprotection via negative feedback mechanisms. |
2001-05-17 |
2023-08-12 |
rat |
| O Vergun, A I Sobolevsky, M V Yelshansky, J Keelan, B I Khodorov, M R Duche. Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. The Journal of physiology. vol 531. issue Pt 1. 2001-05-10. PMID:11179399. |
exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. |
2001-05-10 |
2023-08-12 |
rat |