| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dario Siniscalco, Catia Giordano, Carlo Fuccio, Livio Luongo, Franca Ferraraccio, Francesca Rossi, Vito de Novellis, Kevin A Roth, Sabatino Maion. Involvement of subtype 1 metabotropic glutamate receptors in apoptosis and caspase-7 over-expression in spinal cord of neuropathic rats. Pharmacological research. vol 57. issue 3. 2008-07-18. PMID:18325779. |
the effect of the non-selective, 1-aminoindan-1,5-dicarboxylic acid (aida), and selective (3,4-dihydro-2h-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone (jnj16259685), metabotropic glutamate subtype 1 (mglu1) receptor antagonists, on rat sciatic nerve chronic constrictive injury (cci)-induced hyperalgesia, allodynia, spinal dorsal horn apoptosis, and gliosis was examined at 3 and 7 days post-injury. |
2008-07-18 |
2023-08-12 |
rat |
| J Wiedey, M Sipski Alexander, L Marso. Spinal neurons activated in response to pudendal or pelvic nerve stimulation in female rats. Brain research. vol 1197. 2008-05-20. PMID:18242588. |
co-distribution of fos immunoreactive nuclei with the vesicular glutamate transporters (vglut2 and vglut3) and neurokinin i receptors were found in distinct regions of the dorsal horn, medial and lateral gray. |
2008-05-20 |
2023-08-12 |
rat |
| Doris Schoffnegger, Ruth Ruscheweyh, Jürgen Sandkühle. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain. vol 135. issue 3. 2008-05-02. PMID:18262362. |
we studied whether excitation evoked in deep dorsal horn neurons either via stimulation of primary afferent abeta-fibres, by direct electrical stimulation or via glutamate microinjection leads to activation of neurons in the superficial dorsal horn. |
2008-05-02 |
2023-08-12 |
rat |
| Deborah M Hegarty, Jennifer L Mitchell, Kristin C Swanson, Sue A Aiche. Kainate receptors are primarily postsynaptic to SP-containing axon terminals in the trigeminal dorsal horn. Brain research. vol 1184. 2008-04-08. PMID:17964552. |
these results provide anatomical evidence that kars primarily mediate nociceptive transmission postsynaptic to sp-containing afferents and may also modulate the presynaptic release of sp and glutamate in trigeminal dorsal horn. |
2008-04-08 |
2023-08-12 |
rat |
| Carolina Muscoli, Salvatore Cuzzocrea, Michael M Ndengele, Vincenzo Mollace, Frank Porreca, Francesca Fabrizi, Emanuela Esposito, Emanuela Masini, George M Matuschak, Daniela Salvemin. Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. The Journal of clinical investigation. vol 117. issue 11. 2008-04-02. PMID:17975673. |
our studies revealed that development of antinociceptive tolerance to repeated doses of morphine in mice was consistently associated with the appearance of several tyrosine-nitrated proteins in the dorsal horn of the spinal cord, including the mitochondrial isoform of superoxide (o2-) dismutase, the glutamate transporter glt-1, and the enzyme glutamine synthase. |
2008-04-02 |
2023-08-12 |
mouse |
| Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen, Hui-Lin Pa. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. The Journal of pharmacology and experimental therapeutics. vol 324. issue 3. 2008-03-24. PMID:18079355. |
this study provides the important new information that increased nociceptive inflow augments synaptic glycine release to spinal dorsal horn neurons through endogenous glutamate release. |
2008-03-24 |
2023-08-12 |
rat |
| Erika Polgár, Masahiko Watanabe, Bettina Hartmann, Seth Gn Grant, Andrew J Tod. Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn. Molecular pain. vol 4. 2008-03-21. PMID:18215271. |
glutamate receptors of the ampa type (ampars) mediate fast excitatory transmission in the dorsal horn and are thought to underlie perception of both acute and chronic pain. |
2008-03-21 |
2023-08-12 |
mouse |
| Lisa M Thomson, Gregory W Terman, Jinsong Zeng, Janet Lowe, Charles Chavkin, Sam M Hermes, Deborah M Hegarty, Sue A Aiche. Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. The journal of pain. vol 9. issue 1. 2008-03-07. PMID:17950674. |
we have previously observed increased glutamate release in the spinal cord dorsal horn of neonatal rats made tolerant to the opiate morphine. |
2008-03-07 |
2023-08-12 |
rat |
| Hui-Juan Hu, Benedict J Alter, Yarimar Carrasquillo, Chang-Sheng Qiu, Robert W Gerea. Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 48. 2008-01-03. PMID:18045912. |
metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-kv4.2 signaling in spinal cord dorsal horn neurons. |
2008-01-03 |
2023-08-12 |
mouse |
| Mark H Pitcher, Alfredo Ribeiro-da-Silva, Terence J Coderr. Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. The Journal of comparative neurology. vol 505. issue 4. 2007-12-12. PMID:17912745. |
effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group i metabotropic glutamate receptors. |
2007-12-12 |
2023-08-12 |
rat |
| Mark H Pitcher, Alfredo Ribeiro-da-Silva, Terence J Coderr. Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. The Journal of comparative neurology. vol 505. issue 4. 2007-12-12. PMID:17912745. |
inflammatory pain is thought to induce functional plasticity of spinal dorsal horn neurons and may produce changes in glutamate receptor expression. |
2007-12-12 |
2023-08-12 |
rat |
| Mark H Pitcher, Alfredo Ribeiro-da-Silva, Terence J Coderr. Effects of inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors. The Journal of comparative neurology. vol 505. issue 4. 2007-12-12. PMID:17912745. |
plasticity of group i metabotropic glutamate receptors (mglur1 and mglur5) is important in various neuronal systems, and these receptors are also known to modulate nociceptive neurotransmission in the spinal dorsal horn. |
2007-12-12 |
2023-08-12 |
rat |
| P A Giles, D J Trezise, A E Kin. Differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group I metabotropic glutamate receptor subtypes. Neuropharmacology. vol 53. issue 1. 2007-11-09. PMID:17543352. |
differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group i metabotropic glutamate receptor subtypes. |
2007-11-09 |
2023-08-12 |
rat |
| Chaitali Ghosh, Megan Storey-Workley, Sharon Usip, Jen Hafemeister, Kenneth E Miller, Raymond E Papk. Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition. Journal of neuroscience research. vol 85. issue 6. 2007-07-18. PMID:17304580. |
metabotropic glutamate receptors mglur5 in the spinal dorsal horn and their expression over pregnancy were examined in pregnant rats and pregnant rats treated continuously with an antagonist of mglur5, 2-methyl-6-(phenylethynyl) pyridine (mpep). |
2007-07-18 |
2023-08-12 |
rat |
| B A Rooney, E D Crown, C E Hulsebosch, D J McAdo. Preemptive analgesia with lidocaine prevents Failed Back Surgery Syndrome. Experimental neurology. vol 204. issue 2. 2007-06-26. PMID:17261281. |
amino acid concentrations were measured by dorsal horn microdialysis sampling; eaas aspartate and glutamate were significantly increased by 80% and 65% respectively, as were other amino acids compared to sham control values. |
2007-06-26 |
2023-08-12 |
Not clear |
| Yueh-Hua Tai, Yu-Hsueh Wang, Ru-Yin Tsai, Jhi-Joung Wang, Pao-Luh Tao, Tso-Mei Liu, Ya Chin Wang, Chih-Shung Won. Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats. Pain. vol 129. issue 3. 2007-06-12. PMID:17346885. |
long-term morphine infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (gts), glast, glt-1, and eaac1, expression in the rat spinal cord dorsal horn. |
2007-06-12 |
2023-08-12 |
rat |
| Beth K Rycroft, Kristina S Vikman, MacDonald J Christi. Inflammation reduces the contribution of N-type calcium channels to primary afferent synaptic transmission onto NK1 receptor-positive lamina I neurons in the rat dorsal horn. The Journal of physiology. vol 580. issue Pt.3. 2007-06-06. PMID:17303639. |
n-type calcium channels contribute to the release of glutamate from primary afferent terminals synapsing onto nocisponsive neurons in the dorsal horn of the spinal cord, but little is known of functional adaptations to these channels in persistent pain states. |
2007-06-06 |
2023-08-12 |
rat |
| Bernhard Heinke, Jürgen Sandkühle. Group I metabotropic glutamate receptor-induced Ca(2+)-gradients in rat superficial spinal dorsal horn neurons. Neuropharmacology. vol 52. issue 3. 2007-05-01. PMID:17174986. |
group i metabotropic glutamate receptor-induced ca(2+)-gradients in rat superficial spinal dorsal horn neurons. |
2007-05-01 |
2023-08-12 |
rat |
| Bernhard Heinke, Jürgen Sandkühle. Group I metabotropic glutamate receptor-induced Ca(2+)-gradients in rat superficial spinal dorsal horn neurons. Neuropharmacology. vol 52. issue 3. 2007-05-01. PMID:17174986. |
here, we investigated changes in the free cytosolic ca(2+) concentration ([ca(2+)](i)), induced by the pharmacological activation of metabotropic glutamate receptors (mglurs), in nociceptive neurons of the superficial spinal dorsal horn. |
2007-05-01 |
2023-08-12 |
rat |
| Stephen P Schneider, Tracy M Walke. Morphology and electrophysiological properties of hamster spinal dorsal horn neurons that express VGLUT2 and enkephalin. The Journal of comparative neurology. vol 501. issue 5. 2007-04-27. PMID:17299755. |
therefore, we used immunohistochemistry and confocal microscopy to investigate expression of the vglut2 vesicular glutamate transporter, an isoform reported in nonprimary afferent spinal synapses, and enk in electrophysiologically identified neurons of hamster spinal dorsal horn. |
2007-04-27 |
2023-08-12 |
Not clear |