| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naresh Kumar, Andre Laferriere, Jonathan S C Yu, Tanya Poon, Terence J Coderr. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20412385. |
this study demonstrates that group i antagonists and group ii/iii mglur agonists attenuated the enhanced nociception and noxious stimulus-induced glutamate release in spinal cord dorsal horn of cci and/or cfa rats in vivo, and suggests a possible mechanism for their anti-hyperalgesic effects. |
2010-07-19 |
2023-08-12 |
rat |
| Jason G Meisner, Adam D Marsh, Daniel R Mars. Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury. Journal of neurotrauma. vol 27. issue 4. 2010-07-12. PMID:20059302. |
glutamate decarboxylase (gad)65 and gad67 immunohistochemical staining was reduced in the dorsal horn of sci animals. |
2010-07-12 |
2023-08-12 |
mouse |
| Joong Woo Leem, Hee Kee Kim, Claire E Hulsebosch, Young Seob Gwa. Ionotropic glutamate receptors contribute to maintained neuronal hyperexcitability following spinal cord injury in rats. Experimental neurology. vol 224. issue 1. 2010-06-28. PMID:20211179. |
in this study, we examined whether topical treatment of glutamate receptor antagonists attenuate hyperexcitability of lumbar spinal dorsal horn neurons following low thoracic hemisection spinal cord injury in rats. |
2010-06-28 |
2023-08-12 |
rat |
| Rita Bardoni, Alessia Ghirri, Micaela Zonta, Chiara Betelli, Giovanni Vitale, Valentina Ruggieri, Maurizio Sandrini, Giorgio Carmignot. Glutamate-mediated astrocyte-to-neuron signalling in the rat dorsal horn. The Journal of physiology. vol 588. issue Pt 5. 2010-06-02. PMID:20083514. |
the specific action on dorsal horn neurons of agents released from astrocytes, such as glutamate, has been, however, poorly investigated. |
2010-06-02 |
2023-08-12 |
rat |
| D Spicarova, J Palece. Modulation of AMPA excitatory postsynaptic currents in the spinal cord dorsal horn neurons by insulin. Neuroscience. vol 166. issue 1. 2010-05-04. PMID:20005924. |
glutamate ampa receptors are critical for sensory transmission at the spinal cord dorsal horn (dh). |
2010-05-04 |
2023-08-12 |
mouse |
| Ning Lü, Mei Han, Zhi-Lan Yang, Yan-Qing Wang, Gen-Cheng Wu, Yu-Qiu Zhan. Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Pain. vol 148. issue 3. 2010-04-30. PMID:20036056. |
the results showed that the microinjection of n/ofq into the vlpag produced robust decreases in 5-hydroxytryptamine (5-ht, serotonin), norepinephrine (ne), and gamma-aminobutyric acid (gaba), and increase in glutamate (glu) release in the spinal dorsal horn. |
2010-04-30 |
2023-08-12 |
rat |
| Stefan K Georgiev, Hiroshi Baba, Tatsuro Kohn. Nitrous oxide and the inhibitory synaptic transmission in rat dorsal horn neurons. European journal of pain (London, England). vol 14. issue 1. 2010-04-23. PMID:19261495. |
in addition to this indirect facilitation of inhibition in the spinal cord, we previously showed direct inhibition of glutamate receptors in dorsal horn neurons by n(2)o. |
2010-04-23 |
2023-08-12 |
rat |
| Yuyan Hu, Wenbin Li, Lili Lu, Jinsong Cai, Xiaohui Xian, Min Zhang, Qingjun Li, Li L. An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats. Pain. vol 148. issue 2. 2010-04-14. PMID:20022427. |
it was found that intrathecal administration of cef led to the specific up-regulation of glt-1 expression and glutamate uptake ((3)h-glutamate) in the spinal dorsal horn, and similar anti-nociceptive effects to those of intraperitoneal administration of cef. |
2010-04-14 |
2023-08-12 |
rat |
| Max Larsso. Ionotropic glutamate receptors in spinal nociceptive processing. Molecular neurobiology. vol 40. issue 3. 2010-03-25. PMID:19876771. |
glutamate is the predominant excitatory transmitter used by primary afferent synapses and intrinsic neurons in the spinal cord dorsal horn. |
2010-03-25 |
2023-08-12 |
Not clear |
| Max Larsso. Ionotropic glutamate receptors in spinal nociceptive processing. Molecular neurobiology. vol 40. issue 3. 2010-03-25. PMID:19876771. |
this review will cover recent findings on pre- and postsynaptic regulation of synaptic function by ionotropic glutamate receptors in the dorsal horn and how such mechanisms contribute to acute and chronic pain. |
2010-03-25 |
2023-08-12 |
Not clear |
| S Furuta, T Shimizu, M Narita, K Matsumoto, N Kuzumaki, S Horie, T Suzuki, M Narit. Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19772896. |
we found a dramatic increase in the levels of metabotropic glutamate receptor 5, protein kinase c (pkc) gamma and phosphorylated-pkcgamma within the spinal cord dorsal horn in vgx rats, which suggests that vgx may evoke sensory nerve plasticity. |
2010-02-08 |
2023-08-12 |
rat |
| Jun-Wei Zeng, Xiao-Hong Liu, Yan-Dong Zhao, Zhi Xiao, Wen-Juan He, Zhi-An Hu, Huai-Zhen Rua. Role of P2Y1 receptor in astroglia-to-neuron signaling at dorsal spinal cord. Journal of neuroscience research. vol 87. issue 12. 2010-01-12. PMID:19396875. |
adpbetas caused astrocytic glutamate efflux (43 microm), which in turn induced inward currents in dorsal horn neurons with short time in culture. |
2010-01-12 |
2023-08-12 |
Not clear |
| Yong Chen, Helen H Willcockson, Juli G Valtschanof. Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Experimental neurology. vol 220. issue 2. 2009-12-07. PMID:19815011. |
the vanilloid receptor trpv1, a nonselective cation channel in nociceptive sensory afferents, mediates the release of neurotransmitters, such as glutamate and cgrp in the dorsal horn, which can subsequently activate glia. |
2009-12-07 |
2023-08-12 |
mouse |
| Teruyuki Fukushima, Toshiki Ohtsubo, Masayuki Tsuda, Yuchio Yanagawa, Yuuichi Hor. Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn. Journal of neurophysiology. vol 102. issue 3. 2009-10-23. PMID:19369358. |
in this study, we investigated whether gabaergic neurons in the superficial dorsal horn (sdh) express functional 5-ht3 receptors and how these 5-ht3 receptors affect gabaergic inhibitory synaptic transmission in the sdh, by using slice preparations from adult glutamate decarboxylase 67-green fluorescent protein (gad67-gfp) knock-in mice. |
2009-10-23 |
2023-08-12 |
mouse |
| H Kim, L Cui, J Kim, S J Ki. Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn. Neuroscience. vol 160. issue 2. 2009-10-21. PMID:19236908. |
these data suggest that activation of trpv1 potentiates the glutamate release from excitatory terminals of primary afferent fibers and subsequently increases the neural activity of stt neurons of the rat spinal cord deep dorsal horn. |
2009-10-21 |
2023-08-12 |
rat |
| Achim Schmidtko, Ceng Luo, Wei Gao, Gerd Geisslinger, Rohini Kuner, Irmgard Tegede. Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain. vol 139. issue 3. 2009-09-28. PMID:18701217. |
genetic deletion of synapsin ii reduces neuropathic pain due to reduced glutamate but increased gaba in the spinal cord dorsal horn. |
2009-09-28 |
2023-08-12 |
mouse |
| Achim Schmidtko, Ceng Luo, Wei Gao, Gerd Geisslinger, Rohini Kuner, Irmgard Tegede. Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn. Pain. vol 139. issue 3. 2009-09-28. PMID:18701217. |
this was associated with decreased glutamate release in the dorsal horn of the spinal cord upon sciatic nerve injury or capsaicin application onto the sciatic nerve and reduced calcium signals in spinal cord slices upon persistent activation of primary afferents. |
2009-09-28 |
2023-08-12 |
mouse |
| Terumasa Nakatsuka, Meng Chen, Daisuke Takeda, Christopher King, Jennifer Ling, Hong Xing, Toyofumi Ataka, Charles Vierck, Robert Yezierski, Jianguo G G. Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord. Molecular pain. vol 1. 2009-09-16. PMID:15987503. |
conventionally, feedback and feed-forward inhibitory activity evoked by somatosensory input to the dorsal horn is believed to be driven by glutamate, the principle excitatory neurotransmitter in primary afferent fibers. |
2009-09-16 |
2023-08-12 |
Not clear |
| Ke Ren, Svetlana I Novikova, Fang He, Ronald Dubner, Michael S Lido. Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats. Molecular pain. vol 1. 2009-09-16. PMID:16179088. |
to gain an insight into the long-term molecular changes involved in the above-described long-term nociceptive effects of neonatal noxious insult at the spinal level, we performed dna microarray analysis (using microarrays containing oligo-probes for 205 genes encoding receptors and transporters for glutamate, gaba, and amine neurotransmitters, precursors and receptors for neuropeptides, and neurotrophins, cytokines and their receptors) to compare gene expression profiles in the lumbar spinal dorsal horn (ldh) of adult (p60) male rats that received neonatal car treatment within (at postnatal day 3; p3) and outside (at postnatal 12; p12) of the sensitive period. |
2009-09-16 |
2023-08-12 |
rat |
| Haijun Zhang, Wenjun Xin, Patrick M Doughert. Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes. Molecular pain. vol 5. 2009-09-15. PMID:19570219. |
synaptically evoked glutamate transporter currents in spinal dorsal horn astrocytes. |
2009-09-15 |
2023-08-12 |
Not clear |