| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haijun Zhang, Seo-Yeon Yoon, Hongmei Zhang, Patrick M Doughert. Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy. The journal of pain. vol 13. issue 3. 2012-08-02. PMID:22285612. |
prevented activation of astrocytes and downregulation of glial glutamate transporters in spinal dorsal horn induced by paclitaxel. |
2012-08-02 |
2023-08-12 |
rat |
| K M Wozniak, C Rojas, Y Wu, B S Slushe. The role of glutamate signaling in pain processes and its regulation by GCP II inhibition. Current medicinal chemistry. vol 19. issue 9. 2012-07-16. PMID:22304711. |
glutamate is the predominant excitatory neurotransmitter used by primary afferent synapses and neurons in the spinal cord dorsal horn. |
2012-07-16 |
2023-08-12 |
Not clear |
| In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. vol 22. issue 14. 2012-06-04. PMID:21878793. |
a₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. |
2012-06-04 |
2023-08-12 |
rat |
| In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. A₁ receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. vol 22. issue 14. 2012-06-04. PMID:21878793. |
the results suggest that presynaptic a₁ receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons, and thus adenosine a₁ receptors could be a potential target for the treatment of pain of orofacial tissues. |
2012-06-04 |
2023-08-12 |
rat |
| Enshe Jiang, Xisheng Yan, Han-Rong Wen. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn. Journal of neurochemistry. vol 121. issue 4. 2012-05-30. PMID:22339645. |
glial glutamate transporter and glutamine synthetase regulate gabaergic synaptic strength in the spinal dorsal horn. |
2012-05-30 |
2023-08-12 |
rat |
| Enshe Jiang, Xisheng Yan, Han-Rong Wen. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn. Journal of neurochemistry. vol 121. issue 4. 2012-05-30. PMID:22339645. |
we investigated the role of glial glutamate transporters (glt-1 and glast) and glutamine synthetase in maintaining gabaergic synaptic activity in the spinal dorsal horn. |
2012-05-30 |
2023-08-12 |
rat |
| Enshe Jiang, Xisheng Yan, Han-Rong Wen. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn. Journal of neurochemistry. vol 121. issue 4. 2012-05-30. PMID:22339645. |
thus, our results indicate that deficient glial glutamate transporters and glutamine synthetase significantly attenuate gabaergic synaptic strength in the spinal dorsal horn, which may be a crucial synaptic mechanism underlying glial-neuronal interactions caused by dysfunctional astrocytes in pathological pain conditions. |
2012-05-30 |
2023-08-12 |
rat |
| Ian A Napier, Sarasa A Mohammadi, MacDonald J Christi. Glutamate transporter dysfunction associated with nerve injury-induced pain in mice. Journal of neurophysiology. vol 107. issue 2. 2012-05-07. PMID:22072505. |
we then sought to directly determine whether nerve injury results in glutamate spillover to nmdars at dorsal horn synapses. |
2012-05-07 |
2023-08-12 |
mouse |
| Andrzej Dekundy, Andreas Gravius, Mirko Hechenberger, Małgorzata Pietraszek, Jens Nagel, Carsten Tober, Martine van der Elst, Flora Mela, Christopher G Parsons, Wojciech Danys. Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 12. 2012-03-30. PMID:21161716. |
subtype 5 metabotropic glutamate receptors (mglur5) are abundant in the basal ganglia, amygdala, septum, hippocampus, peripheral sensory neurones and dorsal horn of the spinal cord. |
2012-03-30 |
2023-08-12 |
rat |
| Lisa Wu, Jun Wu, Huiyi H Chang, Leif A Havto. Selective plasticity of primary afferent innervation to the dorsal horn and autonomic nuclei following lumbosacral ventral root avulsion and reimplantation in long term studies. Experimental neurology. vol 233. issue 2. 2012-03-26. PMID:22178333. |
we have conducted studies on the effects of the lumbosacral ventral root avulsion and reimplantation models on the afferent innervation of the dorsal horn and autonomic nuclei at both thoracolumbar and lumbosacral levels through immunohistochemistry for the markers calcitonin gene-related peptide (cgrp) and vesicular glutamate transporter 1 (vglut1). |
2012-03-26 |
2023-08-12 |
rat |
| Young Seob Gwak, Claire E Hulsebosc. Neuronal hyperexcitability: a substrate for central neuropathic pain after spinal cord injury. Current pain and headache reports. vol 15. issue 3. 2012-03-07. PMID:21387163. |
after sci, activated primary afferent neurons produce enhanced release of glutamate, neuropeptides, adenosine triphosphate, and proinflammatory cytokines, which are known to be major components for pain transmission in the spinal dorsal horn. |
2012-03-07 |
2023-08-12 |
Not clear |
| Amteshwar Singh Jaggi, Nirmal Sing. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology. vol 291. issue 1-3. 2012-02-06. PMID:22079234. |
anti-cancer agents activate plasma membrane localized ion channels on dorsal root ganglia and dorsal horn neurons including sodium, calcium, potassium, glutamate activated nmda receptors to alter cytosolic ionic mileu particularly intracellular calcium that trigger secondary changes to induce neuropathic pain. |
2012-02-06 |
2023-08-12 |
Not clear |
| Silver Türk, Tiiu Kullisaa. Are prostatitis symptoms associated with an isoprostane-mediated vicious circle? Medical hypotheses. vol 77. issue 5. 2012-02-01. PMID:21855229. |
glutamate mediates the signal to the neurons in the dorsal horn of the spinal cord, and facilitates calcium influx into their mitochondria. |
2012-02-01 |
2023-08-12 |
Not clear |
| Chih-Ping Yang, Chen-Hwan Cherng, Ching-Tang Wu, Hui-Yi Huang, Pao-Luh Tao, Chih-Shung Won. Intrathecal ultra-low dose naloxone enhances the antinociceptive effect of morphine by enhancing the reuptake of excitatory amino acids from the synaptic cleft in the spinal cord of partial sciatic nerve-transected rats. Anesthesia and analgesia. vol 113. issue 6. 2012-01-16. PMID:21865493. |
in this study, we examined the effects of ultra-low dose naloxone on the antinociceptive effect of morphine and on spinal cord dorsal horn glutamate transporter expression in rats with neuropathic pain. |
2012-01-16 |
2023-08-12 |
rat |
| Shotaro Hobo, James C Eisenach, Ken-ichiro Hayashid. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neuroscience letters. vol 502. issue 1. 2012-01-05. PMID:21802494. |
the present study examined effects of repeated administration of valproate on behavioral hypersensitivity and expression of glutamate transporter-1 (glt-1) and glutamate-aspartate transporter (glast) in the spinal dorsal horn in rats after l5-l6 spinal nerve ligation (snl). |
2012-01-05 |
2023-08-12 |
rat |
| Shotaro Hobo, James C Eisenach, Ken-ichiro Hayashid. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neuroscience letters. vol 502. issue 1. 2012-01-05. PMID:21802494. |
repeated oral administration of valproate reduced hypersensitivity, restored down-regulated expression of glt-1 and glast in the spinal dorsal horn, and enhanced analgesia from the glutamate transporter activator riluzole. |
2012-01-05 |
2023-08-12 |
rat |
| A Nowak, H R Mathieson, R J Chapman, G Janzsó, Y Yanagawa, K Obata, G Szabo, A E Kin. Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones. Journal of chemical neuroanatomy. vol 42. issue 1. 2011-11-23. PMID:21440618. |
gabaergic interneurones, including those within spinal dorsal horn, contain one of the two isoforms of the synthesizing enzyme glutamate decarboxylase (gad), either gad65 or gad67. |
2011-11-23 |
2023-08-12 |
mouse |
| Xiao-Gao Jin, Shao-Rui Chen, Xue-Hong Cao, Li Li, Hui-Lin Pa. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. The Journal of biological chemistry. vol 286. issue 38. 2011-11-23. PMID:21813646. |
nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. |
2011-11-23 |
2023-08-12 |
rat |
| Xiao-Gao Jin, Shao-Rui Chen, Xue-Hong Cao, Li Li, Hui-Lin Pa. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. The Journal of biological chemistry. vol 286. issue 38. 2011-11-23. PMID:21813646. |
our findings suggest that spinal endogenous no enhances inhibitory glycinergic input to dorsal horn neurons through sgc-cgmp-protein kinase g. furthermore, no reduces glutamate release from primary afferent terminals through s-nitrosylation of voltage-activated ca(2+) channels. |
2011-11-23 |
2023-08-12 |
rat |
| You-Hong Jin, Motohide Takemura, Akira Furuyama, Norifumi Yonehar. Peripheral glutamate receptors are required for hyperalgesia induced by capsaicin. Pain research and treatment. vol 2012. 2011-11-23. PMID:22110945. |
in the present study, we examined the c-fos expression in spinal cord dorsal horn following injection of drugs associated with glutamate receptors with/without capsaicin into the hindpaw. |
2011-11-23 |
2023-08-12 |
Not clear |