| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xisheng Yan, Ruchi Yadav, Mei Gao, Han-Rong Wen. Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia. vol 62. issue 7. 2015-01-02. PMID:24677092. |
interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase c. excessive activation of glutamate receptors in spinal dorsal horn neurons is a key mechanism leading to abnormal neuronal activation in pathological pain conditions. |
2015-01-02 |
2023-08-12 |
Not clear |
| Xisheng Yan, Ruchi Yadav, Mei Gao, Han-Rong Wen. Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia. vol 62. issue 7. 2015-01-02. PMID:24677092. |
previous studies have shown that activation of glutamate receptors in the spinal dorsal horn is enhanced by impaired glial glutamate transporter functions and proinflammatory cytokines including interleukin-1 beta (il-1β). |
2015-01-02 |
2023-08-12 |
Not clear |
| Xisheng Yan, Ruchi Yadav, Mei Gao, Han-Rong Wen. Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia. vol 62. issue 7. 2015-01-02. PMID:24677092. |
specifically, we demonstrated that nerve injury results in an increased expression of il-1β and activation of pkc in the spinal dorsal horn as well as suppression of glial glutamate uptake activities. |
2015-01-02 |
2023-08-12 |
Not clear |
| Xisheng Yan, Ruchi Yadav, Mei Gao, Han-Rong Wen. Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia. vol 62. issue 7. 2015-01-02. PMID:24677092. |
we provided evidence that the nerve-injury induced suppression of glial glutamate uptake is at least in part ascribed to endogenous il-1β and activation of pkc in the spinal dorsal horn. |
2015-01-02 |
2023-08-12 |
Not clear |
| Xisheng Yan, Ruchi Yadav, Mei Gao, Han-Rong Wen. Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia. vol 62. issue 7. 2015-01-02. PMID:24677092. |
the signaling pathway regulating glial glutamate transporters revealed in this study provides novel targets to attenuate aberrant activation of glutamate receptors in the spinal dorsal horn, which could ultimately help the development of analgesics. |
2015-01-02 |
2023-08-12 |
Not clear |
| Hong Z Yin, Stephen Yu, Cheng-I Hsu, Joe Liu, Allan Acab, Richard Wu, Anna Tao, Benjamin J Chiang, John H Weis. Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Experimental neurology. vol 261. 2014-12-17. PMID:24918341. |
the bmaa exposures induced changes that in many ways resemble those seen in the g93a rats, with degenerative changes in ventral horn motor neurons (mns) with relatively little dorsal horn pathology, marked ventral horn astrogliosis and increased 3-nitrotyrosine labeling in and surrounding mns, a loss of labeling for the astrocytic glutamate transporter, glt-1, surrounding mns, and mild accumulation and aggregation of tdp-43 in the cytosol of some injured and degenerating mns. |
2014-12-17 |
2023-08-13 |
human |
| Pradeep Punnakkal, Carolin von Schoultz, Karen Haenraets, Hendrik Wildner, Hanns Ulrich Zeilhofe. Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn. The Journal of physiology. vol 592. issue 4. 2014-10-20. PMID:24324003. |
here, we have used bac transgenic mice expressing enhanced green fluorescent protein (egfp) under the control of the vesicular glutamate transporter (vglut2) gene (vglut2::egfp mice) to perform a detailed electrophysiological and morphological characterisation of excitatory dorsal horn neurons, and to compare their properties to those of gabaergic (gad67::egfp tagged) and glycinergic (glyt2::egfp tagged) neurons. |
2014-10-20 |
2023-08-12 |
mouse |
| Masayuki Takahashi, Mamoru Takeda, Shigeji Matsumot. Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons. Brain research bulletin. vol 100. 2014-08-22. PMID:24321530. |
immunoreactivity of sst2a receptors was found in layer ii of the c1 dorsal horn in the rat and most of these neurons co-expressed the gaba synthesizing enzyme glutamate decarboxylase 67. |
2014-08-22 |
2023-08-12 |
rat |
| Seok-Gwon Jeong, In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. Cholinergic modulation of primary afferent glutamatergic transmission in rat medullary dorsal horn neurons. Neuropharmacology. vol 75. 2014-08-19. PMID:23954675. |
in addition, muscarine reduced the frequency of miniature epscs without affecting the current amplitude, suggesting that muscarine acts presynaptically to decrease the probability of glutamate release onto medullary dorsal horn neurons. |
2014-08-19 |
2023-08-12 |
rat |
| Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanill. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24384038. |
neurochemical studies using concentric microdialysis in the ipsilateral dorsal horn of awake, freely moving rats revealed that the systemic s1ra-induced antinociceptive effect occurs concomitantly with an enhancement of noradrenaline levels and an attenuation of formalin-evoked glutamate release in the spinal dorsal horn. |
2014-06-04 |
2023-08-12 |
rat |
| Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanill. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24384038. |
formalin-induced nociceptive effect occurs concomitantly with an enhancement of glutamate (glu) level in the dorsal horn spinal cord. |
2014-06-04 |
2023-08-12 |
rat |
| Han-Rong Weng, Mei Gao, Dylan W Maixne. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Experimental neurology. vol 252. 2014-03-10. PMID:24275526. |
glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. |
2014-03-10 |
2023-08-12 |
rat |
| Han-Rong Weng, Mei Gao, Dylan W Maixne. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Experimental neurology. vol 252. 2014-03-10. PMID:24275526. |
dysfunctional glial glutamate transporters and over production of pro-inflammatory cytokines (including interleukin-1β, il-1β) are two prominent mechanisms by which glial cells enhance neuronal activities in the spinal dorsal horn in neuropathic pain conditions. |
2014-03-10 |
2023-08-12 |
rat |
| Han-Rong Weng, Mei Gao, Dylan W Maixne. Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Experimental neurology. vol 252. 2014-03-10. PMID:24275526. |
in this study, we revealed a dynamic alteration of gsk3β activities and its role in regulating glial glutamate transporter 1 (glt-1) protein expression in the spinal dorsal horn and nociceptive behaviors following the nerve injury. |
2014-03-10 |
2023-08-12 |
rat |
| Chih-Ping Yang, Chen-Hwan Cherng, Ching-Tang Wu, Hui-Yi Huang, Pao-Luh Tao, Sing-Ong Lee, Chih-Shung Won. Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection. Anesthesia and analgesia. vol 117. issue 6. 2014-01-16. PMID:24257399. |
we designed this investigation to examine whether ultra-low dose naloxone administered alone or in combination with morphine could alter the concentration of the excitatory amino acids (eaas) glutamate and aspartate, as well as the expression of tumor necrosis factor-α (tnf-α) and its receptors (tnfr1 and tnfr2) in the spinal cord dorsal horn of rats with partial sciatic nerve transection (pst). |
2014-01-16 |
2023-08-12 |
rat |
| Rita Bardon. Role of presynaptic glutamate receptors in pain transmission at the spinal cord level. Current neuropharmacology. vol 11. issue 5. 2014-01-09. PMID:24403871. |
nociceptive primary afferents release glutamate, activating postsynaptic glutamate receptors on spinal cord dorsal horn neurons. |
2014-01-09 |
2023-08-12 |
Not clear |
| Rita Bardon. Role of presynaptic glutamate receptors in pain transmission at the spinal cord level. Current neuropharmacology. vol 11. issue 5. 2014-01-09. PMID:24403871. |
this review describes the subunit composition, distribution and function of presynaptic glutamate ionotropic (ampa, nmda, kainate) and metabotropic receptors expressed in rodent spinal cord dorsal horn. |
2014-01-09 |
2023-08-12 |
Not clear |
| b' Xisheng Yan, \\xe5\\x96\\x9c\\xe8\\x83\\x9c \\xe4\\xb8\\xa5, Han-Rong Weng, \\xe6\\xb1\\x89\\xe8\\x8d\\xa3 \\xe7\\xbf\\x8. Endogenous interleukin-1\\xce\\xb2 in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003233.' |
endogenous interleukin-1β in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic n-methyl-d-aspartic acid receptors. |
2013-12-31 |
2023-08-12 |
rat |
| b' Xisheng Yan, \\xe5\\x96\\x9c\\xe8\\x83\\x9c \\xe4\\xb8\\xa5, Han-Rong Weng, \\xe6\\xb1\\x89\\xe8\\x8d\\xa3 \\xe7\\xbf\\x8. Endogenous interleukin-1\\xce\\xb2 in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003233.' |
excessive activation of glutamate receptors and overproduction of proinflammatory cytokines, including interleukin-1β (il-1β) in the spinal dorsal horn, are key mechanisms underlying the development and maintenance of neuropathic pain. |
2013-12-31 |
2023-08-12 |
rat |
| b' Xisheng Yan, \\xe5\\x96\\x9c\\xe8\\x83\\x9c \\xe4\\xb8\\xa5, Han-Rong Weng, \\xe6\\xb1\\x89\\xe8\\x8d\\xa3 \\xe7\\xbf\\x8. Endogenous interleukin-1\\xce\\xb2 in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24003233.' |
we demonstrated that endogenous il-1β in neuropathic rats enhances glutamate release from the primary afferent terminals and non-nmda glutamate receptor activities in postsynaptic neurons in the spinal dorsal horn. |
2013-12-31 |
2023-08-12 |
rat |