| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| You-Hong Jin, Motohide Takemura, Akira Furuyama, Norifumi Yonehar. Peripheral glutamate receptors are required for hyperalgesia induced by capsaicin. Pain research and treatment. vol 2012. 2011-11-23. PMID:22110945. |
the subcutaneous injection of capsaicin or glutamate remarkably evoked c-fos expression in ipsilateral sides of spinal cord dorsal horn. |
2011-11-23 |
2023-08-12 |
Not clear |
| Hui-Juan Hu, Robert W Gerea. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn. Journal of neurophysiology. vol 105. issue 6. 2011-10-14. PMID:21451053. |
metabotropic glutamate receptor 5 regulates excitability and kv4.2-containing k⁺ channels primarily in excitatory neurons of the spinal dorsal horn. |
2011-10-14 |
2023-08-12 |
mouse |
| Hui-Juan Hu, Robert W Gerea. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn. Journal of neurophysiology. vol 105. issue 6. 2011-10-14. PMID:21451053. |
immunofluorescence studies revealed that kv4.2 was highly colocalized with markers of excitatory neurons, such as vesicular glutamate transporter 1/2, pkcγ, and neurokinin 1, in cultured dorsal horn neurons. |
2011-10-14 |
2023-08-12 |
mouse |
| Young S Gwak, Claire E Hulsebosc. GABA and central neuropathic pain following spinal cord injury. Neuropharmacology. vol 60. issue 5. 2011-10-03. PMID:21216257. |
however, hyperexcitable neurons and glial activation after spinal cord injury disrupts the balance of chloride ions, glutamate and gaba distribution in the spinal dorsal horn and results in chronic neuropathic pain. |
2011-10-03 |
2023-08-12 |
Not clear |
| Max Larsson, Jonas Broma. Synaptic plasticity and pain: role of ionotropic glutamate receptors. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 17. issue 3. 2011-09-12. PMID:20360599. |
here, the authors review recent findings on the roles of ionotropic glutamate receptors in synaptic plasticity in the dorsal horn in relation to acute and persistent pain. |
2011-09-12 |
2023-08-12 |
Not clear |
| Kohei Koga, Tao Chen, Xiang-Yao Li, Giannina Descalzi, Jennifer Ling, Jianguo Gu, Min Zhu. Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Molecular pain. vol 7. 2011-09-12. PMID:21699733. |
finally, we found that evoked sensory responses between primary afferent c fibers and grp positive superficial dorsal horn neurons are mediated by glutamate but not grp. |
2011-09-12 |
2023-08-12 |
mouse |
| Kohei Koga, Tao Chen, Xiang-Yao Li, Giannina Descalzi, Jennifer Ling, Jianguo Gu, Min Zhu. Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Molecular pain. vol 7. 2011-09-12. PMID:21699733. |
our findings provide the direct evidence that glutamate is the principal excitatory transmitter between c fibers and grp positive dorsal horn neurons. |
2011-09-12 |
2023-08-12 |
mouse |
| Santina Chiechio, Agata Copani, Magda Zammataro, Giuseppe Battaglia, Robert W Gereau, Ferdinando Nicolett. Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain. Trends in pharmacological sciences. vol 31. issue 4. 2011-08-05. PMID:20064669. |
activation of metabotropic glutamate 2 (mglu2) receptors inhibits pain transmission at the synapses between primary afferent fibers and neurons in the dorsal horn of the spinal cord. |
2011-08-05 |
2023-08-12 |
Not clear |
| F Wei, Z Zha. Synaptic organization of substance P, glutamate and GABA-immunoreactive boutons on functionally identified neurons in cat spinal deeper dorsal horn. Science in China. Series C, Life sciences. vol 40. issue 5. 2011-07-14. PMID:20229302. |
synaptic organization of substance p, glutamate and gaba-immunoreactive boutons on functionally identified neurons in cat spinal deeper dorsal horn. |
2011-07-14 |
2023-08-12 |
cat |
| Xue Jun Liu, Michael W Salte. Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn. The European journal of neuroscience. vol 32. issue 2. 2011-01-25. PMID:20629726. |
glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn. |
2011-01-25 |
2023-08-12 |
Not clear |
| Shao-Rui Chen, Hong Chen, Wei-Xiu Yuan, Jürgen Wess, Hui-Lin Pa. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. The Journal of biological chemistry. vol 285. issue 52. 2011-01-24. PMID:20940295. |
our study demonstrates that activation of the m(2) and m(4) receptor subtypes inhibits synaptic glutamate release to dorsal horn neurons. |
2011-01-24 |
2023-08-12 |
mouse |
| H Nie, H Zhang, H R Wen. Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20678556. |
activation of glutamate receptors and glial cells in the spinal dorsal horn are two fundamental processes involved in the pathogenesis of various pain conditions, including neuropathic pain induced by injury to the peripheral or central nervous systems. |
2011-01-11 |
2023-08-12 |
rat |
| Hui Nie, Haijun Zhang, Han-Rong Wen. Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses. Journal of neurophysiology. vol 104. issue 2. 2010-12-01. PMID:20554846. |
on pharmacological blockade of glutamate transporters, slow inward currents (sics) appeared spontaneously and/or were evoked by peripheral synaptic input in the spinal superficial dorsal horn neurons, including the spinothalamic tract neurons. |
2010-12-01 |
2023-08-12 |
Not clear |
| Hui Nie, Haijun Zhang, Han-Rong Wen. Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses. Journal of neurophysiology. vol 104. issue 2. 2010-12-01. PMID:20554846. |
glial-derived glutamate acted on extrasynaptic n-methyl-d-aspartate (nmda) receptors mainly composed of nr2b receptors and generated sics, which led to depolarization and action potential generation in superficial spinal dorsal horn neurons. |
2010-12-01 |
2023-08-12 |
Not clear |
| Hui Nie, Han-Rong Wen. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. Journal of neurophysiology. vol 103. issue 5. 2010-08-25. PMID:20220084. |
glial cell dysfunction and excessive glutamate receptor activation in spinal dorsal horn neurons are hallmark mechanisms of pathological pain. |
2010-08-25 |
2023-08-12 |
rat |
| Hui Nie, Han-Rong Wen. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. Journal of neurophysiology. vol 103. issue 5. 2010-08-25. PMID:20220084. |
we and others recently reported the downregulation of glial glutamate transporter (gt) protein expression in the spinal dorsal horn of neuropathic rats. |
2010-08-25 |
2023-08-12 |
rat |
| Hui Nie, Han-Rong Wen. Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats. Journal of neurophysiology. vol 103. issue 5. 2010-08-25. PMID:20220084. |
it is suggested that extrasynaptic glutamate spillover may be a key synaptic mechanism related to phenotypic alterations induced by nerve injury in the spinal dorsal horn and that glial gts are potential new targets in the development of analgesics. |
2010-08-25 |
2023-08-12 |
rat |
| Tao Chen, Kohei Koga, Xiang-Yao Li, Min Zhu. Spinal microglial motility is independent of neuronal activity and plasticity in adult mice. Molecular pain. vol 6. 2010-08-25. PMID:20380706. |
we found that local application of spinal excitatory neurotransmitters, such as glutamate and substance p did not cause any change in the motility of microglial cells in the spinal cord dorsal horn. |
2010-08-25 |
2023-08-12 |
mouse |
| Naresh Kumar, Andre Laferriere, Jonathan S C Yu, Tanya Poon, Terence J Coderr. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20412385. |
metabotropic glutamate receptors (mglurs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. |
2010-07-19 |
2023-08-12 |
rat |
| Naresh Kumar, Andre Laferriere, Jonathan S C Yu, Tanya Poon, Terence J Coderr. Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20412385. |
here, we used behavioral nociceptive testing and in vivo microdialysis to assess the effect of intrathecal treatment with group i mglur antagonists [cyclopropan[b] chromen-1a-carboxylate, (cpccoet), 2-methyl-6-(phenylethynyl) pyridine (mpep)] or groups ii [aminopyrrolidine-2r,4r-dicarboxylate (apdc)] and iii [l-2-amino-4-phosphonobutyrate (l-ap4)] mglur agonists or vehicle, on nociception and noxious stimulus-induced increases in glutamate release in the spinal cord dorsal horn of rats with a chronic constriction injury (cci) of the sciatic nerve or hind paw injection of complete freund's adjuvant (cfa). |
2010-07-19 |
2023-08-12 |
rat |