| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haijun Zhang, Wenjun Xin, Patrick M Doughert. Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes. Molecular pain. vol 5. 2009-09-15. PMID:19570219. |
the goal of this study was to characterize glutamate transporter function in astrocytes of the spinal cord dorsal horn in real time by recording synaptically evoked glutamate transporter currents. |
2009-09-15 |
2023-08-12 |
Not clear |
| Ru-Rong Ji, Robert W Gereau, Marzia Malcangio, Gary R Strichart. MAP kinase and pain. Brain research reviews. vol 60. issue 1. 2009-08-04. PMID:19150373. |
in particular, erk activation in spinal cord dorsal horn neurons by nociceptive activity, via multiple neurotransmitter receptors, and using different second messenger pathways plays a critical role in central sensitization by regulating the activity of glutamate receptors and potassium channels and inducing gene transcription. |
2009-08-04 |
2023-08-12 |
Not clear |
| Gerald W Zamponi, Richard J Lewis, Slobodan M Todorovic, Stephen P Arneric, Terrance P Snutc. Role of voltage-gated calcium channels in ascending pain pathways. Brain research reviews. vol 60. issue 1. 2009-08-04. PMID:19162069. |
n-type calcium channels are localized to synaptic nerve terminals in laminae 1 and 2 of the dorsal horn where their opening results in the release of neurotransmitters such as glutamate and substance p. the contribution of n-type channels to the processing of pain signals is regulated by alternate splicing of the n-type channel gene, with unique n-type channel splice variants being expressed in small nociceptive neurons. |
2009-08-04 |
2023-08-12 |
Not clear |
| A S Hughes, S Averill, V R King, C Molander, P J Shortlan. Neurochemical characterization of neuronal populations expressing protein kinase C gamma isoform in the spinal cord and gracile nucleus of the rat. Neuroscience. vol 153. issue 2. 2009-06-29. PMID:18387748. |
we show that approximately 90% of the pkcgamma cells in the gracile nucleus and 60% in the dorsal horn were immuno-positive for the ampa receptor subunit glutamate 2/3 (glur2/3). |
2009-06-29 |
2023-08-12 |
rat |
| b' J Galik, D-H Youn, M Kolaj, M Randi\\xc4\\x8. Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18554818.' |
involvement of group i metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn. |
2009-06-29 |
2023-08-12 |
mouse |
| b' J Galik, D-H Youn, M Kolaj, M Randi\\xc4\\x8. Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn. Neuroscience. vol 154. issue 4. 2009-06-29. PMID:18554818.' |
our experiments demonstrate a novel role for group i metabotropic glutamate receptor (mglur) subtypes 1 and 5 in generating a long-lasting synaptic excitation in the substantia gelatinosa (sg) and deep dorsal horn (dh) neurons of the rat spinal cord. |
2009-06-29 |
2023-08-12 |
mouse |
| Wen-Jun Xin, Han-Rong Weng, Patrick M Doughert. Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation. Molecular pain. vol 5. 2009-06-24. PMID:19323820. |
plasticity in expression of the glutamate transporters glt-1 and glast in spinal dorsal horn glial cells following partial sciatic nerve ligation. |
2009-06-24 |
2023-08-12 |
rat |
| Hui Nie, Han-Rong Wen. Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn. Journal of neurophysiology. vol 101. issue 4. 2009-05-26. PMID:19211657. |
glutamate transporters prevent excessive activation of nmda receptors and extrasynaptic glutamate spillover in the spinal dorsal horn. |
2009-05-26 |
2023-08-12 |
rat |
| Hui Nie, Han-Rong Wen. Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn. Journal of neurophysiology. vol 101. issue 4. 2009-05-26. PMID:19211657. |
these data indicate that glutamate transporters regulate spatiotemporal and intensity coding for sensory input and prevent excessive activation of glutamate receptors in the spinal dorsal horn. |
2009-05-26 |
2023-08-12 |
rat |
| Liling Yang, Shuxing Wang, Grewo Lim, Backil Sung, Qing Zeng, Jianren Ma. Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine tolerance. Pain. vol 140. issue 3. 2009-04-17. PMID:18986766. |
the results showed that mg-132 (5 nmol) given intrathecally blocked morphine-induced glutamate transporter downregulation and the decrease in glutamate uptake activity within the spinal cord dorsal horn. |
2009-04-17 |
2023-08-12 |
rat |
| David L Somers, F Richard Clement. Contralateral high or a combination of high- and low-frequency transcutaneous electrical nerve stimulation reduces mechanical allodynia and alters dorsal horn neurotransmitter content in neuropathic rats. The journal of pain. vol 10. issue 2. 2009-04-17. PMID:19010735. |
daily high frequency tens elevated the dorsal horn synaptosomal content of gaba bilaterally (p < .014) and a combination of high- and low-frequency tens elevated the dorsal horn content of aspartate (p < .001), glutamate (p < .001) and glycine (p < .001) bilaterally over that seen in untreated cci rats. |
2009-04-17 |
2023-08-12 |
rat |
| David Nguyen, Ping Deng, Elizabeth A Matthews, Doo-Sik Kim, Guoping Feng, Anthony H Dickenson, Zao C Xu, Z David Lu. Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity. Molecular pain. vol 5. 2009-04-13. PMID:19216737. |
together, these findings support a mechanism of cavalpha2delta1-mediated spinal sensitization in which elevated cavalpha2delta1 causes increased pre-synaptic glutamate release that leads to reduced excitation thresholds of post-synaptic dorsal horn neurons to innocuous stimuli. |
2009-04-13 |
2023-08-12 |
mouse |
| Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, Hui-Lin Pa. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. Journal of neurochemistry. vol 108. issue 1. 2009-04-08. PMID:19012737. |
immunocytochemical labeling revealed that trpv1 and vesicular glutamate transporter-2 were colocalized in dorsal horn neurons and their terminals in the rat spinal cord. |
2009-04-08 |
2023-08-12 |
rat |
| Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, Hui-Lin Pa. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. Journal of neurochemistry. vol 108. issue 1. 2009-04-08. PMID:19012737. |
resiniferatoxin (rtx) treatment or dorsal rhizotomy ablated trpv1-expressing primary afferents but did not affect trpv1- and vesicular glutamate transporter-2-expressing dorsal horn neurons. |
2009-04-08 |
2023-08-12 |
rat |
| Meng Chen, Yuan-Xiang Tao, Jianguo G G. Inward currents induced by ischemia in rat spinal cord dorsal horn neurons. Molecular pain. vol 3. 2009-01-19. PMID:17459156. |
our results suggest that ischemia caused reversal operation of glutamate transporters, leading to the release of glutamate via glutamate transporters and the subsequent activation of glutamate receptors in the spinal dorsal horn neurons. |
2009-01-19 |
2023-08-12 |
rat |
| Jui-An Lin, Ru-Yin Tsai, Yueh-Tzeng Lin, Meei-Shyuan Lee, Chen-Hwan Cherng, Chih-Shung Wong, Jann-Inn Tzen. Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters. Brain research. vol 1232. 2008-12-08. PMID:18680732. |
the expression of glutamate transporters (gts) in the spinal cord dorsal horn was also measured. |
2008-12-08 |
2023-08-12 |
rat |
| Miklós Antal, Yugo Fukazawa, Mária Eördögh, Dóra Muszil, Elek Molnár, Makoto Itakura, Masami Takahashi, Ryuichi Shigemot. Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815255. |
numbers, densities, and colocalization of ampa- and nmda-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats. |
2008-11-12 |
2023-08-12 |
rat |
| Miklós Antal, Yugo Fukazawa, Mária Eördögh, Dóra Muszil, Elek Molnár, Makoto Itakura, Masami Takahashi, Ryuichi Shigemot. Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 39. 2008-11-12. PMID:18815255. |
here we applied highly sensitive freeze-fracture replica labeling to laminae i-ii of the spinal dorsal horn of rats and investigated the numbers, densities, and colocalization of ampa- and nmda-type glutamate receptors at individual postsynaptic membrane specializations with a high resolution. |
2008-11-12 |
2023-08-12 |
rat |
| Liling Yang, Shuxing Wang, Backil Sung, Grewo Lim, Jianren Ma. Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation. The Journal of biological chemistry. vol 283. issue 31. 2008-09-22. PMID:18539596. |
under an in vivo condition, chronic morphine exposure also induced posttranscriptional down-regulation of the glutamate transporter eaac1, which was prevented by mg-132, and transcriptional up-regulation of pten and nedd4 within the spinal cord dorsal horn. |
2008-09-22 |
2023-08-12 |
Not clear |
| Loïs S Miraucourt, Radhouane Dallel, Daniel L Voisi. Glycine inhibitory dysfunction turns touch into pain through PKCgamma interneurons. PloS one. vol 2. issue 11. 2008-08-21. PMID:17987109. |
selective inhibition of pkcgamma as well as selective blockade of glutamate nmda receptors in the superficial dorsal horn prevented both activation of the circuit and allodynia. |
2008-08-21 |
2023-08-12 |
rat |