| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rebecca A Maile, Elise Morgan, Jeff Bagust, Robert J Walke. Effects of amino acid antagonists on spontaneous dorsal root activity and evoked dorsal horn field potentials in an isolated preparation of rat spinal cord. The International journal of neuroscience. vol 117. issue 1. 2007-04-10. PMID:17365101. |
these results suggest that non-nmda glutamate receptors are involved in low and high threshold transmission to dorsal horn neurones while nmda and metabotropic glutamate receptors are primarily involved in high threshold transmission and both gaba and glycine have roles in the transmission or modulation of sensory information within the dorsal horn of the cord. |
2007-04-10 |
2023-08-12 |
rat |
| T J Coderre, N Kumar, C D Lefebvre, J S C Y. A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17241130. |
the highest doses of each of the agents were also assessed on formalin-induced nociceptive behaviors and on formalin-induced increases in extracellular glutamate (glu) and aspartate (asp) in the spinal cord dorsal horn (scdh) of awake behaving rats using in vivo microdialysis. |
2007-04-02 |
2023-08-12 |
rat |
| Hong-Mei Zhang, Shao-Rui Chen, Hui-Lin Pa. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. Journal of neurophysiology. vol 97. issue 1. 2007-03-09. PMID:17050831. |
the m(3) and m(2)/m(4) subtypes on a subpopulation of interneurons are important for regulation of glutamate release from interneurons in the spinal dorsal horn. |
2007-03-09 |
2023-08-12 |
rat |
| Hong-Yi Zhou, Hong-Mei Zhang, Shao-Rui Chen, Hui-Lin Pa. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. Journal of neurophysiology. vol 97. issue 1. 2007-03-09. PMID:17108089. |
our study provides novel information that stimulation of nociceptive primary afferents rapidly suppresses gabaergic input to many dorsal horn neurons through endogenous glutamate and activation of presynaptic group ii and group iii metabotropic glutamate receptors. |
2007-03-09 |
2023-08-12 |
rat |
| Kan Miyoshi, Minoru Narita, Michiko Narita, Tsutomu Suzuk. Involvement of mGluR5 in the ethanol-induced neuropathic pain-like state in the rat. Neuroscience letters. vol 410. issue 2. 2007-01-23. PMID:17081689. |
under these conditions, an immunohistochemical study showed an increase in metabotropic glutamate receptor 5 (mglur5) immunoreactivity in the superficial spinal dorsal horn of chronic ethanol-fed rats. |
2007-01-23 |
2023-08-12 |
rat |
| Lisa M Thomson, Jinsong Zeng, Gregory W Terma. Differential effect of glutamate transporter inhibition on EPSCs in the morphine naïve and morphine tolerant neonatal spinal cord slice. Neuroscience letters. vol 407. issue 1. 2006-11-14. PMID:16949209. |
we directly tested this hypothesis by comparing the effects of glutamate transporter inhibition on excitatory post-synaptic currents (epscs) in the spinal cord dorsal horn of opiate naïve and opiate tolerant rats. |
2006-11-14 |
2023-08-12 |
rat |
| L M Thomson, J Zeng, G W Terma. An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. Neuroscience. vol 141. issue 3. 2006-10-18. PMID:16750886. |
conversely, increasing dorsal horn synaptic glutamate release by gabaa or glycine inhibition increased spontaneous oscillating intermittent synaptic current frequency. |
2006-10-18 |
2023-08-12 |
rat |
| Yueh-Hua Tai, Yu-Hsueh Wang, Jhi-Joung Wang, Pao-Luh Tao, Che-Se Tung, Chih-Shung Won. Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats. Pain. vol 124. issue 1-2. 2006-09-21. PMID:16697108. |
the results showed that amitriptyline alone did not produce an antinociceptive effect, while morphine alone induced antinociceptive tolerance and down-regulation of spinal glutamate transporters (glast, glt-1, and eaac1) in the rat spinal cord dorsal horn. |
2006-09-21 |
2023-08-12 |
rat |
| Masami Suzuki, Minoru Narita, Michiko Narita, Keiichi Niikura, Tsutomu Suzuk. Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord. Neuroscience letters. vol 399. issue 3. 2006-07-26. PMID:16510246. |
in the present study, we found that mice that were tolerant to morphine-induced antinociception exhibited an increase in immunoreactivity for the neural cell adhesion molecule in the dorsal horn of the spinal cord, which was highly overlapped with immunoreactivity for the increased metabotropic glutamate receptor 5 induced by morphine. |
2006-07-26 |
2023-08-12 |
mouse |
| Itsaso Buesa, Vicente Ortiz, Luciano Aguilera, Fernando Torre, Manfred Zimmermann, Jon Jatsu Azku. Disinhibition of spinal responses to primary afferent input by antagonism at GABA receptors in urethane-anaesthetised rats is dependent on NMDA and metabotropic glutamate receptors. Neuropharmacology. vol 50. issue 5. 2006-07-06. PMID:16412481. |
in the present work, extracellular field potentials elicited by electrical peripheral nerve activation were recorded in the urethane-anaesthetised rat following spinal administration of gaba(a) or gaba(b) receptor-antagonists, and the involvement of glutamate receptors of the nmda and metabotropic types in changes induced by altered gabaergic function was examined by pre-treating the spinal dorsal horn with appropriate antagonist drugs. |
2006-07-06 |
2023-08-12 |
rat |
| H-R Weng, J H Chen, J P Cat. Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Neuroscience. vol 138. issue 4. 2006-06-08. PMID:16426766. |
inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. |
2006-06-08 |
2023-08-12 |
rat |
| H-R Weng, J H Chen, J P Cat. Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation. Neuroscience. vol 138. issue 4. 2006-06-08. PMID:16426766. |
this study indicates that glutamate transporters regulate baseline excitability and responses of dorsal horn neurons to peripheral stimulation, and suggests that dysfunction of glutamate transporters may contribute to certain types of pathological pain. |
2006-06-08 |
2023-08-12 |
rat |
| P Brumovsky, C Hofstetter, L Olson, G Ohning, M Villar, T Hökfel. The neuropeptide tyrosine Y1R is expressed in interneurons and projection neurons in the dorsal horn and area X of the rat spinal cord. Neuroscience. vol 138. issue 4. 2006-06-08. PMID:16448775. |
eur j neurosci 11:2211-2225] and are presumably glutamatergic [todd aj, hughes di, polgar e, nagy gg, mackie m, ottersen op, maxwell dj (2003) the expression of vesicular glutamate transporters vglut1 and vglut2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. |
2006-06-08 |
2023-08-12 |
rat |
| J P Cata, H-R Weng, J-H Chen, P M Doughert. Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16361064. |
changes in the signaling of wide dynamic range neurons and the expression of glutamate transporters in the lumbar spinal dorsal horn of rats with taxol-induced hyperalgesia are detailed in this report. |
2006-05-24 |
2023-08-12 |
rat |
| J P Cata, H-R Weng, J-H Chen, P M Doughert. Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxel-induced hyperalgesia. Neuroscience. vol 138. issue 1. 2006-05-24. PMID:16361064. |
the expression of glutamate transporter proteins in the dorsal horn is decreased at the time point corresponding to the physiological changes. |
2006-05-24 |
2023-08-12 |
rat |
| Shuxing Wang, Grewo Lim, Liling Yang, Backil Sung, Jianren Ma. Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats. Pain. vol 120. issue 1-2. 2006-03-30. PMID:16360273. |
previous studies have shown that glucocorticoid receptors (gr) were upregulated, whereas glutamate transporters were downregulated, within the spinal cord dorsal horn after peripheral nerve injury. |
2006-03-30 |
2023-08-12 |
rat |
| Simona Lucifora, Helen H Willcockson, Chun-Rong Lu, Melanie Darstein, Kris D Phend, Juli G Valtschanoff, Aldo Rustion. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Pain. vol 120. issue 1-2. 2006-03-30. PMID:16360275. |
presynaptic ionotropic glutamate receptors are increasingly attributed a role in the modulation of sensory input at the first synapse of dorsal root ganglion (drg) neurons in the spinal dorsal horn. |
2006-03-30 |
2023-08-12 |
rat |
| Chun Lin, Elie D Al-Chae. Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. World journal of gastroenterology. vol 11. issue 41. 2006-03-21. PMID:16425422. |
differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. |
2006-03-21 |
2023-08-12 |
rat |
| Chun Lin, Elie D Al-Chae. Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model. World journal of gastroenterology. vol 11. issue 41. 2006-03-21. PMID:16425422. |
to investigate and compare the effects of spinal d-(-)-2-amino-7-phosphonoheptanoic acid (ap-7) and 6-cyano-7-nitroquinoxaline-2,3-dione disodium (cnqx), two glutamate receptor antagonists, on the responses of dorsal horn neurons to colorectal distension (crd) in adult rats exposed to neonatal colon irritation (ci). |
2006-03-21 |
2023-08-12 |
rat |
| N J Langman, C G S Smith, K J Whitehea. Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo. Pharmacological research. vol 53. issue 2. 2006-02-27. PMID:16280247. |
selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo. |
2006-02-27 |
2023-08-12 |
rat |