| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J T Potts, J F R Paton, J H Mitchell, M G Garry, G Kline, P T Anguelov, S M Le. Contraction-sensitive skeletal muscle afferents inhibit arterial baroreceptor signalling in the nucleus of the solitary tract: role of intrinsic GABA interneurons. Neuroscience. vol 119. issue 1. 2003-07-28. PMID:12763081. |
biotinylated dextran amine (bda, 10%, 25-100 nl) microinjection into dorsal horn of the cervical spinal cord was combined with glutamate decarboxylase (gad) immunohistochemistry to visualize the nature of the relationship of bda-labeled fibers in the nts with gad immunoreactivity (gad-ir). |
2003-07-28 |
2023-08-12 |
rat |
| Aldric T Ham. Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat. Neuropharmacology. vol 44. issue 4. 2003-07-03. PMID:12646279. |
activation of spinal cord dorsal horn ionotropic glutamate receptors leads to pain-related behaviors. |
2003-07-03 |
2023-08-12 |
rat |
| Y Manabe, J M Wang, M Shiote, T Murakami, I Nagano, M Shoji, K Ab. Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats. Neurological research. vol 25. issue 3. 2003-06-06. PMID:12739245. |
with addition of glutamate to primary culture of 11-day-old rat spinal cord, the number of caspase-3 positive small neurons of the dorsal horn greatly increased at 6-24 h in contrast to the case with vehicle. |
2003-06-06 |
2023-08-12 |
rat |
| M J Olave, D J Maxwel. Axon terminals possessing the alpha 2c-adrenergic receptor in the rat dorsal horn are predominantly excitatory. Brain research. vol 965. issue 1-2. 2003-05-01. PMID:12591145. |
in this study we used confocal microscopy to show that most (83.67%) alpha(2c)-adrenergic receptor (alpha(2c)-ar)-immunoreactive terminals in the superficial dorsal horn contain the vesicular glutamate transporter 2 and hence are glutamatergic. |
2003-05-01 |
2023-08-12 |
rat |
| Dominique Derjean, Sandrine Bertrand, Gwendal Le Masson, Marc Landry, Valérie Morisset, Frédéric Nag. Dynamic balance of metabotropic inputs causes dorsal horn neurons to switch functional states. Nature neuroscience. vol 6. issue 3. 2003-04-30. PMID:12592405. |
we show here that deep dorsal horn neurons (dhns) in wistar rats can switch their intrinsic firing properties from tonic to plateau or endogenous bursting patterns, depending upon the balance of control by metabotropic glutamate (mglu) and gaba(b) receptors. |
2003-04-30 |
2023-08-12 |
rat |
| A J Todd, D I Hughes, E Polgár, G G Nagy, M Mackie, O P Ottersen, D J Maxwel. The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. The European journal of neuroscience. vol 17. issue 1. 2003-04-28. PMID:12534965. |
the expression of vesicular glutamate transporters vglut1 and vglut2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn. |
2003-04-28 |
2023-08-12 |
rat |
| Ruth Ruscheweyh, Jürgen Sandkühle. Role of kainate receptors in nociception. Brain research. Brain research reviews. vol 40. issue 1-3. 2003-04-01. PMID:12589919. |
a subtype of ionotropic glutamate receptors, the kainate receptor, is present in spinal dorsal horn. |
2003-04-01 |
2023-08-12 |
Not clear |
| Jean-François Perrier, Aidas Alaburda, Jørn Hounsgaar. Spinal plasticity mediated by postsynaptic L-type Ca2+ channels. Brain research. Brain research reviews. vol 40. issue 1-3. 2003-04-01. PMID:12589920. |
up-regulation is mediated by receptors for glutamate, acetylcholine, noradrenaline and serotonin in motoneurons and by receptors for glutamate and substance p in plateau-generating dorsal horn interneurons. |
2003-04-01 |
2023-08-12 |
Not clear |
| De-Pei Li, Shao-Rui Chen, Yu-Zhen Pan, Allan I Levey, Hui-Lin Pa. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. The Journal of physiology. vol 543. issue Pt 3. 2003-02-25. PMID:12231640. |
in this study, we investigated the mechanisms underlying cholinergic presynaptic regulation of glutamate release onto spinal dorsal horn neurons. |
2003-02-25 |
2023-08-12 |
rat |
| Marian E Fundytus, Michael G Osborne, James L Henry, Terence J Coderre, Andy Dra. Antisense oligonucleotide knockdown of mGluR1 alleviates hyperalgesia and allodynia associated with chronic inflammation. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117595. |
metabotropic glutamate receptors (mglurs) have been implicated in dorsal horn neuronal nociceptive responses and pain associated with short-term inflammation. |
2003-02-05 |
2023-08-12 |
rat |
| Xiangqi Li, J David Clar. Hyperalgesia during opioid abstinence: mediation by glutamate and substance p. Anesthesia and analgesia. vol 95. issue 4. 2002-10-28. PMID:12351280. |
in these studies we attempted to determine whether the activation of spinal cord dorsal horn neurons was greater in mice with oah than in control mice in response to the intrathecal administration of the primary neurotransmitters glutamate and substance p. after mice were treated with an established protocol consisting of the implantation of morphine pellets followed by removal after 6 days, the mice were hyperalgesic as assessed with the hotplate and hargreaves thermal paw withdrawal assays. |
2002-10-28 |
2023-08-12 |
mouse |
| Xiangqi Li, J David Clar. Hyperalgesia during opioid abstinence: mediation by glutamate and substance p. Anesthesia and analgesia. vol 95. issue 4. 2002-10-28. PMID:12351280. |
likewise, it was observed that the dorsal horn regions of oah mice had more fos-positive nuclei after either glutamate or substance p administration than did control mice. |
2002-10-28 |
2023-08-12 |
mouse |
| James E Huettner, Geoffrey A Kerchner, Min Zhu. Glutamate and the presynaptic control of spinal sensory transmission. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 8. issue 2. 2002-10-22. PMID:11954562. |
sensory neurons, in particular the small- and medium-diameter cells that sense painful stimuli, express both ionotropic and metabotropic glutamate receptors, which may regulate transmission between sensory neurons and their targets in the spinal cord dorsal horn. |
2002-10-22 |
2023-08-12 |
Not clear |
| Daniel S Lorrain, Lucia Correa, Jeffery Anderson, Mark Varne. Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment. Neuroscience letters. vol 327. issue 3. 2002-09-09. PMID:12113911. |
the mechanisms underlying these behavioral effects are not entirely understood but may include enhanced release of glutamate within the dorsal horn of the spinal cord. |
2002-09-09 |
2023-08-12 |
rat |
| D A Skyba, E W King, Kathleen A Sluk. Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline. Pain. vol 98. issue 1-2. 2002-09-06. PMID:12098618. |
the purpose of this study was to characterize the involvement of both n-methyl-d-aspartate (nmda) and non-nmda glutamate receptors in the spinal cord dorsal horn in the development and maintenance of mechanical hyperalgesia from repeated intramuscular injections of acidic saline. |
2002-09-06 |
2023-08-12 |
Not clear |
| D A Skyba, E W King, Kathleen A Sluk. Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline. Pain. vol 98. issue 1-2. 2002-09-06. PMID:12098618. |
2-amino-5-phosphonovaleric acid (ap5) (2-20 nmol, 10 microl, ph 7) or 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo[f]quinoxaline-7-sulfonamide (nbqx) (1-10 nmol, 10 microl, ph 8-9) was administered intrathecally to the lumbar spinal cord to block nmda and non-nmda ionotropic glutamate receptors in the dorsal horn, respectively. |
2002-09-06 |
2023-08-12 |
Not clear |
| D A Skyba, E W King, Kathleen A Sluk. Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline. Pain. vol 98. issue 1-2. 2002-09-06. PMID:12098618. |
blockade of non-nmda glutamate receptors in the spinal cord dorsal horn prior to either the first or second intramuscular injection of ph 4.0 saline had no effect on the development of mechanical hyperalgesia. |
2002-09-06 |
2023-08-12 |
Not clear |
| U Karlsson, J Sjödin, K Angeby Möller, S Johansson, L Wikström, J Näsströ. Glutamate-induced currents reveal three functionally distinct NMDA receptor populations in rat dorsal horn - effects of peripheral nerve lesion and inflammation. Neuroscience. vol 112. issue 4. 2002-09-03. PMID:12088745. |
the glutamate dose-response curves indicate that there are three major types of nmda receptors present in dorsal horn neurones. |
2002-09-03 |
2023-08-12 |
rat |
| Toshikazu Nishimori, Tetsuya Ikeda, Ryuji Terayama, Yasushi Ishida, Tadashi Nakamura, Noriko Otahar. Effect of ionotropic glutamate receptor antagonists on Fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve. Brain research. vol 934. issue 1. 2002-07-12. PMID:11937072. |
effect of ionotropic glutamate receptor antagonists on fos-like immunoreactivity in the dorsal horn following transection of the rat sciatic nerve. |
2002-07-12 |
2023-08-12 |
rat |
| David L Somers, F Richard Clement. Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve. Neuroscience letters. vol 323. issue 3. 2002-06-25. PMID:11959412. |
dorsal horn synaptosomal content of aspartate, glutamate, glycine and gaba are differentially altered following chronic constriction injury to the rat sciatic nerve. |
2002-06-25 |
2023-08-12 |
rat |