| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D L Voisin, F Nag. Sustained L-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166132. |
no direct modulation of somatic calcium currents by application of (s)-3,5-dihydroxyphenylglycine, a selective group i metabotropic glutamate receptor agonist and 1s,3r-1-amino-1,3-cyclopentanedicarboxylic acid, a group i and ii metabotropic glutamate receptor agonist, was found, while application of the metabotropic gaba(b) receptor agonist baclofen induced a significant decrease in calcium currents.thus, the present voltage-clamp study shows that rat deep dorsal horn neurons express a non-inactivating, nifedipine sensitive, intermediate threshold (-55mv) calcium current which could provide the depolarizing drive to generate plateau potentials near threshold. |
2001-05-03 |
2023-08-12 |
rat |
| J J Azkue, M Murga, O Fernández-Capetillo, J M Mateos, I Elezgarai, R Benítez, A Osorio, J Díez, N Puente, A Bilbao, A Bidaurrazaga, R Kuhn, P Grande. Immunoreactivity for the group III metabotropic glutamate receptor subtype mGluR4a in the superficial laminae of the rat spinal dorsal horn. The Journal of comparative neurology. vol 430. issue 4. 2001-04-26. PMID:11169479. |
immunoreactivity for the group iii metabotropic glutamate receptor subtype mglur4a in the superficial laminae of the rat spinal dorsal horn. |
2001-04-26 |
2023-08-12 |
rat |
| G W Terman, C L Eastman, C Chavki. Mu opiates inhibit long-term potentiation induction in the spinal cord slice. Journal of neurophysiology. vol 85. issue 2. 2001-04-19. PMID:11160487. |
these studies suggest that mu opioids exert their inhibitory effects presynaptically, likely through the inhibition of glutamate release from primary afferent terminals, and thereby inhibit the induction of ltp in the spinal dorsal horn. |
2001-04-19 |
2023-08-12 |
rat |
| C Tohda, M Sasaki, T Konemura, T Sasamura, M Itoh, Y Kuraish. Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity. Journal of neurochemistry. vol 76. issue 6. 2001-04-12. PMID:11259480. |
the sensitivity of central terminals to capsaicin, which was estimated by measuring the capsaicin-evoked release of glutamate from the dorsal horn, was increased by peripheral inflammation, and such an increase was suppressed by inhibiting the rna translation in the dorsal horn with cycloheximide and an intrathecal injection of vr1 antisense oligonucleotides. |
2001-04-12 |
2023-08-12 |
Not clear |
| Ruth Ruscheweyh, Jürgen Sandkühle. Differential actions of spinal analgesics on mono-versus polysynaptic Adelta-fibre-evoked field potentials in superficial spinal dorsal horn in vitro. Pain. vol 88. issue 1. 2001-03-29. PMID:11098104. |
two classical spinal analgesics, morphine and clonidine, and the metabotropic glutamate receptor agonist (is,3r)-1-aminocyclopentane-1,3-dicarboxylic acid ((1s,3r)-acpd) differentially affected mono- and polysynaptic adelta-fibre-evoked transmission in spinal dorsal horn. |
2001-03-29 |
2023-08-12 |
Not clear |
| M Sato. [Molecular neuropharmacology of nociceptive transmission and opioid receptors]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 12. 2001-03-15. PMID:11193380. |
we designed an in vitro fluorometric on-line monitoring system including an immobilized glutamate dehydrogenase column, and for the first time actually demonstrated that capsaicin induced the release of glutamate from rat dorsal horn slices containing the terminal area of primary afferents, in concentration-dependent, extracellular ca(2+)-dependent and tetrodotoxin-resistant manners. |
2001-03-15 |
2023-08-12 |
rat |
| M Sato. [Molecular neuropharmacology of nociceptive transmission and opioid receptors]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 120. issue 12. 2001-03-15. PMID:11193380. |
the above described facts suggest that glutamate and some sorts of cytokines (il-1 beta and cinc-1) contribute to nociception at least from the primary afferents to the spinal dorsal horn neurons and in higher brain, respectively. |
2001-03-15 |
2023-08-12 |
rat |
| b' J Zhong, G Gerber, L Koji\\xc4\\x87, M Randi\\xc4\\x8. Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134626.' |
dual modulation of excitatory synaptic transmission by agonists at group i metabotropic glutamate receptors in the rat spinal dorsal horn. |
2001-02-15 |
2023-08-12 |
rat |
| b' J Zhong, G Gerber, L Koji\\xc4\\x87, M Randi\\xc4\\x8. Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134626.' |
the effects of group i metabotropic glutamate (mglu) receptors on excitatory transmission in the rat dorsal horn, but mostly substantia gelatinosa, neurons were investigated using conventional intracellular recording in slices. |
2001-02-15 |
2023-08-12 |
rat |
| b' J Zhong, G Gerber, L Koji\\xc4\\x87, M Randi\\xc4\\x8. Dual modulation of excitatory synaptic transmission by agonists at group I metabotropic glutamate receptors in the rat spinal dorsal horn. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134626.' |
these results demonstrate that the pharmacological activation of group i metabotropic glutamate receptors induces long-term depression (ltd) and long-term potentiation (ltp) of synaptic transmission in the spinal dorsal horn. |
2001-02-15 |
2023-08-12 |
rat |
| G A Kerchner, T J Wilding, P Li, M Zhuo, J E Huettne. Presynaptic kainate receptors regulate spinal sensory transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 1. 2001-02-08. PMID:11150320. |
interestingly, although the glutamate receptor subunit 5-selective kainate receptor agonist (rs)-2-alpha-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl) propanoic acid (atpa) (2 micrometer) was able to suppress drg-dorsal horn synaptic transmission to a similar extent as kainate (10 micrometer), it had no effect on excitatory transmission between dorsal horn neurons. |
2001-02-08 |
2023-08-12 |
Not clear |
| b' G Gerber, D H Youn, C H Hsu, D Isaev, M Randi\\xc4\\x8. Spinal dorsal horn synaptic plasticity: involvement of group I metabotropic glutamate receptors. Progress in brain research. vol 129. 2000-12-22. PMID:11098685.' |
spinal dorsal horn synaptic plasticity: involvement of group i metabotropic glutamate receptors. |
2000-12-22 |
2023-08-12 |
Not clear |
| G Gerber, J Zhong, D Youn, M Randi. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience. vol 100. issue 2. 2000-11-28. PMID:11008177. |
group ii and group iii metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. |
2000-11-28 |
2023-08-12 |
rat |
| G Gerber, J Zhong, D Youn, M Randi. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience. vol 100. issue 2. 2000-11-28. PMID:11008177. |
the effects of group ii and group iii metabotropic glutamate receptor agonists on synaptic responses evoked by primary afferent stimulation in the dorsal horn, but mostly substantia gelatinosa, neurons were studied in the spinal cord slice preparation using conventional intracellular recording technique. |
2000-11-28 |
2023-08-12 |
rat |
| G Gerber, J Zhong, D Youn, M Randi. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience. vol 100. issue 2. 2000-11-28. PMID:11008177. |
besides the depressant effect on excitatory synaptic transmission, inhibitory actions of group ii and iii metabotropic glutamate receptor agonists on the inhibitory postsynaptic potentials evoked by primary afferent stimulation in dorsal horn neurons were observed. |
2000-11-28 |
2023-08-12 |
rat |
| G Gerber, J Zhong, D Youn, M Randi. Group II and group III metabotropic glutamate receptor agonists depress synaptic transmission in the rat spinal cord dorsal horn. Neuroscience. vol 100. issue 2. 2000-11-28. PMID:11008177. |
these results suggest that group ii and group iii metabotropic glutamate receptors are expressed at primary afferent synapses in the dorsal horn region, and activation of the receptors suppresses synaptic transmission by an action on the presynaptic site. |
2000-11-28 |
2023-08-12 |
rat |
| J Chen, B Heinke, J Sandkühle. Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. Neuropharmacology. vol 39. issue 12. 2000-11-13. PMID:10974307. |
activation of group i metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. |
2000-11-13 |
2023-08-12 |
rat |
| J Chen, B Heinke, J Sandkühle. Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn. Neuropharmacology. vol 39. issue 12. 2000-11-13. PMID:10974307. |
here, we have identified another form of long-term depression in superficial spinal dorsal horn neurons that is induced by specific group i but not group ii metabotropic glutamate receptor (mglur) agonists. |
2000-11-13 |
2023-08-12 |
rat |
| Y Ding, P Cesare, L Drew, D Nikitaki, J N Woo. ATP, P2X receptors and pain pathways. Journal of the autonomic nervous system. vol 81. issue 1-3. 2000-09-29. PMID:10869734. |
evidence that this receptor may play a role in the excitation of sensory neurons has recently been complemented by studies that suggest an additional presynaptic role in the regulation of glutamate release from primary afferent neurons in the dorsal horn of the spinal cord. |
2000-09-29 |
2023-08-12 |
human |
| J J Azkue, J M Mateos, I Elezgarai, R Benítez, A Osorio, J Díez, A Bilbao, A Bidaurrazaga, P Grande. The metabotropic glutamate receptor subtype mGluR 2/3 is located at extrasynaptic loci in rat spinal dorsal horn synapses. Neuroscience letters. vol 287. issue 3. 2000-09-01. PMID:10863038. |
the metabotropic glutamate receptor subtype mglur 2/3 is located at extrasynaptic loci in rat spinal dorsal horn synapses. |
2000-09-01 |
2023-08-12 |
rat |