| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J J Azkue, J M Mateos, I Elezgarai, R Benítez, A Osorio, J Díez, A Bilbao, A Bidaurrazaga, P Grande. The metabotropic glutamate receptor subtype mGluR 2/3 is located at extrasynaptic loci in rat spinal dorsal horn synapses. Neuroscience letters. vol 287. issue 3. 2000-09-01. PMID:10863038. |
the location of the metabotropic glutamate receptor subtype mglur2/3 was investigated in synaptic structures in the rat superficial spinal dorsal horn laminae by using a pre-embedding immunogold technique. |
2000-09-01 |
2023-08-12 |
rat |
| J Chen, J Sandkühle. Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors. Neuroscience. vol 98. issue 1. 2000-08-24. PMID:10858620. |
short-term depression was not affected by any of these antagonists.thus, a homosynaptic form of long-term depression exists at putative nociceptive synapses in the spinal dorsal horn and its induction requires the activation of both group i and ii metabotropic glutamate receptors. |
2000-08-24 |
2023-08-12 |
rat |
| B A Meyerson, B Linderot. Mechanisms of spinal cord stimulation in neuropathic pain. Neurological research. vol 22. issue 3. 2000-06-08. PMID:10769822. |
these effects were coupled to increased release of gaba and reduced glutamate and aspartate release in the dorsal horn. |
2000-06-08 |
2023-08-12 |
rat |
| W Huang, R K Simpso. Intrathecal treatment with MK-801 suppresses thermal nociceptive responses and prevents c-fos immunoreactivity induced in rat lumbar spinal cord neurons. Neurological research. vol 21. issue 6. 1999-12-10. PMID:10491822. |
sensitization of the second order neurons in the spinal dorsal horn after somatic noxious stimuli is partly mediated by the n-methyl-d-aspartate (nmda) subtype of the glutamate receptor. |
1999-12-10 |
2023-08-12 |
human |
| V Rybalchenko, R Schlichte. Functional high- and low affinity agonist binding sites at native dorsal horn AMPA receptors. Neuroreport. vol 10. issue 8. 1999-11-15. PMID:10501579. |
transmission and processing of nociceptive information in the superficial dorsal horn (dh) of the spinal cord involves activation of ampa-type glutamate receptors (ampars). |
1999-11-15 |
2023-08-12 |
rat |
| W M Walwyn, J Ta-Haung, L Ackerson, N T Maidment, V R Edgerto. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. Pharmacology, biochemistry, and behavior. vol 63. issue 4. 1999-10-22. PMID:10462186. |
extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. |
1999-10-22 |
2023-08-12 |
rat |
| W M Walwyn, J Ta-Haung, L Ackerson, N T Maidment, V R Edgerto. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. Pharmacology, biochemistry, and behavior. vol 63. issue 4. 1999-10-22. PMID:10462186. |
however, there has been no in vivo evidence of the changes in glutamate or any other neurotransmitter in the extracellular space of the dorsal horn during an alternating motor pattern such as hindlimb stepping. |
1999-10-22 |
2023-08-12 |
rat |
| W M Walwyn, J Ta-Haung, L Ackerson, N T Maidment, V R Edgerto. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. Pharmacology, biochemistry, and behavior. vol 63. issue 4. 1999-10-22. PMID:10462186. |
this study describes an in vivo microdialysis technique to measure extracellular glutamate in the dorsal horn of the spinal cord in the fully awake intact rat. |
1999-10-22 |
2023-08-12 |
rat |
| W M Walwyn, J Ta-Haung, L Ackerson, N T Maidment, V R Edgerto. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. Pharmacology, biochemistry, and behavior. vol 63. issue 4. 1999-10-22. PMID:10462186. |
in another series of experiments extracellular glutamate was, therefore, measured in the dorsal horn of the chronic spinally transected rat during 20 min of hindlimb stepping. |
1999-10-22 |
2023-08-12 |
rat |
| G M Pitcher, J L Henr. Mediation and modulation by eicosanoids of responses of spinal dorsal horn neurons to glutamate and substance P receptor agonists: results with indomethacin in the rat in vivo. Neuroscience. vol 93. issue 3. 1999-10-21. PMID:10473275. |
mediation and modulation by eicosanoids of responses of spinal dorsal horn neurons to glutamate and substance p receptor agonists: results with indomethacin in the rat in vivo. |
1999-10-21 |
2023-08-12 |
rat |
| G M Pitcher, J L Henr. Mediation and modulation by eicosanoids of responses of spinal dorsal horn neurons to glutamate and substance P receptor agonists: results with indomethacin in the rat in vivo. Neuroscience. vol 93. issue 3. 1999-10-21. PMID:10473275. |
as indomethacin inhibits cyclo-oxygenase, these are the first data linking prostanoids and possibly arachidonic acid and other eicosanoids to the effects of substance p and glutamate in the spinal dorsal horn. |
1999-10-21 |
2023-08-12 |
rat |
| X M Yu, M W Salte. Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 14. 1999-08-26. PMID:10393883. |
the n-methyl-d-aspartate (nmda) receptor is a principal subtype of glutamate receptor mediating fast excitatory transmission at synapses in the dorsal horn of the spinal cord and other regions of the central nervous system. |
1999-08-26 |
2023-08-12 |
Not clear |
| H Jia, A Rustioni, J G Valtschanof. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn. The Journal of comparative neurology. vol 410. issue 4. 1999-08-03. PMID:10398053. |
metabotropic glutamate receptors in superficial laminae of the rat dorsal horn. |
1999-08-03 |
2023-08-12 |
rat |
| H Jia, A Rustioni, J G Valtschanof. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn. The Journal of comparative neurology. vol 410. issue 4. 1999-08-03. PMID:10398053. |
light and electron microscopic immunocytochemistry were employed here to show the distribution of metabotropic glutamate receptors (mglurs) mglur2/3 and mglur5 in laminae i and ii of the dorsal horn, to identify their pre- and postsynaptic location, and to test colocalization with gamma-aminobutyric acid (gaba). |
1999-08-03 |
2023-08-12 |
rat |
| Y Manabe, K Kashihara, Y Shiro, T Shohmori, K Ab. Enhanced Fos expression in rat lumbar spinal cord cultured with cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Neurological research. vol 21. issue 3. 1999-07-01. PMID:10319342. |
the number of fos-li positive neurons significantly increased in dorsal horn with addition of csf from als patients as well as glutamate at 100 microm. |
1999-07-01 |
2023-08-12 |
rat |
| Y S Shu, Z Q Zhao, M Y Li, G M Zho. Orphanin FQ/nociceptin modulates glutamate- and kainic acid-induced currents in acutely isolated rat spinal dorsal horn neurons. Neuropeptides. vol 32. issue 6. 1999-06-07. PMID:9920456. |
in the present study, the effects of ofq/noc on glutamate (glu), kainic acid (ka) and quisqualic acid (qa) induced currents were examined in isolated rat spinal dorsal horn neurons of young rats using whole-cell patch-clamp techniques. |
1999-06-07 |
2023-08-12 |
rat |
| E A Mayer, T Lembo, L Chan. Approaches to the modulation of abdominal pain. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. vol 13 Suppl A. 1999-05-17. PMID:10202211. |
even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacological treatments are receptors on peripheral terminals of visceral afferent nerves (opioids and serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, calcitonin gene-related peptide and neurokinin-1), and supraspinal targets in the brainstem within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine and acetylcholine). |
1999-05-17 |
2023-08-12 |
Not clear |
| J P Rivot, A Sousa, J Montagne-Clavel, J M Besso. Nitric oxide (NO) release by glutamate and NMDA in the dorsal horn of the spinal cord: an in vivo electrochemical approach in the rat. Brain research. vol 821. issue 1. 1999-04-22. PMID:10064793. |
nitric oxide (no) release by glutamate and nmda in the dorsal horn of the spinal cord: an in vivo electrochemical approach in the rat. |
1999-04-22 |
2023-08-12 |
rat |
| E A Mayer, L Chang, T Lemb. Brain-gut interactions: implications for newer therapy. The European journal of surgery. Supplement. : = Acta chirurgica. Supplement. issue 582. 1999-04-21. PMID:10029365. |
even though the precise mechanisms and sites underlying these alterations remain incompletely understood, plausible targets for the development of effective pharmacologic treatment are receptors on peripheral terminals of visceral afferent nerves (opioids, serotonin), ion channels and receptors on dorsal horn neurons within the spinal cord (opioids, glutamate, cgrp, nk-1) and supraspinal targets in the brainstem, within the limbic system and in the prefrontal cortex (serotonin, catecholamines, dopamine, acetylcholine). |
1999-04-21 |
2023-08-12 |
Not clear |
| M J Milla. The induction of pain: an integrative review. Progress in neurobiology. vol 57. issue 1. 1999-04-14. PMID:9987804. |
in the dorsal horn of the spinal cord, wherein the primary processing of nociceptive information occurs, n-methyl-d-aspartate receptors are activated by glutamate released from nocisponsive afferent fibres. |
1999-04-14 |
2023-08-12 |
Not clear |