| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Ren, Kai-Jie He, Hua Hu, Jin-Bao Zhang, Li-Guo Dong, Dan Li, Jing Chen, Cheng-Jie Mao, Fen Wang, Chun-Feng Li. Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum. Journal of Parkinson's disease. 2021-11-01. PMID:34719508. |
induction of parkinsonian-like changes via targeted downregulation of astrocytic glutamate transporter glt-1 in the striatum. |
2021-11-01 |
2023-08-13 |
Not clear |
| Yan Feng, Shifang Zhou, Jian Su. Exercise increases striatal Glu reuptake and improves motor dysfunction in 6-OHDA-induced Parkinson's disease rats. Experimental brain research. vol 239. issue 11. 2021-10-26. PMID:34463828. |
the purpose of this study is to clarify that exercise may improve the motor dysfunction of parkinson's disease (pd) model rats by increasing the reuptake of glutamate (glu) in the striatum. |
2021-10-26 |
2023-08-13 |
rat |
| Yan Feng, Shifang Zhou, Jian Su. Exercise increases striatal Glu reuptake and improves motor dysfunction in 6-OHDA-induced Parkinson's disease rats. Experimental brain research. vol 239. issue 11. 2021-10-26. PMID:34463828. |
the balance bar test, suspension test, and the tail-lifting handstand test were used to evaluate exercise performance of rats; rt-pcr and western blotting were used to detect protein and mrna expression of glutamate transporter-1 (glt-1) and glutamine synthetase (gs) in the striatum; and isotope labeling was used to detect the ability of glu reuptake in the striatum. |
2021-10-26 |
2023-08-13 |
rat |
| Kate M Wassum, Vanessa M Tolosa, Jianjun Wang, Eric Walker, Harold G Monbouquette, Nigel T Maidmen. Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo. Sensors (Basel, Switzerland). vol 8. issue 8. 2021-10-20. PMID:19543440. |
the mea biosensors also were applied to the detection of stress-induced glutamate release in the dorsal striatum of the freely-moving rat. |
2021-10-20 |
2023-08-12 |
rat |
| V Nguyen, D V Bonds, L Proka. Measurement of Hydroxyl-Radical Formation in the Rat Striatum by In Vivo Microdialysis and GC-MS. Chromatographia. vol 68. issue Suppl 1. 2021-10-20. PMID:19802331. |
our work has demonstrated the applicability of gc-ms for the assay of microdialysates for 2,3- and 2,5-dihydroxybenzoic acid by confirming that local administration of the excitotoxic glutamate into the rat striatum significantly increased in vivo hydroxyl-radical production in this brain region and that subsequent systemic administration of α-phenyl-tert-butylnitrone reversed glutamate-induced oxidative stress. |
2021-10-20 |
2023-08-12 |
rat |
| Si Han Li, Tash-Lynn L Colson, Khaled S Abd-Elrahman, Stephen S G Ferguso. Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice. The Journal of pharmacology and experimental therapeutics. vol 379. issue 1. 2021-10-14. PMID:34330748. |
current evidence indicates that exacerbated postsynaptic glutamate signaling in the striatum plays a key role in the pathophysiology of hd. |
2021-10-14 |
2023-08-13 |
mouse |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology. vol 198. 2021-10-14. PMID:34474045. |
glutamate, gaba, acetylcholine, dopamine, and serotonin interact with each other to regulate the flow of neural information in the striatum. |
2021-10-14 |
2023-08-13 |
rat |
| Claudia Rangel-Barajas, Israel Coronel, Yanping Zhang, Maribel Hernández, Stephen L Boehm I. Low-level developmental lead exposure does not predispose to adult alcohol self-administration, but does increase the risk of relapsing to alcohol seeking in mice: Contrasting role of GLT1 and xCT brain expression. Neuropharmacology. vol 181. 2021-09-23. PMID:33010299. |
because pb exposure is associated with increased glutamatergic tone, we also studied the effects on the expression of synaptic and non-synaptic glutamate transporters in brain regions associated with drug addiction such as the nucleus accumbens (nac), dorsomedial striatum (dms), dorsolateral striatum (dls), and medial prefrontal cortex (mpfc). |
2021-09-23 |
2023-08-13 |
mouse |
| Durairaj Ragu Varman, Mark A Subler, Jolene J Windle, Lankupalle D Jayanthi, Sammanda Ramamoorth. Novelty-induced hyperactivity and suppressed cocaine induced locomotor activation in mice lacking threonine 53 phosphorylation of dopamine transporter. Behavioural brain research. vol 408. 2021-09-02. PMID:33794225. |
dat-ala53 mice displayed unaltered levels of monoamines, glutamate, and gaba in the striatum compared to wt. |
2021-09-02 |
2023-08-13 |
mouse |
| Matsuhiko Oka, Koki Ito, Minori Koga, Ichiro Kusum. Changes in subunit composition of NMDA receptors in animal models of schizophrenia by repeated administration of methamphetamine. Progress in neuro-psychopharmacology & biological psychiatry. vol 103. 2021-08-27. PMID:32473191. |
repeated administration of meth significantly decreased the gene expression levels of glutamate ionotropic receptor nmda type subunit (grin) subtypes grin1 and grin2c in the prefrontal cortex (pfc), grin1 and grin2a in the hippocampus (hpc), and grin1, grin2b, and grin2d in the striatum (st).we observed a significant difference in grin1 expression between the pfc and st. |
2021-08-27 |
2023-08-13 |
mouse |
| Lilian R F Faro, Lorenzo Justo, Raquel Gómez, Rafael Durá. Participation of glutamatergic and nitrergic systems in the striatal dopamine release induced by isatin, a MAO inhibitor. The European journal of neuroscience. vol 54. issue 3. 2021-08-18. PMID:34022091. |
our findings show that the intrastriatal administration of 10 mm isatin significantly increases the in vivo release of dopamine (1,104.7% ± 97.1%), and the amino acids glutamate (428.7% ± 127%) and taurine (221% ± 22%) from rat striatum measured by brain microdialysis. |
2021-08-18 |
2023-08-13 |
rat |
| Andrew H Hoover, Ratnamala Pavuluri, Gajanan P Shelkar, Shashank M Dravid, Yoland Smith, Rosa M Villalb. Ultrastructural localization of glutamate delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:33084025. |
ultrastructural localization of glutamate delta 1 (glud1) receptor immunoreactivity in the mouse and monkey striatum. |
2021-08-16 |
2023-08-13 |
mouse |
| Andrew H Hoover, Ratnamala Pavuluri, Gajanan P Shelkar, Shashank M Dravid, Yoland Smith, Rosa M Villalb. Ultrastructural localization of glutamate delta 1 (GluD1) receptor immunoreactivity in the mouse and monkey striatum. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:33084025. |
the glutamate receptor delta 1 (glud1) is strongly expressed in the striatum. |
2021-08-16 |
2023-08-13 |
mouse |
| J G Ramaekers, N L Mason, E L Theunisse. Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32014378. |
such neuroadaptions are absent in occasional users, who show strong increments of dopamine and glutamate levels in the striatum, a loss of functional connectivity within the mesolimbic circuit and neurocognitive impairments when exposed to cannabis. |
2021-08-10 |
2023-08-13 |
human |
| Arti Rana, Shamsher Singh, Rahul Deshmukh, Anoop Kuma. Pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats. Brain injury. vol 34. issue 8. 2021-07-28. PMID:32493074. |
on 29th day, animals were sacrificed and striatum and cortex were homogenized for the estimation of biochemical (lpo, nitrite, and gsh), neuroinflammatory (il-6, il-1β, and tnf-α), and neurotransmitters (dopamine, norepinephrine, serotonin, gaba, and glutamate) analysis. |
2021-07-28 |
2023-08-13 |
rat |
| Kinga Gzieło, Krzysztof Janeczko, Władysław Węglarz, Krzysztof Jasiński, Krzysztof Kłodowski, Zuzanna Setkowic. MRI spectroscopic and tractography studies indicate consequences of long-term ketogenic diet. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32681181. |
the procedures revealed significant increases in the concentration of glutamine, glutamate, glutathione and naa, accompanied by changes in the pattern of neuronal connections of the striatum and hippocampal formation. |
2021-07-06 |
2023-08-13 |
rat |
| Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Che. Intermittent Hypoxia Activates N-Methyl-D-Aspartate Receptors to Induce Anxiety Behaviors in a Mouse Model of Sleep-Associated Apnea. Molecular neurobiology. vol 58. issue 7. 2021-07-06. PMID:33660202. |
increased glutamate n-methyl-d-aspartate (nmda) receptor subunits 2b (glun2b) and phosphorylated-erk1/2 were seen in the mpfc, striatum, and hippocampus of ih mice, but no significant microglial and astrocyte activation was found in these brain areas. |
2021-07-06 |
2023-08-13 |
mouse |
| Khadga Raj, G D Gupta, Shamsher Sing. l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. Drug and chemical toxicology. 2021-07-02. PMID:34210222. |
on the day 29, all wistar rats were sacrificed and striatum homogenates were used for biochemical (lipid peroxidation, nitrite, glutathione, glutathione peroxidase activity, superoxide dismutase, catalase, mitochondrial complex i, iv, and cyclic adenosine monophosphate), neuroinflammatory markers (tumor necrosis factor-α, interleukin-1β, and interleukin-17), and neurotransmitters (dopamine, norepinephrine, serotonin, gaba, and glutamate) analysis. |
2021-07-02 |
2023-08-13 |
rat |
| Kari A Johnson, Lucas Voyvodic, Gabriel C Loewinger, Yolanda Mateo, David M Lovinge. Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:31995814. |
operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. |
2021-06-23 |
2023-08-13 |
mouse |
| Kari A Johnson, Lucas Voyvodic, Gabriel C Loewinger, Yolanda Mateo, David M Lovinge. Operant self-stimulation of thalamic terminals in the dorsomedial striatum is constrained by metabotropic glutamate receptor 2. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:31995814. |
we evaluated the reinforcing properties of optogenetic stimulation of thalamostriatal terminals, which are associated with vesicular glutamate transporter 2 (vglut2) expression, in the dorsomedial striatum (dms), a region implicated in goal-directed behaviors. |
2021-06-23 |
2023-08-13 |
mouse |