| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Chávez-Pichardo, D Y Reyes-Bravo, M S Mendoza-Trejo, A G Marín-López, M Giordano, N Hernández-Chan, K Domínguez-Marchan, L C Ortega-Rosales, V M Rodrígue. Brain alterations in GABA, glutamate and glutamine markers after chronic atrazine exposure in the male albino rat. Archives of toxicology. vol 94. issue 9. 2021-06-16. PMID:32561961. |
to evaluate the impact of atr on motor and anxiety tasks, tissue levels of gaba, glutamate, glutamine, and extracellular and potassium-evoked release of glutamate in the striatum, we daily exposed sprague-dawley male rats to 1 or 10 mg atr/kg of body weight for 12-14 months. |
2021-06-16 |
2023-08-13 |
rat |
| M E Chávez-Pichardo, D Y Reyes-Bravo, M S Mendoza-Trejo, A G Marín-López, M Giordano, N Hernández-Chan, K Domínguez-Marchan, L C Ortega-Rosales, V M Rodrígue. Brain alterations in GABA, glutamate and glutamine markers after chronic atrazine exposure in the male albino rat. Archives of toxicology. vol 94. issue 9. 2021-06-16. PMID:32561961. |
the groups exposed to 10 mg atr/kg showed increased extracellular levels and release of glutamate in the striatum. |
2021-06-16 |
2023-08-13 |
rat |
| Zhipeng Qi, Xinxin Yang, Yanqi Sang, Yanan Liu, Jiashuo Li, Bin Xu, Wei Liu, Miao He, Zhaofa Xu, Yu Deng, Jinghai Zh. Fluoxetine and Riluzole Mitigates Manganese-Induced Disruption of Glutamate Transporters and Excitotoxicity via Ephrin-A3/GLAST-GLT-1/Glu Signaling Pathway in Striatum of Mice. Neurotoxicity research. vol 38. issue 2. 2021-06-14. PMID:32472497. |
fluoxetine and riluzole mitigates manganese-induced disruption of glutamate transporters and excitotoxicity via ephrin-a3/glast-glt-1/glu signaling pathway in striatum of mice. |
2021-06-14 |
2023-08-13 |
mouse |
| Justyna Pyrzanowska, Ilona Joniec-Maciejak, Kamilla Blecharz-Klin, Agnieszka Piechal, Dagmara Mirowska-Guzel, Izabela Fecka, Ewa Widy-Tyszkiewic. Aspalathus linearis infusion affects hole-board test behaviour and amino acid concentration in the brain. Neuroscience letters. vol 747. 2021-06-03. PMID:33529651. |
excitatory amino acids (aspartate and glutamate) content was decreased in the striatum of animals drinking the infusions whereas taurine level was increased both in the striatum and hippocampus. |
2021-06-03 |
2023-08-13 |
rat |
| Man Xiong, Yezheng Tao, Qinqin Gao, Ban Feng, Wei Yan, Yingying Zhou, Thomas A Kotsonis, Tingli Yuan, Zhiwen You, Ziyan Wu, Jiajie Xi, Alexander Haberman, Julia Graham, Jasper Block, Wenhao Zhou, Yuejun Chen, Su-Chun Zhan. Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function. Cell stem cell. vol 28. issue 1. 2021-05-19. PMID:32966778. |
we transplanted hesc-derived midbrain dopamine (mda) or cortical glutamate neurons into the substantia nigra or striatum of a mouse pd model and found extensive graft integration with host circuitry. |
2021-05-19 |
2023-08-13 |
mouse |
| Li-Min Mao, John Q Wan. Linkage of Non-receptor Tyrosine Kinase Fyn to mGlu5 Receptors in Striatal Neurons in a Depression Model. Neuroscience. vol 433. 2021-05-14. PMID:32145272. |
in this study, we investigated changes in phosphorylation and function of the two key sfk members (fyn and src) and sfk interactions with a metabotropic glutamate (mglu) receptor in the limbic striatum of adult rats in response to chronic passive stress, i.e., prolonged social isolation which is a pre-validated animal paradigm modeling depression in adulthood. |
2021-05-14 |
2023-08-13 |
rat |
| Jae Hyun Yoo, Ji-Won Chun, Mi Ran Choi, Hyun Cho, Jin-Young Kim, Jihye Choi, Dai-Jin Ki. Caudate nucleus volume mediates the link between glutamatergic neurotransmission and problematic smartphone use in youth. Journal of behavioral addictions. 2021-04-27. PMID:33905351. |
we hypothesized that structural changes in the striatum might serve as an important link between alteration in glutamate signaling and development of psu. |
2021-04-27 |
2023-08-13 |
Not clear |
| Clarissa A Pisanò, Alberto Brugnoli, Salvatore Novello, Carla Caccia, Charlotte Keywood, Elsa Melloni, Silvia Vailati, Gloria Padoani, Michele Morar. Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease. Neuropharmacology. vol 167. 2021-04-23. PMID:32086070. |
safinamide inhibited the veratridine-evoked glutamate release in the globus pallidus and subthalamic nucleus but not in the striatum and substantia nigra. |
2021-04-23 |
2023-08-13 |
rat |
| José Luis Castañeda-Cabral, José Guadalupe López-Ortega, Blanca Fabiola Fajardo-Fregoso, Carlos Beas-Zárate, Mónica E Ureña-Guerrer. Glutamate induced neonatal excitotoxicity modifies the expression level of EAAT1 (GLAST) and EAAT2 (GLT-1) proteins in various brain regions of the adult rat. Neuroscience letters. vol 735. 2021-04-23. PMID:32645399. |
in this study, the expression levels of eaat1 (glast) and eaat2 (glt-1) proteins were assessed in the cerebral motor cortex (cmc), striatum, hippocampus and entorhinal cortex (ec) of male adult rats following the neonatal excitotoxic process triggered by monosodium glutamate (msg)-treatment (4 g/kg of body weight at postnatal days 1,3,5 and 7, subcutaneously). |
2021-04-23 |
2023-08-13 |
rat |
| Wenhao Li, Han Gao, Wentao L. Effects of Combined Bushen Zhichan Recipe and Levodopa in a Rodent Model of Parkinson Disease: Potential Mechanisms. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-04-14. PMID:32555131. |
the levodopa and bushen zhichan recipe group exhibited decreased glutamate receptors and increased γ-aminobutyric acid receptors in the striatum. |
2021-04-14 |
2023-08-13 |
rat |
| Crystal M Wilkie, Jessica C Barron, Kyle J Brymer, Jocelyn R Barnes, Firoozeh Nafar, Matthew P Parson. The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics. Frontiers in cellular neuroscience. vol 15. 2021-04-13. PMID:33841104. |
we found that while both ceftriaxone and ldn increased glt-1 expression in multiple brain regions, they did not prevent activity-dependent slowing of glutamate clearance nor did they speed basal clearance rates, even in areas characterized by slow uptake (e.g., striatum). |
2021-04-13 |
2023-08-13 |
mouse |
| Micaela Johanna Glat, Nadia Stefanova, Gregor Karl Wenning, Daniel Offe. Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 2. 2021-03-26. PMID:32065333. |
the aim of the current study was to test this concept by overexpression of excitatory amino acid transporter 2, glutamate dehydrogenase and nuclear factor (erythroid-derived 2)-related factor 2 genes in the striatum of two established mouse models of msa. |
2021-03-26 |
2023-08-13 |
mouse |
| Sara Fernández-García, Sara Conde-Berriozabal, Esther García-García, Clara Gort-Paniello, David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Soria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch, Mercè Masan. M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease. eLife. vol 9. 2021-03-15. PMID:33016873. |
moreover, optogenetically-induced glutamate release from m2 cortex terminals in the dorsolateral striatum (dls) was undetectable in hd mice and striatal neurons show blunted electrophysiological responses. |
2021-03-15 |
2023-08-13 |
mouse |
| Naila Kuhlmann, Miriam Wagner Valladolid, Lucía Quesada-Ramírez, Matthew J Farrer, Austen J Milnerwoo. Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons. Frontiers in cellular neuroscience. vol 15. 2021-03-10. PMID:33679324. |
while mechanisms regulating synapse development and plasticity are quite well described at excitatory synapses of glutamatergic neurons in the neocortex, comparatively little is known of how this translates to glutamate synapses onto gabaergic neurons in the striatum. |
2021-03-10 |
2023-08-13 |
Not clear |
| Willemieke M Kouwenhoven, Guillaume Fortin, Anna-Maija Penttinen, Clélia Florence, Benoît Delignat-Lavaud, Marie-Josée Bourque, Thorsten Trimbuch, Milagros Pereira Luppi, Alix Salvail-Lacoste, Pascale Legault, Jean-François Poulin, Christian Rosenmund, Raj Awatramani, Louis-Éric Trudea. VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 43. 2021-02-01. PMID:32928885. |
a subset of adult ventral tegmental area dopamine (da) neurons expresses vesicular glutamate transporter 2 (vglut2) and releases glutamate as a second neurotransmitter in the striatum, while only few adult substantia nigra da neurons have this capacity. |
2021-02-01 |
2023-08-13 |
Not clear |
| Kari A Johnson, Daniel J Liput, Gregg E Homanics, David M Lovinge. Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. Alcohol (Fayetteville, N.Y.). vol 82. 2021-01-12. PMID:31233806. |
age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure. |
2021-01-12 |
2023-08-13 |
mouse |
| Xing Li, Fan Jiang, Kai Yao, Lujia Yang, Xingyue Gao, Hongxia Chen, Xiaoli Wei, Ning Wu, Ru Zhou, Weixiu Yuan, Shuzhuo Zhan. Neuropeptide S attenuates methamphetamine-induced stereotyped behavior in rats. Biochemical and biophysical research communications. vol 527. issue 1. 2021-01-04. PMID:32446398. |
when meth (10 mg/kg) was administered to rats, the level of nps in the cerebrospinal fluid was not affected, but pretreatment with nps reversed meth-induced glutamate release in the hippocampus and striatum. |
2021-01-04 |
2023-08-13 |
rat |
| Fawaz Alasmari, Laura E Crotty Alexander, Alaa M Hammad, Austin Horton, Hasan Alhaddad, Isaac T Schiefer, John Shin, Alexander Moshensky, Youssef Sar. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Chemico-biological interactions. vol 333. 2020-12-29. PMID:33242460. |
we investigated the effects of daily e-cigarette exposure on protein levels of α7 nachr and α4/β2 nachr, gene expression and protein levels of astroglial glutamate transporters, including glutamate transporter-1 (glt-1) and cystine/glutamate antiporter (xct), in the frontal cortex (fc), striatum (str) and hippocampus (hip). |
2020-12-29 |
2023-08-13 |
mouse |
| Shakshi Sharma, Khadga Raj, Shamsher Sing. Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement-Induced Parkinson's Disease in Experimental Rats. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31654381. |
on the 29th day, all animals were sacrificed and striatum was isolated for biochemical (lpo, nitrite, gsh, mitochondrial complexes i and iv), neuroinflammatory (tnf-α, il-1β, and il-6), and neurotransmitter (dopamine, norepinephrine, serotonin, gaba, glutamate) estimation. |
2020-12-21 |
2023-08-13 |
rat |
| Ilaria Morella, Harriet Hallum, Riccardo Brambill. Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices. Frontiers in cellular neuroscience. vol 14. 2020-12-12. PMID:33304241. |
in the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (erk) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine d1 and ionotropic glutamate receptors. |
2020-12-12 |
2023-08-13 |
Not clear |