| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fudan Zhang, Xu Ho. The role of Forkhead box O in diabetes mellitus. Minerva endocrinology. 2022-06-16. PMID:35708174. |
foxo proteins are emerging as pivotal regulators in the progression of diabetes mellitus, mainly by inhibiting insulin or insulinlike growth factor，but little is known about their roles in diabetes mellitus. |
2022-06-16 |
2023-08-14 |
Not clear |
| Piaopiao Zhao, Xiaoxiao Zhang, Yuning Gong, Weihua Li, Zengrui Wu, Yun Tang, Guixia Li. Investigation of the mechanism of Shen Qi Wan prescription in the treatment of T2DM via network pharmacology and molecular docking. In silico pharmacology. vol 10. issue 1. 2022-06-08. PMID:35673584. |
besides, this study found that sqw treated the t2dm through insulin resistance (has04931), insulin signaling pathway (has04910), adipocytokine signaling pathway (has04920), ampk signaling pathway (has04152) and foxo signaling pathway (has04068) via ingredient-hub target-pathway network analysis. |
2022-06-08 |
2023-08-14 |
Not clear |
| Shanthie Thamotharan, Shubhamoy Ghosh, Laura James-Allan, Margarida Y Y Lei, Carla Janzen, Sherin U Devaska. Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies. PloS one. vol 17. issue 5. 2022-05-25. PMID:35613088. |
in particular genes of the p-i-3-kinase, foxo, insulin signaling and glucogenic pathways were targeted, suggestive of placental connectivity with various maternal organs/cells, altering physiology along with pathogenic mechanisms underlying the subsequent development of gdm. |
2022-05-25 |
2023-08-13 |
Not clear |
| Sujin Nam, Thao Phuong Le, SeYeon Chung, Kwang-Wook Cho. Tctp regulates the level and localization of Foxo for cell growth in Drosophila. Cell death discovery. vol 8. issue 1. 2022-04-01. PMID:35361773. |
insulin signaling regulates organ size by antagonizing the subgroup o of forkhead box transcription factor (foxo) through 14-3-3 in drosophila. |
2022-04-01 |
2023-08-13 |
human |
| Francesca Natale, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Saviana Antonella Barbati, Francesco La Greca, Matteo Spinelli, Salvatore Fusco, Claudio Grass. Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche. Stem cells (Dayton, Ohio). vol 40. issue 3. 2022-03-31. PMID:35356985. |
in an experimental model of insulin resistant nspcs, we identified a novel molecular circuit relying on insulin receptor substrate-1 (irs-1)/ forkhead box o (foxo) signaling cascade and inhibiting the recruitment of transcription factors foxo1 and foxo3a on the promoters of genes regulating proliferation and self-renewal. |
2022-03-31 |
2023-08-13 |
mouse |
| Gourav Bhardwaj, Christie M Penniman, Katherine Klaus, Eric T Weatherford, Hui Pan, Jonathan M Dreyfuss, K Sreekumaran Nair, C Ronald Kahn, Brian T O'Neil. Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors. Frontiers in physiology. vol 12. 2022-02-21. PMID:35185597. |
thus, combined loss of insulin and igf-1 action in muscle transcriptionally alters mitochondrial function and multiple regulatory and signaling pathways, and these changes are mediated by foxo transcription factors. |
2022-02-21 |
2023-08-13 |
mouse |
| Liyang Liu, Jun Bai, Fangxi Liu, Ying Xu, Mei Zhao, Chuansheng Zhao, Zhike Zho. Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer's Disease and Huntington's Disease. Oxidative medicine and cellular longevity. vol 2022. 2022-02-14. PMID:35154571. |
more specifically, foxo1 was involved in the foxo signaling pathway and cellular senescence in ad; correspondingly, foxo1 participated in insulin resistance, insulin, and the foxo signaling pathways in hd. |
2022-02-14 |
2023-08-13 |
Not clear |
| Yi Song, Feng Guo, Yifan Liu, Fengjuan Huang, Xunjie Fan, Lin Zhao, Guijun Qi. Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease. Bioengineered. vol 13. issue 2. 2022-02-07. PMID:35129424. |
metformin mainly affected the ampk and foxo signaling pathways, whereas vildagliptin affected insulin secretion and the hif-1 signaling pathway. |
2022-02-07 |
2023-08-13 |
human |
| María Concepción Izquierdo, Niroshan Shanmugarajah, Samuel X Lee, Michael J Kraakman, Marit Westerterp, Takumi Kitamoto, Michael Harris, Joshua R Cook, Galina A Gusarova, Kendra Zhong, Elijah Marbuary, InSug O-Sullivan, Nikolaus F Rasmus, Stefania Camastra, Terry G Unterman, Ele Ferrannini, Barry E Hurwitz, Rebecca A Haeusle. Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway. The Journal of clinical investigation. 2022-02-01. PMID:35104242. |
the insulin-repressible foxo transcription factors play a key role in mediating the effects of hepatic insulin action on glucose and lipoprotein metabolism. |
2022-02-01 |
2023-08-13 |
mouse |
| Erica P Homan, Bruna B Brandão, Samir Softic, Abdelfattah El Ouaamari, Brian T O'Neill, Rohit N Kulkarni, Jason K Kim, C Ronald Kah. Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue. The Journal of clinical investigation. vol 131. issue 19. 2021-11-29. PMID:34428182. |
differential roles of foxo transcription factors on insulin action in brown and white adipose tissue. |
2021-11-29 |
2023-08-13 |
mouse |
| Devesh Kesharwani, Amit Kumar, Mukta Poojary, Vinod Scaria, Malabika Datt. RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice. Bioscience reports. vol 41. issue 7. 2021-11-15. PMID:34190986. |
here, using rna sequencing, we identified 465 mrnas and 12 long non-coding rnas (lncrnas), to be differentially regulated in the skeletal muscle of diabetic mice and pathway enrichment analysis of these altered transcripts revealed pathways of insulin, foxo and amp-activated protein kinase (ampk) signaling to be majorly over-represented. |
2021-11-15 |
2023-08-13 |
mouse |
| Gourav Bhardwaj, Christie M Penniman, Jayashree Jena, Pablo A Suarez Beltran, Collin Foster, Kennedy Poro, Taylor L Junck, Antentor O Hinton, Rhonda Souvenir, Jordan D Fuqua, Pablo E Morales, Roberto Bravo-Sagua, William I Sivitz, Vitor A Lira, E Dale Abel, Brian T O'Neil. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. The Journal of clinical investigation. vol 131. issue 18. 2021-11-15. PMID:34343133. |
the actions of insulin and igf-1 through the insulin receptor (ir) and igf-1 receptor (igf1r) maintain muscle mass via suppression of forkhead box o (foxo) transcription factors, but whether foxo activation coordinates atrophy in concert with mitochondrial dysfunction is unknown. |
2021-11-15 |
2023-08-13 |
mouse |
| Ya-Fan Dai, Yu-Bang Shen, Shen-Tong Wang, Jia-Hua Zhang, Yu-Hong Su, Sheng-Chen Bao, Xiao-Yan Xu, Jia-Le L. RNA-Seq Transcriptome Analysis of the Liver and Brain of the Black Carp (Mylopharyngodon piceus) During Fasting. Marine biotechnology (New York, N.Y.). vol 23. issue 3. 2021-10-21. PMID:33864541. |
the kegg pathway analysis showed significant differences in expression of genes involved in metabolic and immune pathways, such as the insulin signaling pathway, pi3k-akt signaling pathway, camp signaling pathway, foxo signaling pathway, ampk signaling pathway, endocytosis, and apoptosis. |
2021-10-21 |
2023-08-13 |
Not clear |
| Allison Birnbaum, Xiaofen Wu, Marc Tatar, Nan Liu, Hua Ba. Age-Dependent Changes in Transcription Factor FOXO Targeting in Female Frontiers in genetics. vol 10. 2021-10-11. PMID:31134124. |
although the transcriptional regulation of foxo have been previously characterized (especially in long-lived insulin mutants and under stress conditions), how normal aging impacts the transcriptional activity of foxo is poorly understood. |
2021-10-11 |
2023-08-13 |
Not clear |
| Syed Aun Muhammad, Syeda Tahira Qousain Naqvi, Thanh Nguyen, Xiaogang Wu, Fahad Munir, Muhammad Babar Jamshed, QiYu Zhan. Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1. Computers in biology and medicine. vol 135. 2021-09-13. PMID:34261004. |
from a list of differential expressed genes, cisplatin downregulated the cyclin-dependent kinase inhibitor 1 (cdkn1a), tumor necrosis factor (fas), and sestrin-1 (sesn1) genes responsible for modifying signaling pathways, including the p53, jak-stat, foxo, mapk, mtor, p13-akt, toll-like receptor (tlr), adipocytokine, and insulin signaling pathways. |
2021-09-13 |
2023-08-13 |
Not clear |
| Anna E Garcia Whitlock, Jamarie Sostre-Colón, Matthew Gavin, Niels D Martin, Joseph A Baur, Carrie A Sims, Paul M Titchenel. Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia. Molecular metabolism. vol 51. 2021-08-23. PMID:33964506. |
forkhead box o (foxo) transcription factors are direct targets of insulin signaling in the liver that regulate glucose homeostasis via direct and indirect pathways. |
2021-08-23 |
2023-08-13 |
Not clear |
| Anna E Garcia Whitlock, Jamarie Sostre-Colón, Matthew Gavin, Niels D Martin, Joseph A Baur, Carrie A Sims, Paul M Titchenel. Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia. Molecular metabolism. vol 51. 2021-08-23. PMID:33964506. |
loss of hepatic foxo transcription factors reduces hyperglycemia in chronic insulin resistance; however, the role of foxos in stress-induced hyperglycemia is unknown. |
2021-08-23 |
2023-08-13 |
Not clear |
| Tatiana D Saccon, Augusto Schneider, Cindi G Marinho, Allancer D C Nunes, Sarah Noureddine, Joseph Dhahbi, Yury O Nunez Lopez, Gage LeMunyan, Roberto Salvatori, Carla R P Oliveira, Alécia A Oliveira-Santos, Nicolas Musi, Andrzej Bartke, Manuel H Aguiar-Oliveira, Michal M Masterna. Circulating microRNA profile in humans and mice with congenital GH deficiency. Aging cell. vol 20. issue 7. 2021-08-17. PMID:34118183. |
these regulated mirnas are known for targeting pathways associated with longevity such as mtor, insulin signaling, and foxo. |
2021-08-17 |
2023-08-13 |
mouse |
| Min Tan, Yanxiang Cheng, Xiaozhu Zhong, Dongyong Yang, Sushi Jiang, Yang Ye, Miao Ding, Guijun Guan, Dongzi Yang, Xiaomiao Zha. LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway. Aging. vol 13. issue 3. 2021-08-16. PMID:33495419. |
when insulin binds to the receptor, the pi3k/akt/foxo signaling pathway is activated, and foxo translocates from the nucleus to the cytoplasm, thereby inhibiting the expression of pro-apoptotic genes. |
2021-08-16 |
2023-08-13 |
Not clear |
| Robert Jp Pope, Kathryn L Garner, Margaritis Voliotis, Abigail C Lay, Virginie Ms Betin, Krasimira Tsaneva-Atanasova, Gavin I Welsh, Richard Jm Coward, Craig A McArdl. An information theoretic approach to insulin sensing by human kidney podocytes. Molecular and cellular endocrinology. vol 518. 2021-07-12. PMID:32750396. |
high content imaging was used to measure insulin effects on akt, foxo and erk. |
2021-07-12 |
2023-08-13 |
human |