| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiejie Zhang, Jingrui Huang, Yanhua Zhao, Weishe Zhan. The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics. Journal of human hypertension. 2021-06-25. PMID:34168274. |
the highly enriched pathways were foxo signaling pathway, circadian rhythm, insulin resistance, arachidonic acid metabolism, and drug metabolism-cytochrome p450. |
2021-06-25 |
2023-08-13 |
Not clear |
| Yong Hua Xue, Yi Qin G. Construction of lncRNA regulatory networks reveal the key lncRNAs associated with Pituitary adenomas progression. Mathematical biosciences and engineering : MBE. vol 17. issue 3. 2021-06-21. PMID:32233527. |
bioinformatics analysis showed these lncrnas were involved in regulating mechanical stimulus, gene expression, jak-stat cascade, cell cycle arrest, foxo signaling, hif-1 signaling, insulin signaling, oxytocin signaling, and mapk signaling. |
2021-06-21 |
2023-08-13 |
human |
| Nicolas J Betancourt, Subhash Rajpurohit, Esra Durmaz, Daniel K Fabian, Martin Kapun, Thomas Flatt, Paul Schmid. Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster. Molecular ecology. vol 30. issue 12. 2021-06-21. PMID:33914989. |
in drosophila melanogaster, multiple components of this pathway vary predictably with latitude; this includes foxo, a conserved gene that regulates insulin signalling and has pleiotropic effects on a variety of fitness-associated traits. |
2021-06-21 |
2023-08-13 |
drosophila_melanogaster |
| Neelakanteswar Aluru, Keegan S Krick, Adriane M McDonald, Sibel I Karchne. Developmental Exposure to PCB153 (2,2',4,4',5,5'-Hexachlorobiphenyl) Alters Circadian Rhythms and the Expression of Clock and Metabolic Genes. Toxicological sciences : an official journal of the Society of Toxicology. vol 173. issue 1. 2021-05-27. PMID:31621872. |
kegg pathway analysis revealed enrichment of genes related to circadian rhythm, foxo signaling, and insulin resistance pathways. |
2021-05-27 |
2023-08-13 |
zebrafish |
| Jiahua Zhang, Yubang Shen, Xiaoyan Xu, Yafan Dai, Jiale L. Transcriptome Analysis of the Liver and Muscle Tissues of Black Carp (Mylopharyngodon piceus) of Different Growth Rates. Marine biotechnology (New York, N.Y.). vol 22. issue 5. 2021-05-26. PMID:32914204. |
the kegg pathway analysis showed significant differences in the expression of some genes involved in growth- and development-related metabolic pathways such as the foxo signaling pathway, p53 signaling pathway, pi3k-akt signaling pathway, apoptosis, tgf-β signaling pathway, and insulin signaling pathway. |
2021-05-26 |
2023-08-13 |
Not clear |
| M E Molina Peña, C M Sánchez, C Y Rodríguez-Triviñ. Physiopathological mechanisms of diaphragmatic dysfunction associated with mechanical ventilation. Revista espanola de anestesiologia y reanimacion. vol 67. issue 4. 2021-05-10. PMID:31982168. |
this alteration has been related to disruption on the insulin growth factor/phosphoinositol 3-kinase/kinase b protein pathway (igf/pi3k/akt), in addition to an overexpression of foxo, expression of nf-kb signaling, increase function of muscular ubiquitin ligase and activation of caspasa-3. |
2021-05-10 |
2023-08-13 |
Not clear |
| Lei Sun, Lewei Guo, Jun Wang, Meng Li, Michael Osei Appiah, Hongyu Liu, Jing Zhao, Lianyu Yang, Wenfa L. Photoperiodic effect on the testicular transcriptome in broiler roosters. Journal of animal physiology and animal nutrition. vol 104. issue 3. 2021-03-04. PMID:32100373. |
the differentially expressed genes were enriched in the mammalian targets of rapamycin (mtor), forkhead box (foxo), transforming growth factor beta (tgf-β) and insulin signalling pathway. |
2021-03-04 |
2023-08-13 |
chicken |
| Lei Sun, Lewei Guo, Jun Wang, Meng Li, Michael Osei Appiah, Hongyu Liu, Jing Zhao, Lianyu Yang, Wenfa L. Photoperiodic effect on the testicular transcriptome in broiler roosters. Journal of animal physiology and animal nutrition. vol 104. issue 3. 2021-03-04. PMID:32100373. |
in conclusion, a 16 hr photoperiod for 4 weeks increased the seminiferous tubule duct area and promoted spermatogenesis in the rooster's testicles, and the mtor, foxo, tgf-β and insulin signalling pathways may be involved. |
2021-03-04 |
2023-08-13 |
chicken |
| Noriko Kodani, Jun Naka. Tissue-Specific Metabolic Regulation of FOXO-Binding Protein: FOXO Does Not Act Alone. Cells. vol 9. issue 3. 2021-02-17. PMID:32182991. |
foxo can convert the external stimuli of insulin, growth factors, nutrients, cytokines, and oxidative stress into cell-specific biological responses by regulating the transcriptional activity of target genes. |
2021-02-17 |
2023-08-13 |
Not clear |
| Shweta A More, Akshay S Patil, Nikhil S Sakle, Santosh N Mokal. Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs. Virology. vol 555. 2021-02-15. PMID:33421743. |
kegg pathway analysis involves multiple pathways (p < 0.05), including foxo, gnrh, erbb, neurotrophin, toll-like receptor, il-17, tnf, insulin, hif-1, jak-stat, estrogen, nf-kappa, chemokine, vegf, and thyroid hormone signaling pathway in sars-cov-2. |
2021-02-15 |
2023-08-13 |
Not clear |
| Kun Dong, Qiuchen Zhao, Yaqiang Xue, Yaxun Wei, Yi Zhang, Yan Yan. TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. Gene. vol 768. 2021-01-25. PMID:33122078. |
knock-down of tctp led to 287 differentially expressed genes (degs) that were highly associated with cellular apoptosis and signal response, tnf and nf-κb signaling pathways, glycolysis/gluconeogenesis, insulin resistance, foxo and insulin signaling pathways, adipocytokine and ampk signaling pathways. |
2021-01-25 |
2023-08-13 |
mouse |
| Olatunde P Olademehin, Chengyin Liu, Binayak Rimal, Nathaniel F Adegboyega, Fu Chen, Cheolho Sim, Sung Joon Ki. Dsi-RNA knockdown of genes regulated by Foxo reduces glycogen and lipid accumulations in diapausing Culex pipiens. Scientific reports. vol 10. issue 1. 2021-01-14. PMID:33057122. |
pipiens survive overwinter through diapause which is an important survival strategy that is under the control of insulin signaling and foxo by regulating energy metabolism. |
2021-01-14 |
2023-08-13 |
Not clear |
| Rebecca S Rivard, Julia M Morris, Matthew J Youngma. The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans. PloS one. vol 15. issue 12. 2021-01-13. PMID:33315870. |
insulin and insulin-like growth factors are longevity determinants that negatively regulate forkhead box class o (foxo) transcription factors. |
2021-01-13 |
2023-08-13 |
human |
| Zuoqiong Zhou, Lan Zheng, Changfa Tang, Zhanglin Chen, Runkang Zhu, Xiyang Peng, Xiushan Wu, Ping Zh. Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in physiology. vol 11. 2020-12-18. PMID:33329019. |
high-throughput rna-seq analysis revealed that the differentially expressed genes were enriched in the regulation of autophagy, protein folding, and degradation, myofibril development, angiogenesis, metabolic reprogramming, and insulin and foxo signaling pathways. |
2020-12-18 |
2023-08-13 |
zebrafish |
| Jun Chen, Dong-Nan Cui, Hidayat Ullah, Shuang Li, Fan Pan, Chao-Min Xu, Xiong-Bing Tu, Ze-Hua Zhan. The Function of Insects. vol 11. issue 11. 2020-11-28. PMID:33167530. |
a previous study showed that forkhead box protein o (foxo) in the insulin signaling pathway (isp) plays a vital role in regulating locust diapause by phosphorylation, which can be promoted by the high level of ros. |
2020-11-28 |
2023-08-13 |
Not clear |
| Neil D Marks, Alan D Winter, Henry Y Gu, Kirsty Maitland, Victoria Gillan, Martin Ambroz, Axel Martinelli, Roz Laing, Rachel MacLellan, Jessica Towne, Brett Roberts, Eve Hanks, Eileen Devaney, Collette Britto. Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31772378. |
epistasis studies with c. elegans daf-2 mutants showed that mir-228 and mir-235 synergise with foxo transcription factor daf-16 in the insulin signaling pathway. |
2020-11-09 |
2023-08-13 |
caenorhabditis_elegans |
| Kentaro Kawata, Atsushi Hatano, Katsuyuki Yugi, Hiroyuki Kubota, Takanori Sano, Masashi Fujii, Yoko Tomizawa, Toshiya Kokaji, Kaori Y Tanaka, Shinsuke Uda, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Kaori Saitoh, Keiko Kato, Ayano Ueno, Maki Ohishi, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kurod. Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks. iScience. vol 7. 2020-10-01. PMID:30267682. |
the induced insulin signal was selectively transmitted through the pathway involving erk to an increase in the expression of immediate-early and upregulated genes, whereas the basal insulin signal was selectively transmitted through a pathway involving akt and an increase of foxo phosphorylation and a reduction of downregulated gene expression. |
2020-10-01 |
2023-08-13 |
rat |
| Soheila Asadi, Zohreh Rahimi, Massoud Saidijam, Nooshin Shabab, Mohammad Taghi Goodarz. Effects of Resveratrol on International journal of molecular and cellular medicine. vol 7. issue 3. 2020-10-01. PMID:31565649. |
fork head-related transcription factor (foxo) proteins are important transcriptional factors involved in oxidative stress and insulin resistance. |
2020-10-01 |
2023-08-13 |
Not clear |
| Esra Durmaz, Subhash Rajpurohit, Nicolas Betancourt, Daniel K Fabian, Martin Kapun, Paul Schmidt, Thomas Flat. A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila. Evolution; international journal of organic evolution. vol 73. issue 9. 2020-08-18. PMID:31111462. |
a clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in drosophila. |
2020-08-18 |
2023-08-13 |
drosophila_melanogaster |
| Yingyue Zhao, Shuangshuang Dong, Yan Kong, Qi Rui, Dayong Wan. Molecular basis of intestinal canonical Wnt/β-catenin BAR-1 in response to simulated microgravity in Caenorhabditis elegans. Biochemical and biophysical research communications. vol 522. issue 1. 2020-08-17. PMID:31757422. |
moreover, unc-62 regulated the response to simulated microgravity by suppressing the function of foxo transcriptional factor daf-16 and its target (mitochondrial mn-sod/sod-3) in insulin signaling pathway. |
2020-08-17 |
2023-08-13 |
caenorhabditis_elegans |