| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rohit Pardeshi, Nityanand Bolshette, Kundlik Gadhave, Ashutosh Ahire, Sahabuddin Ahmed, Tommaso Cassano, Veer Bala Gupta, Mangala Lahka. Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease. Psychoneuroendocrinology. vol 83. 2018-04-17. PMID:28624654. |
several pathways, like enzymatic degradation of aβ, forkhead box protein o1 (foxo) signaling, insulin signaling shared common pathological mechanism for both ad and dm. |
2018-04-17 |
2023-08-13 |
Not clear |
| Jianping Guo, Ji Cheng, Brian J North, Wenyi We. Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. Biochimica et biophysica acta. Reviews on cancer. vol 1868. issue 2. 2018-03-06. PMID:28694093. |
although various biological processes predominately governing tumorigenesis such as inflammation, metabolic alteration, oxidative stress and insulin resistance have been associated with ad genesis, the mechanistic connection of these biological processes and signaling pathways including mtor, mapk, sirt, hif, and the foxo pathway controlling aging and the pathological lesions of ad are not well recapitulated. |
2018-03-06 |
2023-08-13 |
human |
| Srividhya Iyer, Li Han, Elena Ambrogini, Maria Yavropoulou, John Fowlkes, Stavros C Manolagas, Maria Almeid. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 32. issue 1. 2018-01-08. PMID:27491024. |
insulin promotes osteoblast formation and inhibits the activity of the foxo transcription factors. |
2018-01-08 |
2023-08-13 |
mouse |
| Wolfgang Link, Pablo J Fernandez-Marco. FOXO transcription factors at the interface of metabolism and cancer. International journal of cancer. vol 141. issue 12. 2017-10-27. PMID:28631330. |
the signalling cascade connecting insulin and foxo proteins provides a compelling example for a conserved pathway at the interface between insulin signalling and cancer. |
2017-10-27 |
2023-08-13 |
Not clear |
| Wolfgang Link, Pablo J Fernandez-Marco. FOXO transcription factors at the interface of metabolism and cancer. International journal of cancer. vol 141. issue 12. 2017-10-27. PMID:28631330. |
there is emerging evidence that deregulation of foxo factors might account for the association between insulin resistance-related metabolic disorders and cancer. |
2017-10-27 |
2023-08-13 |
Not clear |
| Katarzyna Ropka-Molik, Anna Bereta, Kacper Żukowski, Katarzyna Piórkowska, Artur Gurgul, Grzegorz Ża. Transcriptomic gene profiling of porcine muscle tissue depending on histological properties. Animal science journal = Nihon chikusan Gakkaiho. vol 88. issue 8. 2017-09-21. PMID:28026080. |
the degs were included in: pi3k-akt; foxo and mapk signaling pathways, regulation of actin cytoskeleton, lysine degradation and insulin signaling pathway as well as mtor and hippo signaling pathways. |
2017-09-21 |
2023-08-13 |
Not clear |
| Emmanuel Nwadozi, Emilie Roudier, Eric Rullman, Sujeenthar Tharmalingam, Hsin-Yi Liu, Thomas Gustafsson, Tara L Haa. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27235148. |
endothelial foxo proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. |
2017-08-22 |
2023-08-13 |
mouse |
| Emmanuel Nwadozi, Emilie Roudier, Eric Rullman, Sujeenthar Tharmalingam, Hsin-Yi Liu, Thomas Gustafsson, Tara L Haa. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27235148. |
in hf-fed mice, endothelium-directed depletion of foxo1/3/4 (foxo(Δ)) improved insulin sensitivity (+110%) compared to that of the controls (foxo(l/l)). |
2017-08-22 |
2023-08-13 |
mouse |
| Emmanuel Nwadozi, Emilie Roudier, Eric Rullman, Sujeenthar Tharmalingam, Hsin-Yi Liu, Thomas Gustafsson, Tara L Haa. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27235148. |
we conclude that endothelial foxo proteins promote insulin resistance in hf diet, which may in part result from foxo proteins establishing an antiangiogenic and proinflammatory microenvironment within skeletal muscle. |
2017-08-22 |
2023-08-13 |
mouse |
| Emmanuel Nwadozi, Emilie Roudier, Eric Rullman, Sujeenthar Tharmalingam, Hsin-Yi Liu, Thomas Gustafsson, Tara L Haa. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27235148. |
these findings provide mechanistic insight into the development of microvascular dysfunction in the progression of type 2 diabetes.-nwadozi, e., roudier, e., rullman, e., tharmalingam, s., liu, h.-y., gustafsson, t., haas, t. l. endothelial foxo proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. |
2017-08-22 |
2023-08-13 |
mouse |
| Jingmin Zhu, Lingling Hu, Lingyun Li, Xiao Huang, Huahong Sh. Comparison of phenotypic and global gene expression changes in Xenopus tropicalis embryos induced by agonists of RAR and RXR. Toxicology and applied pharmacology. vol 330. 2017-08-14. PMID:28689802. |
at-ra primarily affected the retinol, glycolysis, starch and sucrose metabolisms while fba led to disturbances in more wide-ranging pathways such as the ppar, adipocytokine, insulin, foxo signaling pathways, alanine, aspartate and glutamate metabolism. |
2017-08-14 |
2023-08-13 |
xenopus_laevis |
| Augusto Schneider, Scot J Matkovich, Berta Victoria, Lina Spinel, Andrzej Bartke, Pawel Golusinski, Michal M Masterna. Changes of Ovarian microRNA Profile in Long-Living Ames Dwarf Mice during Aging. PloS one. vol 12. issue 1. 2017-08-09. PMID:28046124. |
many genes likely to be targeted by these mirnas are involved in the foxo, mtor, pi3k/akt and insulin signaling pathways. |
2017-08-09 |
2023-08-13 |
mouse |
| Valentina Guzmán-Pérez, Christiane Bumke-Vogt, Monika Schreiner, Inga Mewis, Andrea Borchert, Andreas F H Pfeiffe. Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells. PloS one. vol 11. issue 9. 2017-08-08. PMID:27622707. |
foxo transcription factors can antagonize insulin effects and trigger a variety of cellular processes involved in tumor suppression, longevity, development and metabolism. |
2017-08-08 |
2023-08-13 |
human |
| Baosheng Zeng, Yuping Huang, Jun Xu, Takahiro Shiotsuki, Hua Bai, Subba Reddy Palli, Yongping Huang, Anjiang Ta. The FOXO transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, The Journal of biological chemistry. vol 292. issue 28. 2017-08-03. PMID:28490635. |
the foxo transcription factor controls insect growth and development by regulating juvenile hormone degradation in the silkworm, forkhead box o (foxo) functions as the terminal transcription factor of the insulin signaling pathway and regulates multiple physiological processes in many organisms, including lifespan in insects. |
2017-08-03 |
2023-08-13 |
Not clear |
| Sojin Lee, H Henry Don. FoxO integration of insulin signaling with glucose and lipid metabolism. The Journal of endocrinology. vol 233. issue 2. 2017-05-22. PMID:28213398. |
foxo integration of insulin signaling with glucose and lipid metabolism. |
2017-05-22 |
2023-08-13 |
Not clear |
| Sojin Lee, H Henry Don. FoxO integration of insulin signaling with glucose and lipid metabolism. The Journal of endocrinology. vol 233. issue 2. 2017-05-22. PMID:28213398. |
foxo6 mediates insulin action on target genes in a mechanism that is fundamentally different from other foxo members. |
2017-05-22 |
2023-08-13 |
Not clear |
| Rute Martins, Gordon J Lithgow, Wolfgang Lin. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging cell. vol 15. issue 2. 2017-01-11. PMID:26643314. |
foxo proteins represent a subfamily of transcription factors conserved from caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin-like growth factor signaling. |
2017-01-11 |
2023-08-13 |
human |
| Chuan-Xu Wang, Ai-Hua Zha. Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO. Gene. vol 587. issue 1. 2017-01-10. PMID:27106118. |
leptin receptor overlapping transcript (leprot) gene participates in insulin pathway through foxo. |
2017-01-10 |
2023-08-13 |
Not clear |
| Wenwei Zhang, So Young Bu, Mara T Mashek, InSug O-Sullivan, Zakaria Sibai, Salmaan A Khan, Olga Ilkayeva, Christopher B Newgard, Douglas G Mashek, Terry G Unterma. Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins. Cell reports. vol 15. issue 2. 2016-12-30. PMID:27050511. |
foxo proteins are major targets of insulin action and contribute to the regulation of gluconeogenesis, glycolysis, and lipogenesis in the liver. |
2016-12-30 |
2023-08-13 |
Not clear |
| Seth A Wescott, Elizabeth A Ronan, X Z Shawn X. Insulin signaling genes modulate nicotine-induced behavioral responses in Caenorhabditis elegans. Behavioural pharmacology. vol 27. issue 1. 2016-09-19. PMID:26317299. |
this phenotype could be suppressed by mutations in daf-16, a gene encoding a foxo transcription factor that acts downstream of insulin signaling. |
2016-09-19 |
2023-08-13 |
caenorhabditis_elegans |