| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei-Juan Cai, Wen-Li Zhao, Yu-Pu Jing, Qian Song, Xiao-Qian Zhang, Jin-Xing Wang, Xiao-Fan Zha. 20-Hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting. Development (Cambridge, England). vol 143. issue 6. 2016-08-01. PMID:26893349. |
insulin inhibits transcription factor forkhead box o (foxo) activity, and the steroid hormone 20-hydroxyecdysone (20e) activates foxo; however, the mechanism is unclear. |
2016-08-01 |
2023-08-13 |
Not clear |
| Mei-Juan Cai, Wen-Li Zhao, Yu-Pu Jing, Qian Song, Xiao-Qian Zhang, Jin-Xing Wang, Xiao-Fan Zha. 20-Hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting. Development (Cambridge, England). vol 143. issue 6. 2016-08-01. PMID:26893349. |
insulin, via akt, induces foxo phosphorylation and cytoplasmic localization. |
2016-08-01 |
2023-08-13 |
Not clear |
| Mei-Juan Cai, Wen-Li Zhao, Yu-Pu Jing, Qian Song, Xiao-Qian Zhang, Jin-Xing Wang, Xiao-Fan Zha. 20-Hydroxyecdysone activates Forkhead box O to promote proteolysis during Helicoverpa armigera molting. Development (Cambridge, England). vol 143. issue 6. 2016-08-01. PMID:26893349. |
hence, 20e activates foxo via upregulating pten expression to counteract insulin activity and promote proteolysis. |
2016-08-01 |
2023-08-13 |
Not clear |
| Utpal B Pajvani, Domenico Accil. The new biology of diabetes. Diabetologia. vol 58. issue 11. 2016-07-26. PMID:26248647. |
work on forkhead box protein o (foxo) transcription factors revealed new aspects of insulin action that have led us to articulate a liver- and beta cell-centric narrative of diabetes pathophysiology and treatment. |
2016-07-26 |
2023-08-13 |
Not clear |
| Yasaman Mirdamadi, Anja Thielitz, Antje Wiede, Alexander Goihl, Eleni Papakonstantinou, Roland Hartig, Christos C Zouboulis, Dirk Reinhold, Luca Simeoni, Ursula Bommhardt, Sven Quist, Harald Gollnic. Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro. Molecular and cellular endocrinology. vol 415. 2016-07-12. PMID:26257240. |
we found that high concentrations of igf-1 and insulin differentially stimulate the pi3k/akt/foxo1 pathway by an early up-regulation of cytoplasmic p-akt and delayed up-regulation of p-foxo1 resulting in foxo1 shift to the cytoplasm and the reduction of foxo transcriptional activity, physiological serum concentration had no effect. |
2016-07-12 |
2023-08-13 |
Not clear |
| Kenneth Maies. FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus. Current neurovascular research. vol 12. issue 4. 2016-06-07. PMID:26256004. |
foxo proteins can regulate insulin signaling, gluconeogenesis, insulin resistance, immune cell migration, and cell senescence. |
2016-06-07 |
2023-08-13 |
Not clear |
| Yi-Bei Wu, Wen-Jia Yang, Yi-Fei Xie, Kang-Kang Xu, Yi Tian, Guo-Rui Yuan, Jin-Jun Wan. Molecular characterization and functional analysis of BdFoxO gene in the oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae). Gene. vol 578. issue 2. 2016-05-31. PMID:26701614. |
the forkhead box o transcription factor (foxo) is an important downstream transcription factor in the well-conserved insulin signaling pathway, which regulates the body size and development of insects. |
2016-05-31 |
2023-08-13 |
drosophila_melanogaster |
| InSug O-Sullivan, Wenwei Zhang, David H Wasserman, Chong Wee Liew, Jonathan Liu, Jihye Paik, Ronald A DePinho, Donna Beer Stolz, C Ronald Kahn, Michael W Schwartz, Terry G Unterma. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature communications. vol 6. 2016-05-06. PMID:25963540. |
foxo proteins are major targets of insulin action. |
2016-05-06 |
2023-08-13 |
mouse |
| Nadine Urban, Dimitrios Tsitsipatis, Andrea Gille, Ingrit Hamann, Xiaoqing Hou, Lars-Oliver Klot. Modulation of cellular thiol status affects FoxO activity and life span. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461409. |
here, we investigated the effect of dem exposure on insulin signaling at the level of foxo transcription factor activity and its potential consequences for stress resistance and life span. |
2016-03-01 |
2023-08-13 |
human |
| Thomas K Sin, Benjamin Y Yung, Parco M Si. Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 2. 2015-10-13. PMID:25612477. |
foxo1, a member of the foxo transcription factor family, is an important player in insulin signaling due to its inhibitory role in glucose uptake and utilization in skeletal muscle. |
2015-10-13 |
2023-08-13 |
Not clear |
| Inês Chaves, Gijsbertus T J van der Horst, Raymond Schellevis, Romana M Nijman, Marian Groot Koerkamp, Frank C P Holstege, Marten P Smidt, Marco F M Hoekma. Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription. Current biology : CB. vol 24. issue 11. 2015-09-14. PMID:24856209. |
finally, we show that insulin, a major regulator of foxo activity [6-9], regulates clock levels in a pi3k- and foxo3-dependent manner. |
2015-09-14 |
2023-08-13 |
mouse |
| Cheolho Sim, David S Kang, Sungshil Kim, Xiaodong Bai, David L Denlinge. Identification of FOXO targets that generate diverse features of the diapause phenotype in the mosquito Culex pipiens. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 12. 2015-06-15. PMID:25775593. |
insulin and juvenile hormone signaling direct entry of the mosquito culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appear to do so by converging on the regulation of forkhead transcription factor (foxo). |
2015-06-15 |
2023-08-13 |
Not clear |
| Ingrit Hamann, Kerstin Petroll, Xiaoqing Hou, Anwar Anwar-Mohamed, Ayman O S El-Kadi, Lars-Oliver Klot. Acute and long-term effects of arsenite in HepG2 cells: modulation of insulin signaling. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 27. issue 2. 2015-01-16. PMID:24535192. |
the phosphoinositide 3'-kinase (pi3k)/akt signaling pathway plays an important role in insulin signaling by controlling glucose metabolism, in part through regulating the activity of foxo transcription factors. |
2015-01-16 |
2023-08-12 |
human |
| Ashley E Webb, Anne Brune. FOXO transcription factors: key regulators of cellular quality control. Trends in biochemical sciences. vol 39. issue 4. 2014-12-19. PMID:24630600. |
foxo transcription factors are conserved regulators of longevity downstream of insulin signaling. |
2014-12-19 |
2023-08-12 |
Not clear |
| S Carbajo-Pescador, J L Mauriz, A García-Palomo, J González-Galleg. FoxO proteins: regulation and molecular targets in liver cancer. Current medicinal chemistry. vol 21. issue 10. 2014-11-10. PMID:24372208. |
human forkhead box class o (foxo) transcription factors, activated in response to a wide range of external stimuli, like growth factors, insulin, nutrient levels and oxidative stress, are able to control several specific geneexpression programs. |
2014-11-10 |
2023-08-12 |
human |
| Annie Dutriaux, Aurélie Godart, Anna Brachet, Joël Silbe. The insulin receptor is required for the development of the Drosophila peripheral nervous system. PloS one. vol 8. issue 9. 2014-04-28. PMID:24069139. |
the foxo transcription factor which is localized in the cytoplasm upon insulin uptake, displays strong genetic interaction with the inr and is involved in ac regulation. |
2014-04-28 |
2023-08-12 |
drosophila_melanogaster |
| Songül Süren-Castillo, Marc Abrisqueta, José L Maestr. FoxO is required for the activation of hypertrehalosemic hormone expression in cockroaches. Biochimica et biophysica acta. vol 1840. issue 1. 2014-03-13. PMID:23994493. |
this pathway, activated by the binding of insulin or igfs (or insect insulin-like peptides), promotes the phosphorylation and inactivation of foxo because of its export from the nucleus to the cytoplasm. |
2014-03-13 |
2023-08-12 |
Not clear |
| Dae Hyun Kim, Ting Zhang, Sojin Lee, H Henry Don. FoxO6 in glucose metabolism (FoxO6). Journal of diabetes. vol 5. issue 3. 2014-03-10. PMID:23324123. |
insulin inhibits foxo6 activity by promoting its phosphorylation and disabling its activity in the nucleus without altering its subcellular distribution via a mechanism that is distinct from other members of the foxo subfamily. |
2014-03-10 |
2023-08-12 |
mouse |
| Tingting Gu, Tao Zhao, Randall S Hewe. Insulin signaling regulates neurite growth during metamorphic neuronal remodeling. Biology open. vol 3. issue 1. 2014-01-16. PMID:24357229. |
foxo, a negative effector in the insulin signaling pathway, blocked metamorphic growth of peptidergic neurons that secrete the neuropeptides ccap and bursicon. |
2014-01-16 |
2023-08-12 |
drosophila_melanogaster |
| Tingting Gu, Tao Zhao, Randall S Hewe. Insulin signaling regulates neurite growth during metamorphic neuronal remodeling. Biology open. vol 3. issue 1. 2014-01-16. PMID:24357229. |
in contrast, expression of wild-type or constitutively active forms of inr, pi3k92e, akt1, rheb, and tor, as well as rna interference for negative regulators of insulin signaling (pten, foxo), stimulated overgrowth. |
2014-01-16 |
2023-08-12 |
drosophila_melanogaster |